DDrare: Database of Drug Development for Rare Diseases

45. 好酸球性多発血管炎性肉芽腫症
［臨床試験数：27，薬物数：41（DrugBank：18），標的遺伝子数：18，標的パスウェイ数：98］

Searched query = "Eosinophilic granulomatosis with Polyangiitis", "EGPA", "Eosinophilic multiple vasculitis granulomatous disease", "Allergic granulomatous angiitis", "Churg-Strauss syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Drug = Anti-thymocyte globulin; Azathioprine; Benralizumab; CYCLOPHOSPHAMIDE; Corticosteroid; Corticosteroid and azathioprine; Cyclophosphamide; Cyclophosphamide, Azathioprine,prednisone,methylprednisolone; Cyclosporine; Filgrastim; Freeze-Dried Sulfonated Human Normal Immunoglobulin (GGS); HPC cell infusion; Human normal immunoglobulin; Hydroxychloroquine; Infliximab; L04AC06; MEDI-563; MEPOLIZUMAB; MESNA; Mepolizumab; Mesna; Methotrexate; Methylprednisolone; Mycophenolate; Mycophenolate mofetil; Mycophenolate mofetil,methotrexate; NUCALA; Naltrexone; Naltrexone Hydrochloride; Nucala; Nucala 100 mg powder for solution for injection; Placebo (physiological saline); Plaquenil - Hydroxychloroquine 200mg Film coated tablets; Prednisolone; Prednisone; Prednisone, methylprednisolone,cyclophosphamides; Procedure: Autologous Peripheral Blood Stem Cell Transplantation; RITUXIMAB; Rituximab; SB-240563; SB-240563 (mepolizumab)

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT00424749 (ClinicalTrials.gov)	June 2007	19/1/2007	Rituxan in Churg Strauss Syndrome With Renal Involvement	A Pilot Study on the Use of Rituximab in the Treatment of Churg- Strauss Syndrome With Renal Involvement	Churg-Strauss Syndrome	Drug: Rituximab;Drug: Prednisone	Fernando Fervenza	Genentech, Inc.;Biogen;National Center for Research Resources (NCRR)	Terminated	18 Years	N/A	All	4	Phase 2	United States
2	NCT00307671 (ClinicalTrials.gov)	July 2005	27/3/2006	Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years	Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years Comparison of Two Strategies Combining Steroids With or Without Immunosuppressants	Vasculitis;Wegener's Granulomatosis;Microscopic Polyangiitis;Churg-Strauss Syndrome;Polyarteritis Nodosa	Drug: prednisone , methylprednisolone,cyclophosphamides;Drug: Cyclophosphamide , Azathioprine,prednisone,methylprednisolone;Drug: Mycophenolate mofetil ,methotrexate	Assistance Publique - Hôpitaux de Paris	NULL	Completed	65 Years	N/A	Both	108	Phase 4	France
3	NCT00006055 (ClinicalTrials.gov)	March 2000	5/7/2000	Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases		Purpura, Schoenlein-Henoch;Graft Versus Host Disease;Anemia, Hemolytic, Autoimmune;Rheumatoid Arthritis;Churg-Strauss Syndrome;Hypersensitivity Vasculitis;Wegener's Granulomatosis;Systemic Lupus Erythematosus;Giant Cell Arteritis;Pure Red Cell Aplasia;Juvenile Rheumatoid Arthritis;Polyarteritis Nodosa;Autoimmune Thrombocytopenic Purpura;Takayasu Arteritis	Drug: anti-thymocyte globulin;Drug: cyclophosphamide;Drug: cyclosporine;Drug: filgrastim;Drug: methylprednisolone;Drug: prednisone;Procedure: Autologous Peripheral Blood Stem Cell Transplantation	Fairview University Medical Center	NULL	Active, not recruiting	1 Year	55 Years	Both	10	N/A	United States

No.

TrialID

Date_
enrollment

Date_
registration

Public_title

Scientific_title

Condition

Intervention

Primary_
sponsor

Secondary_
sponsor

Recruitment_
Status

Inclusion_
agemin

Inclusion_
agemax

Inclusion_
gender

Target_
size

Phase

Countries

NCT00424749
(ClinicalTrials.gov)

June 2007

19/1/2007

Rituxan in Churg Strauss Syndrome With Renal Involvement

A Pilot Study on the Use of Rituximab in the Treatment of Churg- Strauss Syndrome With Renal Involvement

Churg-Strauss Syndrome

Drug: Rituximab;Drug: Prednisone

Fernando Fervenza

Genentech, Inc.;Biogen;National Center for Research Resources (NCRR)

Terminated

18 Years

N/A

All

Phase 2

United States

NCT00307671
(ClinicalTrials.gov)

July 2005

27/3/2006

Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years

Treatment of Necrotizing Vasculitides for Patients Older Than 65 Years Comparison of Two Strategies Combining Steroids With or Without Immunosuppressants

Vasculitis;Wegener's Granulomatosis;Microscopic Polyangiitis;Churg-Strauss Syndrome;Polyarteritis Nodosa

Drug: prednisone , methylprednisolone,cyclophosphamides;Drug: Cyclophosphamide , Azathioprine,prednisone,methylprednisolone;Drug: Mycophenolate mofetil ,methotrexate

Assistance Publique - Hôpitaux de Paris

NULL

Completed

65 Years

N/A

Both

108

Phase 4

France

NCT00006055
(ClinicalTrials.gov)

March 2000

5/7/2000

Autologous Peripheral Blood Stem Cell Transplantation in Patients With Life Threatening Autoimmune Diseases

Purpura, Schoenlein-Henoch;Graft Versus Host Disease;Anemia, Hemolytic, Autoimmune;Rheumatoid Arthritis;Churg-Strauss Syndrome;Hypersensitivity Vasculitis;Wegener's Granulomatosis;Systemic Lupus Erythematosus;Giant Cell Arteritis;Pure Red Cell Aplasia;Juvenile Rheumatoid Arthritis;Polyarteritis Nodosa;Autoimmune Thrombocytopenic Purpura;Takayasu Arteritis

Drug: anti-thymocyte globulin;Drug: cyclophosphamide;Drug: cyclosporine;Drug: filgrastim;Drug: methylprednisolone;Drug: prednisone;Procedure: Autologous Peripheral Blood Stem Cell Transplantation

Fairview University Medical Center

NULL

Active, not recruiting

1 Year

55 Years

Both

N/A

United States