THIAMINE ( DrugBank: Thiamine )

4 diseases

告示番号	疾患名（ページ内リンク）	臨床試験数
8	ハンチントン病	2
13	多発性硬化症／視神経脊髄炎	1
93	原発性胆汁性胆管炎	2
265	脂肪萎縮症	1

8. ハンチントン病

臨床試験数 : 229 / 薬物数 : 193 - (DrugBank : 60) / 標的遺伝子数 : 84 - 標的パスウェイ数 : 158

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04478734 (ClinicalTrials.gov)	January 1, 2022	11/2/2020	Trial of the Combined Use of Thiamine and Biotin in Patients With Huntington's Disease	Multicentric Trial on the Use of Combined Therapy of Thiamine and Biotine in Patients With Huntington´s Disease	Huntington Disease	Drug: Moderate doses of Thiamine y Biotin;Drug: High doses of Thiamine y Biotin	Fundación Pública Andaluza para la gestión de la Investigación en Sevilla	Ciberned (Centro de Investigación Biomédica en Red)	Not yet recruiting	18 Years	N/A	All	24	Phase 2	Spain
2	EUCTR2019-004360-22-ES (EUCTR)	22/10/2021	10/01/2020	Trial on the use of thiamine and biotin in patients with Huntington's disease.	MULTI-TECHNICAL TEST ON THE USE OF COMBINED THERAPY OF THEMIN AND BIOTINE IN PATIENTS WITH HUNTINGTON'S DISEASE - Huntiam	Huntington´s disease MedDRA version: 20.0;Level: PT;Classification code 10070668;Term: Huntington's disease;System Organ Class: 10010331 - Congenital, familial and genetic disorders;Therapeutic area: Diseases [C] - Nervous System Diseases [C10]	Trade Name: Benerva Product Name: Benerva Product Name: Biotina INN or Proposed INN: BIOTIN Other descriptive name: Vitamin B7	Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (Ciberned)	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	24	Phase 2	Spain

13. 多発性硬化症／視神経脊髄炎

臨床試験数 : 3,342 / 薬物数 : 2,355 - (DrugBank : 406) / 標的遺伝子数 : 269 - 標的パスウェイ数 : 241

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT01381354 (ClinicalTrials.gov)	October 2010	26/5/2011	Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS)	Nutrition, Neuromuscular Electrical Stimulation (NMES) and Secondary Progressive Multiple Sclerosis (SPMS)	Multiple Sclerosis	Other: Progressive exercise;Device: Neuromuscular electrical stimulation delivered using the electrical therapy device EMPI 300 PV;Other: Modified paleolithic diet;Dietary Supplement: Omega 3 fatty acids;Dietary Supplement: Full Spectrum vitamin;Dietary Supplement: Essential - hydroxytyrosol;Dietary Supplement: Maltodextrin fiber supplement;Dietary Supplement: Mineral boost (magnesium);Dietary Supplement: Niacinamide;Dietary Supplement: Methyl B12;Dietary Supplement: Taurine;Dietary Supplement: creatine;Dietary Supplement: thiamine;Dietary Supplement: riboflavin;Dietary Supplement: N acetylcysteine;Dietary Supplement: alpha lipoic acid;Dietary Supplement: L acetyl carnitine;Dietary Supplement: methyl folate;Dietary Supplement: coenzyme Q;Behavioral: meditation;Behavioral: self massage;Behavioral: learning;Dietary Supplement: Coconut oil	University of Iowa	Direct MS Canada;DJO Incorporated;Pinnaclife Inc.;TZ Press, LLC	Completed	18 Years	65 Years	All	38	Phase 1	United States

93. 原発性胆汁性胆管炎

臨床試験数 : 282 / 薬物数 : 245 - (DrugBank : 56) / 標的遺伝子数 : 35 - 標的パスウェイ数 : 113

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04893993 (ClinicalTrials.gov)	May 12, 2021	4/5/2021	PBC Induced Fatigue Treated With Thiamine	PBC Induced Fatigue Treated With Thiamine (PIFT) - The Effect of Oral Thiamine Supplement in 4 Weeks to Patients With Primary Biliary Cholangitis (PBC) and Chronic Fatigue. A Randomised Placebo Controlled Crossover Study	Primary Biliary Cirrhosis	Drug: Thiamine;Drug: Placebo	Henning Grønbæk	Aarhus University Hospital;Hospitalsapoteket Region Midtjylland;GCP-unit at Aarhus University Hospital, Aarhus, Denmark;Region Hovedstadens Apotek	Recruiting	18 Years	N/A	All	36	Phase 4	Denmark
2	EUCTR2020-004935-26-DK (EUCTR)	25/02/2021	09/12/2020	Vitamin B1 as treatment for chronic fatigue in patients with primary biliary cholangitis	PBC induced fatigue treated with thiamine- The effect of oral thiamine supplement in 4 weeks to patients with primary biliary cholangitis (PBC) and chronic fatigue.A randomised, double-blinded, placebo-controlled, crossover study - PIFT	Primary biliary cholangitis MedDRA version: 21.0;Level: PT;Classification code 10080429;Term: Primary biliary cholangitis;System Organ Class: 10019805 - Hepatobiliary disorders MedDRA version: 20.1;Level: LLT;Classification code 10066564;Term: Chronic fatigue;System Organ Class: 100000004867;Therapeutic area: Diseases [C] - Symptoms and general pathology [C23]	Trade Name: Tiamin SAD INN or Proposed INN: THIAMINE Other descriptive name: Tiamin DAK	Aarhus University Hospital	NULL	Authorised-recruitment may be ongoing or finished			Female: yes Male: yes	36	Phase 2	Denmark

265. 脂肪萎縮症

臨床試験数 : 116 / 薬物数 : 170 - (DrugBank : 61) / 標的遺伝子数 : 26 - 標的パスウェイ数 : 97

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00202228 (ClinicalTrials.gov)	July 2002	13/9/2005	Lactate Metabolism Study in HIV Infected Persons	Lactic Acid Metabolism in HIV-Infected Persons. Predicting Abnormalities in Lactate Production and Clearance Related to Treatment and Liver Disease and Measuring the Impact of Vitamin Supplementation.	HIV Infections;AIDS;Lactic Acidosis;Lipodystrophy	Drug: cofactor supplementation (thiamine, riboflavin, L-carnitine)	Queen's University	Ontario HIV Treatment Network	Completed	18 Years	N/A	Both	30	Phase 4	Canada

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