Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 TUBB3 10件: Phagosome 💬, Gap junction 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬 D09587 Brentuximab vedotin 2件: 49, 51
2 TUBB4A 10件: Phagosome 💬, Gap junction 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬 D09587 Brentuximab vedotin 2件: 49, 51
3 TUBB4B 10件: Phagosome 💬, Gap junction 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬 D09587 Brentuximab vedotin 2件: 49, 51
4 TNFSF13B 4件: Cytokine-cytokine receptor interaction 💬, NF-kappa B signaling pathway 💬, Intestinal immune network for IgA production 💬, Rheumatoid arthritis 💬 D03068 Belimumab 12件: 11, 13, 43, 44, 46, 49, 51, 53, 66, 222, 296, 300
5 CNR2 1件: Neuroactive ligand-receptor interaction 💬 D11312 Ajulemic acid 2件: 51, 299
6 IL31RA 1件: Cytokine-cytokine receptor interaction 💬 D11080 Nemolizumab 1件: 51
7 CSF3R 5件: Cytokine-cytokine receptor interaction 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Hematopoietic cell lineage 💬, Pathways in cancer 💬 D03235 Filgrastim 34件: 2, 6, 11, 13, 16, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331
8 DHFR 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D00142 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
9 DHFR 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D02115 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
10 DRD2 8件: Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Alcoholism 💬 D00702 Buspirone 3件: 6, 51, 179
11 DRD2 8件: Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Alcoholism 💬 D00726 Metoclopramide 1件: 51
12 DRD2 8件: Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Alcoholism 💬 D01348 Terguride 2件: 51, 86
13 DRD2 8件: Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Alcoholism 💬 D01745 Domperidone 5件: 6, 13, 17, 51, 230
14 DRD2 8件: Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Alcoholism 💬 D02213 Metoclopramide 1件: 51
15 DRD2 8件: Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Alcoholism 💬 D05008 Metoclopramide 1件: 51
16 DRD2 8件: Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Alcoholism 💬 D07593 Buspirone 3件: 6, 51, 179
17 DRD2 8件: Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Alcoholism 💬 D07868 Domperidone 5件: 6, 13, 17, 51, 230
18 EDNRA 7件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vascular smooth muscle contraction 💬, Renin secretion 💬, Pathways in cancer 💬 D01227 Bosentan 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212
19 EDNRA 7件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vascular smooth muscle contraction 💬, Renin secretion 💬, Pathways in cancer 💬 D07077 Ambrisentan 7件: 51, 84, 85, 86, 88, 210, 211
20 EDNRA 7件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vascular smooth muscle contraction 💬, Renin secretion 💬, Pathways in cancer 💬 D07538 Bosentan 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212
21 EDNRA 7件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vascular smooth muscle contraction 💬, Renin secretion 💬, Pathways in cancer 💬 D07741 Zibotentan 1件: 51
22 EDNRA 7件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vascular smooth muscle contraction 💬, Renin secretion 💬, Pathways in cancer 💬 D10135 Macitentan 5件: 51, 85, 86, 88, 210
23 EDNRB 6件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Melanogenesis 💬, Relaxin signaling pathway 💬, Pathways in cancer 💬 D01227 Bosentan 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212
24 EDNRB 6件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Melanogenesis 💬, Relaxin signaling pathway 💬, Pathways in cancer 💬 D07538 Bosentan 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212
25 EDNRB 6件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Melanogenesis 💬, Relaxin signaling pathway 💬, Pathways in cancer 💬 D10135 Macitentan 5件: 51, 85, 86, 88, 210
26 EGFR 48件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, MAPK signaling pathway 💬, ErbB signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, Phospholipase D signaling pathway 💬, Endocytosis 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Adherens junction 💬, Gap junction 💬, JAK-STAT signaling pathway 💬, Regulation of actin cytoskeleton 💬, GnRH signaling pathway 💬, Estrogen signaling pathway 💬, Oxytocin signaling pathway 💬, Relaxin signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Cushing syndrome 💬, Epithelial cell signaling in Helicobacter pylori infection 💬, Shigellosis 💬, Hepatitis C 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Colorectal cancer 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Glioma 💬, Prostate cancer 💬, Melanoma 💬, Bladder cancer 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 D03455 Cetuximab 5件: 34, 51, 86, 89, 331
27 EPHA2 5件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, PI3K-Akt signaling pathway 💬, Axon guidance 💬 D03658 Dasatinib 2件: 51, 85
28 EPHA2 5件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, PI3K-Akt signaling pathway 💬, Axon guidance 💬 D06414 Dasatinib 2件: 51, 85
29 DHFR2 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D00142 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
30 DHFR2 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D02115 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
31 TUBB 10件: Phagosome 💬, Gap junction 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬 D09587 Brentuximab vedotin 2件: 49, 51
32 F2 8件: Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Complement and coagulation cascades 💬, Platelet activation 💬, Regulation of actin cytoskeleton 💬, Pathogenic Escherichia coli infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬 D07144 Dabigatran etexilate 1件: 51
33 F2 8件: Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Complement and coagulation cascades 💬, Platelet activation 💬, Regulation of actin cytoskeleton 💬, Pathogenic Escherichia coli infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬 D09707 Dabigatran 4件: 51, 85, 91, 124
34 FGFR1 16件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, Adherens junction 💬, Signaling pathways regulating pluripotency of stem cells 💬, Thermogenesis 💬, Regulation of actin cytoskeleton 💬, Parathyroid hormone synthesis, secretion and action 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Prostate cancer 💬, Melanoma 💬, Breast cancer 💬, Central carbon metabolism in cancer 💬 D10481 Nintedanib 5件: 51, 85, 89, 227, 228
35 FGFR3 13件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, Endocytosis 💬, PI3K-Akt signaling pathway 💬, Signaling pathways regulating pluripotency of stem cells 💬, Regulation of actin cytoskeleton 💬, Pathways in cancer 💬, MicroRNAs in cancer 💬, Bladder cancer 💬, Central carbon metabolism in cancer 💬 D10481 Nintedanib 5件: 51, 85, 89, 227, 228
36 FGFR2 13件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, Endocytosis 💬, PI3K-Akt signaling pathway 💬, Signaling pathways regulating pluripotency of stem cells 💬, Regulation of actin cytoskeleton 💬, Pathways in cancer 💬, Prostate cancer 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬 D10481 Nintedanib 5件: 51, 85, 89, 227, 228
37 FLT1 9件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Transcriptional misregulation in cancer 💬, Rheumatoid arthritis 💬 D10481 Nintedanib 5件: 51, 85, 89, 227, 228
38 FLT4 8件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Pathways in cancer 💬, Breast cancer 💬 D10481 Nintedanib 5件: 51, 85, 89, 227, 228
39 IL17RA 3件: Cytokine-cytokine receptor interaction 💬, IL-17 signaling pathway 💬, Alcoholic liver disease 💬 D10061 Brodalumab 2件: 37, 51
40 MTOR 51件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, ErbB signaling pathway 💬, HIF-1 signaling pathway 💬, Phospholipase D signaling pathway 💬, Autophagy - other 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Cellular senescence 💬, Apelin signaling pathway 💬, Neutrophil extracellular trap formation 💬, JAK-STAT signaling pathway 💬, Th17 cell differentiation 💬, Thermogenesis 💬, Insulin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Adipocytokine signaling pathway 💬, Type II diabetes mellitus 💬, Insulin resistance 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Pathways of neurodegeneration - multiple diseases 💬, Shigellosis 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Human immunodeficiency virus 1 infection 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Colorectal cancer 💬, Pancreatic cancer 💬, Glioma 💬, Prostate cancer 💬, Acute myeloid leukemia 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Diabetic cardiomyopathy 💬 D00753 Sirolimus 41件: 2, 6, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331
41 FYN 14件: Sphingolipid signaling pathway 💬, Phospholipase D signaling pathway 💬, Axon guidance 💬, Osteoclast differentiation 💬, Focal adhesion 💬, Adherens junction 💬, Platelet activation 💬, Natural killer cell mediated cytotoxicity 💬, T cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, Cholinergic synapse 💬, Prion disease 💬, Pathogenic Escherichia coli infection 💬, Viral myocarditis 💬 D03658 Dasatinib 2件: 51, 85
42 FYN 14件: Sphingolipid signaling pathway 💬, Phospholipase D signaling pathway 💬, Axon guidance 💬, Osteoclast differentiation 💬, Focal adhesion 💬, Adherens junction 💬, Platelet activation 💬, Natural killer cell mediated cytotoxicity 💬, T cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, Cholinergic synapse 💬, Prion disease 💬, Pathogenic Escherichia coli infection 💬, Viral myocarditis 💬 D06414 Dasatinib 2件: 51, 85
43 ABL1 11件: ErbB signaling pathway 💬, Ras signaling pathway 💬, Cell cycle 💬, Axon guidance 💬, Neurotrophin signaling pathway 💬, Pathogenic Escherichia coli infection 💬, Pathways in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Chronic myeloid leukemia 💬, Viral myocarditis 💬 D01441 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
44 ABL1 11件: ErbB signaling pathway 💬, Ras signaling pathway 💬, Cell cycle 💬, Axon guidance 💬, Neurotrophin signaling pathway 💬, Pathogenic Escherichia coli infection 💬, Pathways in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Chronic myeloid leukemia 💬, Viral myocarditis 💬 D03658 Dasatinib 2件: 51, 85
45 ABL1 11件: ErbB signaling pathway 💬, Ras signaling pathway 💬, Cell cycle 💬, Axon guidance 💬, Neurotrophin signaling pathway 💬, Pathogenic Escherichia coli infection 💬, Pathways in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Chronic myeloid leukemia 💬, Viral myocarditis 💬 D06414 Dasatinib 2件: 51, 85
46 ABL1 11件: ErbB signaling pathway 💬, Ras signaling pathway 💬, Cell cycle 💬, Axon guidance 💬, Neurotrophin signaling pathway 💬, Pathogenic Escherichia coli infection 💬, Pathways in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Chronic myeloid leukemia 💬, Viral myocarditis 💬 D08066 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
47 ABL1 11件: ErbB signaling pathway 💬, Ras signaling pathway 💬, Cell cycle 💬, Axon guidance 💬, Neurotrophin signaling pathway 💬, Pathogenic Escherichia coli infection 💬, Pathways in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Chronic myeloid leukemia 💬, Viral myocarditis 💬 D08953 Nilotinib 5件: 6, 8, 34, 51, 86
48 GNRHR 2件: Neuroactive ligand-receptor interaction 💬, GnRH signaling pathway 💬 D00989 Leuprolide 5件: 1, 2, 3, 51, 76
49 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00407 Methylprednisolone 28件: 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
50 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00472 Prednisolone 26件: 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
51 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00473 Prednisone 31件: 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 127, 162, 164, 205, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331
52 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00751 Methylprednisolone 28件: 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
53 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00979 Methylprednisolone 28件: 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
54 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00980 Prednisolone 26件: 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
55 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00981 Prednisolone 26件: 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
56 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00982 Prednisolone 26件: 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
57 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01239 Prednisolone 26件: 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
58 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01998 Prednisolone 26件: 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
59 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D02156 Prednisolone 26件: 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
60 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D03301 Prednisolone 26件: 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
61 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D05000 Methylprednisolone 28件: 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
62 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D05000 Methylprednisolone hemisuccinate 4件: 51, 53, 97, 211
63 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D05001 Methylprednisolone 28件: 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
64 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D05002 Methylprednisolone 28件: 51, 60, 62, 63, 64, 65, 66, 83, 84, 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
65 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D07715 Clobetasol 2件: 51, 162
66 GUCY1A2 11件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, Vascular smooth muscle contraction 💬, Gap junction 💬, Platelet activation 💬, Circadian entrainment 💬, Long-term depression 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Salivary secretion 💬 D09572 Riociguat 6件: 51, 84, 86, 88, 225, 299
67 GUCY1A1 11件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, Vascular smooth muscle contraction 💬, Gap junction 💬, Platelet activation 💬, Circadian entrainment 💬, Long-term depression 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Salivary secretion 💬 D09572 Riociguat 6件: 51, 84, 86, 88, 225, 299
68 GUCY1B1 11件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, Vascular smooth muscle contraction 💬, Gap junction 💬, Platelet activation 💬, Circadian entrainment 💬, Long-term depression 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Salivary secretion 💬 D09572 Riociguat 6件: 51, 84, 86, 88, 225, 299
69 SERPIND1 1件: Complement and coagulation cascades 💬 D08547 Sulodexide 3件: 51, 271, 288
70 HMGCR 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, AMPK signaling pathway 💬, Bile secretion 💬 D00434 Simvastatin 21件: 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
71 HMGCR 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, AMPK signaling pathway 💬, Bile secretion 💬 D00887 Atorvastatin 18件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 299
72 HMGCR 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, AMPK signaling pathway 💬, Bile secretion 💬 D01915 Rosuvastatin 11件: 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299
73 HMGCR 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, AMPK signaling pathway 💬, Bile secretion 💬 D07474 Atorvastatin 18件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 299
74 HMGCR 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, AMPK signaling pathway 💬, Bile secretion 💬 D08492 Rosuvastatin 11件: 6, 18, 46, 49, 51, 56, 79, 96, 97, 271, 299
75 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D00300 Diphenhydramine 10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
76 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D00669 Diphenhydramine 10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
77 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D02419 Diphenhydramine 10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
78 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D03285 Diphenhydramine 10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
79 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D03360 Diphenhydramine 10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
80 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D03854 Diphenhydramine 10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
81 HTR1A 4件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Serotonergic synapse 💬, Taste transduction 💬 D00702 Buspirone 3件: 6, 51, 179
82 HTR1A 4件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Serotonergic synapse 💬, Taste transduction 💬 D07593 Buspirone 3件: 6, 51, 179
83 HTR4 4件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Serotonergic synapse 💬 D09205 Prucalopride 3件: 13, 51, 96
84 TUBB8 10件: Phagosome 💬, Gap junction 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬 D09587 Brentuximab vedotin 2件: 49, 51
85 TUBB2B 10件: Phagosome 💬, Gap junction 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬 D09587 Brentuximab vedotin 2件: 49, 51
86 IGF1R 29件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, Oocyte meiosis 💬, Autophagy - animal 💬, Endocytosis 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Focal adhesion 💬, Adherens junction 💬, Signaling pathways regulating pluripotency of stem cells 💬, Long-term depression 💬, Ovarian steroidogenesis 💬, Progesterone-mediated oocyte maturation 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Proteoglycans in cancer 💬, Glioma 💬, Prostate cancer 💬, Melanoma 💬, Breast cancer 💬, Hepatocellular carcinoma 💬 D09680 Teprotumumab 1件: 51
87 IL1A 21件: MAPK signaling pathway 💬, Cytokine-cytokine receptor interaction 💬, Necroptosis 💬, Cellular senescence 💬, Osteoclast differentiation 💬, Hematopoietic cell lineage 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Type I diabetes mellitus 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pertussis 💬, Leishmaniasis 💬, Tuberculosis 💬, Measles 💬, Influenza A 💬, Inflammatory bowel disease 💬, Rheumatoid arthritis 💬, Graft-versus-host disease 💬, Fluid shear stress and atherosclerosis 💬 D01583 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
88 IL1A 21件: MAPK signaling pathway 💬, Cytokine-cytokine receptor interaction 💬, Necroptosis 💬, Cellular senescence 💬, Osteoclast differentiation 💬, Hematopoietic cell lineage 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Type I diabetes mellitus 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pertussis 💬, Leishmaniasis 💬, Tuberculosis 💬, Measles 💬, Influenza A 💬, Inflammatory bowel disease 💬, Rheumatoid arthritis 💬, Graft-versus-host disease 💬, Fluid shear stress and atherosclerosis 💬 D06635 Rilonacept 4件: 51, 106, 107, 266
89 IL1A 21件: MAPK signaling pathway 💬, Cytokine-cytokine receptor interaction 💬, Necroptosis 💬, Cellular senescence 💬, Osteoclast differentiation 💬, Hematopoietic cell lineage 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Type I diabetes mellitus 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pertussis 💬, Leishmaniasis 💬, Tuberculosis 💬, Measles 💬, Influenza A 💬, Inflammatory bowel disease 💬, Rheumatoid arthritis 💬, Graft-versus-host disease 💬, Fluid shear stress and atherosclerosis 💬 D11253 Bermekimab 1件: 51
90 IL1B 44件: Antifolate resistance 💬, MAPK signaling pathway 💬, Cytokine-cytokine receptor interaction 💬, NF-kappa B signaling pathway 💬, Necroptosis 💬, Osteoclast differentiation 💬, Toll-like receptor signaling pathway 💬, NOD-like receptor signaling pathway 💬, Cytosolic DNA-sensing pathway 💬, C-type lectin receptor signaling pathway 💬, Hematopoietic cell lineage 💬, IL-17 signaling pathway 💬, Th17 cell differentiation 💬, TNF signaling pathway 💬, Inflammatory mediator regulation of TRP channels 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Alcoholic liver disease 💬, Type I diabetes mellitus 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Shigellosis 💬, Salmonella infection 💬, Pertussis 💬, Legionellosis 💬, Yersinia infection 💬, Leishmaniasis 💬, Chagas disease 💬, African trypanosomiasis 💬, Malaria 💬, Amoebiasis 💬, Tuberculosis 💬, Measles 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Herpes simplex virus 1 infection 💬, Coronavirus disease - COVID-19 💬, Inflammatory bowel disease 💬, Rheumatoid arthritis 💬, Graft-versus-host disease 💬, Lipid and atherosclerosis 💬, Fluid shear stress and atherosclerosis 💬 D01583 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228
91 IL1B 44件: Antifolate resistance 💬, MAPK signaling pathway 💬, Cytokine-cytokine receptor interaction 💬, NF-kappa B signaling pathway 💬, Necroptosis 💬, Osteoclast differentiation 💬, Toll-like receptor signaling pathway 💬, NOD-like receptor signaling pathway 💬, Cytosolic DNA-sensing pathway 💬, C-type lectin receptor signaling pathway 💬, Hematopoietic cell lineage 💬, IL-17 signaling pathway 💬, Th17 cell differentiation 💬, TNF signaling pathway 💬, Inflammatory mediator regulation of TRP channels 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Alcoholic liver disease 💬, Type I diabetes mellitus 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Shigellosis 💬, Salmonella infection 💬, Pertussis 💬, Legionellosis 💬, Yersinia infection 💬, Leishmaniasis 💬, Chagas disease 💬, African trypanosomiasis 💬, Malaria 💬, Amoebiasis 💬, Tuberculosis 💬, Measles 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Herpes simplex virus 1 infection 💬, Coronavirus disease - COVID-19 💬, Inflammatory bowel disease 💬, Rheumatoid arthritis 💬, Graft-versus-host disease 💬, Lipid and atherosclerosis 💬, Fluid shear stress and atherosclerosis 💬 D06635 Rilonacept 4件: 51, 106, 107, 266
92 IL4R 8件: Cytokine-cytokine receptor interaction 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Hematopoietic cell lineage 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, Pathways in cancer 💬, Inflammatory bowel disease 💬 D10354 Dupilumab 4件: 51, 98, 160, 162
93 IL6 51件: EGFR tyrosine kinase inhibitor resistance 💬, Antifolate resistance 💬, Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, PI3K-Akt signaling pathway 💬, Cellular senescence 💬, Toll-like receptor signaling pathway 💬, NOD-like receptor signaling pathway 💬, Cytosolic DNA-sensing pathway 💬, C-type lectin receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Hematopoietic cell lineage 💬, IL-17 signaling pathway 💬, Th17 cell differentiation 💬, TNF signaling pathway 💬, Intestinal immune network for IgA production 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Alcoholic liver disease 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Salmonella infection 💬, Pertussis 💬, Legionellosis 💬, Yersinia infection 💬, Chagas disease 💬, African trypanosomiasis 💬, Malaria 💬, Amoebiasis 💬, Tuberculosis 💬, Hepatitis B 💬, Measles 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬,