Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 CSF2 16件: Cytokine-cytokine receptor interaction 💬, JAK-STAT signaling pathway 💬, Hematopoietic cell lineage 💬, Natural killer cell mediated cytotoxicity 💬, IL-17 signaling pathway 💬, T cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, TNF signaling pathway 💬, Shigellosis 💬, Amoebiasis 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Coronavirus disease - COVID-19 💬, Transcriptional misregulation in cancer 💬, Acute myeloid leukemia 💬, Rheumatoid arthritis 💬 D11343 Otilimab 2件: 46, 256
2 CSF3R 5件: Cytokine-cytokine receptor interaction 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Hematopoietic cell lineage 💬, Pathways in cancer 💬 D03235 Filgrastim 34件: 2, 6, 11, 13, 16, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331
3 ADRB2 9件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬 D02147 Salbutamol 14件: 3, 11, 12, 13, 49, 85, 86, 89, 111, 113, 228, 231, 256, 299
4 ADRB2 9件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬 D07713 Clenbuterol 5件: 1, 2, 6, 13, 256
5 DHFR 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D00142 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
6 DHFR 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D02115 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
7 ABAT 7件: Alanine, aspartate and glutamate metabolism 💬, Valine, leucine and isoleucine degradation 💬, beta-Alanine metabolism 💬, Propanoate metabolism 💬, Butanoate metabolism 💬, Metabolic pathways 💬, GABAergic synapse 💬 D00399 Valproic acid 17件: 2, 3, 5, 6, 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331
8 DHFR2 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D00142 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
9 DHFR2 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D02115 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
10 MTOR 51件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, ErbB signaling pathway 💬, HIF-1 signaling pathway 💬, Phospholipase D signaling pathway 💬, Autophagy - other 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Cellular senescence 💬, Apelin signaling pathway 💬, Neutrophil extracellular trap formation 💬, JAK-STAT signaling pathway 💬, Th17 cell differentiation 💬, Thermogenesis 💬, Insulin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Adipocytokine signaling pathway 💬, Type II diabetes mellitus 💬, Insulin resistance 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Pathways of neurodegeneration - multiple diseases 💬, Shigellosis 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Human immunodeficiency virus 1 infection 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Colorectal cancer 💬, Pancreatic cancer 💬, Glioma 💬, Prostate cancer 💬, Acute myeloid leukemia 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Diabetic cardiomyopathy 💬 D00753 Sirolimus 41件: 2, 6, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331
11 GAA 4件: Galactose metabolism 💬, Starch and sucrose metabolism 💬, Metabolic pathways 💬, Lysosome 💬 D03207 Alglucosidase alfa 1件: 256
12 GAA 4件: Galactose metabolism 💬, Starch and sucrose metabolism 💬, Metabolic pathways 💬, Lysosome 💬 D09605 Duvoglustat 1件: 256
13 GAA 4件: Galactose metabolism 💬, Starch and sucrose metabolism 💬, Metabolic pathways 💬, Lysosome 💬 D11744 Avalglucosidase alfa 1件: 256
14 GAA 4件: Galactose metabolism 💬, Starch and sucrose metabolism 💬, Metabolic pathways 💬, Lysosome 💬 D11798 Cipaglucosidase alfa 1件: 256
15 GAD1 7件: Alanine, aspartate and glutamate metabolism 💬, beta-Alanine metabolism 💬, Taurine and hypotaurine metabolism 💬, Butanoate metabolism 💬, Metabolic pathways 💬, GABAergic synapse 💬, Type I diabetes mellitus 💬 D00399 Valproic acid 17件: 2, 3, 5, 6, 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331
16 GAD2 7件: Alanine, aspartate and glutamate metabolism 💬, beta-Alanine metabolism 💬, Taurine and hypotaurine metabolism 💬, Butanoate metabolism 💬, Metabolic pathways 💬, GABAergic synapse 💬, Type I diabetes mellitus 💬 D00399 Valproic acid 17件: 2, 3, 5, 6, 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331
17 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D00300 Diphenhydramine 10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
18 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D00669 Diphenhydramine 10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
19 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D02419 Diphenhydramine 10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
20 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D03285 Diphenhydramine 10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
21 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D03360 Diphenhydramine 10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
22 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D03854 Diphenhydramine 10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
23 IDUA 3件: Glycosaminoglycan degradation 💬, Metabolic pathways 💬, Lysosome 💬 D04670 Laronidase 2件: 19, 256
24 JAK1 27件: EGFR tyrosine kinase inhibitor resistance 💬, PI3K-Akt signaling pathway 💬, Necroptosis 💬, Osteoclast differentiation 💬, Signaling pathways regulating pluripotency of stem cells 💬, NOD-like receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, Leishmaniasis 💬, Toxoplasmosis 💬, Tuberculosis 💬, Hepatitis C 💬, Hepatitis B 💬, Measles 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human papillomavirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Viral carcinogenesis 💬, Pancreatic cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 D09970 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
25 JAK2 24件: EGFR tyrosine kinase inhibitor resistance 💬, Chemokine signaling pathway 💬, PI3K-Akt signaling pathway 💬, Necroptosis 💬, Signaling pathways regulating pluripotency of stem cells 💬, JAK-STAT signaling pathway 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, Cholinergic synapse 💬, Prolactin signaling pathway 💬, Adipocytokine signaling pathway 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Growth hormone synthesis, secretion and action 💬, Leishmaniasis 💬, Toxoplasmosis 💬, Tuberculosis 💬, Hepatitis B 💬, Influenza A 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Lipid and atherosclerosis 💬 D09970 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
26 JAK3 15件: Chemokine signaling pathway 💬, PI3K-Akt signaling pathway 💬, Necroptosis 💬, Signaling pathways regulating pluripotency of stem cells 💬, JAK-STAT signaling pathway 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, Hepatitis B 💬, Measles 💬, Human T-cell leukemia virus 1 infection 💬, Epstein-Barr virus infection 💬, Pathways in cancer 💬, Viral carcinogenesis 💬, Non-small cell lung cancer 💬, Primary immunodeficiency 💬 D09970 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
27 ACHE 2件: Glycerophospholipid metabolism 💬, Cholinergic synapse 💬 D00487 Pyridostigmine 4件: 3, 6, 11, 256
28 PSMB5 8件: Proteasome 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D03150 Bortezomib 16件: 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 228, 256, 283, 288, 331
29 PTGS1 5件: Arachidonic acid metabolism 💬, Metabolic pathways 💬, Platelet activation 💬, Serotonergic synapse 💬, Regulation of lipolysis in adipocytes 💬 D00217 Acetaminophen 18件: 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271, 300, 337
30 PTGS2 22件: Arachidonic acid metabolism 💬, Metabolic pathways 💬, NF-kappa B signaling pathway 💬, VEGF signaling pathway 💬, C-type lectin receptor signaling pathway 💬, IL-17 signaling pathway 💬, TNF signaling pathway 💬, Retrograde endocannabinoid signaling 💬, Serotonergic synapse 💬, Ovarian steroidogenesis 💬, Oxytocin signaling pathway 💬, Regulation of lipolysis in adipocytes 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Leishmaniasis 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Pathways in cancer 💬, Chemical carcinogenesis - DNA adducts 💬, MicroRNAs in cancer 💬, Small cell lung cancer 💬 D00217 Acetaminophen 18件: 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271, 300, 337
31 SCN1A 1件: Dopaminergic synapse 💬 D00358 Lidocaine 1件: 256
32 SCN1A 1件: Dopaminergic synapse 💬 D02086 Lidocaine 1件: 256
33 SCN1A 1件: Dopaminergic synapse 💬 D08127 Lidocaine 1件: 256
34 SCN2A 1件: Taste transduction 💬 D00358 Lidocaine 1件: 256
35 SCN2A 1件: Taste transduction 💬 D02086 Lidocaine 1件: 256
36 SCN2A 1件: Taste transduction 💬 D08127 Lidocaine 1件: 256
37 SCN3A 1件: Taste transduction 💬 D00358 Lidocaine 1件: 256
38 SCN3A 1件: Taste transduction 💬 D02086 Lidocaine 1件: 256
39 SCN3A 1件: Taste transduction 💬 D08127 Lidocaine 1件: 256
40 SCN5A 1件: Adrenergic signaling in cardiomyocytes 💬 D00358 Lidocaine 1件: 256
41 SCN5A 1件: Adrenergic signaling in cardiomyocytes 💬 D02086 Lidocaine 1件: 256
42 SCN5A 1件: Adrenergic signaling in cardiomyocytes 💬 D08127 Lidocaine 1件: 256
43 SCN9A 1件: Taste transduction 💬 D00358 Lidocaine 1件: 256
44 SCN9A 1件: Taste transduction 💬 D02086 Lidocaine 1件: 256
45 SCN9A 1件: Taste transduction 💬 D08127 Lidocaine 1件: 256
46 TYK2 16件: Necroptosis 💬, Osteoclast differentiation 💬, NOD-like receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, Toxoplasmosis 💬, Hepatitis C 💬, Hepatitis B 💬, Measles 💬, Influenza A 💬, Human papillomavirus infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Coronavirus disease - COVID-19 💬 D09970 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
47 UGCG 2件: Sphingolipid metabolism 💬, Metabolic pathways 💬 D05032 Miglustat 3件: 19, 256, 299
48 ALDH5A1 3件: Alanine, aspartate and glutamate metabolism 💬, Butanoate metabolism 💬, Metabolic pathways 💬 D00399 Valproic acid 17件: 2, 3, 5, 6, 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331
49 CACNA1I 7件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, Circadian entrainment 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬 D00399 Valproic acid 17件: 2, 3, 5, 6, 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331
50 CACNA1H 7件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, Circadian entrainment 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬 D00399 Valproic acid 17件: 2, 3, 5, 6, 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331
51 CACNA1G 8件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, Circadian entrainment 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Type II diabetes mellitus 💬, Cushing syndrome 💬 D00399 Valproic acid 17件: 2, 3, 5, 6, 13, 26, 34, 65, 85, 89, 90, 102, 127, 222, 233, 256, 331
52 MS4A1 1件: Hematopoietic cell lineage 💬 D02994 Rituximab 10件: 256, 271, 274, 283, 284, 285, 288, 296, 300, 331