Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 HRH3 1件: Neuroactive ligand-receptor interaction 💬 D10749 Pitolisant 2件: 113, 193
2 MAPK14 62件: Endocrine resistance 💬, MAPK signaling pathway 💬, Rap1 signaling pathway 💬, FoxO signaling pathway 💬, Sphingolipid signaling pathway 💬, Oocyte meiosis 💬, Cellular senescence 💬, Adrenergic signaling in cardiomyocytes 💬, VEGF signaling pathway 💬, Osteoclast differentiation 💬, Signaling pathways regulating pluripotency of stem cells 💬, Platelet activation 💬, Neutrophil extracellular trap formation 💬, Toll-like receptor signaling pathway 💬, NOD-like receptor signaling pathway 💬, RIG-I-like receptor signaling pathway 💬, C-type lectin receptor signaling pathway 💬, IL-17 signaling pathway 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, T cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, TNF signaling pathway 💬, Leukocyte transendothelial migration 💬, Thermogenesis 💬, Neurotrophin signaling pathway 💬, Retrograde endocannabinoid signaling 💬, Dopaminergic synapse 💬, Inflammatory mediator regulation of TRP channels 💬, GnRH signaling pathway 💬, Progesterone-mediated oocyte maturation 💬, Prolactin signaling pathway 💬, Relaxin signaling pathway 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Growth hormone synthesis, secretion and action 💬, Alcoholic liver disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Epithelial cell signaling in Helicobacter pylori infection 💬, Pathogenic Escherichia coli infection 💬, Shigellosis 💬, Salmonella infection 💬, Pertussis 💬, Yersinia infection 💬, Leishmaniasis 💬, Chagas disease 💬, Toxoplasmosis 💬, Tuberculosis 💬, Hepatitis B 💬, Human cytomegalovirus infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Epstein-Barr virus infection 💬, Human immunodeficiency virus 1 infection 💬, Coronavirus disease - COVID-19 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Diabetic cardiomyopathy 💬, Lipid and atherosclerosis 💬, Fluid shear stress and atherosclerosis 💬 D09639 Losmapimod 2件: 113, 222
3 CSF3R 5件: Cytokine-cytokine receptor interaction 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Hematopoietic cell lineage 💬, Pathways in cancer 💬 D03235 Filgrastim 34件: 2, 6, 11, 13, 16, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331
4 ADRA1D 6件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Salivary secretion 💬 D00255 Carvedilol 5件: 6, 57, 86, 113, 210
5 ADRA1D 6件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Salivary secretion 💬 D03415 Carvedilol 5件: 6, 57, 86, 113, 210
6 ADRA1B 6件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Salivary secretion 💬 D00255 Carvedilol 5件: 6, 57, 86, 113, 210
7 ADRA1B 6件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Salivary secretion 💬 D03415 Carvedilol 5件: 6, 57, 86, 113, 210
8 ADRA1A 7件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, AMPK signaling pathway 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Salivary secretion 💬 D00255 Carvedilol 5件: 6, 57, 86, 113, 210
9 ADRA1A 7件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, AMPK signaling pathway 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Salivary secretion 💬 D03415 Carvedilol 5件: 6, 57, 86, 113, 210
10 CCN2 2件: Apelin signaling pathway 💬, Hippo signaling pathway 💬 D10969 Pamrevlumab 2件: 85, 113
11 ADRA2A 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D00514 Dexmedetomidine 13件: 2, 4, 6, 21, 34, 46, 70, 107, 113, 212, 215, 226, 280
12 ADRA2A 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D01205 Dexmedetomidine 13件: 2, 4, 6, 21, 34, 46, 70, 107, 113, 212, 215, 226, 280
13 ADRA2B 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D00514 Dexmedetomidine 13件: 2, 4, 6, 21, 34, 46, 70, 107, 113, 212, 215, 226, 280
14 ADRA2B 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D01205 Dexmedetomidine 13件: 2, 4, 6, 21, 34, 46, 70, 107, 113, 212, 215, 226, 280
15 ADRA2C 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D00514 Dexmedetomidine 13件: 2, 4, 6, 21, 34, 46, 70, 107, 113, 212, 215, 226, 280
16 ADRA2C 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D01205 Dexmedetomidine 13件: 2, 4, 6, 21, 34, 46, 70, 107, 113, 212, 215, 226, 280
17 ADRB1 11件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Gap junction 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬, Dilated cardiomyopathy 💬 D00255 Carvedilol 5件: 6, 57, 86, 113, 210
18 ADRB1 11件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Gap junction 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬, Dilated cardiomyopathy 💬 D00601 Metoprolol 6件: 17, 57, 58, 113, 193, 226
19 ADRB1 11件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Gap junction 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬, Dilated cardiomyopathy 💬 D00634 Bisoprolol 3件: 67, 86, 113
20 ADRB1 11件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Gap junction 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬, Dilated cardiomyopathy 💬 D02342 Bisoprolol 3件: 67, 86, 113
21 ADRB1 11件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Gap junction 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬, Dilated cardiomyopathy 💬 D02358 Metoprolol 6件: 17, 57, 58, 113, 193, 226
22 ADRB1 11件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Gap junction 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬, Dilated cardiomyopathy 💬 D03415 Carvedilol 5件: 6, 57, 86, 113, 210
23 ADRB1 11件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Gap junction 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬, Dilated cardiomyopathy 💬 D05011 Metoprolol 6件: 17, 57, 58, 113, 193, 226
24 ADRB1 11件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Gap junction 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬, Dilated cardiomyopathy 💬 D05127 Nebivolol 4件: 17, 85, 113, 167
25 ADRB2 9件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬 D00255 Carvedilol 5件: 6, 57, 86, 113, 210
26 ADRB2 9件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬 D02147 Salbutamol 14件: 3, 11, 12, 13, 49, 85, 86, 89, 111, 113, 228, 231, 256, 299
27 ADRB2 9件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬 D03415 Carvedilol 5件: 6, 57, 86, 113, 210
28 ACE 6件: Renin-angiotensin system 💬, Renin secretion 💬, Chagas disease 💬, Coronavirus disease - COVID-19 💬, Hypertrophic cardiomyopathy 💬, Diabetic cardiomyopathy 💬 D00362 Lisinopril 7件: 19, 46, 49, 66, 67, 113, 222
29 ACE 6件: Renin-angiotensin system 💬, Renin secretion 💬, Chagas disease 💬, Coronavirus disease - COVID-19 💬, Hypertrophic cardiomyopathy 💬, Diabetic cardiomyopathy 💬 D00421 Ramipril 7件: 46, 49, 66, 67, 113, 218, 257
30 ACE 6件: Renin-angiotensin system 💬, Renin secretion 💬, Chagas disease 💬, Coronavirus disease - COVID-19 💬, Hypertrophic cardiomyopathy 💬, Diabetic cardiomyopathy 💬 D00621 Enalapril 6件: 19, 46, 66, 113, 210, 222
31 ACE 6件: Renin-angiotensin system 💬, Renin secretion 💬, Chagas disease 💬, Coronavirus disease - COVID-19 💬, Hypertrophic cardiomyopathy 💬, Diabetic cardiomyopathy 💬 D00624 Perindopril 4件: 58, 113, 167, 222
32 ACE 6件: Renin-angiotensin system 💬, Renin secretion 💬, Chagas disease 💬, Coronavirus disease - COVID-19 💬, Hypertrophic cardiomyopathy 💬, Diabetic cardiomyopathy 💬 D03753 Perindopril 4件: 58, 113, 167, 222
33 ACE 6件: Renin-angiotensin system 💬, Renin secretion 💬, Chagas disease 💬, Coronavirus disease - COVID-19 💬, Hypertrophic cardiomyopathy 💬, Diabetic cardiomyopathy 💬 D07892 Enalapril 6件: 19, 46, 66, 113, 210, 222
34 ACE 6件: Renin-angiotensin system 💬, Renin secretion 💬, Chagas disease 💬, Coronavirus disease - COVID-19 💬, Hypertrophic cardiomyopathy 💬, Diabetic cardiomyopathy 💬 D08131 Lisinopril 7件: 19, 46, 49, 66, 67, 113, 222
35 DMD 4件: Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬, Viral myocarditis 💬 D09900 Eteplirsen 1件: 113
36 DMD 4件: Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬, Viral myocarditis 💬 D10114 Drisapersen 1件: 113
37 DMD 4件: Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬, Viral myocarditis 💬 D11528 Viltolarsen 1件: 113
38 DMD 4件: Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬, Viral myocarditis 💬 D11707 Golodirsen 1件: 113
39 DMD 4件: Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬, Viral myocarditis 💬 D11988 Casimersen 1件: 113
40 AGTR1 16件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Apelin signaling pathway 💬, Renin-angiotensin system 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Cushing syndrome 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Diabetic cardiomyopathy 💬 D00357 Losartan 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299
41 AGTR1 16件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Apelin signaling pathway 💬, Renin-angiotensin system 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Cushing syndrome 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Diabetic cardiomyopathy 💬 D08146 Losartan 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299
42 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D00966 Tamoxifen 4件: 2, 86, 113, 227
43 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D08409 Prasterone 6件: 49, 53, 83, 86, 96, 113
44 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D08559 Tamoxifen 4件: 2, 86, 113, 227
45 ESR2 7件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, GnRH secretion 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D00966 Tamoxifen 4件: 2, 86, 113, 227
46 ESR2 7件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, GnRH secretion 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D08409 Prasterone 6件: 49, 53, 83, 86, 96, 113
47 ESR2 7件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, GnRH secretion 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D08559 Tamoxifen 4件: 2, 86, 113, 227
48 FDPS 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬 D00942 Risedronic acid 9件: 46, 50, 66, 93, 95, 96, 107, 113, 274
49 FDPS 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬 D03234 Risedronic acid 9件: 46, 50, 66, 93, 95, 96, 107, 113, 274
50 FDPS 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬 D08484 Risedronic acid 9件: 46, 50, 66, 93, 95, 96, 107, 113, 274
51 FNTA 1件: Terpenoid backbone biosynthesis 💬 D04768 Lonafarnib 2件: 113, 333
52 FNTB 1件: Terpenoid backbone biosynthesis 💬 D04768 Lonafarnib 2件: 113, 333
53 ALOX5 6件: Arachidonic acid metabolism 💬, Metabolic pathways 💬, Fc epsilon RI signaling pathway 💬, Serotonergic synapse 💬, Ovarian steroidogenesis 💬, Toxoplasmosis 💬 D01773 Oxatomide 1件: 113
54 MSTN 1件: Cytokine-cytokine receptor interaction 💬 D11047 Domagrozumab 1件: 113
55 GHR 5件: Cytokine-cytokine receptor interaction 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Growth hormone synthesis, secretion and action 💬 D02691 Somatotropin 23件: 2, 3, 13, 19, 46, 65, 74, 75, 76, 78, 96, 107, 113, 187, 191, 193, 195, 236, 238, 265, 274, 276, 299
56 GRIN1 18件: Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬 D00711 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
57 GRIN1 18件: Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬 D08098 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
58 GRIN2A 19件: Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬, Systemic lupus erythematosus 💬 D00711 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
59 GRIN2A 19件: Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬, Systemic lupus erythematosus 💬 D08098 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
60 GRIN2B 19件: Ras signaling pathway 💬, Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬, Systemic lupus erythematosus 💬 D00711 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
61 GRIN2B 19件: Ras signaling pathway 💬, Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬, Systemic lupus erythematosus 💬 D08098 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
62 GRIN2C 15件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬 D00711 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
63 GRIN2C 15件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬 D08098 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
64 GRIN2D 15件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬 D00711 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
65 GRIN2D 15件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬 D08098 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
66 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00472 Prednisolone 10件: 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
67 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00473 Prednisone 16件: 113, 127, 162, 164, 205, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331
68 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00980 Prednisolone 10件: 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
69 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00981 Prednisolone 10件: 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
70 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00982 Prednisolone 10件: 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
71 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01239 Prednisolone 10件: 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
72 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01998 Prednisolone 10件: 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
73 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D02156 Prednisolone 10件: 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
74 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D03301 Prednisolone 10件: 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
75 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D03671 Deflazacort 1件: 113
76 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D11000 Vamorolone 1件: 113
77 IL1B 44件: Antifolate resistance 💬, MAPK signaling pathway 💬, Cytokine-cytokine receptor interaction 💬, NF-kappa B signaling pathway 💬, Necroptosis 💬, Osteoclast differentiation 💬, Toll-like receptor signaling pathway 💬, NOD-like receptor signaling pathway 💬, Cytosolic DNA-sensing pathway 💬, C-type lectin receptor signaling pathway 💬, Hematopoietic cell lineage 💬, IL-17 signaling pathway 💬, Th17 cell differentiation 💬, TNF signaling pathway 💬, Inflammatory mediator regulation of TRP channels 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Alcoholic liver disease 💬, Type I diabetes mellitus 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Shigellosis 💬, Salmonella infection 💬, Pertussis 💬, Legionellosis 💬, Yersinia infection 💬, Leishmaniasis 💬, Chagas disease 💬, African trypanosomiasis 💬, Malaria 💬, Amoebiasis 💬, Tuberculosis 💬, Measles 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Herpes simplex virus 1 infection 💬, Coronavirus disease - COVID-19 💬, Inflammatory bowel disease 💬, Rheumatoid arthritis 💬, Graft-versus-host disease 💬, Lipid and atherosclerosis 💬, Fluid shear stress and atherosclerosis 💬 D09315 Canakinumab 10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269
78 AR 4件: Oocyte meiosis 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Prostate cancer 💬 D00075 Testosterone 9件: 1, 2, 3, 13, 60, 76, 78, 113, 265
79 AR 4件: Oocyte meiosis 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Prostate cancer 💬 D00957 Testosterone 9件: 1, 2, 3, 13, 60, 76, 78, 113, 265
80 AR 4件: Oocyte meiosis 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Prostate cancer 💬 D00958 Testosterone 9件: 1, 2, 3, 13, 60, 76, 78, 113, 265
81 AR 4件: Oocyte meiosis 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Prostate cancer 💬 D00958 Testosterone enanthate 2件: 13, 113
82 AR 4件: Oocyte meiosis 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Prostate cancer 💬 D00959 Testosterone 9件: 1, 2, 3, 13, 60, 76, 78, 113, 265
83 AR 4件: Oocyte meiosis 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Prostate cancer 💬 D00959 Testosterone propionate 1件: 113
84 AR 4件: Oocyte meiosis 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Prostate cancer 💬 D06085 Testosterone 9件: 1, 2, 3, 13, 60, 76, 78, 113, 265
85 AR 4件: Oocyte meiosis 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Prostate cancer 💬 D06087 Testosterone 9件: 1, 2, 3, 13, 60, 76, 78, 113, 265
86 AR 4件: Oocyte meiosis 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Prostate cancer 💬 D08409 Prasterone 6件: 49, 53, 83, 86, 96, 113
87 AR 4件: Oocyte meiosis 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Prostate cancer 💬 D08573 Testosterone decanoate 1件: 113
88 AR 4件: Oocyte meiosis 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Prostate cancer 💬 D08574 Testosterone phenylpropionate 1件: 113
89 MC2R 5件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, Cushing syndrome 💬 D00284 Tetracosactide 5件: 78, 83, 113, 145, 222
90 NR3C2 1件: Aldosterone-regulated sodium reabsorption 💬 D00443 Spironolactone 4件: 113, 210, 218, 225
91 NR3C2 1件: Aldosterone-regulated sodium reabsorption 💬 D01115 Eplerenone 3件: 113, 210, 215
92 ATP4A 4件: Oxidative phosphorylation 💬, Metabolic pathways 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬 D01984 Esomeprazole 8件: 13, 46, 86, 98, 107, 113, 298, 299
93 ATP4A 4件: Oxidative phosphorylation 💬, Metabolic pathways 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬 D04056 Esomeprazole 8件: 13, 46, 86, 98, 107, 113, 298, 299
94 ATP4A 4件: Oxidative phosphorylation 💬, Metabolic pathways 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬 D07917 Esomeprazole 8件: 13, 46, 86, 98, 107, 113, 298, 299
95 ATP4A 4件: Oxidative phosphorylation 💬, Metabolic pathways 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬 D09339 Esomeprazole 8件: 13, 46, 86, 98, 107, 113, 298, 299
96 ATP4B 4件: Oxidative phosphorylation 💬, Metabolic pathways 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬 D01984 Esomeprazole 8件: 13, 46, 86, 98, 107, 113, 298, 299
97 ATP4B 4件: Oxidative phosphorylation 💬, Metabolic pathways 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬 D04056 Esomeprazole 8件: 13, 46, 86, 98, 107, 113, 298, 299
98 ATP4B 4件: Oxidative phosphorylation 💬, Metabolic pathways 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬 D07917 Esomeprazole 8件: 13, 46, 86, 98, 107, 113, 298, 299
99 ATP4B 4件: Oxidative phosphorylation 💬, Metabolic pathways 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬 D09339 Esomeprazole 8件: 13, 46, 86, 98, 107, 113, 298, 299
100 PPP3CA 33件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Oocyte meiosis 💬, Cellular senescence 💬, Wnt signaling pathway 💬, Axon guidance 💬, VEGF signaling pathway 💬, Osteoclast differentiation 💬, C-type lectin receptor signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Renin secretion 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Tuberculosis 💬, Human cytomegalovirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Human immunodeficiency virus 1 infection 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Lipid and atherosclerosis 💬 D00107 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
101 PPP3CA 33件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Oocyte meiosis 💬, Cellular senescence 💬, Wnt signaling pathway 💬, Axon guidance 💬, VEGF signaling pathway 💬, Osteoclast differentiation 💬, C-type lectin receptor signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Renin secretion 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Tuberculosis 💬, Human cytomegalovirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Human immunodeficiency virus 1 infection 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Lipid and atherosclerosis 💬 D00184 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
102 PPP3CA 33件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Oocyte meiosis 💬, Cellular senescence 💬, Wnt signaling pathway 💬, Axon guidance 💬, VEGF signaling pathway 💬, Osteoclast differentiation 💬, C-type lectin receptor signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Renin secretion 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Tuberculosis 💬, Human cytomegalovirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Human immunodeficiency virus 1 infection 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Lipid and atherosclerosis 💬 D08556 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
103 PPP3CB 33件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Oocyte meiosis 💬, Cellular senescence 💬, Wnt signaling pathway 💬, Axon guidance 💬, VEGF signaling pathway 💬, Osteoclast differentiation 💬, C-type lectin receptor signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Renin secretion 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Tuberculosis 💬, Human cytomegalovirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Human immunodeficiency virus 1 infection 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Lipid and atherosclerosis 💬 D00107 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
104 PPP3CB 33件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Oocyte meiosis 💬, Cellular senescence 💬, Wnt signaling pathway 💬, Axon guidance 💬, VEGF signaling pathway 💬,