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No. 薬物名(臨床試験情報から抽出) DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target genes
指定難病告示番号
1[A4250]1件: Odevixibat1件: D11716 1件: SLC10A2 💬1件: Bile secretion 💬3件: 296, 297, 338
2[Maralixibat]1件: Chloride ion---2件: 296, 338
3A4250----4件: 93, 296, 297, 338
4Acetylcysteine1件: Pirfenidone1件: D01583 6件: CCL2,
IL10,
IL1A,
IL1B,
IL6,
TNF 💬
84件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, Autoimmune thyroid disease, C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease, Chemokine signaling pathway, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Dilated cardiomyopathy, EGFR tyrosine kinase inhibitor resistance, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Graft-versus-host disease, HIF-1 signaling pathway, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Inflammatory mediator regulation of TRP channels, Influenza A, Insulin resistance, Intestinal immune network for IgA production, JAK-STAT signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, Measles, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Staphylococcus aureus infection, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Th17 cell differentiation, Toll-like receptor signaling pathway, Toxoplasmosis, Transcriptional misregulation in cancer, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬20件: 6, 13, 19, 20, 34, 49, 51, 53, 58, 85, 90, 94, 111, 164, 193, 233, 296, 298, 299, 337
5Ammonia1件: Spironolactone1件: D00443 1件: NR3C2 💬1件: Aldosterone-regulated sodium reabsorption 💬3件: 86, 88, 296
6BELIMUMAB1件: Azathioprine2件: D00238 ,
D03033
--12件: 11, 13, 43, 44, 46, 49, 51, 53, 66, 222, 296, 300
7Bezafibrate1件: Bezafibrate1件: D01366 1件: PPARA 💬10件: Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬7件: 20, 93, 94, 160, 296, 316, 324
8Bicarbonate Ringer's solution----1件: 296
9Cefoperazone1件: Cefoperazone1件: D07645 --1件: 296
10Chloride1件: Choline1件: D07690 --29件: 6, 11, 13, 14, 34, 46, 50, 51, 53, 60, 65, 67, 78, 96, 97, 107, 127, 168, 171, 193, 227, 228, 251, 271, 288, 296, 297, 299, 338
11Combination Product: high MCT formula1件: Medium-chain triglycerides---1件: 296
12Corticosteroids1件: Adalimumab1件: D02597 1件: TNF 💬67件: AGE-RAGE signaling pathway in diabetic complications, Adipocytokine signaling pathway, African trypanosomiasis, Alcoholic liver disease, Allograft rejection, Alzheimer disease, Amoebiasis, Amyotrophic lateral sclerosis, Antifolate resistance, Antigen processing and presentation, Apoptosis, Asthma, C-type lectin receptor signaling pathway, Chagas disease, Coronavirus disease - COVID-19, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, Graft-versus-host disease, Hematopoietic cell lineage, Hepatitis B, Hepatitis C, Herpes simplex virus 1 infection, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Human papillomavirus infection, Hypertrophic cardiomyopathy, IL-17 signaling pathway, Inflammatory bowel disease, Influenza A, Insulin resistance, Legionellosis, Leishmaniasis, Lipid and atherosclerosis, MAPK signaling pathway, Malaria, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, Natural killer cell mediated cytotoxicity, Necroptosis, Non-alcoholic fatty liver disease, Osteoclast differentiation, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Prion disease, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rheumatoid arthritis, Salmonella infection, Shigellosis, Sphingolipid signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, TNF signaling pathway, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, Type I diabetes mellitus, Type II diabetes mellitus, Viral protein interaction with cytokine and cytokine receptor, Yersinia infection, mTOR signaling pathway 💬10件: 41, 46, 49, 64, 97, 107, 164, 220, 296, 300
13Cysteine1件: Cysteine2件: D00026 ,
D02326
--11件: 6, 13, 19, 34, 84, 85, 88, 90, 254, 296, 310
14Desflurane1件: Propofol1件: D00549 16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬
7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬2件: 22, 296
15Desflurane anesthetics1件: Desflurane1件: D00546 --1件: 296
16Dexamethasone1件: Bortezomib1件: D03150 1件: PSMB5 💬8件: Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Prion disease, Proteasome, Spinocerebellar ataxia 💬25件: 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
17DIMETHYL FUMARATE1件: Dimethyl fumarate1件: D03846 1件: KEAP1 💬6件: Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Parkinson disease, Pathways in cancer, Ubiquitin mediated proteolysis 💬4件: 13, 51, 86, 296
18Eicosapentaenoic acid1件: Icosapent1件: D08061 --6件: 49, 96, 97, 296, 297, 338
19Epadel1件: Icosapent ethyl1件: D01892 --1件: 296
20Filgrastim1件: Cyclosporine1件: D00184 5件: PPP3CA,
PPP3CB,
PPP3CC,
PPP3R1,
PPP3R2 💬
33件: Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Axon guidance, B cell receptor signaling pathway, C-type lectin receptor signaling pathway, Calcium signaling pathway, Cellular senescence, Dopaminergic synapse, Glucagon signaling pathway, Glutamatergic synapse, Human T-cell leukemia virus 1 infection, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Lipid and atherosclerosis, Long-term potentiation, MAPK signaling pathway, Natural killer cell mediated cytotoxicity, Oocyte meiosis, Osteoclast differentiation, Oxytocin signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathways of neurodegeneration - multiple diseases, Prion disease, Renin secretion, T cell receptor signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Tuberculosis, VEGF signaling pathway, Wnt signaling pathway, cGMP-PKG signaling pathway 💬28件: 2, 6, 13, 25, 26, 28, 34, 35, 38, 40, 41, 42, 45, 46, 49, 51, 60, 62, 65, 96, 113, 164, 256, 283, 284, 285, 296, 331
21Gold1件: Gold---43件: 2, 5, 6, 13, 17, 34, 35, 46, 49, 50, 53, 58, 65, 68, 76, 84, 86, 91, 93, 95, 96, 97, 98, 113, 137, 158, 162, 171, 193, 218, 222, 224, 227, 230, 235, 271, 291, 294, 296, 298, 299, 310, 318
22Granulocyte Colony-Stimulating Factor----1件: 296
23ICG Pulsion----1件: 296
24ICG-Pulsion 25mg----1件: 296
25Indocyanine green1件: Indocyanine green1件: D01342 --8件: 22, 46, 51, 96, 235, 278, 291, 296
26Intravenous immunoglobulin (IVIg)1件: Human immunoglobulin G---4件: 14, 17, 164, 296
27Lactated Ringer----1件: 296
28Lactobacillus casei1件: Lactobacillus casei1件: D04351 --3件: 6, 97, 296
29Lactobacillus casei rhamnosus (Lcr35)1件: Neomycin1件: D08260 --1件: 296
30Magnesium1件: Pancrelipase1件: D05349 --19件: 3, 6, 11, 13, 15, 46, 64, 70, 93, 97, 166, 225, 235, 256, 284, 291, 296, 297, 298
31Magnesium gluconate1件: Magnesium sulfate1件: D01108 --2件: 296, 297
32Magnesium sulfate1件: Magnesium sulfate1件: D01108 --3件: 11, 296, 297
33Maralixibat1件: Chloride ion---3件: 296, 297, 338
34Maralixibat (formely SHP625 or LUM001)1件: Chloride ion---3件: 296, 297, 338
35MARALIXIBAT CHLORIDE1件: Chloride ion---3件: 296, 297, 338
36Maralixibat cloruro1件: Chloride ion---2件: 296, 338
37MCT1件: Medium-chain triglycerides---2件: 6, 296
38MCT powder1件: Medium-chain triglycerides---1件: 296
39Meloxicam1件: Meloxicam1件: D00969 1件: PTGS2 💬22件: Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemical carcinogenesis - DNA adducts, Human cytomegalovirus infection, Human papillomavirus infection, IL-17 signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Metabolic pathways, MicroRNAs in cancer, NF-kappa B signaling pathway, Ovarian steroidogenesis, Oxytocin signaling pathway, Pathways in cancer, Pathways of neurodegeneration - multiple diseases, Regulation of lipolysis in adipocytes, Retrograde endocannabinoid signaling, Serotonergic synapse, Small cell lung cancer, TNF signaling pathway, VEGF signaling pathway 💬4件: 46, 49, 271, 296
40Methylprednisolone1件: Methylprednisolone6件: D00407 ,
D00751 ,
D00979 ,
D05000 ,
D05001 ,
D05002
1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬48件: 2, 6, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
41N-acetyl Cysteine1件: Cysteine2件: D00026 ,
D02326
--7件: 13, 19, 34, 85, 88, 296, 310
42Neomycin1件: Fluconazole2件: D00322 ,
D01429
--3件: 96, 97, 296
43Normal Saline----18件: 6, 13, 17, 22, 36, 46, 49, 60, 70, 94, 96, 210, 211, 226, 271, 276, 296, 299
44Obeticholic Acid1件: Obeticholic acid1件: D09360 1件: NR1H4 💬1件: Bile secretion 💬3件: 93, 265, 296
45OCA----2件: 94, 296
46OCA 0.1 mg1件: Obeticholic acid1件: D09360 1件: NR1H4 💬1件: Bile secretion 💬1件: 296
47OCA 1.5mg1件: Obeticholic acid1件: D09360 1件: NR1H4 💬1件: Bile secretion 💬1件: 296
48OCA 5mg1件: Obeticholic acid1件: D09360 1件: NR1H4 💬1件: Bile secretion 💬1件: 296
49Ocaliva1件: Bezafibrate1件: D01366 1件: PPARA 💬10件: Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬2件: 93, 296
50Odevixibat1件: Odevixibat1件: D11716 1件: SLC10A2 💬1件: Bile secretion 💬3件: 296, 297, 338
51Oral Vancomycin1件: Vancomycin2件: D00212 ,
D00926
--2件: 94, 296
52Other Crystalloid----1件: 296
53Pentoxifylline1件: Pentoxifylline1件: D00501 --10件: 26, 56, 84, 93, 96, 113, 220, 222, 296, 298
54PREDNISOLONE1件: Prednisolone8件: D00472 ,
D00980 ,
D00981 ,
D00982 ,
D01239 ,
D01998 ,
D02156 ,
D03301
1件: NR3C1 💬1件: Neuroactive ligand-receptor interaction 💬43件: 3, 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
55Propanolol1件: Propranolol2件: D00483 ,
D08443
3件: ADRB1,
ADRB2,
ADRB3 💬
12件: Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Dilated cardiomyopathy, Gap junction, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Salivary secretion, Thermogenesis, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 296
56PROPOFOL1件: Isoflurane1件: D00545 --9件: 6, 21, 22, 34, 46, 70, 84, 98, 296
57Rifaximin1件: Alemtuzumab1件: D02802 --7件: 6, 65, 93, 96, 97, 99, 296
58Rituximab1件: Rituximab1件: D02994 1件: MS4A1 💬1件: Hematopoietic cell lineage 💬49件: 6, 11, 13, 14, 17, 19, 35, 36, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 127, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331
59Rocuronium1件: Rocuronium1件: D00765 16件: CHRM1,
CHRM2,
CHRM3,
CHRM4,
CHRM5,
CHRNA10,
CHRNA2,
CHRNA3,
CHRNA4,
CHRNA5,
CHRNA6,
CHRNA7,
CHRNA9,
CHRNB2,
CHRNB3,
CHRNB4 💬
15件: Alzheimer disease, Calcium signaling pathway, Chemical carcinogenesis - receptor activation, Cholinergic synapse, Gastric acid secretion, Insulin secretion, Neuroactive ligand-receptor interaction, Nicotine addiction, PI3K-Akt signaling pathway, Pancreatic secretion, Pathways of neurodegeneration - multiple diseases, Regulation of actin cytoskeleton, Salivary secretion, Taste transduction, cAMP signaling pathway 💬1件: 296
60Sevoflurane1件: Lidocaine3件: D00358 ,
D02086 ,
D08127
5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬
3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬7件: 6, 21, 22, 34, 98, 225, 296
61Sevoflurane anesthetics1件: Desflurane1件: D00546 --1件: 296
62Sulfate1件: Filgrastim1件: D03235 1件: CSF3R 💬5件: Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, JAK-STAT signaling pathway, PI3K-Akt signaling pathway, Pathways in cancer 💬27件: 2, 3, 6, 11, 13, 26, 28, 34, 36, 46, 49, 53, 60, 64, 66, 79, 85, 86, 96, 111, 218, 222, 226, 265, 296, 297, 299
63UDCA1件: Ursodeoxycholic acid1件: D00734 1件: NR1H4 💬1件: Bile secretion 💬6件: 46, 67, 93, 94, 97, 296
64Umbilical Cord Derived Mesenchymal Stem Cell (UC -MSC) Transplantation----2件: 93, 296
65Vancomycin1件: Vancomycin2件: D00212 ,
D00926
--7件: 46, 70, 94, 96, 97, 296, 299
66VO4CX----1件: 296