Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 HRH3 1件: Neuroactive ligand-receptor interaction 💬 D10749 Pitolisant 1件: 193
2 CNR1 4件: Rap1 signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Thermogenesis 💬, Retrograde endocannabinoid signaling 💬 D05731 Rimonabant 1件: 193
3 CNR1 4件: Rap1 signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Thermogenesis 💬, Retrograde endocannabinoid signaling 💬 D10915 Cannabidiol 19件: 2, 6, 8, 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271
4 CNR2 1件: Neuroactive ligand-receptor interaction 💬 D10915 Cannabidiol 4件: 193, 206, 226, 271
5 ADRA2A 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D00606 Guanfacine 1件: 193
6 ADRA2A 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D08031 Guanfacine 1件: 193
7 ADRB1 11件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Gap junction 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬, Dilated cardiomyopathy 💬 D00601 Metoprolol 6件: 17, 57, 58, 113, 193, 226
8 ADRB1 11件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Gap junction 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬, Dilated cardiomyopathy 💬 D02358 Metoprolol 6件: 17, 57, 58, 113, 193, 226
9 ADRB1 11件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Gap junction 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬, Dilated cardiomyopathy 💬 D05011 Metoprolol 6件: 17, 57, 58, 113, 193, 226
10 CYP11B1 4件: Steroid hormone biosynthesis 💬, Metabolic pathways 💬, Cortisol synthesis and secretion 💬, Cushing syndrome 💬 D00410 Metyrapone 2件: 75, 193
11 CYP11B1 4件: Steroid hormone biosynthesis 💬, Metabolic pathways 💬, Cortisol synthesis and secretion 💬, Cushing syndrome 💬 D05019 Metyrapone 2件: 75, 193
12 CYP19A1 3件: Steroid hormone biosynthesis 💬, Metabolic pathways 💬, Ovarian steroidogenesis 💬 D00960 Anastrozole 3件: 78, 86, 193
13 MTOR 51件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, ErbB signaling pathway 💬, HIF-1 signaling pathway 💬, Phospholipase D signaling pathway 💬, Autophagy - other 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Cellular senescence 💬, Apelin signaling pathway 💬, Neutrophil extracellular trap formation 💬, JAK-STAT signaling pathway 💬, Th17 cell differentiation 💬, Thermogenesis 💬, Insulin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Adipocytokine signaling pathway 💬, Type II diabetes mellitus 💬, Insulin resistance 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Pathways of neurodegeneration - multiple diseases 💬, Shigellosis 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Human immunodeficiency virus 1 infection 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Colorectal cancer 💬, Pancreatic cancer 💬, Glioma 💬, Prostate cancer 💬, Acute myeloid leukemia 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Diabetic cardiomyopathy 💬 D00753 Sirolimus 41件: 2, 6, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331
14 GABRA1 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
15 GABRA2 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
16 GABRA3 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
17 GABRA4 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
18 GABRA5 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
19 GABRA6 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
20 GABRB1 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
21 GABRB2 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
22 GABRB3 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
23 GABRD 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
24 GABRE 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
25 GABRG1 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
26 GABRG2 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
27 GABRG3 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
28 GABRP 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
29 GHR 5件: Cytokine-cytokine receptor interaction 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Growth hormone synthesis, secretion and action 💬 D02691 Somatotropin 23件: 2, 3, 13, 19, 46, 65, 74, 75, 76, 78, 96, 107, 113, 187, 191, 193, 195, 236, 238, 265, 274, 276, 299
30 GLP1R 3件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Insulin secretion 💬 D04121 Exenatide 6件: 6, 17, 72, 78, 193, 233
31 GLP1R 3件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Insulin secretion 💬 D06404 Liraglutide 3件: 6, 75, 193
32 GRIA1 14件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Long-term depression 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
33 GRIA2 15件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Long-term depression 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
34 GRIA3 13件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Long-term depression 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Transcriptional misregulation in cancer 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
35 GRIA4 10件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Huntington disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
36 GRIK1 2件: Neuroactive ligand-receptor interaction 💬, Glutamatergic synapse 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
37 GRIK2 2件: Neuroactive ligand-receptor interaction 💬, Glutamatergic synapse 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
38 GRIK3 2件: Neuroactive ligand-receptor interaction 💬, Glutamatergic synapse 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
39 GRIK4 2件: Neuroactive ligand-receptor interaction 💬, Glutamatergic synapse 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
40 GRIK5 2件: Neuroactive ligand-receptor interaction 💬, Glutamatergic synapse 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
41 KCNJ11 3件: Insulin secretion 💬, GnRH secretion 💬, Type II diabetes mellitus 💬 D00294 Diazoxide 2件: 13, 193
42 MC2R 5件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, Cushing syndrome 💬 D00146 Corticotropin 15件: 2, 13, 14, 46, 49, 50, 66, 75, 78, 81, 84, 145, 193, 205, 222
43 OXTR 4件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Oxytocin signaling pathway 💬 D00089 Oxytocin 6件: 6, 72, 127, 193, 206, 226
44 OXTR 4件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Oxytocin signaling pathway 💬 D07229 Carbetocin 1件: 193
45 GABRQ 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
46 SCN1A 1件: Dopaminergic synapse 💬 D00537 Topiramate 1件: 193
47 SCN2A 1件: Taste transduction 💬 D00537 Topiramate 1件: 193
48 SCN3A 1件: Taste transduction 💬 D00537 Topiramate 1件: 193
49 SCN5A 1件: Adrenergic signaling in cardiomyocytes 💬 D00537 Topiramate 1件: 193
50 SCN9A 1件: Taste transduction 💬 D00537 Topiramate 1件: 193
51 SSTR2 4件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Growth hormone synthesis, secretion and action 💬, Gastric acid secretion 💬 D00442 Octreotide 7件: 67, 75, 84, 85, 89, 193, 227
52 SSTR2 4件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Growth hormone synthesis, secretion and action 💬, Gastric acid secretion 💬 D06495 Octreotide 7件: 67, 75, 84, 85, 89, 193, 227
53 ABCC8 3件: ABC transporters 💬, Insulin secretion 💬, Type II diabetes mellitus 💬 D00294 Diazoxide 2件: 13, 193
54 CA2 7件: Nitrogen metabolism 💬, Metabolic pathways 💬, Proximal tubule bicarbonate reclamation 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Bile secretion 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
55 CA4 3件: Nitrogen metabolism 💬, Metabolic pathways 💬, Proximal tubule bicarbonate reclamation 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
56 CACNA1C 34件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Dopaminergic synapse 💬, Taste transduction 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Type II diabetes mellitus 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
57 CACNA1D 35件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cellular senescence 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Tight junction 💬, Circadian entrainment 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Dopaminergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Type II diabetes mellitus 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Carbohydrate digestion and absorption 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
58 CACNA1F 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193
59 CACNA1S 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D00537 Topiramate 6件: 6, 97, 140, 144, 156, 193