159. 色素性乾皮症
［臨床試験数：5，薬物数：13（DrugBank：4），標的遺伝子数：4，標的パスウェイ数：13］
Searched query = "Xeroderma pigmentosum", "XP"
The queries were searched in Public_title, Scientific_title, and Condition. Export date: 03/15/2021. Trials are sorted by Date_enrollment from most recent to oldest in the table.
| No. | TrialID | Date_ enrollment | Date_ registration | Public_title | Scientific_title | Condition | Intervention | Primary_ sponsor | Secondary_ sponsor | Recruitment_ Status | Inclusion_ agemin | Inclusion_ agemax | Inclusion_ gender | Target_ size | Phase | Countries |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | NCT04500548 (ClinicalTrials.gov) | February 26, 2021 | 4/8/2020 | Testing the Combination of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) in Children, Adolescent, and Young Adult Patients With Relapsed/Refractory Cancers That Have an Increased Number of Genetic Changes, The 3CI Study | 3CI Study: Childhood Cancer Combination Immunotherapy. Phase Ib and Expansion Study of Nivolumab Combination Immunotherapy in Children, Adolescent, and Young Adult (CAYA) Patients With Relapsed/Refractory Hypermutant Cancers | Constitutional Mismatch Repair Deficiency Syndrome;Hematopoietic and Lymphoid Cell Neoplasm;Lynch Syndrome;Recurrent Lymphoma;Recurrent Malignant Solid Neoplasm;Recurrent Neuroblastoma;Recurrent Primary Central Nervous System Neoplasm;Refractory Lymphoma;Refractory Malignant Solid Neoplasm;Refractory Neuroblastoma;Refractory Primary Central Nervous System Neoplasm;Xeroderma Pigmentosum | Procedure: Biospecimen Collection;Biological: Ipilimumab;Biological: Nivolumab | National Cancer Institute (NCI) | NULL | Not yet recruiting | 12 Months | 25 Years | All | 40 | Phase 1 | NULL |
| 2 | EUCTR2010-022968-13-ES (EUCTR) | 22/03/2011 | 25/01/2011 | Estudio clínico de fase II, multicéntrico, abierto de trabectedina (Yondelis®) en pacientes con cáncer de mama avanzado, HER2 negativo, positivo para receptores hormonales, con sobreexpresión o subexpresión del gen xeroderma pigmentosum de clase G (XPG). | Estudio clínico de fase II, multicéntrico, abierto de trabectedina (Yondelis®) en pacientes con cáncer de mama avanzado, HER2 negativo, positivo para receptores hormonales, con sobreexpresión o subexpresión del gen xeroderma pigmentosum de clase G (XPG). | Cáncer de mama avanzado. MedDRA version: 13;Level: LLT;Classification code 10006204;Term: Carcinoma de mama | Trade Name: YONDELIS 0,25 mg polvo para concentrado para solución para perfusión INN or Proposed INN: TRABECTEDINA Other descriptive name: TRABECTEDINA Trade Name: YONDELIS 1 mg polvo para concentrado para solución para perfusión INN or Proposed INN: TRABECTEDINA Other descriptive name: TRABECTEDINA | PharmaMar S.A. Sociedad Unipersonal | NULL | Authorised-recruitment may be ongoing or finished | Female: yes Male: no | 100 | Spain | |||
| 3 | EUCTR2010-022968-13-BE (EUCTR) | 16/03/2011 | 04/01/2011 | Study of the medicinal product Trabectedin in Patients with AdvancedBreast Carcinoma. | Multicenter, Open-Label, Phase II Study of Trabectedin (Yondelis®) in Patients with Hormonal Receptors Positive, HER2 Negative, Advanced Breast Carcinoma, Overexpressing or Underexpressing Xeroderma Pigmentosum G Gene (XPG) | Advanced Breast Carcinoma MedDRA version: 14.0;Level: LLT;Classification code 10006204;Term: Breast carcinoma;System Organ Class: 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps);Therapeutic area: Diseases [C] - Cancer [C04] | Trade Name: Yondelis 0.25 mg powder for concentrate for solution for infusion. INN or Proposed INN: trabectedine Trade Name: Yondelis 1 mg powder for concentrate for solution for infusion. INN or Proposed INN: trabectedine | Pharma Mar, S.A. Sociedad Unipersonal | NULL | Not Recruiting | Female: yes Male: yes | 100 | Phase 2 | Spain;Belgium | ||
| 4 | NCT00002811 (ClinicalTrials.gov) | July 1996 | 1/11/1999 | T4N5 Liposome Lotion Compared With Placebo Lotion for Preventing Actinic Keratoses in Patients With Xeroderma Pigmentosum | A RANDOMIZED, DOUBLE BLIND, MULTI-CENTER CLINICAL STUDY TO TEST THE SAFETY AND EFFICACY OF T4N5 LIPOSOME LOTION ON PATIENTS WITH XERODERMA PIGMENTOSUM IN THE PROTECTION AGAINST ACTINIC KERATOSES | Precancerous Condition | Drug: liposomal T4N5 lotion | Applied Genetics | NULL | Active, not recruiting | 2 Years | 60 Years | Both | 30 | Phase 3 | United States;Germany;United Kingdom |
| 5 | NCT00025012 (ClinicalTrials.gov) | June 1991 | 11/10/2001 | Isotretinoin in Preventing Skin Cancer | Use Of Isotretinion For Prevention Of Skin Cancer In Patients With Xeroderma Pigmentosum Or Nevoid Basal Cell Carcinoma Syndrome | Melanoma (Skin);Non-melanomatous Skin Cancer | Drug: isotretinoin | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | NULL | Completed | 2 Years | N/A | Both | N/A | United States |