Drug Description in Trials / DrugBank / KEGG DRUG


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No. DrugBank 薬物名(臨床試験情報から抽出) KEGG DRUG KEGG GENES KEGG PATHWAY 指定難病告示番号
1 ACR-16 0件: ---1件: 8 💬
2 Alprazolam 1件: Alprazolam1件: Alprazolam 💬16件: GABRA1,
GABRA2,
GABRA3,
GABRA4,
GABRA5,
GABRA6,
GABRB1,
GABRB2,
GABRB3,
GABRD,
GABRE,
GABRG1,
GABRG2,
GABRG3,
GABRP,
GABRQ 💬
7件: GABAergic synapse, Morphine addiction, Neuroactive ligand-receptor interaction, Nicotine addiction, Retrograde endocannabinoid signaling, Serotonergic synapse, Taste transduction 💬2件: 8, 75 💬
3 Amantadine 3件: Amantadine; AMANTADINE HYDROCHLORIDE; GOCOVRI1件: Amantadine 💬5件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬
20件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬4件: 6, 8, 13, 127 💬
4 AMT-130 2件: AMT-130; RAAV5-miHTT---1件: 8 💬
5 ANX005 1件: ANX005---3件: 2, 8, 61 💬
6 Atomoxetine 2件: Atomoxetine; Strattera1件: Atomoxetine 💬1件: SLC6A2 💬1件: Synaptic vesicle cycle 💬4件: 6, 8, 13, 17 💬
7 Bevantolol 1件: Bevantolol---1件: 8 💬
8 Biotin 4件: Biotin; Biotina; D-BIOTIN; Vitamin B71件: Biotin 💬--5件: 2, 8, 10, 13, 20 💬
9 Branaplam 1件: BRANAPLAM1件: Branaplam 💬1件: SMN2 💬-2件: 3, 8 💬
10 Bupropion 2件: Bupropion; Bupropion Hydrochloride1件: Bupropion 💬2件: SLC6A2,
SLC6A3 💬
7件: Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Pathways of neurodegeneration - multiple diseases, Synaptic vesicle cycle 💬5件: 8, 18, 21, 96, 171 💬
11 Cannabidiol 4件: CANNABIDIOL; Epidiolex; Epidyolex; SATIVEX1件: Cannabidiol 💬2件: CNR1,
CNR2 💬
4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬20件: 2, 6, 8, 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
12 Cholesterol 1件: Cholesterol1件: Cholesterol 💬--6件: 8, 19, 90, 160, 222, 310 💬
13 Citalopram 1件: Citalopram1件: Citalopram 💬1件: SLC6A4 💬2件: Serotonergic synapse, Synaptic vesicle cycle 💬7件: 6, 8, 13, 18, 46, 98, 127 💬
14 Creatine 1件: Creatine---11件: 1, 2, 5, 6, 8, 46, 49, 50, 113, 156, 201 💬
15 Cysteamine 8件: 2-aminoethanethiol; Beta-Mercaptoethylamine; CYSTADROPS; CYSTAGON; CYSTEAMINE; Mercaptamina; Mercaptamine; PROCYSBI1件: Cysteamine 💬--4件: 8, 19, 21, 299 💬
16 Deutetrabenazine 1件: Deutetrabenazine1件: Deutetrabenazine 💬1件: SLC18A2 💬7件: Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Serotonergic synapse, Synaptic vesicle cycle 💬1件: 8 💬
17 Dextromethorphan 4件: Dextromethorphan; DEXTROMETHORPHAN HYDROBROMIDE; Dextrometorfano; Nuedexta1件: Dextromethorphan 💬6件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D,
SIGMAR1 💬
20件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬11件: 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬
18 Digoxin 1件: Digoxin1件: Digoxin 💬4件: ATP1A1,
ATP1A2,
ATP1A3,
ATP1A4 💬
18件: Adrenergic signaling in cardiomyocytes, Aldosterone synthesis and secretion, Aldosterone-regulated sodium reabsorption, Bile secretion, Carbohydrate digestion and absorption, Cardiac muscle contraction, Endocrine and other factor-regulated calcium reabsorption, Gastric acid secretion, Insulin secretion, Mineral absorption, Pancreatic secretion, Protein digestion and absorption, Proximal tubule bicarbonate reclamation, Salivary secretion, Thyroid hormone signaling pathway, Thyroid hormone synthesis, cAMP signaling pathway, cGMP-PKG signaling pathway 💬3件: 8, 46, 210 💬
19 Dronabinol 4件: DELTA-9-TETRAHYDROCANNABINOL; DRONABINOL; SATIVEX; Tetrahydrocannabinol1件: Dronabinol 💬2件: CNR1,
CNR2 💬
4件: Neuroactive ligand-receptor interaction, Rap1 signaling pathway, Retrograde endocannabinoid signaling, Thermogenesis 💬8件: 2, 8, 13, 36, 46, 96, 271, 298 💬
20 Epigallocatechin 1件: Epigallocatechin---5件: 8, 13, 28, 85, 113 💬
21 Epigallocatechin gallate 3件: EGCG; Epigallocatechin gallate; Epigallocatechin-3-gallate---9件: 6, 8, 13, 17, 28, 85, 113, 206, 299 💬
22 Fenofibrate 1件: Fenofibrate1件: Fenofibrate 💬1件: PPARA 💬10件: Adipocytokine signaling pathway, Alcoholic liver disease, Chemical carcinogenesis - receptor activation, Diabetic cardiomyopathy, Glucagon signaling pathway, Hepatitis C, Insulin resistance, Non-alcoholic fatty liver disease, PPAR signaling pathway, cAMP signaling pathway 💬6件: 8, 79, 93, 94, 97, 265 💬
23 GSK-356278 0件: ---1件: 8 💬
24 Haloperidol 1件: Haloperidol1件: Haloperidol 💬1件: DRD2 💬8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 8 💬
25 Icosapent 2件: Eicosapentaenoic acid; Icosapent1件: Icosapent 💬--11件: 8, 46, 48, 49, 96, 97, 113, 296, 297, 301, 338 💬
26 Icosapent ethyl 2件: Ethyl-EPA; Icosapent1件: Icosapent ethyl 💬--2件: 8, 296 💬
27 Idebenone 2件: Idebenone; Raxone1件: Idebenone 💬--6件: 6, 8, 13, 18, 113, 302 💬
28 Indopan 0件: ---4件: 8, 46, 97, 321 💬
29 Ketoconazole 2件: Ketoconazole; NIZORAL1件: Ketoconazole 💬1件: CYP17A1 💬6件: Cortisol synthesis and secretion, Cushing syndrome, Metabolic pathways, Ovarian steroidogenesis, Prolactin signaling pathway, Steroid hormone biosynthesis 💬3件: 8, 13, 75 💬
30 Laquinimod 1件: LAQUINIMOD---4件: 8, 13, 49, 96 💬
31 Latrepirdine 2件: Dimebon; Latrepirdine1件: Latrepirdine 💬6件: ACHE,
GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬
22件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Cholinergic synapse, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Glycerophospholipid metabolism, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬1件: 8 💬
32 LAX-101 1件: LAX-101---1件: 8 💬
33 Lithium citrate 2件: Lithium; LITHIUM CITRATE1件: Lithium citrate 💬--5件: 2, 5, 6, 7, 8 💬
34 Manganese citrate 1件: Release---12件: 6, 8, 13, 46, 65, 78, 81, 96, 97, 206, 226, 299 💬
35 Melatonin 2件: Circadin; MELATONIN1件: Melatonin 💬2件: MTNR1A,
MTNR1B 💬
2件: Circadian entrainment, Neuroactive ligand-receptor interaction 💬12件: 6, 8, 13, 37, 46, 49, 72, 78, 90, 97, 145, 202 💬
36 Memantine 3件: EBIXA; MEMANTINE; MEMANTINE HYDROCHLORIDE1件: Memantine 💬5件: GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬
20件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Spinocerebellar ataxia, Systemic lupus erythematosus, cAMP signaling pathway 💬8件: 2, 6, 8, 13, 49, 127, 205, 206 💬
37 Metformin 5件: Metformin; Metformin HCl; Metformin hydrochloride; METFORMINA; Metformine1件: Metformin 💬2件: PRKAA1,
PRKAA2 💬
20件: AMPK signaling pathway, Adipocytokine signaling pathway, Alcoholic liver disease, Apelin signaling pathway, Autophagy - animal, Circadian rhythm, Fluid shear stress and atherosclerosis, FoxO signaling pathway, Glucagon signaling pathway, Hypertrophic cardiomyopathy, Insulin resistance, Insulin signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Non-alcoholic fatty liver disease, Oxytocin signaling pathway, PI3K-Akt signaling pathway, Thermogenesis, Tight junction, mTOR signaling pathway 💬25件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬
38 Minocycline 3件: Minocycline; MINOCYCLINE HYDROCHLORIDE; Minomycin1件: Minocycline 💬--14件: 2, 6, 8, 13, 46, 84, 85, 90, 94, 162, 201, 206, 280, 299 💬
39 Neflamapimod 1件: Neflamapimod1件: Neflamapimod 💬4件: MAPK11,
MAPK12,
MAPK13,
MAPK14 💬
62件: AGE-RAGE signaling pathway in diabetic complications, Adrenergic signaling in cardiomyocytes, Alcoholic liver disease, Amyotrophic lateral sclerosis, C-type lectin receptor signaling pathway, Cellular senescence, Chagas disease, Chemical carcinogenesis - reactive oxygen species, Coronavirus disease - COVID-19, Diabetic cardiomyopathy, Dopaminergic synapse, Endocrine resistance, Epithelial cell signaling in Helicobacter pylori infection, Epstein-Barr virus infection, Fc epsilon RI signaling pathway, Fluid shear stress and atherosclerosis, FoxO signaling pathway, GnRH signaling pathway, Growth hormone synthesis, secretion and action, Hepatitis B, Human cytomegalovirus infection, Human immunodeficiency virus 1 infection, IL-17 signaling pathway, Inflammatory mediator regulation of TRP channels, Kaposi sarcoma-associated herpesvirus infection, Leishmaniasis, Leukocyte transendothelial migration, Lipid and atherosclerosis, MAPK signaling pathway, NOD-like receptor signaling pathway, Neurotrophin signaling pathway, Neutrophil extracellular trap formation, Non-alcoholic fatty liver disease, Oocyte meiosis, Osteoclast differentiation, PD-L1 expression and PD-1 checkpoint pathway in cancer, Pathogenic Escherichia coli infection, Pathways of neurodegeneration - multiple diseases, Pertussis, Platelet activation, Prion disease, Progesterone-mediated oocyte maturation, Prolactin signaling pathway, Proteoglycans in cancer, RIG-I-like receptor signaling pathway, Rap1 signaling pathway, Relaxin signaling pathway, Retrograde endocannabinoid signaling, Salmonella infection, Shigellosis, Signaling pathways regulating pluripotency of stem cells, Sphingolipid signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Thermogenesis, Toll-like receptor signaling pathway, Toxoplasmosis, Tuberculosis, VEGF signaling pathway, Yersinia infection 💬1件: 8 💬
40 Nilotinib 2件: Nilotinib; TASIGNA1件: Nilotinib 💬4件: ABL1,
KIT,
PDGFRA,
PDGFRB 💬
33件: Acute myeloid leukemia, Axon guidance, Breast cancer, Calcium signaling pathway, Cell cycle, Central carbon metabolism in cancer, Chemical carcinogenesis - reactive oxygen species, Choline metabolism in cancer, Chronic myeloid leukemia, EGFR tyrosine kinase inhibitor resistance, Endocytosis, ErbB signaling pathway, Focal adhesion, Gap junction, Glioma, Hematopoietic cell lineage, Human cytomegalovirus infection, Human papillomavirus infection, JAK-STAT signaling pathway, MAPK signaling pathway, Melanogenesis, Melanoma, MicroRNAs in cancer, Neurotrophin signaling pathway, PI3K-Akt signaling pathway, Pathogenic Escherichia coli infection, Pathways in cancer, Phospholipase D signaling pathway, Prostate cancer, Rap1 signaling pathway, Ras signaling pathway, Regulation of actin cytoskeleton, Viral myocarditis 💬5件: 6, 8, 34, 51, 86 💬
41 Olanzapine 2件: Olanzapine; Zyprexa1件: Olanzapine 💬11件: ADRA1A,
ADRA1B,
ADRA1D,
DRD2,
DRD3,
DRD4,
HRH1,
HTR2A,
HTR2B,
HTR2C,
HTR6 💬
16件: AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Salivary secretion, Serotonergic synapse, Vascular smooth muscle contraction, cAMP signaling pathway, cGMP-PKG signaling pathway 💬2件: 2, 8 💬
42 Omeprazole 4件: Losec; Omeprazol; Omeprazole; OMEPRAZOLE MAGNESIUM1件: Omeprazole 💬2件: ATP4A,
ATP4B 💬
4件: Collecting duct acid secretion, Gastric acid secretion, Metabolic pathways, Oxidative phosphorylation 💬14件: 6, 8, 21, 46, 51, 85, 96, 97, 225, 271, 282, 294, 298, 299 💬
43 Phenylbutyric acid 4件: 4-phenylbutyrate; Pheburane; Phenylbutyrate; Sodium phenylbutyrate---14件: 2, 3, 6, 8, 15, 21, 93, 94, 231, 244, 251, 297, 299, 338 💬
44 Pridopidine 1件: Pridopidine1件: Pridopidine 💬1件: DRD2 💬8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬3件: 2, 6, 8 💬
45 Quinidine 4件: Nuedexta; Quinidina; Quinidine; Quinidine Sulfate1件: Quinidine 💬5件: SCN1A,
SCN2A,
SCN3A,
SCN5A,
SCN9A 💬
3件: Adrenergic signaling in cardiomyocytes, Dopaminergic synapse, Taste transduction 💬3件: 2, 8, 13 💬
46 Ramelteon 2件: Ramelteon; ROZEREM1件: Ramelteon 💬2件: MTNR1A,
MTNR1B 💬
2件: Circadian entrainment, Neuroactive ligand-receptor interaction 💬3件: 6, 8, 46 💬
47 Resveratrol 1件: Resveratrol---6件: 2, 8, 18, 89, 97, 113 💬
48 Rilmenidine 2件: HYPERIUM; Rilmenidine1件: Rilmenidine 💬3件: ADRA2A,
ADRA2B,
ADRA2C 💬
2件: Neuroactive ligand-receptor interaction, cGMP-PKG signaling pathway 💬1件: 8 💬
49 Riluzole 2件: Rilutek; Riluzole1件: Riluzole 💬14件: GRIA1,
GRIA2,
GRIA3,
GRIA4,
GRIK1,
GRIK2,
GRIK3,
GRIK4,
GRIK5,
GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D 💬
23件: Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium signaling pathway, Circadian entrainment, Cocaine addiction, Dopaminergic synapse, Glutamatergic synapse, Huntington disease, Long-term depression, Long-term potentiation, Neuroactive ligand-receptor interaction, Nicotine addiction, Pathways of neurodegeneration - multiple diseases, Prion disease, Rap1 signaling pathway, Ras signaling pathway, Retrograde endocannabinoid signaling, Spinocerebellar ataxia, Systemic lupus erythematosus, Transcriptional misregulation in cancer, cAMP signaling pathway 💬9件: 2, 3, 5, 8, 13, 17, 18, 203, 206 💬
50 Risperidone 1件: Risperidone1件: Risperidone 💬2件: DRD2,
HTR2A 💬
11件: Alcoholism, Calcium signaling pathway, Cocaine addiction, Dopaminergic synapse, Gap junction, Inflammatory mediator regulation of TRP channels, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, Serotonergic synapse, cAMP signaling pathway 💬5件: 8, 156, 179, 187, 206 💬
51 Rolipram 1件: Rolipram1件: Rolipram 💬4件: PDE4A,
PDE4B,
PDE4C,
PDE4D 💬
5件: Metabolic pathways, Morphine addiction, Parathyroid hormone synthesis, secretion and action, Purine metabolism, cAMP signaling pathway 💬2件: 8, 13 💬
52 Selisistat 1件: Selisistat---1件: 8 💬
53 SRX-246 0件: ---1件: 8 💬
54 Tetrabenazine 2件: Tetrabenazine; Xenazine1件: Tetrabenazine 💬1件: SLC18A2 💬7件: Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Serotonergic synapse, Synaptic vesicle cycle 💬1件: 8 💬
55 Thiamine 2件: Thiamine; Vitamin B11件: Thiamine 💬--4件: 8, 93, 145, 265 💬
56 Tiapride 0件: 1件: Tiapride 💬1件: DRD2 💬8件: Alcoholism, Cocaine addiction, Dopaminergic synapse, Gap junction, Neuroactive ligand-receptor interaction, Parkinson disease, Rap1 signaling pathway, cAMP signaling pathway 💬1件: 8 💬
57 Triheptanoin 1件: Triheptanoin1件: Triheptanoin 💬--10件: 2, 8, 65, 149, 156, 248, 256, 257, 317, 324 💬
58 Ubidecarenone 3件: Coenzyme Q-10; Coenzyme Q10; CoQ101件: Ubidecarenone 💬--12件: 2, 5, 6, 8, 10, 18, 46, 57, 86, 113, 214, 215 💬
59 Ubiquinol 1件: Ubiquinol---3件: 6, 8, 17 💬
60 Ursodeoxycholic acid 4件: UDCA; Ursodeoxycholic acid; Ursodiol; Ursofalk1件: Ursodiol 💬1件: NR1H4 💬1件: Bile secretion 💬14件: 6, 8, 20, 46, 67, 84, 93, 94, 95, 96, 97, 234, 296, 299 💬
61 Valbenazine 1件: Valbenazine1件: Valbenazine 💬1件: SLC18A2 💬7件: Alcoholism, Amphetamine addiction, Cocaine addiction, Dopaminergic synapse, Parkinson disease, Serotonergic synapse, Synaptic vesicle cycle 💬1件: 8 💬
62 Warfarin 2件: Warfarin; Warfarin Sodium1件: Warfarin 💬2件: NQO1,
VKORC1 💬
7件: Biosynthesis of cofactors, Chemical carcinogenesis - reactive oxygen species, Fluid shear stress and atherosclerosis, Hepatocellular carcinoma, Metabolic pathways, Pathways in cancer, Ubiquinone and other terpenoid-quinone biosynthesis 💬11件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91 💬