Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 TNFSF13B 4件: Cytokine-cytokine receptor interaction 💬, NF-kappa B signaling pathway 💬, Intestinal immune network for IgA production 💬, Rheumatoid arthritis 💬 D03068 Belimumab 12件: 11, 13, 43, 44, 46, 49, 51, 53, 66, 222, 296, 300
2 DHODH 3件: Pyrimidine metabolism 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬 D00749 Leflunomide 12件: 11, 40, 46, 49, 53, 66, 107, 162, 224, 270, 271, 300
3 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00407 Methylprednisolone 1件: 300
4 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00472 Prednisolone 2件: 300, 307
5 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00473 Prednisone 2件: 300, 331
6 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00751 Methylprednisolone 1件: 300
7 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00979 Methylprednisolone 1件: 300
8 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00980 Prednisolone 2件: 300, 307
9 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00981 Prednisolone 2件: 300, 307
10 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00982 Prednisolone 2件: 300, 307
11 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01239 Prednisolone 2件: 300, 307
12 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01998 Prednisolone 2件: 300, 307
13 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D02156 Prednisolone 2件: 300, 307
14 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D03301 Prednisolone 2件: 300, 307
15 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D05000 Methylprednisolone 1件: 300
16 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D05001 Methylprednisolone 1件: 300
17 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D05002 Methylprednisolone 1件: 300
18 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D00300 Diphenhydramine 10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
19 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D00664 Cetirizine 4件: 13, 28, 35, 300
20 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D00669 Diphenhydramine 10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
21 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D02419 Diphenhydramine 10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
22 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D03285 Diphenhydramine 10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
23 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D03360 Diphenhydramine 10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
24 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D03854 Diphenhydramine 10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
25 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D07662 Cetirizine 4件: 13, 28, 35, 300
26 HRH2 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gastric acid secretion 💬 D00318 Famotidine 7件: 6, 46, 61, 86, 98, 107, 300
27 IMPDH1 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D00752 Mycophenolate mofetil 34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
28 IMPDH1 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D05094 Mycophenolate mofetil 34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
29 IMPDH1 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D05095 Mycophenolate mofetil 34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
30 IMPDH1 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D05096 Mycophenolic acid 36件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300
31 IMPDH2 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D00752 Mycophenolate mofetil 34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
32 IMPDH2 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D05094 Mycophenolate mofetil 34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
33 IMPDH2 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D05095 Mycophenolate mofetil 34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
34 IMPDH2 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D05096 Mycophenolic acid 36件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300
35 PTGS1 5件: Arachidonic acid metabolism 💬, Metabolic pathways 💬, Platelet activation 💬, Serotonergic synapse 💬, Regulation of lipolysis in adipocytes 💬 D00217 Acetaminophen 18件: 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271, 300, 337
36 PTGS2 22件: Arachidonic acid metabolism 💬, Metabolic pathways 💬, NF-kappa B signaling pathway 💬, VEGF signaling pathway 💬, C-type lectin receptor signaling pathway 💬, IL-17 signaling pathway 💬, TNF signaling pathway 💬, Retrograde endocannabinoid signaling 💬, Serotonergic synapse 💬, Ovarian steroidogenesis 💬, Oxytocin signaling pathway 💬, Regulation of lipolysis in adipocytes 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Leishmaniasis 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Pathways in cancer 💬, Chemical carcinogenesis - DNA adducts 💬, MicroRNAs in cancer 💬, Small cell lung cancer 💬 D00217 Acetaminophen 18件: 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271, 300, 337
37 BTK 7件: NF-kappa B signaling pathway 💬, Osteoclast differentiation 💬, Platelet activation 💬, B cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, Epstein-Barr virus infection 💬, Primary immunodeficiency 💬 D11422 Zanubrutinib 2件: 300, 331
38 TNF 67件: Antifolate resistance 💬, MAPK signaling pathway 💬, Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, NF-kappa B signaling pathway 💬, Sphingolipid signaling pathway 💬, mTOR signaling pathway 💬, Apoptosis 💬, Necroptosis 💬, TGF-beta signaling pathway 💬, Osteoclast differentiation 💬, Antigen processing and presentation 💬, Toll-like receptor signaling pathway 💬, NOD-like receptor signaling pathway 💬, RIG-I-like receptor signaling pathway 💬, C-type lectin receptor signaling pathway 💬, Hematopoietic cell lineage 💬, Natural killer cell mediated cytotoxicity 💬, IL-17 signaling pathway 💬, T cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, TNF signaling pathway 💬, Adipocytokine signaling pathway 💬, Type II diabetes mellitus 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Alcoholic liver disease 💬, Type I diabetes mellitus 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Shigellosis 💬, Salmonella infection 💬, Pertussis 💬, Legionellosis 💬, Yersinia infection 💬, Leishmaniasis 💬, Chagas disease 💬, African trypanosomiasis 💬, Malaria 💬, Toxoplasmosis 💬, Amoebiasis 💬, Tuberculosis 💬, Hepatitis C 💬, Hepatitis B 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human papillomavirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Human immunodeficiency virus 1 infection 💬, Coronavirus disease - COVID-19 💬, Proteoglycans in cancer 💬, Asthma 💬, Inflammatory bowel disease 💬, Systemic lupus erythematosus 💬, Rheumatoid arthritis 💬, Allograft rejection 💬, Graft-versus-host disease 💬, Hypertrophic cardiomyopathy 💬, Dilated cardiomyopathy 💬, Lipid and atherosclerosis 💬, Fluid shear stress and atherosclerosis 💬 D00754 Thalidomide 20件: 2, 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331
39 TNF 67件: Antifolate resistance 💬, MAPK signaling pathway 💬, Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, NF-kappa B signaling pathway 💬, Sphingolipid signaling pathway 💬, mTOR signaling pathway 💬, Apoptosis 💬, Necroptosis 💬, TGF-beta signaling pathway 💬, Osteoclast differentiation 💬, Antigen processing and presentation 💬, Toll-like receptor signaling pathway 💬, NOD-like receptor signaling pathway 💬, RIG-I-like receptor signaling pathway 💬, C-type lectin receptor signaling pathway 💬, Hematopoietic cell lineage 💬, Natural killer cell mediated cytotoxicity 💬, IL-17 signaling pathway 💬, T cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, TNF signaling pathway 💬, Adipocytokine signaling pathway 💬, Type II diabetes mellitus 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Alcoholic liver disease 💬, Type I diabetes mellitus 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Shigellosis 💬, Salmonella infection 💬, Pertussis 💬, Legionellosis 💬, Yersinia infection 💬, Leishmaniasis 💬, Chagas disease 💬, African trypanosomiasis 💬, Malaria 💬, Toxoplasmosis 💬, Amoebiasis 💬, Tuberculosis 💬, Hepatitis C 💬, Hepatitis B 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human papillomavirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Human immunodeficiency virus 1 infection 💬, Coronavirus disease - COVID-19 💬, Proteoglycans in cancer 💬, Asthma 💬, Inflammatory bowel disease 💬, Systemic lupus erythematosus 💬, Rheumatoid arthritis 💬, Allograft rejection 💬, Graft-versus-host disease 💬, Hypertrophic cardiomyopathy 💬, Dilated cardiomyopathy 💬, Lipid and atherosclerosis 💬, Fluid shear stress and atherosclerosis 💬 D04687 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331
40 CD19 5件: PI3K-Akt signaling pathway 💬, Hematopoietic cell lineage 💬, B cell receptor signaling pathway 💬, Epstein-Barr virus infection 💬, Primary immunodeficiency 💬 D11757 Inebilizumab 4件: 11, 13, 51, 300
41 MS4A1 1件: Hematopoietic cell lineage 💬 D02994 Rituximab 2件: 300, 331
42 CD80 10件: Cell adhesion molecules 💬, Toll-like receptor signaling pathway 💬, Intestinal immune network for IgA production 💬, Type I diabetes mellitus 💬, Autoimmune thyroid disease 💬, Systemic lupus erythematosus 💬, Rheumatoid arthritis 💬, Allograft rejection 💬, Graft-versus-host disease 💬, Viral myocarditis 💬 D03203 Abatacept 26件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300
43 CD86 12件: Cell adhesion molecules 💬, Toll-like receptor signaling pathway 💬, Intestinal immune network for IgA production 💬, Type I diabetes mellitus 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Transcriptional misregulation in cancer 💬, Autoimmune thyroid disease 💬, Systemic lupus erythematosus 💬, Rheumatoid arthritis 💬, Allograft rejection 💬, Graft-versus-host disease 💬, Viral myocarditis 💬 D03203 Abatacept 26件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 95, 96, 97, 107, 160, 164, 222, 271, 284, 285, 300