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No. 薬物名(臨床試験情報から抽出) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target genes
指定難病告示番号
1Acetate1件: Benazepril2件: D00620 ,
D07499
1件: ACE 💬6件: Chagas disease, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Hypertrophic cardiomyopathy, Renin secretion, Renin-angiotensin system 💬43件: 1, 2, 6, 10, 13, 35, 40, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 162, 171, 206, 222, 224, 225, 227, 235, 265, 288, 298, 299
2Acetazolamide1件: Acetazolamide2件: D00218 ,
D01196
13件: CA1,
CA12,
CA13,
CA14,
CA2,
CA3,
CA4,
CA5A,
CA5B,
CA6,
CA7,
CA8,
CA9 💬
7件: Bile secretion, Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Nitrogen metabolism, Pancreatic secretion, Proximal tubule bicarbonate reclamation 💬6件: 13, 90, 115, 155, 225, 230
3Acetazolamide Sandoz 2501件: Acetazolamide2件: D00218 ,
D01196
13件: CA1,
CA12,
CA13,
CA14,
CA2,
CA3,
CA4,
CA5A,
CA5B,
CA6,
CA7,
CA8,
CA9 💬
7件: Bile secretion, Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Nitrogen metabolism, Pancreatic secretion, Proximal tubule bicarbonate reclamation 💬1件: 225
4Adempas1件: Riociguat1件: D09572 3件: GUCY1A1,
GUCY1A2,
GUCY1B1 💬
11件: Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬5件: 51, 86, 88, 225, 299
5Amiloride1件: Amiloride2件: D00649 ,
D07447
3件: SCNN1A,
SCNN1B,
SCNN1G 💬
2件: Aldosterone-regulated sodium reabsorption, Taste transduction 💬4件: 13, 67, 225, 299
6Anhydrous Amiloride Hydrochloride1件: Amiloride2件: D00649 ,
D07447
3件: SCNN1A,
SCNN1B,
SCNN1G 💬
2件: Aldosterone-regulated sodium reabsorption, Taste transduction 💬1件: 225
7Atorvastatin1件: Simvastatin1件: D00434 1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬18件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 299
8Calcitonin1件: Sildenafil2件: D02229 ,
D08514
1件: PDE5A 💬3件: Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬1件: 225
9CALCITONIN (SALMON)1件: Sildenafil2件: D02229 ,
D08514
1件: PDE5A 💬3件: Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬1件: 225
10Chlorothiazide1件: Chlorothiazide2件: D00519 ,
D03471
--1件: 225
11Confortid1件: Sildenafil2件: D02229 ,
D08514
1件: PDE5A 💬3件: Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬1件: 225
12Desmopressin1件: Desmopressin2件: D00291 ,
D02235
2件: AVPR2,
F8 💬
4件: Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬5件: 6, 64, 72, 225, 288
13DESMOPRESSIN ACETATE TRIHYDRATE1件: Desmopressin2件: D00291 ,
D02235
2件: AVPR2,
F8 💬
4件: Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬1件: 225
14Desmopressine1件: Desmopressin2件: D00291 ,
D02235
2件: AVPR2,
F8 💬
4件: Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬2件: 225, 288
15Desmopressine nasal spray 10 mg/ml, flacon 60 doses1件: Desmopressin2件: D00291 ,
D02235
2件: AVPR2,
F8 💬
4件: Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬1件: 225
16Esidrix1件: Sildenafil2件: D02229 ,
D08514
1件: PDE5A 💬3件: Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬1件: 225
17FLUCONAZOLE1件: Fluconazole2件: D00322 ,
D01429
--2件: 96, 225
18Hydrochloorthiazide1件: Amiloride2件: D00649 ,
D07447
3件: SCNN1A,
SCNN1B,
SCNN1G 💬
2件: Aldosterone-regulated sodium reabsorption, Taste transduction 💬1件: 225
19HYDROCHLOROTHIAZIDE1件: Hydrochlorothiazide1件: D00340 --4件: 13, 67, 225, 235
20Hydrochlorothiazide/amiloride1件: Sildenafil2件: D02229 ,
D08514
1件: PDE5A 💬3件: Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬1件: 225
21INDOMETACIN1件: Sildenafil2件: D02229 ,
D08514
1件: PDE5A 💬3件: Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬1件: 225
22Indomethacin1件: Indomethacin3件: D00141 ,
D01565 ,
D02110
2件: PTGS1,
PTGS2 💬
23件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Platelet activation, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬3件: 225, 271, 298
23Losec1件: Omeprazole4件: D00455 ,
D01207 ,
D05259 ,
D05261
2件: ATP4A,
ATP4B 💬
4件: Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬3件: 46, 225, 294
24Magnesium1件: Pancrelipase1件: D05349 --19件: 3, 6, 11, 13, 15, 46, 64, 70, 93, 97, 166, 225, 235, 256, 284, 291, 296, 297, 298
25Metformin1件: Metformin2件: D00944 ,
D04966
2件: PRKAA1,
PRKAA2 💬
20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬24件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
26Miacalcic1件: Sildenafil2件: D02229 ,
D08514
1件: PDE5A 💬3件: Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬1件: 225
27Midamor1件: Amiloride2件: D00649 ,
D07447
3件: SCNN1A,
SCNN1B,
SCNN1G 💬
2件: Aldosterone-regulated sodium reabsorption, Taste transduction 💬1件: 225
28Omeprazole1件: Omeprazole4件: D00455 ,
D01207 ,
D05259 ,
D05261
2件: ATP4A,
ATP4B 💬
4件: Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬16件: 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
29OMEPRAZOLE MAGNESIUM1件: Sildenafil2件: D02229 ,
D08514
1件: PDE5A 💬3件: Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬1件: 225
30PB----2件: 67, 225
31RIOCIGUAT1件: Riociguat1件: D09572 3件: GUCY1A1,
GUCY1A2,
GUCY1B1 💬
11件: Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬6件: 51, 84, 86, 88, 225, 299
32Salmon1件: Salmon, unspecified---3件: 96, 97, 225
33Sevoflurane1件: Lidocaine3件: D00358 ,
D02086 ,
D08127
5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬
3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬7件: 6, 21, 22, 34, 98, 225, 296
34Sildenafil1件: Sildenafil2件: D02229 ,
D08514
1件: PDE5A 💬3件: Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬17件: 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301
35Sildenafil citrate1件: Sildenafil2件: D02229 ,
D08514
1件: PDE5A 💬3件: Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬4件: 51, 85, 86, 225
36Spirix1件: Sildenafil2件: D02229 ,
D08514
1件: PDE5A 💬3件: Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬1件: 225
37Spironolactone1件: Spironolactone1件: D00443 1件: NR3C2 💬1件: Aldosterone-regulated sodium reabsorption 💬7件: 58, 67, 86, 113, 210, 218, 225
38SUB216051件: Desmopressin2件: D00291 ,
D02235
2件: AVPR2,
F8 💬
4件: Complement and coagulation cascades, Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬1件: 225
39TOLVAPTAN1件: Tolvaptan1件: D01213 1件: AVPR2 💬3件: Neuroactive ligand-receptor interaction, Phospholipase D signaling pathway, Vasopressin-regulated water reabsorption 💬3件: 67, 72, 225
40VIAGRA1件: Sildenafil2件: D02229 ,
D08514
1件: PDE5A 💬3件: Metabolic pathways, Purine metabolism, cGMP-PKG signaling pathway 💬3件: 86, 96, 225