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No. 薬物名(臨床試験情報から抽出) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target genes
指定難病告示番号
112-Lead ECG1件: Cannabidiol1件: D10915 2件: CNR1,
CNR2 💬
4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬2件: 140, 144
2[TAK-935]----2件: 140, 144
3[ZX008]1件: Fenfluramine1件: D07945 4件: HTR2A,
HTR2B,
HTR2C,
SLC6A4 💬
6件: Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle 💬2件: 140, 144
4Any other approved Antiepileptic Drug1件: Rufinamide1件: D05775 5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬
3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 144
5Cannabidiol1件: Cannabidiol1件: D10915 2件: CNR1,
CNR2 💬
4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬18件: 6, 8, 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271
6Cannabidiol (CBD)1件: Cannabidiol1件: D10915 2件: CNR1,
CNR2 💬
4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬7件: 6, 13, 140, 144, 145, 156, 158
7Cannabidiol Oral Solution1件: Vigabatrin1件: D00535 1件: ABAT 💬7件: Alanine, aspartate and glutamate metabolism, Butanoate metabolism, GABAergic synapse, Metabolic pathways, Propanoate metabolism, Valine, leucine and isoleucine degradation, beta-Alanine metabolism 💬4件: 140, 144, 145, 193
8Carisbamate1件: Carisbamate1件: D06573 --1件: 144
9CBD1件: Cannabidiol1件: D10915 2件: CNR1,
CNR2 💬
4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬12件: 2, 6, 8, 13, 36, 46, 140, 144, 145, 156, 158, 206
10CBD - Oral Solution, is known as Epidiolex, and is the approved name in the USA.1件: Cannabidiol1件: D10915 2件: CNR1,
CNR2 💬
4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬2件: 140, 144
11Clobazam1件: Clobazam1件: D01253 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬
7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬2件: 140, 144
12Clobazam High Dose1件: Clobazam1件: D01253 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬
7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 144
13Clobazam Low Dose1件: Clobazam1件: D01253 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬
7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 144
14Clobazam Medium Dose1件: Clobazam1件: D01253 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬
7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 144
15Clobazam PhEur1件: Clobazam1件: D01253 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬
7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 144
16Clobazam Tablets1件: Clobazam1件: D01253 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬
7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 144
17Clobazam Tablets 10mg1件: Clobazam1件: D01253 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬
7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 144
18Clobazam Tablets 20mg1件: Clobazam1件: D01253 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬
7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 144
19Clobazam Tablets 5mg1件: Clobazam1件: D01253 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬
7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 144
20E2007----2件: 6, 144
21E20801件: Rufinamide1件: D05775 5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬
3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 144
22Ezogabine1件: Ezogabine1件: D09569 5件: KCNQ1,
KCNQ2,
KCNQ3,
KCNQ4,
KCNQ5 💬
6件: Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection 💬2件: 2, 144
23EZOGABINE (US ONLY)1件: Ezogabine1件: D09569 5件: KCNQ1,
KCNQ2,
KCNQ3,
KCNQ4,
KCNQ5 💬
6件: Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection 💬1件: 144
24Ezogabine/retigabine1件: Ezogabine1件: D09569 5件: KCNQ1,
KCNQ2,
KCNQ3,
KCNQ4,
KCNQ5 💬
6件: Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection 💬1件: 144
25Fenfluramina1件: Fenfluramine1件: D07945 4件: HTR2A,
HTR2B,
HTR2C,
SLC6A4 💬
6件: Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle 💬2件: 140, 144
26Fenfluramina Cloridrato1件: Fenfluramine1件: D07945 4件: HTR2A,
HTR2B,
HTR2C,
SLC6A4 💬
6件: Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle 💬2件: 140, 144
27FENFLURAMINE1件: Fenfluramine1件: D07945 4件: HTR2A,
HTR2B,
HTR2C,
SLC6A4 💬
6件: Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle 💬4件: 140, 144, 145, 149
28Fenfluramine HCl, DL-Fenfluramine, (±)-Fenfluramine1件: Fenfluramine1件: D07945 4件: HTR2A,
HTR2B,
HTR2C,
SLC6A4 💬
6件: Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle 💬1件: 144
29FENFLURAMINE HYDROCHLORIDE1件: Fenfluramine1件: D07945 4件: HTR2A,
HTR2B,
HTR2C,
SLC6A4 💬
6件: Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle 💬2件: 140, 144
30FENFLURAMINE HYDROCHLORIDE (colorless)1件: Fenfluramine1件: D07945 4件: HTR2A,
HTR2B,
HTR2C,
SLC6A4 💬
6件: Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle 💬2件: 140, 144
31Fycompa1件: Perampanel1件: D08964 4件: GRIA1,
GRIA2,
GRIA3,
GRIA4 💬
16件: Amphetamine addiction, Amyotrophic lateral sclerosis, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Transcriptional misregulation in cancer, cAMP signaling pathway 💬2件: 2, 144
32GW5828921件: Ezogabine1件: D09569 5件: KCNQ1,
KCNQ2,
KCNQ3,
KCNQ4,
KCNQ5 💬
6件: Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection 💬1件: 144
33GWP42003-P----5件: 140, 144, 145, 156, 158
34GWP42003-P 20 mg/kg/day Dose----2件: 140, 144
35Inovelon1件: Rufinamide1件: D05775 5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬
3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 144
36Investigators Choice of Approved AED1件: Rufinamide1件: D05775 5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬
3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 144
37Investigators choice of approved AEDs1件: Rufinamide1件: D05775 5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬
3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 144
38Lamictal1件: Lamotrigine1件: D00354 5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬
3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 144
39Lamotrigine1件: Lamotrigine1件: D00354 5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬
3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬5件: 13, 34, 38, 114, 144
40Melatonin1件: Melatonin1件: D08170 2件: MTNR1A,
MTNR1B 💬
2件: Circadian entrainment, Neuroactive ligand-receptor interaction 💬12件: 6, 8, 13, 37, 46, 49, 90, 97, 144, 145, 149, 202
41PEG1件: Carbidopa1件: D00558 1件: DDC 💬9件: Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Metabolic pathways, Phenylalanine metabolism, Serotonergic synapse, Tryptophan metabolism, Tyrosine metabolism 💬12件: 6, 13, 41, 46, 65, 78, 96, 97, 140, 144, 240, 299
42Perampanel1件: Perampanel1件: D08964 4件: GRIA1,
GRIA2,
GRIA3,
GRIA4 💬
16件: Amphetamine addiction, Amyotrophic lateral sclerosis, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Transcriptional misregulation in cancer, cAMP signaling pathway 💬3件: 2, 6, 144
43Placebo1件: Guselkumab1件: D10438 1件: IL23A 💬9件: C-type lectin receptor signaling pathway, Cytokine-cytokine receptor interaction, Inflammatory bowel disease, JAK-STAT signaling pathway, Pathways in cancer, Pertussis, Rheumatoid arthritis, Th17 cell differentiation, Tuberculosis 💬27件: 3, 5, 6, 13, 14, 37, 40, 46, 49, 50, 51, 53, 63, 66, 67, 79, 85, 86, 88, 96, 97, 140, 144, 149, 226, 271, 276
44Potiga1件: Ezogabine1件: D09569 5件: KCNQ1,
KCNQ2,
KCNQ3,
KCNQ4,
KCNQ5 💬
6件: Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection 💬1件: 144
45RETIGABINE1件: Riluzole1件: D00775 14件: GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬
23件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Systemic lupus erythematosus, Transcriptional misregulation in cancer, cAMP signaling pathway 💬2件: 2, 144
46RETIGABINE/EZOGABINE1件: Ezogabine1件: D09569 5件: KCNQ1,
KCNQ2,
KCNQ3,
KCNQ4,
KCNQ5 💬
6件: Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection 💬1件: 144
47RUFINAMIDE1件: Rufinamide1件: D05775 5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬
3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 144
48Rufinamide (E2080)1件: Rufinamide1件: D05775 5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬
3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 144
49Rufinamide oral suspension1件: Rufinamide1件: D05775 5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬
3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 144
50Sodio valproato1件: Lamotrigine1件: D00354 5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬
3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 144
51SOTICLESTAT----2件: 140, 144
52TAK-935----2件: 140, 144
53Topimarate1件: Lamotrigine1件: D00354 5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬
3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 144
54Topimarato1件: Lamotrigine1件: D00354 5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬
3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 144
55TOPIRAMATE1件: Topiramate1件: D00537 36件: CA2,
CA4,
CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S,
GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ,
GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬
53件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Arrhythmogenic right ventricular cardiomyopathy, Bile secretion, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cocaine addiction, Collecting duct acid secretion, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Gastric acid secretion, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Huntington disease, Hypertrophic cardiomyopathy, Insulin secretion, Long-term depression, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Nitrogen metabolism, Oxytocin signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Prion disease, Proximal tubule bicarbonate reclamation, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Spinocerebellar ataxia, Taste transduction, Tight junction, Transcriptional misregulation in cancer, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬6件: 6, 97, 140, 144, 156, 193
56Turmeric1件: Turmeric---4件: 140, 144, 158, 299
57ZX0081件: Fenfluramine1件: D07945 4件: HTR2A,
HTR2B,
HTR2C,
SLC6A4 💬
6件: Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle 💬2件: 140, 144
58ZX008 (Fenfluramine Hydrochloride)1件: Fenfluramine1件: D07945 4件: HTR2A,
HTR2B,
HTR2C,
SLC6A4 💬
6件: Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Serotonergic synapse, Synaptic vesicle cycle 💬2件: 140, 144
59ZX008 0.2 or 0.8 mg/kg/day----1件: 144
60ZX008 0.2 to 0.8 mg/kg/day1件: Cannabidiol1件: D10915 2件: CNR1,
CNR2 💬
4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬2件: 140, 144