Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 CNR2 1件: Neuroactive ligand-receptor interaction 💬 D11312 Ajulemic acid 3件: 50, 51, 299
2 DHFR 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D00142 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
3 DHFR 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D02115 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
4 S1PR1 3件: FoxO signaling pathway 💬, Sphingolipid signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D11460 Siponimod 2件: 13, 50
5 DHFR2 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D00142 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
6 DHFR2 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D02115 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
7 FDPS 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬 D00939 Alendronic acid 7件: 19, 41, 46, 50, 271, 274, 299
8 FDPS 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬 D00942 Risedronic acid 9件: 46, 50, 66, 93, 95, 96, 107, 113, 274
9 FDPS 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬 D03234 Risedronic acid 9件: 46, 50, 66, 93, 95, 96, 107, 113, 274
10 FDPS 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬 D07119 Alendronic acid 7件: 19, 41, 46, 50, 271, 274, 299
11 FDPS 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬 D08484 Risedronic acid 9件: 46, 50, 66, 93, 95, 96, 107, 113, 274
12 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00407 Methylprednisolone 29件: 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
13 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00472 Prednisolone 27件: 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
14 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00473 Prednisone 32件: 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 127, 162, 164, 205, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331
15 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00751 Methylprednisolone 29件: 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
16 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00979 Methylprednisolone 29件: 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
17 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00980 Prednisolone 27件: 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
18 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00981 Prednisolone 27件: 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
19 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00982 Prednisolone 27件: 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
20 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01239 Prednisolone 27件: 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
21 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01998 Prednisolone 27件: 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
22 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D02156 Prednisolone 27件: 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
23 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D03301 Prednisolone 27件: 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
24 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D05000 Methylprednisolone 29件: 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
25 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D05000 Methylprednisolone hemisuccinate 5件: 50, 51, 53, 97, 211
26 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D05001 Methylprednisolone 29件: 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
27 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D05002 Methylprednisolone 29件: 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
28 IL1A 21件: MAPK signaling pathway 💬, Cytokine-cytokine receptor interaction 💬, Necroptosis 💬, Cellular senescence 💬, Osteoclast differentiation 💬, Hematopoietic cell lineage 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Type I diabetes mellitus 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pertussis 💬, Leishmaniasis 💬, Tuberculosis 💬, Measles 💬, Influenza A 💬, Inflammatory bowel disease 💬, Rheumatoid arthritis 💬, Graft-versus-host disease 💬, Fluid shear stress and atherosclerosis 💬 D01583 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
29 IL1B 44件: Antifolate resistance 💬, MAPK signaling pathway 💬, Cytokine-cytokine receptor interaction 💬, NF-kappa B signaling pathway 💬, Necroptosis 💬, Osteoclast differentiation 💬, Toll-like receptor signaling pathway 💬, NOD-like receptor signaling pathway 💬, Cytosolic DNA-sensing pathway 💬, C-type lectin receptor signaling pathway 💬, Hematopoietic cell lineage 💬, IL-17 signaling pathway 💬, Th17 cell differentiation 💬, TNF signaling pathway 💬, Inflammatory mediator regulation of TRP channels 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Alcoholic liver disease 💬, Type I diabetes mellitus 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Shigellosis 💬, Salmonella infection 💬, Pertussis 💬, Legionellosis 💬, Yersinia infection 💬, Leishmaniasis 💬, Chagas disease 💬, African trypanosomiasis 💬, Malaria 💬, Amoebiasis 💬, Tuberculosis 💬, Measles 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Herpes simplex virus 1 infection 💬, Coronavirus disease - COVID-19 💬, Inflammatory bowel disease 💬, Rheumatoid arthritis 💬, Graft-versus-host disease 💬, Lipid and atherosclerosis 💬, Fluid shear stress and atherosclerosis 💬 D01583 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
30 IL1B 44件: Antifolate resistance 💬, MAPK signaling pathway 💬, Cytokine-cytokine receptor interaction 💬, NF-kappa B signaling pathway 💬, Necroptosis 💬, Osteoclast differentiation 💬, Toll-like receptor signaling pathway 💬, NOD-like receptor signaling pathway 💬, Cytosolic DNA-sensing pathway 💬, C-type lectin receptor signaling pathway 💬, Hematopoietic cell lineage 💬, IL-17 signaling pathway 💬, Th17 cell differentiation 💬, TNF signaling pathway 💬, Inflammatory mediator regulation of TRP channels 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Alcoholic liver disease 💬, Type I diabetes mellitus 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Shigellosis 💬, Salmonella infection 💬, Pertussis 💬, Legionellosis 💬, Yersinia infection 💬, Leishmaniasis 💬, Chagas disease 💬, African trypanosomiasis 💬, Malaria 💬, Amoebiasis 💬, Tuberculosis 💬, Measles 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Herpes simplex virus 1 infection 💬, Coronavirus disease - COVID-19 💬, Inflammatory bowel disease 💬, Rheumatoid arthritis 💬, Graft-versus-host disease 💬, Lipid and atherosclerosis 💬, Fluid shear stress and atherosclerosis 💬 D09911 Gevokizumab 4件: 41, 50, 56, 269
31 IL1R1 13件: MAPK signaling pathway 💬, Cytokine-cytokine receptor interaction 💬, NF-kappa B signaling pathway 💬, Osteoclast differentiation 💬, Hematopoietic cell lineage 💬, Th17 cell differentiation 💬, Inflammatory mediator regulation of TRP channels 💬, Pathogenic Escherichia coli infection 💬, Shigellosis 💬, Amoebiasis 💬, Human cytomegalovirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Fluid shear stress and atherosclerosis 💬 D02934 Anakinra 19件: 2, 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299
32 IL2RA 11件: Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, Endocytosis 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Hematopoietic cell lineage 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, Measles 💬, Human T-cell leukemia virus 1 infection 💬, Pathways in cancer 💬 D03058 Basiliximab 6件: 2, 50, 66, 97, 222, 228
33 IL6 51件: EGFR tyrosine kinase inhibitor resistance 💬, Antifolate resistance 💬, Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, PI3K-Akt signaling pathway 💬, Cellular senescence 💬, Toll-like receptor signaling pathway 💬, NOD-like receptor signaling pathway 💬, Cytosolic DNA-sensing pathway 💬, C-type lectin receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Hematopoietic cell lineage 💬, IL-17 signaling pathway 💬, Th17 cell differentiation 💬, TNF signaling pathway 💬, Intestinal immune network for IgA production 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Alcoholic liver disease 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬, Pertussis 💬, Legionellosis 💬, Yersinia infection 💬, Chagas disease 💬, African trypanosomiasis 💬, Malaria 💬, Amoebiasis 💬, Tuberculosis 💬, Hepatitis B 💬, Measles 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Inflammatory bowel disease 💬, Rheumatoid arthritis 💬, Graft-versus-host disease 💬, Hypertrophic cardiomyopathy 💬, Lipid and atherosclerosis 💬 D01583 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
34 IL6R 12件: EGFR tyrosine kinase inhibitor resistance 💬, Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, HIF-1 signaling pathway 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Hematopoietic cell lineage 💬, Th17 cell differentiation 💬, Non-alcoholic fatty liver disease 💬, Human cytomegalovirus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬 D02596 Tocilizumab 21件: 2, 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331
35 IL10 22件: Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, FoxO signaling pathway 💬, C-type lectin receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, T cell receptor signaling pathway 💬, Intestinal immune network for IgA production 💬, Pertussis 💬, Yersinia infection 💬, Leishmaniasis 💬, Chagas disease 💬, African trypanosomiasis 💬, Malaria 💬, Toxoplasmosis 💬, Amoebiasis 💬, Staphylococcus aureus infection 💬, Tuberculosis 💬, Asthma 💬, Autoimmune thyroid disease 💬, Inflammatory bowel disease 💬, Systemic lupus erythematosus 💬, Allograft rejection 💬 D01583 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
36 IL12A 25件: Cytokine-cytokine receptor interaction 💬, Toll-like receptor signaling pathway 💬, RIG-I-like receptor signaling pathway 💬, C-type lectin receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Th1 and Th2 cell differentiation 💬, Alcoholic liver disease 💬, Type I diabetes mellitus 💬, Pertussis 💬, Legionellosis 💬, Leishmaniasis 💬, Chagas disease 💬, African trypanosomiasis 💬, Malaria 💬, Toxoplasmosis 💬, Amoebiasis 💬, Tuberculosis 💬, Measles 💬, Influenza A 💬, Herpes simplex virus 1 infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Inflammatory bowel disease 💬, Allograft rejection 💬, Lipid and atherosclerosis 💬 D09214 Ustekinumab 17件: 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
37 IL12B 25件: Cytokine-cytokine receptor interaction 💬, Toll-like receptor signaling pathway 💬, RIG-I-like receptor signaling pathway 💬, C-type lectin receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Th1 and Th2 cell differentiation 💬, Alcoholic liver disease 💬, Type I diabetes mellitus 💬, Pertussis 💬, Legionellosis 💬, Leishmaniasis 💬, Chagas disease 💬, African trypanosomiasis 💬, Toxoplasmosis 💬, Amoebiasis 💬, Tuberculosis 💬, Measles 💬, Influenza A 💬, Herpes simplex virus 1 infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Inflammatory bowel disease 💬, Allograft rejection 💬, Lipid and atherosclerosis 💬 D09214 Ustekinumab 17件: 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
38 JAK1 27件: EGFR tyrosine kinase inhibitor resistance 💬, PI3K-Akt signaling pathway 💬, Necroptosis 💬, Osteoclast differentiation 💬, Signaling pathways regulating pluripotency of stem cells 💬, NOD-like receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, Leishmaniasis 💬, Toxoplasmosis 💬, Tuberculosis 💬, Hepatitis C 💬, Hepatitis B 💬, Measles 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human papillomavirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Viral carcinogenesis 💬, Pancreatic cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 D09970 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
39 JAK1 27件: EGFR tyrosine kinase inhibitor resistance 💬, PI3K-Akt signaling pathway 💬, Necroptosis 💬, Osteoclast differentiation 💬, Signaling pathways regulating pluripotency of stem cells 💬, NOD-like receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, Leishmaniasis 💬, Toxoplasmosis 💬, Tuberculosis 💬, Hepatitis C 💬, Hepatitis B 💬, Measles 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human papillomavirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Viral carcinogenesis 💬, Pancreatic cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 D10308 Baricitinib 13件: 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325
40 JAK2 24件: EGFR tyrosine kinase inhibitor resistance 💬, Chemokine signaling pathway 💬, PI3K-Akt signaling pathway 💬, Necroptosis 💬, Signaling pathways regulating pluripotency of stem cells 💬, JAK-STAT signaling pathway 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, Cholinergic synapse 💬, Prolactin signaling pathway 💬, Adipocytokine signaling pathway 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Growth hormone synthesis, secretion and action 💬, Leishmaniasis 💬, Toxoplasmosis 💬, Tuberculosis 💬, Hepatitis B 💬, Influenza A 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Lipid and atherosclerosis 💬 D09970 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
41 JAK2 24件: EGFR tyrosine kinase inhibitor resistance 💬, Chemokine signaling pathway 💬, PI3K-Akt signaling pathway 💬, Necroptosis 💬, Signaling pathways regulating pluripotency of stem cells 💬, JAK-STAT signaling pathway 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, Cholinergic synapse 💬, Prolactin signaling pathway 💬, Adipocytokine signaling pathway 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Growth hormone synthesis, secretion and action 💬, Leishmaniasis 💬, Toxoplasmosis 💬, Tuberculosis 💬, Hepatitis B 💬, Influenza A 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Lipid and atherosclerosis 💬 D10308 Baricitinib 13件: 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325
42 JAK3 15件: Chemokine signaling pathway 💬, PI3K-Akt signaling pathway 💬, Necroptosis 💬, Signaling pathways regulating pluripotency of stem cells 💬, JAK-STAT signaling pathway 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, Hepatitis B 💬, Measles 💬, Human T-cell leukemia virus 1 infection 💬, Epstein-Barr virus infection 💬, Pathways in cancer 💬, Viral carcinogenesis 💬, Non-small cell lung cancer 💬, Primary immunodeficiency 💬 D09970 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
43 LTA 7件: Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, NF-kappa B signaling pathway 💬, TNF signaling pathway 💬, Type I diabetes mellitus 💬, Human T-cell leukemia virus 1 infection 💬, Herpes simplex virus 1 infection 💬 D00742 Etanercept 17件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298
44 MC2R 5件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, Cushing syndrome 💬 D00146 Corticotropin 15件: 2, 13, 14, 46, 49, 50, 66, 75, 78, 81, 84, 145, 193, 205, 222
45 PDCD1 3件: Cell adhesion molecules 💬, T cell receptor signaling pathway 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 D10316 Nivolumab 12件: 13, 26, 41, 46, 49, 50, 51, 53, 85, 96, 97, 159
46 PDE4A 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D08860 Apremilast 7件: 46, 50, 56, 97, 107, 162, 271
47 PDE4B 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D08860 Apremilast 7件: 46, 50, 56, 97, 107, 162, 271
48 PDE4C 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D08860 Apremilast 7件: 46, 50, 56, 97, 107, 162, 271
49 PDE4D 5件: Purine metabolism 💬, Metabolic pathways 💬, cAMP signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Morphine addiction 💬 D08860 Apremilast 7件: 46, 50, 56, 97, 107, 162, 271
50 IL23A 9件: Cytokine-cytokine receptor interaction 💬, C-type lectin receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Th17 cell differentiation 💬, Pertussis 💬, Tuberculosis 💬, Pathways in cancer 💬, Inflammatory bowel disease 💬, Rheumatoid arthritis 💬 D09214 Ustekinumab 17件: 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
51 S1PR5 2件: Sphingolipid signaling pathway 💬, Neuroactive ligand-receptor interaction 💬 D11460 Siponimod 2件: 13, 50
52 PPP3CA 33件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Oocyte meiosis 💬, Cellular senescence 💬, Wnt signaling pathway 💬, Axon guidance 💬, VEGF signaling pathway 💬, Osteoclast differentiation 💬, C-type lectin receptor signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Renin secretion 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Tuberculosis 💬, Human cytomegalovirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Human immunodeficiency virus 1 infection 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Lipid and atherosclerosis 💬 D00107 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
53 PPP3CA 33件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Oocyte meiosis 💬, Cellular senescence 💬, Wnt signaling pathway 💬, Axon guidance 💬, VEGF signaling pathway 💬, Osteoclast differentiation 💬, C-type lectin receptor signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Renin secretion 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Tuberculosis 💬, Human cytomegalovirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Human immunodeficiency virus 1 infection 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Lipid and atherosclerosis 💬 D00184 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
54 PPP3CA 33件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Oocyte meiosis 💬, Cellular senescence 💬, Wnt signaling pathway 💬, Axon guidance 💬, VEGF signaling pathway 💬, Osteoclast differentiation 💬, C-type lectin receptor signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Renin secretion 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Tuberculosis 💬, Human cytomegalovirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Human immunodeficiency virus 1 infection 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Lipid and atherosclerosis 💬 D08556 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
55 PPP3CB 33件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Oocyte meiosis 💬, Cellular senescence 💬, Wnt signaling pathway 💬, Axon guidance 💬, VEGF signaling pathway 💬, Osteoclast differentiation 💬, C-type lectin receptor signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Renin secretion 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Tuberculosis 💬, Human cytomegalovirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Human immunodeficiency virus 1 infection 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Lipid and atherosclerosis 💬 D00107 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
56 PPP3CB 33件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Oocyte meiosis 💬, Cellular senescence 💬, Wnt signaling pathway 💬, Axon guidance 💬, VEGF signaling pathway 💬, Osteoclast differentiation 💬, C-type lectin receptor signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Renin secretion 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Tuberculosis 💬, Human cytomegalovirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Human immunodeficiency virus 1 infection 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Lipid and atherosclerosis 💬 D00184 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
57 PPP3CB 33件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Oocyte meiosis 💬, Cellular senescence 💬, Wnt signaling pathway 💬, Axon guidance 💬, VEGF signaling pathway 💬, Osteoclast differentiation 💬, C-type lectin receptor signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Renin secretion 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Tuberculosis 💬, Human cytomegalovirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Human immunodeficiency virus 1 infection 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Lipid and atherosclerosis 💬 D08556 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
58 PPP3CC 33件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Oocyte meiosis 💬, Cellular senescence 💬, Wnt signaling pathway 💬, Axon guidance 💬, VEGF signaling pathway 💬, Osteoclast differentiation 💬, C-type lectin receptor signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Renin secretion 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Tuberculosis 💬, Human cytomegalovirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Human immunodeficiency virus 1 infection 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Lipid and atherosclerosis 💬 D00107 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
59 PPP3CC 33件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Oocyte meiosis 💬, Cellular senescence 💬, Wnt signaling pathway 💬, Axon guidance 💬, VEGF signaling pathway 💬, Osteoclast differentiation 💬, C-type lectin receptor signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Renin secretion 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Tuberculosis 💬, Human cytomegalovirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Human immunodeficiency virus 1 infection 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Lipid and atherosclerosis 💬 D00184 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326
60 PPP3CC 33件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Oocyte meiosis 💬, Cellular senescence 💬, Wnt signaling pathway 💬, Axon guidance 💬, VEGF signaling pathway 💬, Osteoclast differentiation 💬, C-type lectin receptor signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Dopaminergic synapse 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Renin secretion 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Tuberculosis 💬, Human cytomegalovirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Human immunodeficiency virus 1 infection 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Lipid and atherosclerosis 💬 D08556 Tacrolimus 34件: 2, 6, 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299
61 PPP3R1 32件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Oocyte meiosis 💬, Cellular senescence 💬, Wnt signaling pathway 💬, Axon guidance 💬, VEGF signaling pathway 💬, Osteoclast differentiation 💬, C-type lectin receptor signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Long-term potentiation 💬, Glutamatergic synapse 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Renin secretion 💬, Alzheimer disease 💬,