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No. 薬物名(臨床試験情報から抽出) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target genes
指定難病告示番号
1(R)-tetrahydrofuran-3-yl 4-(6-(5-(4-ethoxy-1-isopropylpiperidin-4- yl)pyridine-2-yl)pyrrolo[1,2-b]pyridazin-4-yl)piperazine-1-carboxylate sesquisuccinate1件: Piperazine6件: D00807 ,
D01393 ,
D02127 ,
D02145 ,
D05486 ,
D06224
--1件: 272
2(R)-tetrahydrofuran-3-yl 4-(6-(5-(4-ethoxy-1-isopropylpiperidin-4- yl)pyridine-2yl)pyrrolo[1,2-b]pyridazin-4-yl)piperazine-1-carboxylate1件: Piperazine6件: D00807 ,
D01393 ,
D02127 ,
D02145 ,
D05486 ,
D06224
--1件: 272
3[Not Applicable]1件: Clidinium---4件: 13, 20, 50, 272
4[not assigned]1件: Clidinium---1件: 272
5AZD05301件: Saracatinib1件: D09664 2件: ABL1,
SRC 💬
49件: Adherens junction, Axon guidance, Bacterial invasion of epithelial cells, Bladder cancer, C-type lectin receptor signaling pathway, Cell cycle, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Fluid shear stress and atherosclerosis, Focal adhesion, GABAergic synapse, Gap junction, GnRH signaling pathway, Hepatitis B, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, MicroRNAs in cancer, Mitophagy - animal, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Oxytocin signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Platelet activation, Prolactin signaling pathway, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Thyroid hormone signaling pathway, Tight junction, Tuberculosis, VEGF signaling pathway, Viral carcinogenesis, Viral myocarditis, Yersinia infection 💬1件: 272
6AZD0530 Difumarate----1件: 272
7DS-6016a----1件: 272
8Garetosmab1件: Garetosmab1件: D11443 --1件: 272
9INCB000928----1件: 272
10INCB000928 fumarate dihydrate----1件: 272
11IPN601201件: Palovarotene1件: D09365 --1件: 272
12IPN60130----1件: 272
13IPN60130 10 mg capsules1件: Piperazine6件: D00807 ,
D01393 ,
D02127 ,
D02145 ,
D05486 ,
D06224
--1件: 272
14IPN60130 50 mg capsules1件: Piperazine6件: D00807 ,
D01393 ,
D02127 ,
D02145 ,
D05486 ,
D06224
--1件: 272
15Midazolam1件: Caffeine2件: D00528 ,
D01453
11件: ADORA1,
ADORA2A,
PDE1B,
PDE2A,
PDE3A,
PDE3B,
PDE4A,
PDE4B,
PDE4C,
PDE4D,
PDE5A 💬
22件: Alcoholism, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pathway, Glucagon signaling pathway, Insulin signaling pathway, Metabolic pathways, Morphine addiction, Neuroactive ligand-receptor interaction, Olfactory transduction, Parathyroid hormone synthesis, secretion and action, Parkinson disease, Progesterone-mediated oocyte maturation, Purine metabolism, Rap1 signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Sphingolipid signaling pathway, Taste transduction, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬12件: 2, 3, 6, 13, 21, 46, 70, 96, 97, 231, 272, 298
16Not applicable1件: Clidinium---4件: 13, 20, 50, 272
17PALOVAROTENE1件: Palovarotene1件: D09365 --1件: 272
18PALOVAROTENE - 1.5mg1件: Palovarotene1件: D09365 --1件: 272
19PALOVAROTENE - 10 mg1件: Palovarotene1件: D09365 --1件: 272
20PALOVAROTENE - 1mg1件: Palovarotene1件: D09365 --1件: 272
21PALOVAROTENE - 2 mg1件: Palovarotene1件: D09365 --1件: 272
22PALOVAROTENE - 2.5 mg1件: Palovarotene1件: D09365 --1件: 272
23PALOVAROTENE - 3 mg1件: Palovarotene1件: D09365 --1件: 272
24PALOVAROTENE - 4 mg1件: Palovarotene1件: D09365 --1件: 272
25PALOVAROTENE - 5 mg1件: Palovarotene1件: D09365 --1件: 272
26PALOVAROTENE 1.5 mg1件: Clidinium---1件: 272
27Palovarotene dose level 11件: Palovarotene1件: D09365 --1件: 272
28Palovarotene dose level 21件: Palovarotene1件: D09365 --1件: 272
29Palovarotene dose level 31件: Palovarotene1件: D09365 --1件: 272
30Palovarotene dose level 41件: Palovarotene1件: D09365 --1件: 272
31PALOVAROTENE-2 mg1件: Clidinium---1件: 272
32PALOVAROTENE-3 mg1件: Clidinium---1件: 272
33PALOVAROTENE-4 mg1件: Clidinium---1件: 272
34Perhexiline1件: Perhexiline2件: D05442 ,
D08340
8件: CACNA1C,
CACNA1D,
CACNA1F,
CACNA1S,
CPT1A,
CPT1B,
CPT1C,
CPT2 💬
47件: AMPK signaling pathway, Adipocytokine signaling pathway, Adrenergic signaling in cardiomyocytes, Alcoholic liver disease, Aldosterone synthesis and secretion, Alzheimer disease, Amphetamine addiction, Arrhythmogenic right ventricular cardiomyopathy, Calcium signaling pathway, Carbohydrate digestion and absorption, Cardiac muscle contraction, Cellular senescence, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Circadian entrainment, Cortisol synthesis and secretion, Cushing syndrome, Diabetic cardiomyopathy, Dilated cardiomyopathy, Dopaminergic synapse, Fatty acid degradation, Fatty acid metabolism, GABAergic synapse, Glucagon signaling pathway, Glutamatergic synapse, GnRH secretion, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hypertrophic cardiomyopathy, Insulin resistance, Insulin secretion, Long-term potentiation, MAPK signaling pathway, Oxytocin signaling pathway, PPAR signaling pathway, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction, Thermogenesis, Tight junction, Type II diabetes mellitus, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬2件: 58, 272
35Piperazine1件: Piperazine6件: D00807 ,
D01393 ,
D02127 ,
D02145 ,
D05486 ,
D06224
--2件: 58, 272
36REGN2477----1件: 272
37Saracatinib1件: Saracatinib1件: D09664 2件: ABL1,
SRC 💬
49件: Adherens junction, Axon guidance, Bacterial invasion of epithelial cells, Bladder cancer, C-type lectin receptor signaling pathway, Cell cycle, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Fluid shear stress and atherosclerosis, Focal adhesion, GABAergic synapse, Gap junction, GnRH signaling pathway, Hepatitis B, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, MicroRNAs in cancer, Mitophagy - animal, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Oxytocin signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Platelet activation, Prolactin signaling pathway, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Thyroid hormone signaling pathway, Tight junction, Tuberculosis, VEGF signaling pathway, Viral carcinogenesis, Viral myocarditis, Yersinia infection 💬3件: 6, 89, 272
38SARACATINIB DIFUMARATE1件: Saracatinib1件: D09664 2件: ABL1,
SRC 💬
49件: Adherens junction, Axon guidance, Bacterial invasion of epithelial cells, Bladder cancer, C-type lectin receptor signaling pathway, Cell cycle, Chemical carcinogenesis - reactive oxygen species, Chemical carcinogenesis - receptor activation, Chemokine signaling pathway, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, ErbB signaling pathway, Estrogen signaling pathway, Fluid shear stress and atherosclerosis, Focal adhesion, GABAergic synapse, Gap junction, GnRH signaling pathway, Hepatitis B, Herpes simplex virus 1 infection, Human cytomegalovirus infection, Inflammatory mediator regulation of TRP channels, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, MicroRNAs in cancer, Mitophagy - animal, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Oxytocin signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Platelet activation, Prolactin signaling pathway, Proteoglycans in cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Relaxin signaling pathway, Shigellosis, Thyroid hormone signaling pathway, Tight junction, Tuberculosis, VEGF signaling pathway, Viral carcinogenesis, Viral myocarditis, Yersinia infection 💬1件: 272