Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 TNFSF13B 4件: Cytokine-cytokine receptor interaction 💬, NF-kappa B signaling pathway 💬, Intestinal immune network for IgA production 💬, Rheumatoid arthritis 💬 D03068 Belimumab 12件: 11, 13, 43, 44, 46, 49, 51, 53, 66, 222, 296, 300
2 TNFSF13B 4件: Cytokine-cytokine receptor interaction 💬, NF-kappa B signaling pathway 💬, Intestinal immune network for IgA production 💬, Rheumatoid arthritis 💬 D11127 Tibulizumab 1件: 53
3 CHRM1 8件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D00465 Oxybutynin 3件: 6, 13, 53
4 CHRM1 8件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D00722 Oxybutynin 3件: 6, 13, 53
5 CHRM2 6件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬 D00465 Oxybutynin 3件: 6, 13, 53
6 CHRM2 6件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬 D00525 Pilocarpine 3件: 6, 53, 299
7 CHRM2 6件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬 D00722 Oxybutynin 3件: 6, 13, 53
8 CHRM2 6件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬 D02200 Pilocarpine 3件: 6, 53, 299
9 CHRM2 6件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬 D05478 Pilocarpine 3件: 6, 53, 299
10 CHRM3 11件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Taste transduction 💬, Regulation of actin cytoskeleton 💬, Insulin secretion 💬, Salivary secretion 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D00465 Oxybutynin 3件: 6, 13, 53
11 CHRM3 11件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Taste transduction 💬, Regulation of actin cytoskeleton 💬, Insulin secretion 💬, Salivary secretion 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D00525 Pilocarpine 3件: 6, 53, 299
12 CHRM3 11件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Taste transduction 💬, Regulation of actin cytoskeleton 💬, Insulin secretion 💬, Salivary secretion 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D00646 Tolterodine 2件: 17, 53
13 CHRM3 11件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Taste transduction 💬, Regulation of actin cytoskeleton 💬, Insulin secretion 💬, Salivary secretion 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D00661 Cevimeline 1件: 53
14 CHRM3 11件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Taste transduction 💬, Regulation of actin cytoskeleton 💬, Insulin secretion 💬, Salivary secretion 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D00722 Oxybutynin 3件: 6, 13, 53
15 CHRM3 11件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Taste transduction 💬, Regulation of actin cytoskeleton 💬, Insulin secretion 💬, Salivary secretion 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D01148 Tolterodine 2件: 17, 53
16 CHRM3 11件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Taste transduction 💬, Regulation of actin cytoskeleton 💬, Insulin secretion 💬, Salivary secretion 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D01269 Solifenacin 3件: 6, 13, 53
17 CHRM3 11件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Taste transduction 💬, Regulation of actin cytoskeleton 💬, Insulin secretion 💬, Salivary secretion 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D02200 Pilocarpine 3件: 6, 53, 299
18 CHRM3 11件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Taste transduction 💬, Regulation of actin cytoskeleton 💬, Insulin secretion 💬, Salivary secretion 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D05478 Pilocarpine 3件: 6, 53, 299
19 CHRM3 11件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Taste transduction 💬, Regulation of actin cytoskeleton 💬, Insulin secretion 💬, Salivary secretion 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D07667 Cevimeline 1件: 53
20 CHRM3 11件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Taste transduction 💬, Regulation of actin cytoskeleton 💬, Insulin secretion 💬, Salivary secretion 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D08522 Solifenacin 3件: 6, 13, 53
21 CHRM4 3件: Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬 D00465 Oxybutynin 3件: 6, 13, 53
22 CHRM4 3件: Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬 D00722 Oxybutynin 3件: 6, 13, 53
23 CHRM5 6件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D00465 Oxybutynin 3件: 6, 13, 53
24 CHRM5 6件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D00722 Oxybutynin 3件: 6, 13, 53
25 TNFRSF13C 5件: Cytokine-cytokine receptor interaction 💬, NF-kappa B signaling pathway 💬, Intestinal immune network for IgA production 💬, Human T-cell leukemia virus 1 infection 💬, Primary immunodeficiency 💬 D12151 Ianalumab 5件: 35, 46, 49, 53, 95
26 ADRB3 8件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Thermogenesis 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬 D09535 Mirabegron 4件: 6, 13, 53, 226
27 DHFR 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D00142 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
28 DHFR 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D02115 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
29 DHODH 3件: Pyrimidine metabolism 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬 D00749 Leflunomide 12件: 11, 40, 46, 49, 53, 66, 107, 162, 224, 270, 271, 300
30 DHFR2 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D00142 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
31 DHFR2 5件: One carbon pool by folate 💬, Folate biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Antifolate resistance 💬 D02115 Methotrexate 38件: 11, 13, 19, 34, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 107, 162, 164, 172, 256, 270, 271, 283, 284, 285, 286, 326, 331
32 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D08409 Prasterone 6件: 49, 53, 83, 86, 96, 113
33 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D11513 Estetrol 1件: 53
34 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D11514 Estetrol 1件: 53
35 ESR2 7件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, GnRH secretion 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D08409 Prasterone 6件: 49, 53, 83, 86, 96, 113
36 ESR2 7件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, GnRH secretion 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D11513 Estetrol 1件: 53
37 ESR2 7件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, GnRH secretion 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D11514 Estetrol 1件: 53
38 FCER1A 4件: Sphingolipid signaling pathway 💬, Phospholipase D signaling pathway 💬, Fc epsilon RI signaling pathway 💬, Asthma 💬 D05251 Omalizumab 7件: 46, 53, 65, 98, 162, 226, 299
39 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00088 Hydrocortisone 8件: 53, 75, 78, 81, 83, 97, 98, 299
40 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00292 Dexamethasone 19件: 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
41 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00473 Prednisone 30件: 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 127, 162, 164, 205, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331
42 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00975 Dexamethasone 19件: 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
43 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01510 Dexamethasone 19件: 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
44 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01615 Dexamethasone 19件: 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
45 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01632 Dexamethasone 19件: 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
46 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01948 Dexamethasone 19件: 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
47 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D02174 Dexamethasone 19件: 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
48 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D02591 Dexamethasone 19件: 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
49 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D02592 Dexamethasone 19件: 53, 63, 64, 65, 70, 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
50 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D05000 Methylprednisolone hemisuccinate 3件: 53, 97, 211
51 IL6R 12件: EGFR tyrosine kinase inhibitor resistance 💬, Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, HIF-1 signaling pathway 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Hematopoietic cell lineage 💬, Th17 cell differentiation 💬, Non-alcoholic fatty liver disease 💬, Human cytomegalovirus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬 D02596 Tocilizumab 21件: 2, 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331
52 IL12A 25件: Cytokine-cytokine receptor interaction 💬, Toll-like receptor signaling pathway 💬, RIG-I-like receptor signaling pathway 💬, C-type lectin receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Th1 and Th2 cell differentiation 💬, Alcoholic liver disease 💬, Type I diabetes mellitus 💬, Pertussis 💬, Legionellosis 💬, Leishmaniasis 💬, Chagas disease 💬, African trypanosomiasis 💬, Malaria 💬, Toxoplasmosis 💬, Amoebiasis 💬, Tuberculosis 💬, Measles 💬, Influenza A 💬, Herpes simplex virus 1 infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Inflammatory bowel disease 💬, Allograft rejection 💬, Lipid and atherosclerosis 💬 D09214 Ustekinumab 17件: 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
53 IL12B 25件: Cytokine-cytokine receptor interaction 💬, Toll-like receptor signaling pathway 💬, RIG-I-like receptor signaling pathway 💬, C-type lectin receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Th1 and Th2 cell differentiation 💬, Alcoholic liver disease 💬, Type I diabetes mellitus 💬, Pertussis 💬, Legionellosis 💬, Leishmaniasis 💬, Chagas disease 💬, African trypanosomiasis 💬, Toxoplasmosis 💬, Amoebiasis 💬, Tuberculosis 💬, Measles 💬, Influenza A 💬, Herpes simplex virus 1 infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Inflammatory bowel disease 💬, Allograft rejection 💬, Lipid and atherosclerosis 💬 D09214 Ustekinumab 17件: 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
54 IL17A 6件: Cytokine-cytokine receptor interaction 💬, IL-17 signaling pathway 💬, Th17 cell differentiation 💬, Alcoholic liver disease 💬, Inflammatory bowel disease 💬, Rheumatoid arthritis 💬 D11127 Tibulizumab 1件: 53
55 IMPDH1 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D00752 Mycophenolate mofetil 34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
56 IMPDH1 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D01392 Mizoribine 8件: 46, 49, 51, 53, 66, 94, 222, 224
57 IMPDH1 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D05094 Mycophenolate mofetil 34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
58 IMPDH1 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D05095 Mycophenolate mofetil 34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
59 IMPDH1 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D05096 Mycophenolic acid 36件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300
60 IMPDH2 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D00752 Mycophenolate mofetil 34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
61 IMPDH2 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D01392 Mizoribine 8件: 46, 49, 51, 53, 66, 94, 222, 224
62 IMPDH2 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D05094 Mycophenolate mofetil 34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
63 IMPDH2 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D05095 Mycophenolate mofetil 34件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300
64 IMPDH2 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D05096 Mycophenolic acid 36件: 2, 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300
65 AR 4件: Oocyte meiosis 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Prostate cancer 💬 D08409 Prasterone 6件: 49, 53, 83, 86, 96, 113
66 ITGAL 12件: Rap1 signaling pathway 💬, Cell adhesion molecules 💬, Neutrophil extracellular trap formation 💬, Natural killer cell mediated cytotoxicity 💬, Leukocyte transendothelial migration 💬, Regulation of actin cytoskeleton 💬, Malaria 💬, Staphylococcus aureus infection 💬, Human T-cell leukemia virus 1 infection 💬, Epstein-Barr virus infection 💬, Rheumatoid arthritis 💬, Viral myocarditis 💬 D03959 Efalizumab 9件: 11, 13, 37, 46, 49, 53, 61, 95, 96
67 JAK1 27件: EGFR tyrosine kinase inhibitor resistance 💬, PI3K-Akt signaling pathway 💬, Necroptosis 💬, Osteoclast differentiation 💬, Signaling pathways regulating pluripotency of stem cells 💬, NOD-like receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, Leishmaniasis 💬, Toxoplasmosis 💬, Tuberculosis 💬, Hepatitis C 💬, Hepatitis B 💬, Measles 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human papillomavirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Viral carcinogenesis 💬, Pancreatic cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 D09970 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
68 JAK1 27件: EGFR tyrosine kinase inhibitor resistance 💬, PI3K-Akt signaling pathway 💬, Necroptosis 💬, Osteoclast differentiation 💬, Signaling pathways regulating pluripotency of stem cells 💬, NOD-like receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, Leishmaniasis 💬, Toxoplasmosis 💬, Tuberculosis 💬, Hepatitis C 💬, Hepatitis B 💬, Measles 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human papillomavirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Viral carcinogenesis 💬, Pancreatic cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 D10308 Baricitinib 13件: 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325
69 JAK1 27件: EGFR tyrosine kinase inhibitor resistance 💬, PI3K-Akt signaling pathway 💬, Necroptosis 💬, Osteoclast differentiation 💬, Signaling pathways regulating pluripotency of stem cells 💬, NOD-like receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, Leishmaniasis 💬, Toxoplasmosis 💬, Tuberculosis 💬, Hepatitis C 💬, Hepatitis B 💬, Measles 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human papillomavirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Viral carcinogenesis 💬, Pancreatic cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 D10871 Filgotinib 6件: 46, 53, 96, 97, 222, 271
70 JAK2 24件: EGFR tyrosine kinase inhibitor resistance 💬, Chemokine signaling pathway 💬, PI3K-Akt signaling pathway 💬, Necroptosis 💬, Signaling pathways regulating pluripotency of stem cells 💬, JAK-STAT signaling pathway 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, Cholinergic synapse 💬, Prolactin signaling pathway 💬, Adipocytokine signaling pathway 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Growth hormone synthesis, secretion and action 💬, Leishmaniasis 💬, Toxoplasmosis 💬, Tuberculosis 💬, Hepatitis B 💬, Influenza A 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Lipid and atherosclerosis 💬 D09970 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
71 JAK2 24件: EGFR tyrosine kinase inhibitor resistance 💬, Chemokine signaling pathway 💬, PI3K-Akt signaling pathway 💬, Necroptosis 💬, Signaling pathways regulating pluripotency of stem cells 💬, JAK-STAT signaling pathway 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, Cholinergic synapse 💬, Prolactin signaling pathway 💬, Adipocytokine signaling pathway 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Growth hormone synthesis, secretion and action 💬, Leishmaniasis 💬, Toxoplasmosis 💬, Tuberculosis 💬, Hepatitis B 💬, Influenza A 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Lipid and atherosclerosis 💬 D10308 Baricitinib 13件: 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325
72 JAK3 15件: Chemokine signaling pathway 💬, PI3K-Akt signaling pathway 💬, Necroptosis 💬, Signaling pathways regulating pluripotency of stem cells 💬, JAK-STAT signaling pathway 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, Hepatitis B 💬, Measles 💬, Human T-cell leukemia virus 1 infection 💬, Epstein-Barr virus infection 💬, Pathways in cancer 💬, Viral carcinogenesis 💬, Non-small cell lung cancer 💬, Primary immunodeficiency 💬 D09970 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271
73 LTA 7件: Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, NF-kappa B signaling pathway 💬, TNF signaling pathway 💬, Type I diabetes mellitus 💬, Human T-cell leukemia virus 1 infection 💬, Herpes simplex virus 1 infection 💬 D00742 Etanercept 17件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298
74 LTB 3件: Cytokine-cytokine receptor interaction 💬, NF-kappa B signaling pathway 💬, Rheumatoid arthritis 💬 D08866 Baminercept 4件: 13, 46, 53, 97
75 NFKB1 76件: Antifolate resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, cAMP signaling pathway 💬, Chemokine signaling pathway 💬, NF-kappa B signaling pathway 💬, HIF-1 signaling pathway 💬, Sphingolipid signaling pathway 💬, PI3K-Akt signaling pathway 💬, Apoptosis 💬, Longevity regulating pathway 💬, Cellular senescence 💬, Osteoclast differentiation 💬, Neutrophil extracellular trap formation 💬, Toll-like receptor signaling pathway 💬, NOD-like receptor signaling pathway 💬, RIG-I-like receptor signaling pathway 💬, Cytosolic DNA-sensing pathway 💬, C-type lectin receptor signaling pathway 💬, IL-17 signaling pathway 💬, Th1 and Th2 cell differentiation 💬, Th17 cell differentiation 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, TNF signaling pathway 💬, Neurotrophin signaling pathway 💬, Prolactin signaling pathway 💬, Adipocytokine signaling pathway 💬, Relaxin signaling pathway 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Alcoholic liver disease 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Cocaine addiction 💬, Epithelial cell signaling in Helicobacter pylori infection 💬, Pathogenic Escherichia coli infection 💬, Shigellosis 💬, Salmonella infection 💬, Pertussis 💬, Legionellosis 💬, Yersinia infection 💬, Leishmaniasis 💬, Chagas disease 💬, Toxoplasmosis 💬, Amoebiasis 💬, Tuberculosis 💬, Hepatitis C 💬, Hepatitis B 💬, Measles 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human papillomavirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Human immunodeficiency virus 1 infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Viral carcinogenesis 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Pancreatic cancer 💬, Prostate cancer 💬, Chronic myeloid leukemia 💬, Acute myeloid leukemia 💬, Small cell lung cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Inflammatory bowel disease 💬, Diabetic cardiomyopathy 💬, Lipid and atherosclerosis 💬, Fluid shear stress and atherosclerosis 💬 D01146 Iguratimod 4件: 46, 51, 53, 271
76 NGFR 8件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Cytokine-cytokine receptor interaction 💬, PI3K-Akt signaling pathway 💬, Apoptosis - multiple species 💬, Neurotrophin signaling pathway 💬, Transcriptional misregulation in cancer 💬 D11028 Cenegermin 2件: 53, 90
77 PDCD1 3件: Cell adhesion molecules 💬, T cell receptor signaling pathway 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 D10316 Nivolumab 12件: 13, 26, 41, 46, 49, 50, 51, 53, 85, 96, 97, 159
78 IL23A 9件: Cytokine-cytokine receptor interaction 💬, C-type lectin receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Th17 cell differentiation 💬, Pertussis 💬, Tuberculosis 💬, Pathways in cancer 💬, Inflammatory bowel disease 💬, Rheumatoid arthritis 💬 D09214 Ustekinumab 17件: 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271
79 PIK3CA 106件: Inositol phosphate metabolism 💬, Metabolic pathways 💬, EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, Platinum drug resistance 💬, ErbB signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Chemokine signaling pathway 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, Phosphatidylinositol signaling system 💬, Sphingolipid signaling pathway 💬, Phospholipase D signaling pathway 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Apoptosis 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Cellular senescence 💬, Axon guidance 💬, VEGF signaling pathway 💬, Osteoclast differentiation 💬, Focal adhesion 💬, Signaling pathways regulating pluripotency of stem cells 💬, Platelet activation 💬, Neutrophil extracellular trap formation 💬, Toll-like receptor signaling pathway 💬, C-type lectin receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, Fc gamma R-mediated phagocytosis 💬, TNF signaling pathway 💬, Leukocyte transendothelial migration 💬, Neurotrophin signaling pathway 💬, Cholinergic synapse 💬, Inflammatory mediator regulation of TRP channels 💬, Regulation of actin cytoskeleton 💬, Insulin signaling pathway 💬, Progesterone-mediated oocyte maturation 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Regulation of lipolysis in adipocytes 💬, Relaxin signaling pathway 💬, GnRH secretion 💬, Type II diabetes mellitus 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Growth hormone synthesis, secretion and action 💬, Aldosterone-regulated sodium reabsorption 💬, Carbohydrate digestion and absorption 💬, Alzheimer disease 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Bacterial invasion of epithelial cells 💬, Shigellosis 💬, Salmonella infection 💬, Yersinia infection 💬, Chagas disease 💬, Amoebiasis 💬, Hepatitis C 💬, Hepatitis B 💬, Measles 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human papillomavirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Human immunodeficiency virus 1 infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Viral carcinogenesis 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Colorectal cancer 💬, Renal cell carcinoma 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Glioma 💬, Prostate cancer 💬, Melanoma 💬, Chronic myeloid leukemia 💬, Acute myeloid leukemia 💬, Small cell lung cancer 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Diabetic cardiomyopathy 💬, Lipid and atherosclerosis 💬, Fluid shear stress and atherosclerosis 💬 D11158 Leniolisib 2件: 53, 65
80 PIK3CB 106件: Inositol phosphate metabolism 💬, Metabolic pathways 💬, EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, Platinum drug resistance 💬, ErbB signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Chemokine signaling pathway 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, Phosphatidylinositol signaling system 💬, Sphingolipid signaling pathway 💬, Phospholipase D signaling pathway 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Apoptosis 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Cellular senescence 💬, Axon guidance 💬, VEGF signaling pathway 💬, Osteoclast differentiation 💬, Focal adhesion 💬, Signaling pathways regulating pluripotency of stem cells 💬, Platelet activation 💬, Neutrophil extracellular trap formation 💬, Toll-like receptor signaling pathway 💬, C-type lectin receptor signaling pathway 💬, JAK-STAT signaling pathway 💬, Natural killer cell mediated cytotoxicity 💬, T cell receptor signaling pathway 💬, B cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, Fc gamma R-mediated phagocytosis 💬, TNF signaling pathway 💬, Leukocyte transendothelial migration 💬, Neurotrophin signaling pathway 💬, Cholinergic synapse 💬, Inflammatory mediator regulation of TRP channels 💬, Regulation of actin cytoskeleton 💬, Insulin signaling pathway 💬, Progesterone-mediated oocyte maturation 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Regulation of lipolysis in adipocytes 💬, Relaxin signaling pathway 💬, GnRH secretion 💬, Type II diabetes mellitus 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Growth hormone synthesis, secretion and action 💬, Aldosterone-regulated sodium reabsorption 💬, Carbohydrate digestion and absorption 💬, Alzheimer disease 💬, Spinocerebellar ataxia 💬, Prion disease 💬, Bacterial invasion of epithelial cells 💬, Shigellosis 💬, Salmonella infection 💬, Yersinia infection 💬, Chagas disease 💬, Amoebiasis 💬, Hepatitis C 💬, Hepatitis B 💬, Measles 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human papillomavirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Human immunodeficiency virus 1 infection 💬, Coronavirus disease - COVID-19 💬,