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Target Gene/Pathway
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Showing 1 to 5 of 5 drugs
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DrugBank
薬物名(臨床試験情報から抽出)
KEGG DRUG
KEGG GENES
KEGG PATHWAY
指定難病告示番号
1
Anakinra
2件:
Anakinra
Anakinra
;
Kineret
1件:
Anakinra
Anakinra
💬
1. Anakinra
×
Name
Other Names
Anakinra
Anakinra (USAN/INN)
Kineret (TN)
アナキンラ
2件:
IL1R1
IL1R1
,
IL1R2
💬
1. Anakinra
×
Name
Full Name
IL1R1
interleukin 1 receptor type 1
IL1R2
interleukin 1 receptor type 2
15件:
Amoebiasis
Amoebiasis
,
Cytokine-cytokine receptor interaction
,
Fluid shear stress and atherosclerosis
,
Hematopoietic cell lineage
,
Human T-cell leukemia virus 1 infection
,
Human cytomegalovirus infection
,
Inflammatory mediator regulation of TRP channels
,
MAPK signaling pathway
,
NF-kappa B signaling pathway
,
Osteoclast differentiation
,
Pathogenic Escherichia coli infection
,
Prostate cancer
,
Shigellosis
,
Th17 cell differentiation
,
Transcriptional misregulation in cancer
💬
15件:
Amoebiasis
,
Cytokine-cytokine receptor interaction
,
Fluid shear stress and atherosclerosis
,
Hem
...
18件:
2
2
,
13
,
15
,
28
,
37
,
41
,
46
,
49
,
50
,
56
,
65
,
84
,
86
,
97
,
106
,
107
,
266
,
299
💬
1. Anakinra
×
告示番号
日本語名
英語名
2
筋萎縮性側索硬化症
Amyotrophic lateral sclerosis
13
多発性硬化症/視神経脊髄炎
Multiple sclerosis/Neuromyelitis optica
15
封入体筋炎
Inclusion body myositis
28
全身性アミロイドーシス
Systemic amyloidosis
37
膿疱性乾癬(汎発型)
Generalised pustular psoriasis
41
巨細胞性動脈炎;側頭動脈炎
Giant cell arteritis
46
悪性関節リウマチ
Malignant rheumatoid arthritis
49
全身性エリテマトーデス
Systemic lupus erythematosus
50
皮膚筋炎/多発性筋炎
Dermatomyositis
56
ベーチェット病
Behcet disease
65
原発性免疫不全症候群
Primary immunodeficiency
84
サルコイドーシス
Sarcoidosis
86
肺動脈性肺高血圧症
Pulmonary arterial hypertension
97
潰瘍性大腸炎
Ulcerative colitis
106
クリオピリン関連周期熱症候群
Cryopyrin-associated periodic syndrome
107
若年性特発性関節炎
Juvenile idiopathic arthritis
266
家族性地中海熱
Familial mediterranean fever
299
嚢胞性線維症;膵囊胞線維症
Cystic fibrosis
2
Canakinumab
2件:
CANAKINUMAB
CANAKINUMAB
;
ILARIS
1件:
Canakinumab
Canakinumab
💬
2. Canakinumab
×
Name
Other Names
Canakinumab
Canakinumab (USAN/INN)
Canakinumab (genetical recombination) (JAN)
Ilaris (TN)
カナキヌマブ
イラリス
1件:
IL1B
IL1B
💬
2. Canakinumab
×
Name
Full Name
IL1B
interleukin 1 beta
44件:
AGE-RAGE signaling pathway in diabetic complications
AGE-RAGE signaling pathway in diabetic complications
,
African trypanosomiasis
,
Alcoholic liver disease
,
Alzheimer disease
,
Amoebiasis
,
Antifolate resistance
,
C-type lectin receptor signaling pathway
,
Chagas disease
,
Coronavirus disease - COVID-19
,
Cytokine-cytokine receptor interaction
,
Cytosolic DNA-sensing pathway
,
Fluid shear stress and atherosclerosis
,
Graft-versus-host disease
,
Hematopoietic cell lineage
,
Herpes simplex virus 1 infection
,
Human cytomegalovirus infection
,
IL-17 signaling pathway
,
Inflammatory bowel disease
,
Inflammatory mediator regulation of TRP channels
,
Influenza A
,
Legionellosis
,
Leishmaniasis
,
Lipid and atherosclerosis
,
MAPK signaling pathway
,
Malaria
,
Measles
,
NF-kappa B signaling pathway
,
NOD-like receptor signaling pathway
,
Necroptosis
,
Non-alcoholic fatty liver disease
,
Osteoclast differentiation
,
Pathogenic Escherichia coli infection
,
Pathways of neurodegeneration - multiple diseases
,
Pertussis
,
Prion disease
,
Rheumatoid arthritis
,
Salmonella infection
,
Shigellosis
,
TNF signaling pathway
,
Th17 cell differentiation
,
Toll-like receptor signaling pathway
,
Tuberculosis
,
Type I diabetes mellitus
,
Yersinia infection
💬
44件:
AGE-RAGE signaling pathway in diabetic complications
,
African trypanosomiasis
,
Alcoholic liver
...
10件:
46
46
,
56
,
84
,
106
,
107
,
108
,
113
,
266
,
267
,
269
💬
2. Canakinumab
×
告示番号
日本語名
英語名
46
悪性関節リウマチ
Malignant rheumatoid arthritis
56
ベーチェット病
Behcet disease
84
サルコイドーシス
Sarcoidosis
106
クリオピリン関連周期熱症候群
Cryopyrin-associated periodic syndrome
107
若年性特発性関節炎
Juvenile idiopathic arthritis
108
TNF受容体関連周期性症候群
TNF receptor-associated periodic syndrome
113
筋ジストロフィー
Muscular dystrophy
266
家族性地中海熱
Familial mediterranean fever
267
高IgD症候群
Hyper-IgD syndrome
269
化膿性無菌性関節炎・壊疽性膿皮症・アクネ症候群;PAPA症候群
Pyogenic arthritis
3
Colchicine
2件:
COLCHICINA
COLCHICINA
;
Colchicine
1件:
Colchicine
Colchicine
💬
3. Colchicine
×
Name
Other Names
Colchicine
Colchicine (JP18/USP)
Colchicine (TN)
COLCRYS
GLOPERBA
MITIGARE
コルヒチン
9件:
TUBB
TUBB
,
TUBB1
,
TUBB2A
,
TUBB2B
,
TUBB3
,
TUBB4A
,
TUBB4B
,
TUBB6
,
TUBB8
💬
3. Colchicine
×
Name
Full Name
TUBB
tubulin beta class I
TUBB1
tubulin beta 1 class VI
TUBB2A
tubulin beta 2A class IIa
TUBB2B
tubulin beta 2B class IIb
TUBB3
tubulin beta 3 class III
TUBB4A
tubulin beta 4A class IVa
TUBB4B
tubulin beta 4B class IVb
TUBB6
tubulin beta 6 class V
TUBB8
tubulin beta 8 class VIII
10件:
Alzheimer disease
Alzheimer disease
,
Amyotrophic lateral sclerosis
,
Gap junction
,
Huntington disease
,
Parkinson disease
,
Pathogenic Escherichia coli infection
,
Pathways of neurodegeneration - multiple diseases
,
Phagosome
,
Prion disease
,
Salmonella infection
💬
10件:
Alzheimer disease
,
Amyotrophic lateral sclerosis
,
Gap junction
,
Huntington disease
,
Parkinson d
...
7件:
2
2
,
42
,
46
,
56
,
93
,
210
,
266
💬
3. Colchicine
×
告示番号
日本語名
英語名
2
筋萎縮性側索硬化症
Amyotrophic lateral sclerosis
42
結節性多発動脈炎
Polyarteritis nodosa
46
悪性関節リウマチ
Malignant rheumatoid arthritis
56
ベーチェット病
Behcet disease
93
原発性胆汁性胆管炎
Primary biliary cholangitis
210
単心室症
Single Ventricle
266
家族性地中海熱
Familial mediterranean fever
4
Rilonacept
1件:
Rilonacept
Rilonacept
1件:
Rilonacept
Rilonacept
💬
4. Rilonacept
×
Name
Other Names
Rilonacept
Rilonacept (USAN/INN)
Arcalyst (TN)
リロナセプト
2件:
IL1A
IL1A
,
IL1B
💬
4. Rilonacept
×
Name
Full Name
IL1A
interleukin 1 alpha
IL1B
interleukin 1 beta
45件:
AGE-RAGE signaling pathway in diabetic complications
AGE-RAGE signaling pathway in diabetic complications
,
African trypanosomiasis
,
Alcoholic liver disease
,
Alzheimer disease
,
Amoebiasis
,
Antifolate resistance
,
C-type lectin receptor signaling pathway
,
Cellular senescence
,
Chagas disease
,
Coronavirus disease - COVID-19
,
Cytokine-cytokine receptor interaction
,
Cytosolic DNA-sensing pathway
,
Fluid shear stress and atherosclerosis
,
Graft-versus-host disease
,
Hematopoietic cell lineage
,
Herpes simplex virus 1 infection
,
Human cytomegalovirus infection
,
IL-17 signaling pathway
,
Inflammatory bowel disease
,
Inflammatory mediator regulation of TRP channels
,
Influenza A
,
Legionellosis
,
Leishmaniasis
,
Lipid and atherosclerosis
,
MAPK signaling pathway
,
Malaria
,
Measles
,
NF-kappa B signaling pathway
,
NOD-like receptor signaling pathway
,
Necroptosis
,
Non-alcoholic fatty liver disease
,
Osteoclast differentiation
,
Pathogenic Escherichia coli infection
,
Pathways of neurodegeneration - multiple diseases
,
Pertussis
,
Prion disease
,
Rheumatoid arthritis
,
Salmonella infection
,
Shigellosis
,
TNF signaling pathway
,
Th17 cell differentiation
,
Toll-like receptor signaling pathway
,
Tuberculosis
,
Type I diabetes mellitus
,
Yersinia infection
💬
45件:
AGE-RAGE signaling pathway in diabetic complications
,
African trypanosomiasis
,
Alcoholic liver
...
4件:
51
51
,
106
,
107
,
266
💬
4. Rilonacept
×
告示番号
日本語名
英語名
51
全身性強皮症
Scleroderma
106
クリオピリン関連周期熱症候群
Cryopyrin-associated periodic syndrome
107
若年性特発性関節炎
Juvenile idiopathic arthritis
266
家族性地中海熱
Familial mediterranean fever
5
Tocilizumab
3件:
ACTEMRA
ACTEMRA
;
RoActemra
;
Tocilizumab
1件:
Tocilizumab
Tocilizumab
💬
5. Tocilizumab
×
Name
Other Names
Tocilizumab
Tocilizumab (USAN/INN)
Tocilizumab (genetical recombination) (JAN)
Actemra (TN)
トシリズマブ
アクテムラ
1件:
IL6R
IL6R
💬
5. Tocilizumab
×
Name
Full Name
IL6R
interleukin 6 receptor
12件:
Coronavirus disease - COVID-19
Coronavirus disease - COVID-19
,
Cytokine-cytokine receptor interaction
,
EGFR tyrosine kinase inhibitor resistance
,
HIF-1 signaling pathway
,
Hematopoietic cell lineage
,
Human cytomegalovirus infection
,
JAK-STAT signaling pathway
,
Non-alcoholic fatty liver disease
,
PI3K-Akt signaling pathway
,
Pathways in cancer
,
Th17 cell differentiation
,
Viral protein interaction with cytokine and cytokine receptor
💬
12件:
Coronavirus disease - COVID-19
,
Cytokine-cytokine receptor interaction
,
EGFR tyrosine kinase in
...
21件:
2
2
,
11
,
13
,
40
,
41
,
42
,
43
,
44
,
46
,
49
,
50
,
51
,
53
,
54
,
55
,
56
,
86
,
107
,
266
,
271
,
331
💬
5. Tocilizumab
×
告示番号
日本語名
英語名
2
筋萎縮性側索硬化症
Amyotrophic lateral sclerosis
11
重症筋無力症
Myasthenia gravis
13
多発性硬化症/視神経脊髄炎
Multiple sclerosis/Neuromyelitis optica
40
高安動脈炎;大動脈炎症候群
Takayasu arteritis
41
巨細胞性動脈炎;側頭動脈炎
Giant cell arteritis
42
結節性多発動脈炎
Polyarteritis nodosa
43
顕微鏡的多発血管炎
Microscopic polyangiitis
44
多発血管炎性肉芽腫症;ウェゲナー肉芽腫症
Wegener granulomatosis
46
悪性関節リウマチ
Malignant rheumatoid arthritis
49
全身性エリテマトーデス
Systemic lupus erythematosus
50
皮膚筋炎/多発性筋炎
Dermatomyositis
51
全身性強皮症
Scleroderma
53
シェーグレン症候群
Sjogren syndrome
54
成人スチル病
Adult still disease
55
再発性多発軟骨炎
Relapsing polychondritis
56
ベーチェット病
Behcet disease
86
肺動脈性肺高血圧症
Pulmonary arterial hypertension
107
若年性特発性関節炎
Juvenile idiopathic arthritis
266
家族性地中海熱
Familial mediterranean fever
271
強直性脊椎炎
Ankylosing spondylitis
331
特発性多中心性キャッスルマン病
Idiopathic multicentric castleman disease