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Metreleptin    (DrugBank: Metreleptin)

1 disease
告示番号疾患名（ページ内リンク）臨床試験数
265脂肪萎縮症11

265. 脂肪萎縮症　［臨床試験数：109，薬物数：164（DrugBank：59），標的遺伝子数：26，標的パスウェイ数：94］
Searched query = "Lipodystrophy", "Berardinelli-Seip syndrome", "Lawrence syndrome", "Barraquer-Simons syndrome"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
11 / 109 trials found
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
1NCT04026178
(ClinicalTrials.gov)		November 14, 201830/10/2018Immunogenicity of Metreleptin in Patients With Generalized LipodystrophyA 36-Month, Multicenter, Open Label Phase 4 Study to Evaluate the Immunogenicity of Daily SC Metreleptin Treatment in Patients With Generalized LipodystrophyGeneralized LipodystrophyDrug: MetreleptinAegerion Pharmaceuticals, Inc.NULLRecruiting1 YearN/AAll10Phase 4United States
2EUCTR2017-003014-22-AT
(EUCTR)		25/06/201829/05/2018Leptin in hepatic lipid metabolism in humansThe role of leptin in regulating hepatic lipid metabolism in humans - Leptin and hepatic lipid metabolism lipodystrophy patients, patients after liver transplantation and healthy controls;Therapeutic area: Diseases [C] - Nutritional and Metabolic Diseases [C18]Trade Name: Myalept
Product Name: Myalept
INN or Proposed INN: metrelpetin
Other descriptive name: METRELEPTIN		Medical University of ViennaNULLAuthorised-recruitment may be ongoing or finishedFemale: yes
Male: yes		43Phase 2Austria
3NCT02654977
(ClinicalTrials.gov)		September 29, 201520/1/2015CLINICAL PROTOCOL to Investigate the Long-term Safety and Efficacy of Metreleptin in Various Forms of Partial LipodystrophyCLINICAL PROTOCOL to Investigate the Long-term Safety and Efficacy of Recombinant Human Leptin (METRELEPTIN) in Various Forms of Partial LipodystrophyFamilial Partial Lipodystrophy;Nonalcoholic Steatohepatitis;NAFLDDrug: MetreleptinUniversity of MichiganNULLCompleted5 YearsN/AAll11Phase 2United States
4NCT02404896
(ClinicalTrials.gov)		January 201520/1/2015Expanded Access Metreleptin StudyExpanded-Access for the Use of Metreleptin in Patients With Partial Lipodystrophy Associated With Diabetes Mellitus or HypertriglyceridemiaFamilial Partial LipodystrophyDrug: MetreleptinUniversity of MichiganNULLActive, not recruiting18 YearsN/AAll11Phase 2United States
5NCT02262806
(ClinicalTrials.gov)		October 14, 20149/10/2014Compassionate Use of Metreleptin in Previously Treated People With Partial LipodystrophyCompassionate Use of Metreleptin in Previously-Treated Patients With Partial LipodystrophyDiabetes;Lipodystrophy;HyperlipidemiaDrug: MetreleptinNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NULLRecruitingN/AN/AAll35Phase 3United States
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
6NCT02262832
(ClinicalTrials.gov)		October 9, 201410/10/2014Compassionate Use of Metreleptin in Previously Treated People With Generalized LipodystrophyCompassionate Use of Metreleptin in Previously-Treated Patients With Generalized LipodystrophyLipodystrophy;Diabetes;HyperlipidemiaDrug: MetreleptinNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NULLRecruitingN/AN/AAll30Phase 3United States
7NCT01778556
(ClinicalTrials.gov)		January 26, 201326/1/2013Short-term Effects of Leptin in People With LipodystrophyShort Term Effects of Leptin Withdrawal or Initiation in Lipodystrophy Independent of Energy IntakeLipodystrophyBiological: MetreleptinNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NULLCompleted14 Years70 YearsAll25Phase 2United States
8NCT01679197
(ClinicalTrials.gov)		October 8, 201231/8/2012Clinical Protocol to Investigate the Efficacy of Recombinant Human Leptin (Metreleptin) in Nonalcoholic Steatohepatitis (NASH) or Nonalcoholic Fatty Liver Disease (NAFLD) Associated With LipodystrophyClinical Protocol to Investigate the Efficacy of Recombinant Human Leptin (Metreleptin) in Nonalcoholic Steatohepatitis (NASH) or Nonalcoholic Fatty Liver Disease (NAFLD) Associated With LipodystrophyFatty Liver Disease, Nonalcoholic;Nonalcoholic Steatohepatitis;LipodystrophyDrug: MetreleptinUniversity of MichiganNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)Completed5 YearsN/AAll23Phase 2United States
9NCT00677313
(ClinicalTrials.gov)		November 200812/5/2008An Open-Label Treatment Protocol to Provide Metreleptin for the Treatment of Diabetes Mellitus and/or Hypertriglyceridemia Associated With LipodystrophyAn Open-Label Treatment Protocol to Provide Metreleptin for the Treatment of Diabetes Mellitus and/or Hypertriglyceridemia Associated With LipodystrophyLipodystrophyDrug: metreleptinBristol-Myers SquibbNULLActive, not recruiting5 YearsN/ABoth41N/AUnited States
10NCT01511016
(ClinicalTrials.gov)		February 200311/1/2012Leptin for Abnormal Lipid Kinetics in HIV Lipodystrophy SyndromeThe Effect of Leptin Therapy on Abnormal Lipid Kinetics in Subjects With HIV Lipodystrophy SyndromeHIV LipodystrophyDrug: Human recombinant leptin (metreleptin);Drug: PlaceboBaylor College of MedicineNULLCompleted18 Years64 YearsMale17N/AUnited States
No.TrialIDDate_
enrollment		Date_
registration		Public_titleScientific_titleConditionInterventionPrimary_
sponsor		Secondary_
sponsor		Recruitment_
Status		Inclusion_
agemin		Inclusion_
agemax		Inclusion_
gender		Target_
size		PhaseCountries
11NCT00025883
(ClinicalTrials.gov)		October 200127/10/2001Leptin to Treat LipodystrophyLong-Term Efficacy of Leptin Replacement in Treatment of LipodystrophyLipodystrophyDrug: MetreleptinNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NULLCompleted6 MonthsN/AAll103Phase 2United States

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