Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 ADRA2A 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D00514 Dexmedetomidine 13件: 2, 4, 6, 21, 34, 46, 70, 107, 113, 212, 215, 226, 280
2 ADRA2A 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D01205 Dexmedetomidine 13件: 2, 4, 6, 21, 34, 46, 70, 107, 113, 212, 215, 226, 280
3 ADRA2B 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D00514 Dexmedetomidine 13件: 2, 4, 6, 21, 34, 46, 70, 107, 113, 212, 215, 226, 280
4 ADRA2B 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D01205 Dexmedetomidine 13件: 2, 4, 6, 21, 34, 46, 70, 107, 113, 212, 215, 226, 280
5 ADRA2C 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D00514 Dexmedetomidine 13件: 2, 4, 6, 21, 34, 46, 70, 107, 113, 212, 215, 226, 280
6 ADRA2C 2件: cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D01205 Dexmedetomidine 13件: 2, 4, 6, 21, 34, 46, 70, 107, 113, 212, 215, 226, 280
7 DDC 9件: Tyrosine metabolism 💬, Phenylalanine metabolism 💬, Tryptophan metabolism 💬, Metabolic pathways 💬, Serotonergic synapse 💬, Dopaminergic synapse 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Alcoholism 💬 D00558 Carbidopa 9件: 2, 4, 6, 13, 17, 90, 140, 164, 201
8 DRD1 10件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Morphine addiction 💬, Alcoholism 💬 D00059 Levodopa 8件: 2, 4, 6, 17, 90, 140, 164, 201
9 DRD2 8件: Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Alcoholism 💬 D00059 Levodopa 8件: 2, 4, 6, 17, 90, 140, 164, 201
10 DRD3 2件: Neuroactive ligand-receptor interaction 💬, Dopaminergic synapse 💬 D00059 Levodopa 8件: 2, 4, 6, 17, 90, 140, 164, 201
11 DRD4 2件: Neuroactive ligand-receptor interaction 💬, Dopaminergic synapse 💬 D00059 Levodopa 8件: 2, 4, 6, 17, 90, 140, 164, 201
12 DRD5 4件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Dopaminergic synapse 💬 D00059 Levodopa 8件: 2, 4, 6, 17, 90, 140, 164, 201
13 GRIN1 18件: Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬 D00711 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
14 GRIN1 18件: Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬 D07283 Esketamine 3件: 2, 4, 70
15 GRIN1 18件: Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬 D08098 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
16 GRIN2A 19件: Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬, Systemic lupus erythematosus 💬 D00711 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
17 GRIN2A 19件: Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬, Systemic lupus erythematosus 💬 D07283 Esketamine 3件: 2, 4, 70
18 GRIN2A 19件: Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬, Systemic lupus erythematosus 💬 D08098 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
19 GRIN2B 19件: Ras signaling pathway 💬, Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬, Systemic lupus erythematosus 💬 D00711 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
20 GRIN2B 19件: Ras signaling pathway 💬, Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬, Systemic lupus erythematosus 💬 D07283 Esketamine 3件: 2, 4, 70
21 GRIN2B 19件: Ras signaling pathway 💬, Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬, Systemic lupus erythematosus 💬 D08098 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
22 GRIN2C 15件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬 D00711 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
23 GRIN2C 15件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬 D07283 Esketamine 3件: 2, 4, 70
24 GRIN2C 15件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬 D08098 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
25 GRIN2D 15件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬 D00711 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
26 GRIN2D 15件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬 D07283 Esketamine 3件: 2, 4, 70
27 GRIN2D 15件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Nicotine addiction 💬, Alcoholism 💬 D08098 Ketamine 8件: 2, 4, 6, 13, 70, 113, 156, 215
28 KCNA4 2件: Cortisol synthesis and secretion 💬, Cushing syndrome 💬 D04127 Dalfampridine 5件: 3, 4, 6, 13, 14
29 KCNC3 1件: Spinocerebellar ataxia 💬 D04127 Dalfampridine 4件: 4, 6, 13, 14
30 KCND2 1件: Serotonergic synapse 💬 D04127 Dalfampridine 4件: 4, 6, 13, 14
31 KCND3 1件: Spinocerebellar ataxia 💬 D04127 Dalfampridine 4件: 4, 6, 13, 14
32 SV2A 1件: ECM-receptor interaction 💬 D00709 Levetiracetam 4件: 4, 6, 13, 307