Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 HDAC6 4件: Neutrophil extracellular trap formation 💬, Amyotrophic lateral sclerosis 💬, Alcoholism 💬, Viral carcinogenesis 💬 D06320 Vorinostat 3件: 19, 75, 96
2 HDAC5 5件: Apelin signaling pathway 💬, Neutrophil extracellular trap formation 💬, Alcoholism 💬, Viral carcinogenesis 💬, MicroRNAs in cancer 💬 D06320 Vorinostat 3件: 19, 75, 96
3 CHRM1 8件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D00397 Tropicamide 3件: 6, 13, 19
4 CHRM2 6件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬 D00397 Tropicamide 3件: 6, 13, 19
5 CHRM3 11件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Taste transduction 💬, Regulation of actin cytoskeleton 💬, Insulin secretion 💬, Salivary secretion 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D00397 Tropicamide 3件: 6, 13, 19
6 CHRM4 3件: Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬 D00397 Tropicamide 3件: 6, 13, 19
7 CHRM5 6件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D00397 Tropicamide 3件: 6, 13, 19
8 TPP1 1件: Lysosome 💬 D10813 Cerliponase alfa 1件: 19
9 CSF3R 5件: Cytokine-cytokine receptor interaction 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Hematopoietic cell lineage 💬, Pathways in cancer 💬 D03247 Lenograstim 7件: 2, 13, 16, 18, 19, 57, 65
10 ACE 6件: Renin-angiotensin system 💬, Renin secretion 💬, Chagas disease 💬, Coronavirus disease - COVID-19 💬, Hypertrophic cardiomyopathy 💬, Diabetic cardiomyopathy 💬 D00362 Lisinopril 7件: 19, 46, 49, 66, 67, 113, 222
11 ACE 6件: Renin-angiotensin system 💬, Renin secretion 💬, Chagas disease 💬, Coronavirus disease - COVID-19 💬, Hypertrophic cardiomyopathy 💬, Diabetic cardiomyopathy 💬 D00459 Quinapril 1件: 19
12 ACE 6件: Renin-angiotensin system 💬, Renin secretion 💬, Chagas disease 💬, Coronavirus disease - COVID-19 💬, Hypertrophic cardiomyopathy 💬, Diabetic cardiomyopathy 💬 D00621 Enalapril 6件: 19, 46, 66, 113, 210, 222
13 ACE 6件: Renin-angiotensin system 💬, Renin secretion 💬, Chagas disease 💬, Coronavirus disease - COVID-19 💬, Hypertrophic cardiomyopathy 💬, Diabetic cardiomyopathy 💬 D03752 Quinapril 1件: 19
14 ACE 6件: Renin-angiotensin system 💬, Renin secretion 💬, Chagas disease 💬, Coronavirus disease - COVID-19 💬, Hypertrophic cardiomyopathy 💬, Diabetic cardiomyopathy 💬 D07892 Enalapril 6件: 19, 46, 66, 113, 210, 222
15 ACE 6件: Renin-angiotensin system 💬, Renin secretion 💬, Chagas disease 💬, Coronavirus disease - COVID-19 💬, Hypertrophic cardiomyopathy 💬, Diabetic cardiomyopathy 💬 D08131 Lisinopril 7件: 19, 46, 49, 66, 67, 113, 222
16 DHFR 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D00142 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
17 DHFR 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D02115 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
18 NQO1 7件: Ubiquinone and other terpenoid-quinone biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Pathways in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Hepatocellular carcinoma 💬, Fluid shear stress and atherosclerosis 💬 D00564 Warfarin 13件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
19 NQO1 7件: Ubiquinone and other terpenoid-quinone biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Pathways in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Hepatocellular carcinoma 💬, Fluid shear stress and atherosclerosis 💬 D01280 Warfarin 13件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
20 NQO1 7件: Ubiquinone and other terpenoid-quinone biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Pathways in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Hepatocellular carcinoma 💬, Fluid shear stress and atherosclerosis 💬 D08682 Warfarin 13件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
21 AGTR1 16件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Apelin signaling pathway 💬, Renin-angiotensin system 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Cushing syndrome 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Diabetic cardiomyopathy 💬 D00150 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224
22 AGTR1 16件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Apelin signaling pathway 💬, Renin-angiotensin system 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Cushing syndrome 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Diabetic cardiomyopathy 💬 D00357 Losartan 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299
23 AGTR1 16件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Apelin signaling pathway 💬, Renin-angiotensin system 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Cushing syndrome 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Diabetic cardiomyopathy 💬 D02014 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224
24 AGTR1 16件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Apelin signaling pathway 💬, Renin-angiotensin system 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Cushing syndrome 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Diabetic cardiomyopathy 💬 D08146 Losartan 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299
25 AGTR2 3件: Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Renin-angiotensin system 💬 D00150 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224
26 AGTR2 3件: Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Renin-angiotensin system 💬 D02014 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224
27 DHFR2 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D00142 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
28 DHFR2 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D02115 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
29 FDPS 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬 D00939 Alendronic acid 7件: 19, 41, 46, 50, 271, 274, 299
30 FDPS 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬 D07119 Alendronic acid 7件: 19, 41, 46, 50, 271, 274, 299
31 POLA2 1件: DNA replication 💬 D03546 Clofarabine 9件: 19, 20, 40, 46, 49, 60, 96, 234, 326
32 MTOR 51件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, ErbB signaling pathway 💬, HIF-1 signaling pathway 💬, Phospholipase D signaling pathway 💬, Autophagy - other 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Cellular senescence 💬, Apelin signaling pathway 💬, Neutrophil extracellular trap formation 💬, JAK-STAT signaling pathway 💬, Th17 cell differentiation 💬, Thermogenesis 💬, Insulin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Adipocytokine signaling pathway 💬, Type II diabetes mellitus 💬, Insulin resistance 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Pathways of neurodegeneration - multiple diseases 💬, Shigellosis 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Human immunodeficiency virus 1 infection 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Colorectal cancer 💬, Pancreatic cancer 💬, Glioma 💬, Prostate cancer 💬, Acute myeloid leukemia 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Diabetic cardiomyopathy 💬 D00753 Sirolimus 41件: 2, 6, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331
33 GALNS 3件: Glycosaminoglycan degradation 💬, Metabolic pathways 💬, Lysosome 💬 D10333 Elosulfase alfa 1件: 19
34 GBA 4件: Other glycan degradation 💬, Sphingolipid metabolism 💬, Metabolic pathways 💬, Lysosome 💬 D02810 Alglucerase 1件: 19
35 GBA 4件: Other glycan degradation 💬, Sphingolipid metabolism 💬, Metabolic pathways 💬, Lysosome 💬 D03020 Imiglucerase 1件: 19
36 GBA 4件: Other glycan degradation 💬, Sphingolipid metabolism 💬, Metabolic pathways 💬, Lysosome 💬 D09029 Velaglucerase alfa 1件: 19
37 GBA 4件: Other glycan degradation 💬, Sphingolipid metabolism 💬, Metabolic pathways 💬, Lysosome 💬 D09675 Taliglucerase alfa 1件: 19
38 GHR 5件: Cytokine-cytokine receptor interaction 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Growth hormone synthesis, secretion and action 💬 D02691 Somatotropin 23件: 2, 3, 13, 19, 46, 65, 74, 75, 76, 78, 96, 107, 113, 187, 191, 193, 195, 236, 238, 265, 274, 276, 299
39 GLA 6件: Galactose metabolism 💬, Glycerolipid metabolism 💬, Sphingolipid metabolism 💬, Glycosphingolipid biosynthesis - globo and isoglobo series 💬, Metabolic pathways 💬, Lysosome 💬 D02784 Agalsidase alfa 1件: 19
40 GLA 6件: Galactose metabolism 💬, Glycerolipid metabolism 💬, Sphingolipid metabolism 💬, Glycosphingolipid biosynthesis - globo and isoglobo series 💬, Metabolic pathways 💬, Lysosome 💬 D03228 Agalsidase beta 1件: 19
41 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00407 Methylprednisolone 42件: 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
42 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00473 Prednisone 43件: 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 127, 162, 164, 205, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331
43 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00751 Methylprednisolone 42件: 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
44 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00979 Methylprednisolone 42件: 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
45 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D05000 Methylprednisolone 42件: 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
46 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D05001 Methylprednisolone 42件: 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
47 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D05002 Methylprednisolone 42件: 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
48 GUSB 8件: Pentose and glucuronate interconversions 💬, Ascorbate and aldarate metabolism 💬, Glycosaminoglycan degradation 💬, Porphyrin metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Lysosome 💬 D11004 Vestronidase alfa 1件: 19
49 HDAC1 15件: Cell cycle 💬, Longevity regulating pathway - multiple species 💬, Notch signaling pathway 💬, Neutrophil extracellular trap formation 💬, Thyroid hormone signaling pathway 💬, Huntington disease 💬, Amphetamine addiction 💬, Alcoholism 💬, Human papillomavirus infection 💬, Epstein-Barr virus infection 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Viral carcinogenesis 💬, MicroRNAs in cancer 💬, Chronic myeloid leukemia 💬 D06320 Vorinostat 3件: 19, 75, 96
50 HDAC2 15件: Cell cycle 💬, Longevity regulating pathway - multiple species 💬, Notch signaling pathway 💬, Neutrophil extracellular trap formation 💬, Thyroid hormone signaling pathway 💬, Huntington disease 💬, Amphetamine addiction 💬, Alcoholism 💬, Human papillomavirus infection 💬, Epstein-Barr virus infection 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Viral carcinogenesis 💬, MicroRNAs in cancer 💬, Chronic myeloid leukemia 💬 D06320 Vorinostat 3件: 19, 75, 96
51 IDS 3件: Glycosaminoglycan degradation 💬, Metabolic pathways 💬, Lysosome 💬 D04499 Idursulfase 1件: 19
52 IDS 3件: Glycosaminoglycan degradation 💬, Metabolic pathways 💬, Lysosome 💬 D11025 Idursulfase beta 1件: 19
53 IDS 3件: Glycosaminoglycan degradation 💬, Metabolic pathways 💬, Lysosome 💬 D11812 Pabinafusp alfa 1件: 19
54 IDUA 3件: Glycosaminoglycan degradation 💬, Metabolic pathways 💬, Lysosome 💬 D04670 Laronidase 2件: 19, 256
55 IL1R1 13件: MAPK signaling pathway 💬, Cytokine-cytokine receptor interaction 💬, NF-kappa B signaling pathway 💬, Osteoclast differentiation 💬, Hematopoietic cell lineage 💬, Th17 cell differentiation 💬, Inflammatory mediator regulation of TRP channels 💬, Pathogenic Escherichia coli infection 💬, Shigellosis 💬, Amoebiasis 💬, Human cytomegalovirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Fluid shear stress and atherosclerosis 💬 D02934 Anakinra 19件: 2, 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299
56 IMPDH1 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D00752 Mycophenolate mofetil 34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
57 IMPDH1 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D05094 Mycophenolate mofetil 34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
58 IMPDH1 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D05095 Mycophenolate mofetil 34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
59 IMPDH1 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D05096 Mycophenolic acid 36件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300
60 IMPDH2 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D00752 Mycophenolate mofetil 34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
61 IMPDH2 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D05094 Mycophenolate mofetil 34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
62 IMPDH2 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D05095 Mycophenolate mofetil 34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
63 IMPDH2 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D05096 Mycophenolic acid 36件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300
64 LIPA 3件: Steroid biosynthesis 💬, Lysosome 💬, Cholesterol metabolism 💬 D10377 Sebelipase alfa 1件: 19
65 ARSB 3件: Glycosaminoglycan degradation 💬, Metabolic pathways 💬, Lysosome 💬 D06565 Galsulfase 1件: 19
66 MAN2B1 2件: Other glycan degradation 💬, Lysosome 💬 D11024 Velmanase alfa 1件: 19
67 HDAC7 3件: Neutrophil extracellular trap formation 💬, Alcoholism 💬, Viral carcinogenesis 💬 D06320 Vorinostat 3件: 19, 75, 96
68 POLA1 1件: DNA replication 💬 D03546 Clofarabine 9件: 19, 20, 40, 46, 49, 60, 96, 234, 326
69 PPP3CA 33件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Oocyte meiosis 💬, Cellular senescence 💬, Wnt signaling pathway 💬, Axon guidance 💬, VEGF signaling pathway 💬, Osteoclast differentiation 💬, C-type lectin receptor signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Renin secretion 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Tuberculosis 💬, Human cytomegalovirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Human immunodeficiency virus 1 infection 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Lipid and atherosclerosis 💬 D00184 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
70 PPP3CB 33件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Oocyte meiosis 💬, Cellular senescence 💬, Wnt signaling pathway 💬, Axon guidance 💬, VEGF signaling pathway 💬, Osteoclast differentiation 💬, C-type lectin receptor signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Renin secretion 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Tuberculosis 💬, Human cytomegalovirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Human immunodeficiency virus 1 infection 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Lipid and atherosclerosis 💬 D00184 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
71 PPP3CC 33件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Oocyte meiosis 💬, Cellular senescence 💬, Wnt signaling pathway 💬, Axon guidance 💬, VEGF signaling pathway 💬, Osteoclast differentiation 💬, C-type lectin receptor signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Renin secretion 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Tuberculosis 💬, Human cytomegalovirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Human immunodeficiency virus 1 infection 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Lipid and atherosclerosis 💬 D00184 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
72 PPP3R1 32件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Oocyte meiosis 💬, Cellular senescence 💬, Wnt signaling pathway 💬, Axon guidance 💬, VEGF signaling pathway 💬, Osteoclast differentiation 💬, C-type lectin receptor signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Renin secretion 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Tuberculosis 💬, Human cytomegalovirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Human immunodeficiency virus 1 infection 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Lipid and atherosclerosis 💬 D00184 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
73 PPP3R2 32件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Oocyte meiosis 💬, Cellular senescence 💬, Wnt signaling pathway 💬, Axon guidance 💬, VEGF signaling pathway 💬, Osteoclast differentiation 💬, C-type lectin receptor signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Renin secretion 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Tuberculosis 💬, Human cytomegalovirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Human immunodeficiency virus 1 infection 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Lipid and atherosclerosis 💬 D00184 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
74 CACNA2D3 7件: MAPK signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Oxytocin signaling pathway 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D00332 Gabapentin 5件: 6, 13, 19, 70, 298
75 HDAC8 3件: Neutrophil extracellular trap formation 💬, Alcoholism 💬, Viral carcinogenesis 💬 D06320 Vorinostat 3件: 19, 75, 96
76 RRM1 5件: Purine metabolism 💬, Pyrimidine metabolism 💬, Glutathione metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D01907 Fludarabine 19件: 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326
77 RRM1 5件: Purine metabolism 💬, Pyrimidine metabolism 💬, Glutathione metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D03546 Clofarabine 9件: 19, 20, 40, 46, 49, 60, 96, 234, 326
78 RRM1 5件: Purine metabolism 💬, Pyrimidine metabolism 💬, Glutathione metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D07966 Fludarabine 19件: 13, 19, 28, 36, 46, 49, 51, 60, 61, 62, 65, 85, 96, 164, 283, 284, 285, 286, 326
79 RRM2 6件: Purine metabolism 💬, Pyrimidine metabolism 💬, Glutathione metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬, p53 signaling pathway 💬 D00341 Hydroxyurea 8件: 3, 13, 19, 20, 65, 85, 86, 284
80 SLC6A1 2件: Synaptic vesicle cycle 💬, GABAergic synapse 💬 D00332 Gabapentin 5件: 6, 13, 19, 70, 298
81 SMPD1 5件: Sphingolipid metabolism 💬, Metabolic pathways 💬, Sphingolipid signaling pathway 💬, Lysosome 💬, Necroptosis 💬 D10820 Olipudase alfa 1件: 19
82 TFRC 5件: HIF-1 signaling pathway 💬, Endocytosis 💬, Phagosome 💬, Ferroptosis 💬, Hematopoietic cell lineage 💬 D11812 Pabinafusp alfa 1件: 19
83 THRA 2件: Neuroactive ligand-receptor interaction 💬, Thyroid hormone signaling pathway 💬 D01010 Levothyroxine 5件: 19, 49, 78, 80, 222
84 THRA 2件: Neuroactive ligand-receptor interaction 💬, Thyroid hormone signaling pathway 💬 D08125 Levothyroxine 5件: 19, 49, 78, 80, 222
85 THRB 2件: Neuroactive ligand-receptor interaction 💬, Thyroid hormone signaling pathway 💬 D01010 Levothyroxine 5件: 19, 49, 78, 80, 222
86 THRB 2件: Neuroactive ligand-receptor interaction 💬, Thyroid hormone signaling pathway 💬 D08125 Levothyroxine 5件: 19, 49, 78, 80, 222
87 TNF 67件: Antifolate resistance 💬, MAPK signaling pathway 💬, Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, NF-kappa B signaling pathway 💬, Sphingolipid signaling pathway 💬, mTOR signaling pathway 💬, Apoptosis 💬, Necroptosis 💬, TGF-beta signaling pathway 💬, Osteoclast differentiation 💬, Antigen processing and presentation 💬, Toll-like receptor signaling pathway 💬, NOD-like receptor signaling pathway 💬, RIG-I-like receptor signaling pathway 💬, C-type lectin receptor signaling pathway 💬, Hematopoietic cell lineage 💬, Natural killer cell mediated cytotoxicity 💬, IL-17 signaling pathway 💬, T cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, TNF signaling pathway 💬, Adipocytokine signaling pathway 💬, Type II diabetes mellitus 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Alcoholic liver disease 💬, Type I diabetes mellitus 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Shigellosis 💬, Salmonella infection 💬, Pertussis 💬, Legionellosis 💬, Yersinia infection 💬, Leishmaniasis 💬, Chagas disease 💬, African trypanosomiasis 💬, Malaria 💬, Toxoplasmosis 💬, Amoebiasis 💬, Tuberculosis 💬, Hepatitis C 💬, Hepatitis B 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human papillomavirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Human immunodeficiency virus 1 infection 💬, Coronavirus disease - COVID-19 💬, Proteoglycans in cancer 💬, Asthma 💬, Inflammatory bowel disease 💬, Systemic lupus erythematosus 💬, Rheumatoid arthritis 💬, Allograft rejection 💬, Graft-versus-host disease 💬, Hypertrophic cardiomyopathy 💬, Dilated cardiomyopathy 💬, Lipid and atherosclerosis 💬, Fluid shear stress and atherosclerosis 💬 D02597 Adalimumab 18件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271
88 UGCG 2件: Sphingolipid metabolism 💬, Metabolic pathways 💬 D05032 Miglustat 3件: 19, 256, 299
89 UGCG 2件: Sphingolipid metabolism 💬, Metabolic pathways 💬 D09893 Eliglustat 1件: 19
90 UGCG 2件: Sphingolipid metabolism 💬, Metabolic pathways 💬 D11439 Lucerastat 1件: 19
91 UGCG 2件: Sphingolipid metabolism 💬, Metabolic pathways 💬 D11633 Venglustat 3件: 6, 19, 67
92 VDR 5件: Parathyroid hormone synthesis, secretion and action 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Mineral absorption 💬, Tuberculosis 💬, Chemical carcinogenesis - receptor activation 💬 D00188 Cholecalciferol 25件: 6, 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 75, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299
93 VDR 5件: Parathyroid hormone synthesis, secretion and action 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Mineral absorption 💬, Tuberculosis 💬, Chemical carcinogenesis - receptor activation 💬 D00930 Paricalcitol 4件: 19, 66, 218, 238
94 TRPV1 2件: Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D00250 Capsaicin 5件: 2, 6, 19, 86, 226
95 CACNA2D1 7件: MAPK signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Oxytocin signaling pathway 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D00332 Gabapentin 5件: 6, 13, 19, 70, 298
96 IL1R2 7件: Cytokine-cytokine receptor interaction 💬, Hematopoietic cell lineage 💬, Amoebiasis 💬, Human T-cell leukemia virus 1 infection 💬, Transcriptional misregulation in cancer 💬, Prostate cancer 💬, Fluid shear stress and atherosclerosis 💬 D02934 Anakinra 19件: 2, 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299
97 CXCR4 12件: Calcium signaling pathway 💬, Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, Chemokine signaling pathway 💬, Endocytosis 💬, Axon guidance 💬, Leukocyte transendothelial migration 💬, Intestinal immune network for IgA production 💬, Regulation of actin cytoskeleton 💬, Human cytomegalovirus infection 💬, Human immunodeficiency virus 1 infection 💬, Pathways in cancer 💬 D08971 Plerixafor 6件: 19, 20, 51, 65, 285, 299
98 VKORC1 3件: Ubiquinone and other terpenoid-quinone biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬 D00564 Warfarin 13件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
99 VKORC1 3件: Ubiquinone and other terpenoid-quinone biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬 D01280 Warfarin 13件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
100 VKORC1 3件: Ubiquinone and other terpenoid-quinone biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬 D08682 Warfarin 13件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
101 HDAC11 3件: Neutrophil extracellular trap formation 💬, Alcoholism 💬, Viral carcinogenesis 💬 D06320 Vorinostat 3件: 19, 75, 96
102 HDAC10 3件: Neutrophil extracellular trap formation 💬, Alcoholism 💬, Viral carcinogenesis 💬 D06320 Vorinostat 3件: 19, 75, 96
103 CASP9 35件: Platinum drug resistance 💬, p53 signaling pathway 💬, PI3K-Akt signaling pathway 💬, Apoptosis 💬, Apoptosis - multiple species 💬, VEGF signaling pathway 💬, Thyroid hormone signaling pathway 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Legionellosis 💬, Toxoplasmosis 💬, Tuberculosis 💬, Hepatitis C 💬, Hepatitis B 💬, Measles 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Human immunodeficiency virus 1 infection 💬,