Target Gene/Pathway PATHWAY / GENE


Search results


No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 CA5B 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D00218 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
2 CA5B 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D01196 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
3 F8 1件: Complement and coagulation cascades 💬 D00291 Desmopressin 2件: 225, 288
4 F8 1件: Complement and coagulation cascades 💬 D02235 Desmopressin 2件: 225, 288
5 CA14 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D00218 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
6 CA14 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D01196 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
7 GUCY1A2 11件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, Vascular smooth muscle contraction 💬, Gap junction 💬, Platelet activation 💬, Circadian entrainment 💬, Long-term depression 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Salivary secretion 💬 D09572 Riociguat 6件: 51, 84, 86, 88, 225, 299
8 GUCY1A1 11件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, Vascular smooth muscle contraction 💬, Gap junction 💬, Platelet activation 💬, Circadian entrainment 💬, Long-term depression 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Salivary secretion 💬 D09572 Riociguat 6件: 51, 84, 86, 88, 225, 299
9 GUCY1B1 11件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, Vascular smooth muscle contraction 💬, Gap junction 💬, Platelet activation 💬, Circadian entrainment 💬, Long-term depression 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Salivary secretion 💬 D09572 Riociguat 6件: 51, 84, 86, 88, 225, 299
10 HMGCR 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, AMPK signaling pathway 💬, Bile secretion 💬 D00887 Atorvastatin 18件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 299
11 HMGCR 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, AMPK signaling pathway 💬, Bile secretion 💬 D07474 Atorvastatin 18件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 299
12 CA13 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D00218 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
13 CA13 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D01196 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
14 NR3C2 1件: Aldosterone-regulated sodium reabsorption 💬 D00443 Spironolactone 1件: 225
15 ATP4A 4件: Oxidative phosphorylation 💬, Metabolic pathways 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬 D00455 Omeprazole 16件: 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
16 ATP4A 4件: Oxidative phosphorylation 💬, Metabolic pathways 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬 D01207 Omeprazole 16件: 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
17 ATP4A 4件: Oxidative phosphorylation 💬, Metabolic pathways 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬 D05259 Omeprazole 16件: 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
18 ATP4A 4件: Oxidative phosphorylation 💬, Metabolic pathways 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬 D05261 Omeprazole 16件: 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
19 ATP4B 4件: Oxidative phosphorylation 💬, Metabolic pathways 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬 D00455 Omeprazole 16件: 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
20 ATP4B 4件: Oxidative phosphorylation 💬, Metabolic pathways 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬 D01207 Omeprazole 16件: 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
21 ATP4B 4件: Oxidative phosphorylation 💬, Metabolic pathways 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬 D05259 Omeprazole 16件: 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
22 ATP4B 4件: Oxidative phosphorylation 💬, Metabolic pathways 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬 D05261 Omeprazole 16件: 6, 8, 13, 21, 46, 51, 85, 96, 97, 98, 225, 271, 282, 294, 298, 299
23 AVPR2 3件: Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vasopressin-regulated water reabsorption 💬 D00291 Desmopressin 6件: 6, 64, 72, 75, 225, 288
24 AVPR2 3件: Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vasopressin-regulated water reabsorption 💬 D01213 Tolvaptan 3件: 67, 72, 225
25 AVPR2 3件: Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vasopressin-regulated water reabsorption 💬 D02235 Desmopressin 6件: 6, 64, 72, 75, 225, 288
26 PRKAA1 20件: FoxO signaling pathway 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Apelin signaling pathway 💬, Tight junction 💬, Circadian rhythm 💬, Thermogenesis 💬, Insulin signaling pathway 💬, Adipocytokine signaling pathway 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, Alcoholic liver disease 💬, Hypertrophic cardiomyopathy 💬, Fluid shear stress and atherosclerosis 💬 D00944 Metformin 24件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
27 PRKAA1 20件: FoxO signaling pathway 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Apelin signaling pathway 💬, Tight junction 💬, Circadian rhythm 💬, Thermogenesis 💬, Insulin signaling pathway 💬, Adipocytokine signaling pathway 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, Alcoholic liver disease 💬, Hypertrophic cardiomyopathy 💬, Fluid shear stress and atherosclerosis 💬 D04966 Metformin 24件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
28 PRKAA2 20件: FoxO signaling pathway 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Apelin signaling pathway 💬, Tight junction 💬, Circadian rhythm 💬, Thermogenesis 💬, Insulin signaling pathway 💬, Adipocytokine signaling pathway 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, Alcoholic liver disease 💬, Hypertrophic cardiomyopathy 💬, Fluid shear stress and atherosclerosis 💬 D00944 Metformin 24件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
29 PRKAA2 20件: FoxO signaling pathway 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Apelin signaling pathway 💬, Tight junction 💬, Circadian rhythm 💬, Thermogenesis 💬, Insulin signaling pathway 💬, Adipocytokine signaling pathway 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, Alcoholic liver disease 💬, Hypertrophic cardiomyopathy 💬, Fluid shear stress and atherosclerosis 💬 D04966 Metformin 24件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
30 PTGS1 5件: Arachidonic acid metabolism 💬, Metabolic pathways 💬, Platelet activation 💬, Serotonergic synapse 💬, Regulation of lipolysis in adipocytes 💬 D00141 Indomethacin 3件: 225, 271, 298
31 PTGS1 5件: Arachidonic acid metabolism 💬, Metabolic pathways 💬, Platelet activation 💬, Serotonergic synapse 💬, Regulation of lipolysis in adipocytes 💬 D01565 Indomethacin 3件: 225, 271, 298
32 PTGS1 5件: Arachidonic acid metabolism 💬, Metabolic pathways 💬, Platelet activation 💬, Serotonergic synapse 💬, Regulation of lipolysis in adipocytes 💬 D02110 Indomethacin 3件: 225, 271, 298
33 PTGS2 22件: Arachidonic acid metabolism 💬, Metabolic pathways 💬, NF-kappa B signaling pathway 💬, VEGF signaling pathway 💬, C-type lectin receptor signaling pathway 💬, IL-17 signaling pathway 💬, TNF signaling pathway 💬, Retrograde endocannabinoid signaling 💬, Serotonergic synapse 💬, Ovarian steroidogenesis 💬, Oxytocin signaling pathway 💬, Regulation of lipolysis in adipocytes 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Leishmaniasis 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Pathways in cancer 💬, Chemical carcinogenesis - DNA adducts 💬, MicroRNAs in cancer 💬, Small cell lung cancer 💬 D00141 Indomethacin 3件: 225, 271, 298
34 PTGS2 22件: Arachidonic acid metabolism 💬, Metabolic pathways 💬, NF-kappa B signaling pathway 💬, VEGF signaling pathway 💬, C-type lectin receptor signaling pathway 💬, IL-17 signaling pathway 💬, TNF signaling pathway 💬, Retrograde endocannabinoid signaling 💬, Serotonergic synapse 💬, Ovarian steroidogenesis 💬, Oxytocin signaling pathway 💬, Regulation of lipolysis in adipocytes 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Leishmaniasis 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Pathways in cancer 💬, Chemical carcinogenesis - DNA adducts 💬, MicroRNAs in cancer 💬, Small cell lung cancer 💬 D01565 Indomethacin 3件: 225, 271, 298
35 PTGS2 22件: Arachidonic acid metabolism 💬, Metabolic pathways 💬, NF-kappa B signaling pathway 💬, VEGF signaling pathway 💬, C-type lectin receptor signaling pathway 💬, IL-17 signaling pathway 💬, TNF signaling pathway 💬, Retrograde endocannabinoid signaling 💬, Serotonergic synapse 💬, Ovarian steroidogenesis 💬, Oxytocin signaling pathway 💬, Regulation of lipolysis in adipocytes 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Leishmaniasis 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Pathways in cancer 💬, Chemical carcinogenesis - DNA adducts 💬, MicroRNAs in cancer 💬, Small cell lung cancer 💬 D02110 Indomethacin 3件: 225, 271, 298
36 SCNN1A 2件: Taste transduction 💬, Aldosterone-regulated sodium reabsorption 💬 D00649 Amiloride 4件: 13, 67, 225, 299
37 SCNN1A 2件: Taste transduction 💬, Aldosterone-regulated sodium reabsorption 💬 D07447 Amiloride 4件: 13, 67, 225, 299
38 SCNN1B 2件: Taste transduction 💬, Aldosterone-regulated sodium reabsorption 💬 D00649 Amiloride 4件: 13, 67, 225, 299
39 SCNN1B 2件: Taste transduction 💬, Aldosterone-regulated sodium reabsorption 💬 D07447 Amiloride 4件: 13, 67, 225, 299
40 SCNN1G 2件: Taste transduction 💬, Aldosterone-regulated sodium reabsorption 💬 D00649 Amiloride 4件: 13, 67, 225, 299
41 SCNN1G 2件: Taste transduction 💬, Aldosterone-regulated sodium reabsorption 💬 D07447 Amiloride 4件: 13, 67, 225, 299
42 CA1 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D00218 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
43 CA1 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D01196 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
44 CA2 7件: Nitrogen metabolism 💬, Metabolic pathways 💬, Proximal tubule bicarbonate reclamation 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Bile secretion 💬 D00218 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
45 CA2 7件: Nitrogen metabolism 💬, Metabolic pathways 💬, Proximal tubule bicarbonate reclamation 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Bile secretion 💬 D01196 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
46 CA3 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D00218 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
47 CA3 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D01196 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
48 CA4 3件: Nitrogen metabolism 💬, Metabolic pathways 💬, Proximal tubule bicarbonate reclamation 💬 D00218 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
49 CA4 3件: Nitrogen metabolism 💬, Metabolic pathways 💬, Proximal tubule bicarbonate reclamation 💬 D01196 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
50 CA5A 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D00218 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
51 CA5A 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D01196 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
52 CA6 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D00218 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
53 CA6 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D01196 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
54 CA7 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D00218 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
55 CA7 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D01196 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
56 CA8 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D00218 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
57 CA8 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D01196 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
58 CA9 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D00218 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
59 CA9 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D01196 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
60 CA12 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D00218 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
61 CA12 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D01196 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
62 PDE5A 3件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬 D02229 Sildenafil 17件: 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301
63 PDE5A 3件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬 D08514 Sildenafil 17件: 6, 46, 50, 51, 85, 86, 90, 113, 210, 211, 212, 225, 226, 278, 294, 299, 301