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No. 薬物名（臨床試験情報から抽出） DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1Any other approved Antiepileptic Drug----1件: 144 💬
2Cannabidiol1件: Cannabidiol1件: Cannabidiol 💬2件: CNR1,
CNR2 💬		4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬18件: 6, 8, 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
3Cannabidiol (CBD)1件: Cannabidiol1件: Cannabidiol 💬2件: CNR1,
CNR2 💬		4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬7件: 6, 13, 140, 144, 145, 156, 158 💬
4Cannabidiol Oral Solution1件: Cannabidiol1件: Cannabidiol 💬2件: CNR1,
CNR2 💬		4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬4件: 140, 144, 145, 193 💬
5Carisbamate1件: Carisbamate1件: Carisbamate 💬--1件: 144 💬
6CBD----13件: 2, 6, 8, 13, 36, 46, 51, 140, 144, 145, 156, 158, 206 💬
7CBD - Oral Solution, is known as Epidiolex, and is the approved name in the USA.1件: Cannabidiol1件: Cannabidiol 💬2件: CNR1,
CNR2 💬		4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬2件: 140, 144 💬
8Clemizole1件: Clemizole---2件: 140, 144 💬
9Clemizole HCl1件: Clemizole---1件: 144 💬
10Clobazam1件: Clobazam1件: Clobazam 💬16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬2件: 140, 144 💬
11Clobazam High Dose1件: Clobazam1件: Clobazam 💬16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 144 💬
12Clobazam Low Dose1件: Clobazam1件: Clobazam 💬16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 144 💬
13Clobazam Medium Dose1件: Clobazam1件: Clobazam 💬16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 144 💬
14Clobazam PhEur1件: Clobazam1件: Clobazam 💬16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 144 💬
15Clobazam Tablets1件: Clobazam1件: Clobazam 💬16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 144 💬
16Clobazam Tablets 10mg1件: Clobazam1件: Clobazam 💬16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 144 💬
17Clobazam Tablets 20mg1件: Clobazam1件: Clobazam 💬16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 144 💬
18Clobazam Tablets 5mg1件: Clobazam1件: Clobazam 💬16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬		7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬1件: 144 💬
19E2007----2件: 6, 144 💬
20E2080----1件: 144 💬
21Epidiolex1件: Cannabidiol1件: Cannabidiol 💬2件: CNR1,
CNR2 💬		4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬2件: 140, 144 💬
22Epidiolex 100 mg/mL Oral Solution1件: Cannabidiol1件: Cannabidiol 💬2件: CNR1,
CNR2 💬		4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬2件: 140, 144 💬
23Ezogabine1件: Ezogabine1件: Ezogabine 💬5件: KCNQ1,
KCNQ2,
KCNQ3,
KCNQ4,
KCNQ5 💬		6件: Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection 💬2件: 2, 144 💬
24EZOGABINE (US ONLY)1件: Ezogabine1件: Ezogabine 💬5件: KCNQ1,
KCNQ2,
KCNQ3,
KCNQ4,
KCNQ5 💬		6件: Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection 💬1件: 144 💬
25Ezogabine/retigabine1件: Ezogabine1件: Ezogabine 💬5件: KCNQ1,
KCNQ2,
KCNQ3,
KCNQ4,
KCNQ5 💬		6件: Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection 💬1件: 144 💬
26Fenfluramina1件: Fenfluramine1件: Fenfluramine 💬5件: HTR1D,
HTR2A,
HTR2C,
SIGMAR1,
SLC6A4 💬		10件: Amyotrophic lateral sclerosis, Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways of neurodegeneration - multiple diseases, Serotonergic synapse, Synaptic vesicle cycle, Taste transduction, cAMP signaling pathway 💬2件: 140, 144 💬
27Fenfluramina Cloridrato1件: Fenfluramine1件: Fenfluramine 💬5件: HTR1D,
HTR2A,
HTR2C,
SIGMAR1,
SLC6A4 💬		10件: Amyotrophic lateral sclerosis, Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways of neurodegeneration - multiple diseases, Serotonergic synapse, Synaptic vesicle cycle, Taste transduction, cAMP signaling pathway 💬2件: 140, 144 💬
28FENFLURAMINE1件: Fenfluramine1件: Fenfluramine 💬5件: HTR1D,
HTR2A,
HTR2C,
SIGMAR1,
SLC6A4 💬		10件: Amyotrophic lateral sclerosis, Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways of neurodegeneration - multiple diseases, Serotonergic synapse, Synaptic vesicle cycle, Taste transduction, cAMP signaling pathway 💬4件: 140, 144, 145, 149 💬
29Fenfluramine HCl, DL-Fenfluramine, (±)-Fenfluramine1件: Fenfluramine1件: Fenfluramine 💬5件: HTR1D,
HTR2A,
HTR2C,
SIGMAR1,
SLC6A4 💬		10件: Amyotrophic lateral sclerosis, Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways of neurodegeneration - multiple diseases, Serotonergic synapse, Synaptic vesicle cycle, Taste transduction, cAMP signaling pathway 💬1件: 144 💬
30FENFLURAMINE HYDROCHLORIDE1件: Fenfluramine1件: Fenfluramine 💬5件: HTR1D,
HTR2A,
HTR2C,
SIGMAR1,
SLC6A4 💬		10件: Amyotrophic lateral sclerosis, Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways of neurodegeneration - multiple diseases, Serotonergic synapse, Synaptic vesicle cycle, Taste transduction, cAMP signaling pathway 💬2件: 140, 144 💬
31FENFLURAMINE HYDROCHLORIDE (colorless)1件: Fenfluramine1件: Fenfluramine 💬5件: HTR1D,
HTR2A,
HTR2C,
SIGMAR1,
SLC6A4 💬		10件: Amyotrophic lateral sclerosis, Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways of neurodegeneration - multiple diseases, Serotonergic synapse, Synaptic vesicle cycle, Taste transduction, cAMP signaling pathway 💬2件: 140, 144 💬
32Fycompa1件: Perampanel1件: Perampanel 💬4件: GRIA1,
GRIA2,
GRIA3,
GRIA4 💬		16件: Amphetamine addiction, Amyotrophic lateral sclerosis, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Transcriptional misregulation in cancer, cAMP signaling pathway 💬2件: 2, 144 💬
33GW582892----1件: 144 💬
34GWP42003-P----5件: 140, 144, 145, 156, 158 💬
35GWP42003-P 20 mg/kg/day Dose----2件: 140, 144 💬
36Inovelon1件: Rufinamide1件: Rufinamide 💬5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 144 💬
37Investigators Choice of Approved AED----1件: 144 💬
38Investigators choice of approved AEDs----1件: 144 💬
39Lamictal1件: Lamotrigine1件: Lamotrigine 💬5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 144 💬
40Lamotrigine1件: Lamotrigine1件: Lamotrigine 💬5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬5件: 13, 34, 38, 114, 144 💬
41LP352----2件: 140, 144 💬
42MIC----2件: 140, 144 💬
43PEG----15件: 6, 13, 41, 46, 60, 65, 78, 96, 97, 140, 144, 240, 246, 299, 337 💬
44Perampanel1件: Perampanel1件: Perampanel 💬4件: GRIA1,
GRIA2,
GRIA3,
GRIA4 💬		16件: Amphetamine addiction, Amyotrophic lateral sclerosis, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Transcriptional misregulation in cancer, cAMP signaling pathway 💬3件: 2, 6, 144 💬
45Placebo----28件: 3, 5, 6, 11, 13, 14, 37, 40, 46, 49, 50, 51, 53, 63, 66, 67, 79, 85, 86, 88, 96, 97, 140, 144, 149, 226, 271, 276 💬
46Potiga1件: Ezogabine1件: Ezogabine 💬5件: KCNQ1,
KCNQ2,
KCNQ3,
KCNQ4,
KCNQ5 💬		6件: Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection 💬1件: 144 💬
47RETIGABINE1件: Ezogabine1件: Ezogabine 💬5件: KCNQ1,
KCNQ2,
KCNQ3,
KCNQ4,
KCNQ5 💬		6件: Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection 💬2件: 2, 144 💬
48RETIGABINE/EZOGABINE1件: Ezogabine1件: Ezogabine 💬5件: KCNQ1,
KCNQ2,
KCNQ3,
KCNQ4,
KCNQ5 💬		6件: Adrenergic signaling in cardiomyocytes, Cholinergic synapse, Gastric acid secretion, Pancreatic secretion, Protein digestion and absorption, Vibrio cholerae infection 💬1件: 144 💬
49RUFINAMIDE1件: Rufinamide1件: Rufinamide 💬5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 144 💬
50Rufinamide (E2080)1件: Rufinamide1件: Rufinamide 💬5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 144 💬
51Rufinamide oral suspension1件: Rufinamide1件: Rufinamide 💬5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬1件: 144 💬
52Sodio valproato----1件: 144 💬
53SOTICLESTAT1件: Soticlestat1件: Soticlestat 💬1件: CYP46A1 💬1件: Primary bile acid biosynthesis 💬2件: 140, 144 💬
54TAK-935----2件: 140, 144 💬
55Topimarate----1件: 144 💬
56Topimarato----1件: 144 💬
57TOPIRAMATE1件: Topiramate1件: Topiramate 💬36件: CA2,
CA4,
CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S,
GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ,
GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬		53件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Arrhythmogenic right ventricular cardiomyopathy, Bile secretion, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cocaine addiction, Collecting duct acid secretion, Cortisol synthesis and secretion, Cushing syndrome, Dilated cardiomyopathy, Dopaminergic synapse, GABAergic synapse, Gastric acid secretion, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Huntington disease, Hypertrophic cardiomyopathy, Insulin secretion, Long-term depression, Long-term potentiation, MAPK signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Nitrogen metabolism, Oxytocin signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Prion disease, Proximal tubule bicarbonate reclamation, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Spinocerebellar ataxia, Taste transduction, Tight junction, Transcriptional misregulation in cancer, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬6件: 6, 97, 140, 144, 156, 193 💬
58Turmeric1件: Turmeric---4件: 140, 144, 158, 299 💬
59ZX008----2件: 140, 144 💬
60ZX008 (Fenfluramine Hydrochloride)1件: Fenfluramine1件: Fenfluramine 💬5件: HTR1D,
HTR2A,
HTR2C,
SIGMAR1,
SLC6A4 💬		10件: Amyotrophic lateral sclerosis, Calcium signaling pathway, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Pathways of neurodegeneration - multiple diseases, Serotonergic synapse, Synaptic vesicle cycle, Taste transduction, cAMP signaling pathway 💬2件: 140, 144 💬
61ZX008 0.2 or 0.8 mg/kg/day----1件: 144 💬
62ZX008 0.2 to 0.8 mg/kg/day----2件: 140, 144 💬