DDrare: Database of Drug Development for Rare Diseases

70. 広範脊柱管狭窄症
［臨床試験数：91，薬物数：195（DrugBank：54），標的遺伝子数：60，標的パスウェイ数：85］

Searched query = "Spinal stenosis", "Extensive spinal canal stenosis"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.

Drug = 0.5% marcaine; 0.9% Saline; 0002-8971; 1mg/kg/hr TXA intravenous infusion till the last suture; AK1320 MS; Acetaminophen; Acetate; Adjunctive analgesics; Adjunctive anti-depressants; AlloGen-LI; Alprostadil; Amino acids; Aminocaproic acid; Amniotic Fluid Allograft; Apple; Bilateral transforaminal epidural steroid injections; Bone Marrow Concentrate; Botulinum toxin type A; Botulinum toxin type A (Nabota®) injection into the gastrocnemius muscle; Bupivacaine; Bupivacaïne HCl 0,125% / Sufentanil 50 µg flacon à 50 ml; Buprenorphine; CO; Caudal Epidural Injection with Celestone; Caudal Epidural Injection with DepoMedrol; Caudal Epidural Injection with generic Celestone; Caudal epidural injection; Celebrex 200Mg Capsule; Celecoxib; Cilostazol; Combination Product: Goldic serum; Control group; Creatinine; DEXMEDETOMIDINE; DEXMEDETOMIDINE HYDROCHLORIDE; Darvocet; Decadron Phosphate, Injectable; Deksmedetomidiini; Demineralized Bone Matrix; DepoMedrol; Depomedrol; Device: Apple Watch and App; Device: Bioactive Glass-Ceramic Spacer; Device: Cervical Orthosis (CO); Device: Interbody cage (PEEK); Device: Interbody cage (titanium); Device: MILD® (Minimally Invasive Lumbar Decompression); Device: MRI; Device: MasterGraft Granules; Device: No Orthosis; Device: Philips Intelivue MP70 monitor; Device: Pleth Variability Index (PVI); Device: Therm-AppTM TH, thermographic camera; Device: Titanium cage; Dexamethasone; Dexamethasone sodium phosphate; Dexdor; Dexmedetomidine; Dexmedetomidine group; Dexmedetomidine with ropivacaine; Dextrose; Diphenhydramine; EACA; ESKETAMINE HYDROCHLORIDE; Epidural Steroid Injection; Epidural injection; Epidural local anesthetic injection; Epidural steroid injection; Epsilon-Aminocaproic Acid (EACA); Erector spinae plane block (Group E); Erythropoietin; Esketamine; Fentanyl; Forsteo; Forteo; Gabapentin; Heparin; Herbal medicine; Hyaluronic Acid; Hyaluronic acid; Hydromorphone; I-FACTOR; KETAMINE; Kenalog Injectable Product; Ketamine; Ketanest; Ketanest-S; Ketorolac; Limaprost; Liposomal bupivacaine; Lumbar Interbody Fusion with Autograft; Lumbar Interbody Fusion with NeoFuse; MONITOR; Magnesium; Magnesium with ropivacaine; Midazolam; Mirogabalin; Misoprostol; Modal; Modified-thoracolumbar interfascial plane block; Morphine; Morphine PCA; Multi-modal pain management [Acetaminophen + Gabapentin]; Multi-modal pain management [Fentanyl]; Multi-modal pain management [Intravenous Ketamine]; Multi-modal pain management [Valium + Gabapentin]; NS-304; NS-304 Placebo; NSAIDs; NeoFuse; Nicardipine; Normal saline; NuCel; OXYCODONE; OXYCODONE HYDROCHLORIDE; Oksikodoni; Opana; Other: Control; Other: Conventional PCA mode; Other: Epiduroscopy; Other: Group Exercise: community setting; Other: Individualized exercises: clinical setting; Other: Joint Mobilizations (spine, sacroiliac, hip); Other: Optimizing basal infusion (B.I); Other: Other intervention(s); Other: no intervention; Other: physical therapy; Oxanest; Oxycodone; Oxycodone Orion; Oxygen; PCA; PLF with NeoFuse; Parathyroid hormone; Phosphate; Polydeoxyribonucleotides; Predinose oral; Pregabalin; Pregabalin 75mg; Procedure: Acupuncture; Procedure: Allograft; Procedure: Bee venom pharmacopuncture; Procedure: Chuna manipulation; Procedure: Chuna manual medicine; Procedure: Cupping; Procedure: Electroacupuncture; Procedure: Epidural Steroid Injection; Procedure: Epidural local anesthetic injection; Procedure: Epidural steroid with local anesthetic injection; Procedure: Lumbar epidural injection; Procedure: MILD Procedure; Procedure: Manual therapy; Procedure: Other intervention(s); Procedure: PLF with autograft; Procedure: Percutaneous Lumbar Decompression; Procedure: Pharmacopuncture; Procedure: epidural steroid (dexamethasone) injection; Procedure: lumbar interlaminar epidural steroid injection; Procedure: posterolateral spinal fusion with instrumentation; Prolotherapy solution of 20% dextrose; Remifentanil; RhPTH; RhPTH (1-34); Ropivacaine; Ropivacaine plus normal saline; S-ketamine; S-ketamine & midazolam; Selexipag; Standard analgesia use [Fentanyl]; Standard analgesia use [Hydromorphone]; Standard analgesia use [Oxygen]; Standard analgesia use [Volatile Anesthesia]; Steroid injections; Sufentanil; Sugar Pill; Teicoplanin; Teriparatide; Teriparatide [rDNA origin] contains recombinant human parathyroid hormone (1-34); Titanium; Tramadol; Tramadol with ropivacaine; Tranexamic Acid; Tranexamic Acid 100 MG/ML; Tranexamic acid; Transdermal fentanyl matrix, gabapentin; Transforaminal Epidural Injection; Triamcinolone; Triamcinolone Acetonide and normal saline solution; Tylenol; Vancomycin; ViviGen Cellular Bone Matrix; With U-VANCO (vancomycin hydrochloride); Without U-VANCO (vancomycin hydrochloride); Wound topically irrigated with 500mg TXA; Xylocaine

No.	TrialID	Date_ enrollment	Date_ registration	Public_title	Scientific_title	Condition	Intervention	Primary_ sponsor	Secondary_ sponsor	Recruitment_ Status	Inclusion_ agemin	Inclusion_ agemax	Inclusion_ gender	Target_ size	Phase	Countries
1	JPRN-UMIN000012918	2014/04/01	01/03/2014	Long-term efficacy and safety of Limaprost for the treatment of Lumbar Spinal Stenosis		Lumbar Spinal Stenosis	Limaprost alfadex(15 micro g/day), 1yrs.	Kansai LSS Forum	NULL	Pending	50years-old	80years-old	Male and Female	300	Not selected	Japan
2	NCT01888536 (ClinicalTrials.gov)	February 2013	25/6/2013	A Study to Evaluate Efficacy of ?Opast Tablet?for Neurologic Claudication in Patients With Lumbar Spinal Stenosis	A Randomized, Double-Blind, Comparative, Multi-Center, Phase ? Clinical Trial to Evaluate Efficacy of ?Opast Tablet?for Neurologic Claudication in Patients With Lumbar Spinal Stenosis	Neurologic Claudication in Patients With Lumbar Spinal Stenosis	Drug: Limaprost;Drug: Pregabalin;Drug: Placebo(for Pregabalin);Drug: Placebo(for Limaprost)	Yungjin Pharm. Co., Ltd.	NULL	Completed	20 Years	75 Years	Both	182	Phase 4	Korea, Republic of
3	JPRN-UMIN000004825	2011/01/01	06/01/2011	A randomized comparative study of Celecoxib and Limaprost alfadex on the patients with lumber spinal stenosis for the effectiveness for symptoms and QOL		Lumbar spinal stenosis	15ug/day Limaprost arfadex for 8 weeks 200mg/day Celecoxib for 8 weeks	University of Tsukuba, Course of life-style related disorders donated by JA Ibaraki Public Welfare Federation	Mito Kyodo Hospital	Complete: follow-up complete	40years-old	85years-old	Male and Female	134	Phase 3	Japan

No.

TrialID

Date_
enrollment

Date_
registration

Public_title

Scientific_title

Condition

Intervention

Primary_
sponsor

Secondary_
sponsor

Recruitment_
Status

Inclusion_
agemin

Inclusion_
agemax

Inclusion_
gender

Target_
size

Phase

Countries

JPRN-UMIN000012918

2014/04/01

01/03/2014

Long-term efficacy and safety of Limaprost for the treatment of Lumbar Spinal Stenosis

Lumbar Spinal Stenosis

Limaprost alfadex(15 micro g/day), 1yrs.

Kansai LSS Forum

NULL

Pending

50years-old

80years-old

Male and Female

300

Not selected

Japan

NCT01888536
(ClinicalTrials.gov)

February 2013

25/6/2013

A Study to Evaluate Efficacy of ?Opast Tablet?for Neurologic Claudication in Patients With Lumbar Spinal Stenosis

A Randomized, Double-Blind, Comparative, Multi-Center, Phase ? Clinical Trial to Evaluate Efficacy of ?Opast Tablet?for Neurologic Claudication in Patients With Lumbar Spinal Stenosis

Neurologic Claudication in Patients With Lumbar Spinal Stenosis

Drug: Limaprost;Drug: Pregabalin;Drug: Placebo(for Pregabalin);Drug: Placebo(for Limaprost)

Yungjin Pharm. Co., Ltd.

NULL

Completed

20 Years

75 Years

Both

182

Phase 4

Korea, Republic of

JPRN-UMIN000004825

2011/01/01

06/01/2011

A randomized comparative study of Celecoxib and Limaprost alfadex on the patients with lumber spinal stenosis for the effectiveness for symptoms and QOL

Lumbar spinal stenosis

15ug/day Limaprost arfadex for 8 weeks
200mg/day Celecoxib for 8 weeks

University of Tsukuba, Course of life-style related disorders donated by JA Ibaraki Public Welfare Federation

Mito Kyodo Hospital

Complete: follow-up complete

40years-old

85years-old

Male and Female

134

Phase 3

Japan