Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 PDE10A 4件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Morphine addiction 💬 D00371 Theophylline 2件: 236, 299
2 PDE10A 4件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Morphine addiction 💬 D01712 Theophylline 2件: 236, 299
3 PDE10A 4件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Morphine addiction 💬 D02017 Theophylline 2件: 236, 299
4 PDE10A 4件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Morphine addiction 💬 D06103 Theophylline 2件: 236, 299
5 PDE10A 4件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Morphine addiction 💬 D06104 Theophylline 2件: 236, 299
6 ADORA1 7件: cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Sphingolipid signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Morphine addiction 💬 D00371 Theophylline 2件: 236, 299
7 ADORA1 7件: cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Sphingolipid signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Morphine addiction 💬 D01712 Theophylline 2件: 236, 299
8 ADORA1 7件: cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Sphingolipid signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Morphine addiction 💬 D02017 Theophylline 2件: 236, 299
9 ADORA1 7件: cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Sphingolipid signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Morphine addiction 💬 D06103 Theophylline 2件: 236, 299
10 ADORA1 7件: cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Sphingolipid signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Morphine addiction 💬 D06104 Theophylline 2件: 236, 299
11 ADORA2A 7件: Rap1 signaling pathway 💬, Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vascular smooth muscle contraction 💬, Parkinson disease 💬, Alcoholism 💬 D02017 Theophylline 2件: 236, 299
12 ADORA2B 5件: Rap1 signaling pathway 💬, Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vascular smooth muscle contraction 💬, Alcoholism 💬 D00371 Theophylline 2件: 236, 299
13 ADORA2B 5件: Rap1 signaling pathway 💬, Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vascular smooth muscle contraction 💬, Alcoholism 💬 D01712 Theophylline 2件: 236, 299
14 ADORA2B 5件: Rap1 signaling pathway 💬, Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vascular smooth muscle contraction 💬, Alcoholism 💬 D06103 Theophylline 2件: 236, 299
15 ADORA2B 5件: Rap1 signaling pathway 💬, Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vascular smooth muscle contraction 💬, Alcoholism 💬 D06104 Theophylline 2件: 236, 299
16 GHR 5件: Cytokine-cytokine receptor interaction 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Growth hormone synthesis, secretion and action 💬 D02691 Somatotropin 23件: 2, 3, 13, 19, 46, 65, 74, 75, 76, 78, 96, 107, 113, 187, 191, 193, 195, 236, 238, 265, 274, 276, 299
17 PDE7B 3件: Purine metabolism 💬, Metabolic pathways 💬, Morphine addiction 💬 D00371 Theophylline 2件: 236, 299
18 PDE7B 3件: Purine metabolism 💬, Metabolic pathways 💬, Morphine addiction 💬 D01712 Theophylline 2件: 236, 299
19 PDE7B 3件: Purine metabolism 💬, Metabolic pathways 💬, Morphine addiction 💬 D02017 Theophylline 2件: 236, 299
20 PDE7B 3件: Purine metabolism 💬, Metabolic pathways 💬, Morphine addiction 💬 D06103 Theophylline 2件: 236, 299
21 PDE7B 3件: Purine metabolism 💬, Metabolic pathways 💬, Morphine addiction 💬 D06104 Theophylline 2件: 236, 299
22 PDE11A 4件: Purine metabolism 💬, Metabolic pathways 💬, Cushing syndrome 💬, Morphine addiction 💬 D00371 Theophylline 2件: 236, 299
23 PDE11A 4件: Purine metabolism 💬, Metabolic pathways 💬, Cushing syndrome 💬, Morphine addiction 💬 D01712 Theophylline 2件: 236, 299
24 PDE11A 4件: Purine metabolism 💬, Metabolic pathways 💬, Cushing syndrome 💬, Morphine addiction 💬 D02017 Theophylline 2件: 236, 299
25 PDE11A 4件: Purine metabolism 💬, Metabolic pathways 💬, Cushing syndrome 💬, Morphine addiction 💬 D06103 Theophylline 2件: 236, 299
26 PDE11A 4件: Purine metabolism 💬, Metabolic pathways 💬, Cushing syndrome 💬, Morphine addiction 💬 D06104 Theophylline 2件: 236, 299
27 PDE1A 7件: Purine metabolism 💬, Metabolic pathways 💬, Calcium signaling pathway 💬, Olfactory transduction 💬, Taste transduction 💬, Renin secretion 💬, Morphine addiction 💬 D00371 Theophylline 2件: 236, 299
28 PDE1A 7件: Purine metabolism 💬, Metabolic pathways 💬, Calcium signaling pathway 💬, Olfactory transduction 💬, Taste transduction 💬, Renin secretion 💬, Morphine addiction 💬 D01712 Theophylline 2件: 236, 299
29 PDE1A 7件: Purine metabolism 💬, Metabolic pathways 💬, Calcium signaling pathway 💬, Olfactory transduction 💬, Taste transduction 💬, Renin secretion 💬, Morphine addiction 💬 D02017 Theophylline 2件: 236, 299
30 PDE1A 7件: Purine metabolism 💬, Metabolic pathways 💬, Calcium signaling pathway 💬, Olfactory transduction 💬, Taste transduction 💬, Renin secretion 💬, Morphine addiction 💬 D06103 Theophylline 2件: 236, 299
31 PDE1A 7件: Purine metabolism 💬, Metabolic pathways 💬, Calcium signaling pathway 💬, Olfactory transduction 💬, Taste transduction 💬, Renin secretion 💬, Morphine addiction 💬 D06104 Theophylline 2件: 236, 299
32 PDE1C 7件: Purine metabolism 💬, Metabolic pathways 💬, Calcium signaling pathway 💬, Olfactory transduction 💬, Taste transduction 💬, Renin secretion 💬, Morphine addiction 💬 D00371 Theophylline 2件: 236, 299
33 PDE1C 7件: Purine metabolism 💬, Metabolic pathways 💬, Calcium signaling pathway 💬, Olfactory transduction 💬, Taste transduction 💬, Renin secretion 💬, Morphine addiction 💬 D01712 Theophylline 2件: 236, 299
34 PDE1C 7件: Purine metabolism 💬, Metabolic pathways 💬, Calcium signaling pathway 💬, Olfactory transduction 💬, Taste transduction 💬, Renin secretion 💬, Morphine addiction 💬 D02017 Theophylline 2件: 236, 299
35 PDE1C 7件: Purine metabolism 💬, Metabolic pathways 💬, Calcium signaling pathway 💬, Olfactory transduction 💬, Taste transduction 💬, Renin secretion 💬, Morphine addiction 💬 D06103 Theophylline 2件: 236, 299
36 PDE1C 7件: Purine metabolism 💬, Metabolic pathways 💬, Calcium signaling pathway 💬, Olfactory transduction 💬, Taste transduction 💬, Renin secretion 💬, Morphine addiction 💬 D06104 Theophylline 2件: 236, 299
37 PDE2A 6件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, Olfactory transduction 💬, Aldosterone synthesis and secretion 💬, Morphine addiction 💬 D00371 Theophylline 2件: 236, 299
38 PDE2A 6件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, Olfactory transduction 💬, Aldosterone synthesis and secretion 💬, Morphine addiction 💬 D01712 Theophylline 2件: 236, 299
39 PDE2A 6件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, Olfactory transduction 💬, Aldosterone synthesis and secretion 💬, Morphine addiction 💬 D02017 Theophylline 2件: 236, 299
40 PDE2A 6件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, Olfactory transduction 💬, Aldosterone synthesis and secretion 💬, Morphine addiction 💬 D06103 Theophylline 2件: 236, 299
41 PDE2A 6件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, Olfactory transduction 💬, Aldosterone synthesis and secretion 💬, Morphine addiction 💬 D06104 Theophylline 2件: 236, 299
42 PDE3A 6件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Renin secretion 💬, Morphine addiction 💬 D00371 Theophylline 2件: 236, 299
43 PDE3A 6件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Renin secretion 💬, Morphine addiction 💬 D01712 Theophylline 2件: 236, 299
44 PDE3A 6件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Renin secretion 💬, Morphine addiction 💬 D02017 Theophylline 2件: 236, 299
45 PDE3A 6件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Renin secretion 💬, Morphine addiction 💬 D06103 Theophylline 2件: 236, 299
46 PDE3A 6件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Renin secretion 💬, Morphine addiction 💬 D06104 Theophylline 2件: 236, 299
47 PDE3B 11件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Apelin signaling pathway 💬, Insulin signaling pathway 💬, Progesterone-mediated oocyte maturation 💬, Glucagon signaling pathway 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Morphine addiction 💬 D00371 Theophylline 2件: 236, 299
48 PDE3B 11件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Apelin signaling pathway 💬, Insulin signaling pathway 💬, Progesterone-mediated oocyte maturation 💬, Glucagon signaling pathway 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Morphine addiction 💬 D01712 Theophylline 2件: 236, 299
49 PDE3B 11件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Apelin signaling pathway 💬, Insulin signaling pathway 💬, Progesterone-mediated oocyte maturation 💬, Glucagon signaling pathway 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Morphine addiction 💬 D02017 Theophylline 2件: 236, 299
50 PDE3B 11件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Apelin signaling pathway 💬, Insulin signaling pathway 💬, Progesterone-mediated oocyte maturation 💬, Glucagon signaling pathway 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Morphine addiction 💬 D06103 Theophylline 2件: 236, 299
51 PDE3B 11件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Apelin signaling pathway 💬, Insulin signaling pathway 💬, Progesterone-mediated oocyte maturation 💬, Glucagon signaling pathway 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Morphine addiction 💬 D06104 Theophylline 2件: 236, 299
52 PDE4A 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D00371 Theophylline 2件: 236, 299
53 PDE4A 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D01712 Theophylline 2件: 236, 299
54 PDE4A 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D02017 Theophylline 2件: 236, 299
55 PDE4A 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D06103 Theophylline 2件: 236, 299
56 PDE4A 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D06104 Theophylline 2件: 236, 299
57 PDE4B 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D00371 Theophylline 2件: 236, 299
58 PDE4B 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D01712 Theophylline 2件: 236, 299
59 PDE4B 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D02017 Theophylline 2件: 236, 299
60 PDE4B 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D06103 Theophylline 2件: 236, 299
61 PDE4B 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D06104 Theophylline 2件: 236, 299
62 PDE4C 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D00371 Theophylline 2件: 236, 299
63 PDE4C 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D01712 Theophylline 2件: 236, 299
64 PDE4C 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D02017 Theophylline 2件: 236, 299
65 PDE4C 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D06103 Theophylline 2件: 236, 299
66 PDE4C 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D06104 Theophylline 2件: 236, 299
67 PDE4D 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D00371 Theophylline 2件: 236, 299
68 PDE4D 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D01712 Theophylline 2件: 236, 299
69 PDE4D 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D02017 Theophylline 2件: 236, 299
70 PDE4D 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D06103 Theophylline 2件: 236, 299
71 PDE4D 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D06104 Theophylline 2件: 236, 299
72 PDE7A 3件: Purine metabolism 💬, Metabolic pathways 💬, Morphine addiction 💬 D00371 Theophylline 2件: 236, 299
73 PDE7A 3件: Purine metabolism 💬, Metabolic pathways 💬, Morphine addiction 💬 D01712 Theophylline 2件: 236, 299
74 PDE7A 3件: Purine metabolism 💬, Metabolic pathways 💬, Morphine addiction 💬 D02017 Theophylline 2件: 236, 299
75 PDE7A 3件: Purine metabolism 💬, Metabolic pathways 💬, Morphine addiction 💬 D06103 Theophylline 2件: 236, 299
76 PDE7A 3件: Purine metabolism 💬, Metabolic pathways 💬, Morphine addiction 💬 D06104 Theophylline 2件: 236, 299
77 PDE8A 5件: Purine metabolism 💬, Metabolic pathways 💬, Cortisol synthesis and secretion 💬, Cushing syndrome 💬, Morphine addiction 💬 D00371 Theophylline 2件: 236, 299
78 PDE8A 5件: Purine metabolism 💬, Metabolic pathways 💬, Cortisol synthesis and secretion 💬, Cushing syndrome 💬, Morphine addiction 💬 D01712 Theophylline 2件: 236, 299
79 PDE8A 5件: Purine metabolism 💬, Metabolic pathways 💬, Cortisol synthesis and secretion 💬, Cushing syndrome 💬, Morphine addiction 💬 D02017 Theophylline 2件: 236, 299
80 PDE8A 5件: Purine metabolism 💬, Metabolic pathways 💬, Cortisol synthesis and secretion 💬, Cushing syndrome 💬, Morphine addiction 💬 D06103 Theophylline 2件: 236, 299
81 PDE8A 5件: Purine metabolism 💬, Metabolic pathways 💬, Cortisol synthesis and secretion 💬, Cushing syndrome 💬, Morphine addiction 💬 D06104 Theophylline 2件: 236, 299
82 PDE1B 7件: Purine metabolism 💬, Metabolic pathways 💬, Calcium signaling pathway 💬, Olfactory transduction 💬, Taste transduction 💬, Renin secretion 💬, Morphine addiction 💬 D00371 Theophylline 2件: 236, 299
83 PDE1B 7件: Purine metabolism 💬, Metabolic pathways 💬, Calcium signaling pathway 💬, Olfactory transduction 💬, Taste transduction 💬, Renin secretion 💬, Morphine addiction 💬 D01712 Theophylline 2件: 236, 299
84 PDE1B 7件: Purine metabolism 💬, Metabolic pathways 💬, Calcium signaling pathway 💬, Olfactory transduction 💬, Taste transduction 💬, Renin secretion 💬, Morphine addiction 💬 D02017 Theophylline 2件: 236, 299
85 PDE1B 7件: Purine metabolism 💬, Metabolic pathways 💬, Calcium signaling pathway 💬, Olfactory transduction 💬, Taste transduction 💬, Renin secretion 💬, Morphine addiction 💬 D06103 Theophylline 2件: 236, 299
86 PDE1B 7件: Purine metabolism 💬, Metabolic pathways 💬, Calcium signaling pathway 💬, Olfactory transduction 💬, Taste transduction 💬, Renin secretion 💬, Morphine addiction 💬 D06104 Theophylline 2件: 236, 299
87 PDE8B 5件: Purine metabolism 💬, Metabolic pathways 💬, Cortisol synthesis and secretion 💬, Cushing syndrome 💬, Morphine addiction 💬 D00371 Theophylline 2件: 236, 299
88 PDE8B 5件: Purine metabolism 💬, Metabolic pathways 💬, Cortisol synthesis and secretion 💬, Cushing syndrome 💬, Morphine addiction 💬 D01712 Theophylline 2件: 236, 299
89 PDE8B 5件: Purine metabolism 💬, Metabolic pathways 💬, Cortisol synthesis and secretion 💬, Cushing syndrome 💬, Morphine addiction 💬 D02017 Theophylline 2件: 236, 299
90 PDE8B 5件: Purine metabolism 💬, Metabolic pathways 💬, Cortisol synthesis and secretion 💬, Cushing syndrome 💬, Morphine addiction 💬 D06103 Theophylline 2件: 236, 299
91 PDE8B 5件: Purine metabolism 💬, Metabolic pathways 💬, Cortisol synthesis and secretion 💬, Cushing syndrome 💬, Morphine addiction 💬 D06104 Theophylline 2件: 236, 299