Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 CNR1 4件: Rap1 signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Thermogenesis 💬, Retrograde endocannabinoid signaling 💬 D10915 Cannabidiol 19件: 2, 6, 8, 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271
2 CNR2 1件: Neuroactive ligand-receptor interaction 💬 D10915 Cannabidiol 9件: 144, 145, 156, 157, 158, 193, 206, 226, 271
3 GABRA1 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
4 GABRA1 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D01253 Clobazam 2件: 140, 144
5 GABRA2 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
6 GABRA2 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D01253 Clobazam 2件: 140, 144
7 GABRA3 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
8 GABRA3 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D01253 Clobazam 2件: 140, 144
9 GABRA4 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
10 GABRA4 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D01253 Clobazam 2件: 140, 144
11 GABRA5 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
12 GABRA5 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D01253 Clobazam 2件: 140, 144
13 GABRA6 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
14 GABRA6 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D01253 Clobazam 2件: 140, 144
15 GABRB1 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
16 GABRB1 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D01253 Clobazam 2件: 140, 144
17 GABRB2 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
18 GABRB2 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D01253 Clobazam 2件: 140, 144
19 GABRB3 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
20 GABRB3 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D01253 Clobazam 2件: 140, 144
21 GABRD 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
22 GABRD 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D01253 Clobazam 2件: 140, 144
23 GABRE 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
24 GABRE 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D01253 Clobazam 2件: 140, 144
25 GABRG1 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
26 GABRG1 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D01253 Clobazam 2件: 140, 144
27 GABRG2 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
28 GABRG2 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D01253 Clobazam 2件: 140, 144
29 GABRG3 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
30 GABRG3 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D01253 Clobazam 2件: 140, 144
31 GABRP 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
32 GABRP 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D01253 Clobazam 2件: 140, 144
33 GRIA1 14件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Long-term depression 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
34 GRIA1 14件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Long-term depression 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Nicotine addiction 💬 D08964 Perampanel 3件: 2, 6, 144
35 GRIA2 15件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Long-term depression 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
36 GRIA2 15件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Long-term depression 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬 D08964 Perampanel 3件: 2, 6, 144
37 GRIA3 13件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Long-term depression 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Transcriptional misregulation in cancer 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
38 GRIA3 13件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Long-term depression 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Transcriptional misregulation in cancer 💬 D08964 Perampanel 3件: 2, 6, 144
39 GRIA4 10件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Huntington disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
40 GRIA4 10件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Huntington disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Nicotine addiction 💬 D08964 Perampanel 3件: 2, 6, 144
41 GRIK1 2件: Neuroactive ligand-receptor interaction 💬, Glutamatergic synapse 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
42 GRIK2 2件: Neuroactive ligand-receptor interaction 💬, Glutamatergic synapse 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
43 GRIK3 2件: Neuroactive ligand-receptor interaction 💬, Glutamatergic synapse 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
44 GRIK4 2件: Neuroactive ligand-receptor interaction 💬, Glutamatergic synapse 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
45 GRIK5 2件: Neuroactive ligand-receptor interaction 💬, Glutamatergic synapse 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
46 HTR2A 5件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Serotonergic synapse 💬, Inflammatory mediator regulation of TRP channels 💬 D07945 Fenfluramine 4件: 140, 144, 145, 149
47 HTR2B 5件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Serotonergic synapse 💬, Inflammatory mediator regulation of TRP channels 💬 D07945 Fenfluramine 4件: 140, 144, 145, 149
48 HTR2C 5件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Serotonergic synapse 💬, Inflammatory mediator regulation of TRP channels 💬 D07945 Fenfluramine 4件: 140, 144, 145, 149
49 KCNQ1 6件: Adrenergic signaling in cardiomyocytes 💬, Cholinergic synapse 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Protein digestion and absorption 💬, Vibrio cholerae infection 💬 D09569 Ezogabine 2件: 2, 144
50 KCNQ2 1件: Cholinergic synapse 💬 D09569 Ezogabine 1件: 144
51 KCNQ3 1件: Cholinergic synapse 💬 D09569 Ezogabine 1件: 144
52 MTNR1A 2件: Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬 D08170 Melatonin 12件: 6, 8, 13, 37, 46, 49, 90, 97, 144, 145, 149, 202
53 MTNR1B 2件: Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬 D08170 Melatonin 12件: 6, 8, 13, 37, 46, 49, 90, 97, 144, 145, 149, 202
54 GABRQ 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
55 GABRQ 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D01253 Clobazam 2件: 140, 144
56 KCNQ5 1件: Cholinergic synapse 💬 D09569 Ezogabine 1件: 144
57 SCN1A 1件: Dopaminergic synapse 💬 D00354 Lamotrigine 1件: 144
58 SCN1A 1件: Dopaminergic synapse 💬 D00537 Topiramate 3件: 144, 156, 193
59 SCN1A 1件: Dopaminergic synapse 💬 D05775 Rufinamide 1件: 144
60 SCN2A 1件: Taste transduction 💬 D00354 Lamotrigine 1件: 144
61 SCN2A 1件: Taste transduction 💬 D00537 Topiramate 3件: 144, 156, 193
62 SCN2A 1件: Taste transduction 💬 D05775 Rufinamide 1件: 144
63 SCN3A 1件: Taste transduction 💬 D00354 Lamotrigine 1件: 144
64 SCN3A 1件: Taste transduction 💬 D00537 Topiramate 3件: 144, 156, 193
65 SCN3A 1件: Taste transduction 💬 D05775 Rufinamide 1件: 144
66 SCN5A 1件: Adrenergic signaling in cardiomyocytes 💬 D00354 Lamotrigine 1件: 144
67 SCN5A 1件: Adrenergic signaling in cardiomyocytes 💬 D00537 Topiramate 3件: 144, 156, 193
68 SCN5A 1件: Adrenergic signaling in cardiomyocytes 💬 D05775 Rufinamide 1件: 144
69 SCN9A 1件: Taste transduction 💬 D00354 Lamotrigine 1件: 144
70 SCN9A 1件: Taste transduction 💬 D00537 Topiramate 3件: 144, 156, 193
71 SCN9A 1件: Taste transduction 💬 D05775 Rufinamide 1件: 144
72 SLC6A4 2件: Synaptic vesicle cycle 💬, Serotonergic synapse 💬 D07945 Fenfluramine 4件: 140, 144, 145, 149
73 CA2 7件: Nitrogen metabolism 💬, Metabolic pathways 💬, Proximal tubule bicarbonate reclamation 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Bile secretion 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
74 CA4 3件: Nitrogen metabolism 💬, Metabolic pathways 💬, Proximal tubule bicarbonate reclamation 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
75 CACNA1C 34件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Dopaminergic synapse 💬, Taste transduction 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Type II diabetes mellitus 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
76 CACNA1D 35件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cellular senescence 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Tight junction 💬, Circadian entrainment 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Dopaminergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Type II diabetes mellitus 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Carbohydrate digestion and absorption 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
77 CACNA1F 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
78 CACNA1S 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
79 KCNQ4 1件: Cholinergic synapse 💬 D09569 Ezogabine 1件: 144