Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 CHRNA4 4件: Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Nicotine addiction 💬, Chemical carcinogenesis - receptor activation 💬 D08669 Varenicline 2件: 6, 18
2 CHRNB2 4件: Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Nicotine addiction 💬, Chemical carcinogenesis - receptor activation 💬 D08669 Varenicline 2件: 6, 18
3 CSF3R 5件: Cytokine-cytokine receptor interaction 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Hematopoietic cell lineage 💬, Pathways in cancer 💬 D03247 Lenograstim 7件: 2, 13, 16, 18, 19, 57, 65
4 EPOR 5件: Cytokine-cytokine receptor interaction 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Hematopoietic cell lineage 💬, Pathways in cancer 💬 D03231 Erythropoietin 10件: 2, 6, 13, 18, 22, 46, 47, 70, 95, 96
5 GABBR1 7件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, GABAergic synapse 💬, Taste transduction 💬, Estrogen signaling pathway 💬, GnRH secretion 💬, Morphine addiction 💬 D00241 Baclofen 7件: 2, 10, 13, 18, 65, 149, 206
6 GABRA1 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00697 Flumazenil 5件: 6, 13, 17, 18, 206
7 GABRA2 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00697 Flumazenil 5件: 6, 13, 17, 18, 206
8 GABRA3 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00697 Flumazenil 5件: 6, 13, 17, 18, 206
9 GABRA4 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00697 Flumazenil 5件: 6, 13, 17, 18, 206
10 GABRA5 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00697 Flumazenil 5件: 6, 13, 17, 18, 206
11 GABRA6 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00697 Flumazenil 5件: 6, 13, 17, 18, 206
12 GABRB1 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00697 Flumazenil 5件: 6, 13, 17, 18, 206
13 GABRB2 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00697 Flumazenil 5件: 6, 13, 17, 18, 206
14 GABRB3 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00697 Flumazenil 5件: 6, 13, 17, 18, 206
15 GABRD 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00697 Flumazenil 5件: 6, 13, 17, 18, 206
16 GABRE 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00697 Flumazenil 5件: 6, 13, 17, 18, 206
17 GABRG1 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00697 Flumazenil 5件: 6, 13, 17, 18, 206
18 GABRG2 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00697 Flumazenil 5件: 6, 13, 17, 18, 206
19 GABRG3 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00697 Flumazenil 5件: 6, 13, 17, 18, 206
20 GABRP 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00697 Flumazenil 5件: 6, 13, 17, 18, 206
21 GRIA1 14件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Long-term depression 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Nicotine addiction 💬 D00775 Riluzole 9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
22 GRIA2 15件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Long-term depression 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬 D00775 Riluzole 9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
23 GRIA3 13件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Long-term depression 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Transcriptional misregulation in cancer 💬 D00775 Riluzole 9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
24 GRIA4 10件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Huntington disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Nicotine addiction 💬 D00775 Riluzole 9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
25 GRIK1 2件: Neuroactive ligand-receptor interaction 💬, Glutamatergic synapse 💬 D00775 Riluzole 9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
26 GRIK2 2件: Neuroactive ligand-receptor interaction 💬, Glutamatergic synapse 💬 D00775 Riluzole 9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
27 GRIK3 2件: Neuroactive ligand-receptor interaction 💬, Glutamatergic synapse 💬 D00775 Riluzole 9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
28 GRIK4 2件: Neuroactive ligand-receptor interaction 💬, Glutamatergic synapse 💬 D00775 Riluzole 9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
29 GRIK5 2件: Neuroactive ligand-receptor interaction 💬, Glutamatergic synapse 💬 D00775 Riluzole 9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
30 GRIN1 18件: Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬 D00775 Riluzole 9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
31 GRIN2A 19件: Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬, Systemic lupus erythematosus 💬 D00775 Riluzole 9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
32 GRIN2B 19件: Ras signaling pathway 💬, Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬, Systemic lupus erythematosus 💬 D00775 Riluzole 9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
33 GRIN2C 15件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬 D00775 Riluzole 9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
34 GRIN2D 15件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬 D00775 Riluzole 9件: 2, 3, 5, 8, 13, 17, 18, 203, 206
35 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00407 Methylprednisolone 43件: 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
36 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00751 Methylprednisolone 43件: 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
37 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00979 Methylprednisolone 43件: 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
38 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D05000 Methylprednisolone 43件: 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
39 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D05001 Methylprednisolone 43件: 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
40 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D05002 Methylprednisolone 43件: 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
41 HMGCR 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, AMPK signaling pathway 💬, Bile secretion 💬 D01915 Rosuvastatin 11件: 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299
42 HMGCR 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, AMPK signaling pathway 💬, Bile secretion 💬 D08492 Rosuvastatin 11件: 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299
43 IFNGR1 18件: Cytokine-cytokine receptor interaction 💬, HIF-1 signaling pathway 💬, Necroptosis 💬, Osteoclast differentiation 💬, JAK-STAT signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, Leishmaniasis 💬, Chagas disease 💬, Toxoplasmosis 💬, Tuberculosis 💬, Influenza A 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Pathways in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Inflammatory bowel disease 💬 D00747 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326
44 IFNGR2 17件: Cytokine-cytokine receptor interaction 💬, HIF-1 signaling pathway 💬, Necroptosis 💬, Osteoclast differentiation 💬, JAK-STAT signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, Leishmaniasis 💬, Chagas disease 💬, Toxoplasmosis 💬, Tuberculosis 💬, Influenza A 💬, Herpes simplex virus 1 infection 💬, Pathways in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Inflammatory bowel disease 💬 D00747 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326
45 NFE2L2 7件: Protein processing in endoplasmic reticulum 💬, Parkinson disease 💬, Pathways in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Hepatocellular carcinoma 💬, Lipid and atherosclerosis 💬, Fluid shear stress and atherosclerosis 💬 D10964 Omaveloxolone 1件: 18
46 GABRQ 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00697 Flumazenil 5件: 6, 13, 17, 18, 206
47 SLC6A2 1件: Synaptic vesicle cycle 💬 D00817 Bupropion 4件: 18, 21, 96, 171
48 SLC6A2 1件: Synaptic vesicle cycle 💬 D07591 Bupropion 4件: 18, 21, 96, 171
49 SLC6A2 1件: Synaptic vesicle cycle 💬 D07938 Bupropion 4件: 18, 21, 96, 171
50 SLC6A3 7件: Synaptic vesicle cycle 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Alcoholism 💬 D00817 Bupropion 5件: 8, 18, 21, 96, 171
51 SLC6A3 7件: Synaptic vesicle cycle 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Alcoholism 💬 D07591 Bupropion 5件: 8, 18, 21, 96, 171
52 SLC6A3 7件: Synaptic vesicle cycle 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Alcoholism 💬 D07938 Bupropion 5件: 8, 18, 21, 96, 171
53 SLC6A4 2件: Synaptic vesicle cycle 💬, Serotonergic synapse 💬 D00822 Citalopram 7件: 6, 8, 13, 18, 46, 98, 127
54 SLC6A4 2件: Synaptic vesicle cycle 💬, Serotonergic synapse 💬 D07704 Citalopram 7件: 6, 8, 13, 18, 46, 98, 127
55 VDR 5件: Parathyroid hormone synthesis, secretion and action 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Mineral absorption 💬, Tuberculosis 💬, Chemical carcinogenesis - receptor activation 💬 D00129 Calcitriol 9件: 18, 37, 46, 49, 66, 96, 158, 235, 326
56 GABBR2 7件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, GABAergic synapse 💬, Taste transduction 💬, Estrogen signaling pathway 💬, GnRH secretion 💬, Morphine addiction 💬 D00241 Baclofen 7件: 2, 10, 13, 18, 65, 149, 206