DDrare: Database of Drug Development for Rare Diseases

70. 広範脊柱管狭窄症
［臨床試験数：91，薬物数：195（DrugBank：54），標的遺伝子数：60，標的パスウェイ数：85］

Searched query = "Spinal stenosis", "Extensive spinal canal stenosis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Drug = 0.5% marcaine; 0.9% Saline; 0002-8971; 1mg/kg/hr TXA intravenous infusion till the last suture; AK1320 MS; Acetaminophen; Acetate; Adjunctive analgesics; Adjunctive anti-depressants; AlloGen-LI; Alprostadil; Amino acids; Aminocaproic acid; Amniotic Fluid Allograft; Apple; Bilateral transforaminal epidural steroid injections; Bone Marrow Concentrate; Botulinum toxin type A; Botulinum toxin type A (Nabota®) injection into the gastrocnemius muscle; Bupivacaine; Bupivacaïne HCl 0,125% / Sufentanil 50 µg flacon à 50 ml; Buprenorphine; CO; Caudal Epidural Injection with Celestone; Caudal Epidural Injection with DepoMedrol; Caudal Epidural Injection with generic Celestone; Caudal epidural injection; Celebrex 200Mg Capsule; Celecoxib; Cilostazol; Combination Product: Goldic serum; Control group; Creatinine; DEXMEDETOMIDINE; DEXMEDETOMIDINE HYDROCHLORIDE; Darvocet; Decadron Phosphate, Injectable; Deksmedetomidiini; Demineralized Bone Matrix; DepoMedrol; Depomedrol; Device: Apple Watch and App; Device: Bioactive Glass-Ceramic Spacer; Device: Cervical Orthosis (CO); Device: Interbody cage (PEEK); Device: Interbody cage (titanium); Device: MILD® (Minimally Invasive Lumbar Decompression); Device: MRI; Device: MasterGraft Granules; Device: No Orthosis; Device: Philips Intelivue MP70 monitor; Device: Pleth Variability Index (PVI); Device: Therm-AppTM TH, thermographic camera; Device: Titanium cage; Dexamethasone; Dexamethasone sodium phosphate; Dexdor; Dexmedetomidine; Dexmedetomidine group; Dexmedetomidine with ropivacaine; Dextrose; Diphenhydramine; EACA; ESKETAMINE HYDROCHLORIDE; Epidural Steroid Injection; Epidural injection; Epidural local anesthetic injection; Epidural steroid injection; Epsilon-Aminocaproic Acid (EACA); Erector spinae plane block (Group E); Erythropoietin; Esketamine; Fentanyl; Forsteo; Forteo; Gabapentin; Heparin; Herbal medicine; Hyaluronic Acid; Hyaluronic acid; Hydromorphone; I-FACTOR; KETAMINE; Kenalog Injectable Product; Ketamine; Ketanest; Ketanest-S; Ketorolac; Limaprost; Liposomal bupivacaine; Lumbar Interbody Fusion with Autograft; Lumbar Interbody Fusion with NeoFuse; MONITOR; Magnesium; Magnesium with ropivacaine; Midazolam; Mirogabalin; Misoprostol; Modal; Modified-thoracolumbar interfascial plane block; Morphine; Morphine PCA; Multi-modal pain management [Acetaminophen + Gabapentin]; Multi-modal pain management [Fentanyl]; Multi-modal pain management [Intravenous Ketamine]; Multi-modal pain management [Valium + Gabapentin]; NS-304; NS-304 Placebo; NSAIDs; NeoFuse; Nicardipine; Normal saline; NuCel; OXYCODONE; OXYCODONE HYDROCHLORIDE; Oksikodoni; Opana; Other: Control; Other: Conventional PCA mode; Other: Epiduroscopy; Other: Group Exercise: community setting; Other: Individualized exercises: clinical setting; Other: Joint Mobilizations (spine, sacroiliac, hip); Other: Optimizing basal infusion (B.I); Other: Other intervention(s); Other: no intervention; Other: physical therapy; Oxanest; Oxycodone; Oxycodone Orion; Oxygen; PCA; PLF with NeoFuse; Parathyroid hormone; Phosphate; Polydeoxyribonucleotides; Predinose oral; Pregabalin; Pregabalin 75mg; Procedure: Acupuncture; Procedure: Allograft; Procedure: Bee venom pharmacopuncture; Procedure: Chuna manipulation; Procedure: Chuna manual medicine; Procedure: Cupping; Procedure: Electroacupuncture; Procedure: Epidural Steroid Injection; Procedure: Epidural local anesthetic injection; Procedure: Epidural steroid with local anesthetic injection; Procedure: Lumbar epidural injection; Procedure: MILD Procedure; Procedure: Manual therapy; Procedure: Other intervention(s); Procedure: PLF with autograft; Procedure: Percutaneous Lumbar Decompression; Procedure: Pharmacopuncture; Procedure: epidural steroid (dexamethasone) injection; Procedure: lumbar interlaminar epidural steroid injection; Procedure: posterolateral spinal fusion with instrumentation; Prolotherapy solution of 20% dextrose; Remifentanil; RhPTH; RhPTH (1-34); Ropivacaine; Ropivacaine plus normal saline; S-ketamine; S-ketamine & midazolam; Selexipag; Standard analgesia use [Fentanyl]; Standard analgesia use [Hydromorphone]; Standard analgesia use [Oxygen]; Standard analgesia use [Volatile Anesthesia]; Steroid injections; Sufentanil; Sugar Pill; Teicoplanin; Teriparatide; Teriparatide [rDNA origin] contains recombinant human parathyroid hormone (1-34); Titanium; Tramadol; Tramadol with ropivacaine; Tranexamic Acid; Tranexamic Acid 100 MG/ML; Tranexamic acid; Transdermal fentanyl matrix, gabapentin; Transforaminal Epidural Injection; Triamcinolone; Triamcinolone Acetonide and normal saline solution; Tylenol; Vancomycin; ViviGen Cellular Bone Matrix; With U-VANCO (vancomycin hydrochloride); Without U-VANCO (vancomycin hydrochloride); Wound topically irrigated with 500mg TXA; Xylocaine

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	NCT04537026 (ClinicalTrials.gov)	January 15, 2021	28/8/2020	The SAFE Trial. Sterile Amniotic Fluid Filtrate Epidural Injection.	A Phase I/II Double-Blinded Randomized Prospective Study of Sterile Amniotic Fluid Filtrate Epidural Injection for the Treatment of Lumbosacral Radicular Pain Due to Spinal Stenosis: The SAFE Trial (Improving Safety and Outcomes in the Treatment of Pain and Disability Related to Spinal Stenosis).	Lumbar Spinal Stenosis	Drug: Amniotic Fluid Allograft;Drug: Dexamethasone sodium phosphate	University of Utah	Cell Therapy & Regenerative Medicine;SKAGGs Foundation	Not yet recruiting	18 Years	N/A	All	112	Phase 1;Phase 2	NULL
2	NCT04540068 (ClinicalTrials.gov)	October 2020	1/9/2020	Prediction of TEI Success in Sciatica	Prediction Of Transforaminal Epidural Injection Success in Sciatica	Sciatica;Lumbar Disc Herniation;Lumbar Spinal Stenosis;Lumbar Radiculopathy	Drug: Transforaminal Epidural Injection	EJAVerheijen	Spaarne Gasthuis	Not yet recruiting	18 Years	N/A	All	538		Netherlands
3	NCT02838615 (ClinicalTrials.gov)	July 2016	25/5/2016	Comparison of Transforaminal vs. Parasagittal Interlaminar Epidural Injection	Comparison of Lumbar Epidural Steroid Injection: Transforaminal vs. Parasagittal Interlaminar Approach	Spinal Stenosis	Procedure: epidural steroid (dexamethasone) injection	Keimyung University Dongsan Medical Center	NULL	Completed	N/A	N/A	All	56	N/A	NULL
4	NCT02725723 (ClinicalTrials.gov)	March 2016	21/3/2016	Thermographic Images as an Objective Method for Assessing the Efficacy of Steroidal Epidural Injections	Thermographic Images as an Objective Method for Assessing the Efficacy of Steroidal Epidural Injections	Spinal Stenosis	Device: Therm-AppTM TH, thermographic camera;Drug: epidural injection	Tel-Aviv Sourasky Medical Center	NULL	Not yet recruiting	18 Years	80 Years	Both	40	Phase 2;Phase 3	NULL
5	NCT01943435 (ClinicalTrials.gov)	November 20, 2013	8/9/2013	Study Comparing 3 Different Treatments for Arthritis of the Lower Back (Lumbar Spinal Stenosis)	A Comparison of Non-Surgical Treatment Methods for Patients With Lumbar Spinal Stenosis	Lumbar Spinal Stenosis	Drug: NSAIDs; adjunctive analgesics; adjunctive anti-depressants;Procedure: Lumbar epidural injection;Other: Joint Mobilizations (spine, sacroiliac, hip);Other: Individualized exercises: clinical setting;Other: Group Exercise: community setting	Michael Schneider, DC, PhD	Patient-Centered Outcomes Research Institute	Completed	60 Years	N/A	All	259	N/A	United States
No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
6	NCT00370799 (ClinicalTrials.gov)	January 2007	30/8/2006	Effectiveness of Caudal Epidural Injections in Treatment of Chronic Low Back and Lower Extremity Pain	A Randomized, Prospective, Double-Blind Controlled Evaluation of the Effectiveness of Caudal Epidural Injections in Lumbar Disc Herniations, Spinal Stenosis, Discogenic Pain, and Post-Lumbar Laminectomy Syndrome	Low Back Pain	Drug: Caudal epidural injection;Drug: Caudal Epidural Injection with generic Celestone;Drug: Caudal Epidural Injection with Celestone;Drug: Caudal Epidural Injection with DepoMedrol	Pain Management Center of Paducah	NULL	Completed	18 Years	N/A	Both	240	Phase 0	United States

No.

TrialID

Date_
enrollment

Date_
registration

Public_title

Scientific_title

Condition

Intervention

Primary_
sponsor

Secondary_
sponsor

Recruitment_
Status

Inclusion_
agemin

Inclusion_
agemax

Inclusion_
gender

Target_
size

Phase

Countries

NCT04537026
(ClinicalTrials.gov)

January 15, 2021

28/8/2020

The SAFE Trial. Sterile Amniotic Fluid Filtrate Epidural Injection.

A Phase I/II Double-Blinded Randomized Prospective Study of Sterile Amniotic Fluid Filtrate Epidural Injection for the Treatment of Lumbosacral Radicular Pain Due to Spinal Stenosis: The SAFE Trial (Improving Safety and Outcomes in the Treatment of Pain and Disability Related to Spinal Stenosis).

Lumbar Spinal Stenosis

Drug: Amniotic Fluid Allograft;Drug: Dexamethasone sodium phosphate

University of Utah

Cell Therapy & Regenerative Medicine;SKAGGs Foundation

Not yet recruiting

18 Years

N/A

All

112

Phase 1;Phase 2

NULL

NCT04540068
(ClinicalTrials.gov)

October 2020

1/9/2020

Prediction of TEI Success in Sciatica

Prediction Of Transforaminal Epidural Injection Success in Sciatica

Sciatica;Lumbar Disc Herniation;Lumbar Spinal Stenosis;Lumbar Radiculopathy

Drug: Transforaminal Epidural Injection

EJAVerheijen

Spaarne Gasthuis

Not yet recruiting

18 Years

N/A

All

538

Netherlands

NCT02838615
(ClinicalTrials.gov)

July 2016

25/5/2016

Comparison of Transforaminal vs. Parasagittal Interlaminar Epidural Injection

Comparison of Lumbar Epidural Steroid Injection: Transforaminal vs. Parasagittal Interlaminar Approach

Spinal Stenosis

Procedure: epidural steroid (dexamethasone) injection

Keimyung University Dongsan Medical Center

NULL

Completed

N/A

All

N/A

NULL

NCT02725723
(ClinicalTrials.gov)

March 2016

21/3/2016

Thermographic Images as an Objective Method for Assessing the Efficacy of Steroidal Epidural Injections

Spinal Stenosis

Device: Therm-AppTM TH, thermographic camera;Drug: epidural injection

Tel-Aviv Sourasky Medical Center

NULL

Not yet recruiting

18 Years

80 Years

Both

Phase 2;Phase 3

NULL

NCT01943435
(ClinicalTrials.gov)

November 20, 2013

8/9/2013

Study Comparing 3 Different Treatments for Arthritis of the Lower Back (Lumbar Spinal Stenosis)

A Comparison of Non-Surgical Treatment Methods for Patients With Lumbar Spinal Stenosis

Lumbar Spinal Stenosis

Drug: NSAIDs; adjunctive analgesics; adjunctive anti-depressants;Procedure: Lumbar epidural injection;Other: Joint Mobilizations (spine, sacroiliac, hip);Other: Individualized exercises: clinical setting;Other: Group Exercise: community setting

Michael Schneider, DC, PhD

Patient-Centered Outcomes Research Institute

Completed

60 Years

N/A

All

259

N/A

United States

No.

TrialID

Date_
enrollment

Date_
registration

Public_title

Scientific_title

Condition

Intervention

Primary_
sponsor

Secondary_
sponsor

Recruitment_
Status

Inclusion_
agemin

Inclusion_
agemax

Inclusion_
gender

Target_
size

Phase

Countries

NCT00370799
(ClinicalTrials.gov)

January 2007

30/8/2006

Effectiveness of Caudal Epidural Injections in Treatment of Chronic Low Back and Lower Extremity Pain

A Randomized, Prospective, Double-Blind Controlled Evaluation of the Effectiveness of Caudal Epidural Injections in Lumbar Disc Herniations, Spinal Stenosis, Discogenic Pain, and Post-Lumbar Laminectomy Syndrome

Low Back Pain

Drug: Caudal epidural injection;Drug: Caudal Epidural Injection with generic Celestone;Drug: Caudal Epidural Injection with Celestone;Drug: Caudal Epidural Injection with DepoMedrol

Pain Management Center of Paducah

NULL

Completed

18 Years

N/A

Both

240

Phase 0

United States