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No. 薬物名（臨床試験情報から抽出） DrugBank KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
111C-ACETATE2件: Acetate,
Acetic acid C-11		---4件: 6, 13, 86, 88 💬
2[18F]Fluoro-2-deoxy-2-D-glucose2件: D-glucose,
Dextrose, unspecified form		1件: Glucose 💬--2件: 86, 88 💬
3Acetate1件: Acetate---41件: 1, 2, 6, 10, 13, 46, 49, 51, 60, 64, 67, 70, 71, 73, 75, 76, 78, 79, 81, 83, 85, 86, 88, 90, 96, 97, 113, 145, 156, 171, 206, 222, 224, 225, 227, 235, 251, 265, 288, 298, 299 💬
4ACT-064992----5件: 51, 85, 86, 88, 210 💬
5ACT-293987----3件: 51, 86, 88 💬
6Adempas1件: Riociguat1件: Riociguat 💬3件: GUCY1A1,
GUCY1A2,
GUCY1B1 💬		11件: Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬5件: 51, 86, 88, 225, 299 💬
7Adempas (Riociguat, BAY63-2521)1件: Riociguat1件: Riociguat 💬3件: GUCY1A1,
GUCY1A2,
GUCY1B1 💬		11件: Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬2件: 86, 88 💬
8Adempas®1件: Riociguat1件: Riociguat 💬3件: GUCY1A1,
GUCY1A2,
GUCY1B1 💬		11件: Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬2件: 86, 88 💬
9Ambrisentan1件: Ambrisentan1件: Ambrisentan 💬1件: EDNRA 💬7件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬7件: 51, 84, 85, 86, 88, 210, 211 💬
10Ambrisentan 5 mg1件: Ambrisentan1件: Ambrisentan 💬1件: EDNRA 💬7件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 88 💬
11Atorvastatin1件: Atorvastatin1件: Atorvastatin 💬1件: HMGCR 💬4件: AMPK signaling pathway, Bile secretion, Metabolic pathways, Terpenoid backbone biosynthesis 💬19件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬
12BARNASCAN----1件: 88 💬
13BAY 63-2521----2件: 86, 88 💬
14BAY 63-2521 coated tablets 0.5 mg----2件: 86, 88 💬
15BAY 63-2521 coated tablets 1 mg----2件: 86, 88 💬
16BAY 63-2521 coated tablets 1.5 mg----2件: 86, 88 💬
17BAY 63-2521 coated tablets 2 mg----2件: 86, 88 💬
18BAY 63-2521 coated tablets 2.5 mg----2件: 86, 88 💬
19BAY 63-2521 IR coated tablet 1.0 mg----1件: 88 💬
20BAY 63-2521 IR coated tablet 1.5 mg----1件: 88 💬
21BAY 63-2521 IR coated tablet 2.0 mg----1件: 88 💬
22BAY 63-2521 IR coated tablet 2.5 mg----1件: 88 💬
23BAY 63-2521 IR tablet 0.5 mg----1件: 88 💬
24BAY 63-2521 IR tablet 1.0 mg----1件: 88 💬
25BAY 63-2521 IR tablet 1.5 mg----1件: 88 💬
26BAY 63-2521 IR tablet 2.0 mg----1件: 88 💬
27BAY 63-2521 IR tablet 2.5 mg----1件: 88 💬
28BAY 63-2521 tablets 0.5 mg----2件: 86, 88 💬
29BAY 63-2521 tablets 1 mg----2件: 86, 88 💬
30BAY 63-2521 tablets 1.5 mg----2件: 86, 88 💬
31BAY 63-2521 tablets 2 mg----2件: 86, 88 💬
32BAY 63-2521 tablets 2.5 mg----2件: 86, 88 💬
33BAY1237592----2件: 86, 88 💬
34Blood sample----20件: 8, 13, 46, 49, 51, 53, 61, 66, 84, 88, 96, 97, 107, 127, 235, 274, 280, 288, 294, 299 💬
35Bosentan1件: Bosentan2件: Bosentan ,
Bosentan 💬		2件: EDNRA,
EDNRB 💬		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬10件: 41, 47, 51, 84, 85, 86, 88, 210, 211, 212 💬
36BOSENTAN MONOHYDRATE1件: Bosentan2件: Bosentan ,
Bosentan 💬		2件: EDNRA,
EDNRB 💬		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬4件: 51, 84, 86, 88 💬
37BPA----1件: 88 💬
38Cysteine1件: Cysteine---10件: 13, 19, 34, 84, 85, 88, 90, 254, 296, 310 💬
39D-glucose2件: D-glucose,
Dextrose, unspecified form		1件: Glucose 💬--3件: 49, 86, 88 💬
40Dapagliflozin1件: Dapagliflozin1件: Dapagliflozin 💬1件: SLC5A2 💬-7件: 19, 49, 66, 67, 86, 88, 222 💬
41Dapagliflozin 10 MG [Farxiga]1件: Dapagliflozin1件: Dapagliflozin 💬1件: SLC5A2 💬-2件: 86, 88 💬
42Edoxaban1件: Edoxaban1件: Edoxaban 💬1件: F10 💬1件: Complement and coagulation cascades 💬2件: 46, 88 💬
43Fludeoxyglucose1件: Fludeoxyglucose1件: Fludeoxyglucose F 18 💬--3件: 84, 85, 88 💬
44Forxiga1件: Dapagliflozin1件: Dapagliflozin 💬1件: SLC5A2 💬-2件: 86, 88 💬
45Forxiga (dapagliflozin)1件: Dapagliflozin1件: Dapagliflozin 💬1件: SLC5A2 💬-2件: 86, 88 💬
46Glucose2件: D-glucose,
Dextrose, unspecified form		1件: Glucose 💬--12件: 2, 6, 13, 49, 50, 66, 86, 88, 96, 97, 257, 299 💬
47GSK1325760----2件: 86, 88 💬
48Imatinib1件: Imatinib1件: Imatinib 💬3件: ABL1,
KIT,
PDGFRA 💬		32件: Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬
49IMATINIB MESILATE1件: Imatinib1件: Imatinib 💬3件: ABL1,
KIT,
PDGFRA 💬		32件: Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬3件: 13, 86, 88 💬
50JNJ-67896062 / ACT-064992----2件: 86, 88 💬
51JNJ-67896062/ ACT-064992----2件: 86, 88 💬
52Macitentan1件: Macitentan1件: Macitentan 💬2件: EDNRA,
EDNRB 💬		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬5件: 51, 85, 86, 88, 210 💬
53Macitentan 10 mg1件: Macitentan1件: Macitentan 💬2件: EDNRA,
EDNRB 💬		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬3件: 51, 86, 88 💬
54Macitentan 10mg1件: Macitentan1件: Macitentan 💬2件: EDNRA,
EDNRB 💬		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬2件: 51, 88 💬
55MACITENTAN COMPRESSE1件: Macitentan1件: Macitentan 💬2件: EDNRA,
EDNRB 💬		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬2件: 86, 88 💬
56MACITENTAN TABLETS1件: Macitentan1件: Macitentan 💬2件: EDNRA,
EDNRB 💬		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬2件: 86, 88 💬
57Methyl 4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo [3,4-b]pyridine-3-yl]-5-pyrimidinyl(methyl)carb----2件: 86, 88 💬
58Methyl [4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]meth----2件: 86, 88 💬
59MK-4836----2件: 86, 88 💬
60MultiHance1件: Gadobenic acid1件: Gadobenic acid 💬--2件: 86, 88 💬
61N-acetyl cysteine1件: Cysteine---6件: 13, 34, 85, 88, 296, 310 💬
62NITRIC OXIDE1件: Nitric Oxide1件: Nitric oxide 💬--7件: 85, 86, 88, 210, 251, 294, 299 💬
63NS-304----3件: 70, 86, 88 💬
64NS-304 Placebo----2件: 70, 88 💬
65Opsumit1件: Macitentan1件: Macitentan 💬2件: EDNRA,
EDNRB 💬		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬3件: 86, 88, 210 💬
66Opsumit®1件: Macitentan1件: Macitentan 💬2件: EDNRA,
EDNRB 💬		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬3件: 86, 88, 210 💬
67Oxygen1件: Oxygen1件: Oxygen 💬--13件: 6, 49, 70, 85, 86, 88, 90, 96, 168, 193, 271, 299, 330 💬
68Oxygen, liquid1件: Oxygen1件: Oxygen 💬--2件: 86, 88 💬
69Placebo----28件: 3, 5, 6, 11, 13, 14, 37, 40, 46, 49, 50, 51, 53, 63, 66, 67, 79, 85, 86, 88, 96, 97, 140, 144, 149, 226, 271, 276 💬
70Potassium1件: Potassium1件: Potassium 💬--13件: 36, 46, 66, 67, 88, 93, 94, 98, 115, 167, 179, 215, 235 💬
71Remodulin1件: Treprostinil1件: Treprostinil 💬1件: PTGIR 💬3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬2件: 86, 88 💬
72Remodulin (R)1件: Treprostinil1件: Treprostinil 💬1件: PTGIR 💬3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬1件: 88 💬
73Remodulin 10mg/ml 20ml1件: Treprostinil1件: Treprostinil 💬1件: PTGIR 💬3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬1件: 88 💬
74Remodulin 1mg/ml 20ml1件: Treprostinil1件: Treprostinil 💬1件: PTGIR 💬3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬1件: 88 💬
75Remodulin 2.5mg/ml 20ml1件: Treprostinil1件: Treprostinil 💬1件: PTGIR 💬3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬1件: 88 💬
76Remodulin 5mg/ml 20ml1件: Treprostinil1件: Treprostinil 💬1件: PTGIR 💬3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬1件: 88 💬
77RIOCIGUAT1件: Riociguat1件: Riociguat 💬3件: GUCY1A1,
GUCY1A2,
GUCY1B1 💬		11件: Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬6件: 51, 84, 86, 88, 225, 299 💬
78Riociguat (Adempas, BAY63-2521)1件: Riociguat1件: Riociguat 💬3件: GUCY1A1,
GUCY1A2,
GUCY1B1 💬		11件: Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬4件: 51, 86, 88, 299 💬
79Riociguat Oral Tablet1件: Riociguat1件: Riociguat 💬3件: GUCY1A1,
GUCY1A2,
GUCY1B1 💬		11件: Circadian entrainment, Gap junction, Long-term depression, Metabolic pathways, Oxytocin signaling pathway, Platelet activation, Purine metabolism, Renin secretion, Salivary secretion, Vascular smooth muscle contraction, cGMP-PKG signaling pathway 💬3件: 51, 86, 88 💬
80Ro 47-0203----4件: 51, 85, 86, 88 💬
81Sauerstoff----2件: 86, 88 💬
82SELEXIPAG1件: Selexipag1件: Selexipag 💬1件: PTGIR 💬3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬5件: 51, 70, 84, 86, 88 💬
83Systemic anticoagulation----1件: 88 💬
84Tracleer1件: Bosentan2件: Bosentan ,
Bosentan 💬		2件: EDNRA,
EDNRB 💬		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬8件: 13, 51, 84, 85, 86, 88, 210, 211 💬
85TRACLEER 125MG 56CPR RIV.1件: Bosentan2件: Bosentan ,
Bosentan 💬		2件: EDNRA,
EDNRB 💬		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬1件: 88 💬
86TRACLEER*56CPR RIV 125MG1件: Bosentan2件: Bosentan ,
Bosentan 💬		2件: EDNRA,
EDNRB 💬		9件: Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction, Pathways in cancer, Relaxin signaling pathway, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬3件: 51, 86, 88 💬
87Treprostinil1件: Treprostinil1件: Treprostinil 💬1件: PTGIR 💬3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬6件: 51, 84, 85, 86, 88, 210 💬
88TREPROSTINIL SODIUM1件: Treprostinil1件: Treprostinil 💬1件: PTGIR 💬3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬3件: 51, 86, 88 💬
89Uptravi1件: Selexipag1件: Selexipag 💬1件: PTGIR 💬3件: Neuroactive ligand-receptor interaction, Platelet activation, Vascular smooth muscle contraction 💬3件: 84, 86, 88 💬
90Volibris1件: Ambrisentan1件: Ambrisentan 💬1件: EDNRA 💬7件: Calcium signaling pathway, Neuroactive ligand-receptor interaction, Pathways in cancer, Renin secretion, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬4件: 51, 85, 86, 88 💬
91Warfarin1件: Warfarin1件: Warfarin 💬2件: NQO1,
VKORC1 💬		7件: Biosynthesis of cofactors, Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Metabolic pathways, Pathways in cancer, Ubiquinone and other terpenoid-quinone biosynthesis 💬11件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91 💬
92Warfarin Potassium2件: Potassium,
Warfarin		2件: Potassium ,
Warfarin 💬		2件: NQO1,
VKORC1 💬		7件: Biosynthesis of cofactors, Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Metabolic pathways, Pathways in cancer, Ubiquinone and other terpenoid-quinone biosynthesis 💬1件: 88 💬