Target Gene/Pathway Pathway / Gene

  

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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 CD52 💬 - Alemtuzumab 💬 Alemtuzumab 22件: 13, 15, 19, 20, 36, 43, 44, 46, 49, 51, 60, 62, 63, 65, 85, 96, 164, 234, 283, 284, 285, 326 💬
2 TNFSF13B 💬 4件: Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Intestinal immune network for IgA production, Rheumatoid arthritis Belimumab 💬 Belimumab 13件: 11, 13, 43, 44, 46, 49, 51, 53, 63, 66, 222, 296, 300 💬
3 CYSLTR1 💬 2件: Calcium signaling pathway, Neuroactive ligand-receptor interaction Montelukast 💬 Montelukast 8件: 6, 13, 46, 61, 63, 85, 98, 228 💬
4 PDE10A 💬 4件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Morphine addiction Aminophylline 💬 Aminophylline 1件: 63 💬
5 TNFRSF13C 💬 5件: Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Intestinal immune network for IgA production, Human T-cell leukemia virus 1 infection, Primary immunodeficiency Ianalumab 💬 Ianalumab 7件: 35, 46, 49, 53, 61, 63, 95 💬
6 ADORA1 💬 7件: cGMP-PKG signaling pathway, cAMP signaling pathway, Sphingolipid signaling pathway, Neuroactive ligand-receptor interaction, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction Aminophylline 💬 Aminophylline 1件: 63 💬
7 ADORA2B 💬 5件: Rap1 signaling pathway, Calcium signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction, Alcoholism Aminophylline 💬 Aminophylline 1件: 63 💬
8 DNMT1 💬 3件: Cysteine and methionine metabolism, Metabolic pathways, MicroRNAs in cancer Decitabine 💬 Decitabine 3件: 13, 60, 63 💬
9 DNMT3A 💬 3件: Cysteine and methionine metabolism, Metabolic pathways, MicroRNAs in cancer Decitabine 💬 Decitabine 3件: 13, 60, 63 💬
10 DNMT3B 💬 3件: Cysteine and methionine metabolism, Metabolic pathways, MicroRNAs in cancer Decitabine 💬 Decitabine 3件: 13, 60, 63 💬
11 ESR1 💬 9件: Endocrine resistance, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Pathways in cancer, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Breast cancer Danazol 💬 Danazol 5件: 60, 63, 64, 65, 285 💬
12 FCGRT 💬 - Efgartigimod alfa 💬 Efgartigimod alfa 6件: 11, 14, 35, 53, 63, 162 💬
13 FCGRT 💬 - Rozanolixizumab 💬 Rozanolixizumab 3件: 11, 14, 63 💬
14 MTOR 💬 51件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, ErbB signaling pathway, HIF-1 signaling pathway, Phospholipase D signaling pathway, Autophagy - other, Autophagy - animal, mTOR signaling pathway, PI3K-Akt signaling pathway, AMPK signaling pathway, Longevity regulating pathway, Longevity regulating pathway - multiple species, Cellular senescence, Apelin signaling pathway, Neutrophil extracellular trap formation, JAK-STAT signaling pathway, Th17 cell differentiation, Thermogenesis, Insulin signaling pathway, Thyroid hormone signaling pathway, Adipocytokine signaling pathway, Type II diabetes mellitus, Insulin resistance, Growth hormone synthesis, secretion and action, Alzheimer disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Pathways of neurodegeneration - multiple diseases, Shigellosis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Herpes simplex virus 1 infection, Human immunodeficiency virus 1 infection, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Colorectal cancer, Pancreatic cancer, Glioma, Prostate cancer, Acute myeloid leukemia, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Diabetic cardiomyopathy Sirolimus 💬 Sirolimus 40件: 2, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬
15 PDE7B 💬 3件: Purine metabolism, Metabolic pathways, Morphine addiction Aminophylline 💬 Aminophylline 1件: 63 💬
16 NR3C1 💬 1件: Neuroactive ligand-receptor interaction Dexamethasone 💬 Dexamethasone 22件: 13, 14, 16, 28, 35, 46, 53, 63, 64, 65, 70, 81, 84, 96, 97, 162, 222, 235, 257, 283, 296, 299 💬
17 NR3C1 💬 1件: Neuroactive ligand-receptor interaction Methylprednisolone 💬 Methylprednisolone 46件: 2, 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬
18 NR3C1 💬 1件: Neuroactive ligand-receptor interaction Prednisolone 💬 Prednisolone 42件: 3, 11, 13, 14, 25, 26, 35, 38, 39, 40, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300 💬
19 NR3C1 💬 1件: Neuroactive ligand-receptor interaction Prednisone 💬 Prednisone 45件: 2, 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 162, 164, 205, 222, 224, 228, 283, 284, 288, 299, 300, 307, 331 💬
20 HMGCR 💬 4件: Terpenoid backbone biosynthesis, Metabolic pathways, AMPK signaling pathway, Bile secretion Atorvastatin 💬 Atorvastatin 19件: 13, 46, 49, 51, 58, 63, 79, 84, 88, 93, 96, 97, 160, 222, 225, 265, 271, 297, 299 💬
21 ITGA4 💬 14件: PI3K-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, Cell adhesion molecules, Hematopoietic cell lineage, Leukocyte transendothelial migration, Intestinal immune network for IgA production, Regulation of actin cytoskeleton, Yersinia infection, Leishmaniasis, Human papillomavirus infection, Hypertrophic cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy Natalizumab 💬 Natalizumab 6件: 13, 15, 25, 46, 63, 96 💬
22 AR 💬 4件: Oocyte meiosis, Pathways in cancer, Chemical carcinogenesis - receptor activation, Prostate cancer Danazol 💬 Danazol 5件: 60, 63, 64, 65, 285 💬
23 MPL 💬 2件: Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway Romiplostim 💬 Romiplostim 4件: 60, 63, 64, 65 💬
24 MPL 💬 2件: Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway Avatrombopag 💬 Avatrombopag 2件: 60, 63 💬
25 ATP4A 💬 4件: Oxidative phosphorylation, Metabolic pathways, Collecting duct acid secretion, Gastric acid secretion Lansoprazole 💬 Lansoprazole 7件: 63, 71, 85, 98, 166, 222, 299 💬
26 ATP4A 💬 4件: Oxidative phosphorylation, Metabolic pathways, Collecting duct acid secretion, Gastric acid secretion Vonoprazan 💬 Vonoprazan 2件: 63, 98 💬
27 ATP4B 💬 4件: Oxidative phosphorylation, Metabolic pathways, Collecting duct acid secretion, Gastric acid secretion Lansoprazole 💬 Lansoprazole 7件: 63, 71, 85, 98, 166, 222, 299 💬
28 ATP4B 💬 4件: Oxidative phosphorylation, Metabolic pathways, Collecting duct acid secretion, Gastric acid secretion Vonoprazan 💬 Vonoprazan 2件: 63, 98 💬
29 PDE11A 💬 4件: Purine metabolism, Metabolic pathways, Cushing syndrome, Morphine addiction Aminophylline 💬 Aminophylline 1件: 63 💬
30 PDE1A 💬 7件: Purine metabolism, Metabolic pathways, Calcium signaling pathway, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction Aminophylline 💬 Aminophylline 1件: 63 💬
31 PDE1C 💬 7件: Purine metabolism, Metabolic pathways, Calcium signaling pathway, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction Aminophylline 💬 Aminophylline 1件: 63 💬
32 PDE2A 💬 6件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, Olfactory transduction, Aldosterone synthesis and secretion, Morphine addiction Aminophylline 💬 Aminophylline 1件: 63 💬
33 PDE3A 💬 6件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, cAMP signaling pathway, Renin secretion, Morphine addiction Aminophylline 💬 Aminophylline 1件: 63 💬
34 PDE3B 💬 11件: Purine metabolism, Metabolic pathways, cGMP-PKG signaling pathway, cAMP signaling pathway, Apelin signaling pathway, Insulin signaling pathway, Progesterone-mediated oocyte maturation, Glucagon signaling pathway, Regulation of lipolysis in adipocytes, Renin secretion, Morphine addiction Aminophylline 💬 Aminophylline 1件: 63 💬
35 PDE4A 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Aminophylline 💬 Aminophylline 1件: 63 💬
36 PDE4B 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Aminophylline 💬 Aminophylline 1件: 63 💬
37 PDE4C 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Aminophylline 💬 Aminophylline 1件: 63 💬
38 PDE4D 💬 5件: Purine metabolism, Metabolic pathways, cAMP signaling pathway, Parathyroid hormone synthesis, secretion and action, Morphine addiction Aminophylline 💬 Aminophylline 1件: 63 💬
39 PDE7A 💬 3件: Purine metabolism, Metabolic pathways, Morphine addiction Aminophylline 💬 Aminophylline 1件: 63 💬
40 PDE8A 💬 5件: Purine metabolism, Metabolic pathways, Cortisol synthesis and secretion, Cushing syndrome, Morphine addiction Aminophylline 💬 Aminophylline 1件: 63 💬
41 PDE1B 💬 7件: Purine metabolism, Metabolic pathways, Calcium signaling pathway, Olfactory transduction, Taste transduction, Renin secretion, Morphine addiction Aminophylline 💬 Aminophylline 1件: 63 💬
42 PGR 💬 5件: Oocyte meiosis, Progesterone-mediated oocyte maturation, Estrogen signaling pathway, Chemical carcinogenesis - receptor activation, Breast cancer Danazol 💬 Danazol 5件: 60, 63, 64, 65, 285 💬
43 PML 💬 7件: Ubiquitin mediated proteolysis, Endocytosis, Influenza A, Herpes simplex virus 1 infection, Pathways in cancer, Transcriptional misregulation in cancer, Acute myeloid leukemia Tretinoin 💬 Tretinoin 6件: 2, 62, 63, 75, 94, 231 💬
44 PPP3CA 💬 33件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis Cyclosporine 💬 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
45 PPP3CB 💬 33件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis Cyclosporine 💬 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
46 PPP3CC 💬 33件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Dopaminergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis Cyclosporine 💬 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
47 PPP3R1 💬 32件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis Cyclosporine 💬 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
48 PPP3R2 💬 32件: MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, Oocyte meiosis, Cellular senescence, Wnt signaling pathway, Axon guidance, VEGF signaling pathway, Osteoclast differentiation, C-type lectin receptor signaling pathway, Natural killer cell mediated cytotoxicity, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, B cell receptor signaling pathway, Long-term potentiation, Glutamatergic synapse, Oxytocin signaling pathway, Glucagon signaling pathway, Renin secretion, Alzheimer disease, Amyotrophic lateral sclerosis, Prion disease, Pathways of neurodegeneration - multiple diseases, Amphetamine addiction, Tuberculosis, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Kaposi sarcoma-associated herpesvirus infection, Human immunodeficiency virus 1 infection, PD-L1 expression and PD-1 checkpoint pathway in cancer, Lipid and atherosclerosis Cyclosporine 💬 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
49 PSMB5 💬 8件: Proteasome, Alzheimer disease, Parkinson disease, Amyotrophic lateral sclerosis, Huntington disease, Spinocerebellar ataxia, Prion disease, Pathways of neurodegeneration - multiple diseases Bortezomib 💬 Bortezomib 17件: 11, 13, 26, 28, 46, 49, 51, 61, 63, 64, 66, 222, 228, 256, 283, 288, 331 💬
50 RARA 💬 5件: Th17 cell differentiation, Estrogen signaling pathway, Pathways in cancer, Transcriptional misregulation in cancer, Acute myeloid leukemia Tretinoin 💬 Tretinoin 6件: 2, 62, 63, 75, 94, 231 💬
51 RARB 💬 4件: Pathways in cancer, Small cell lung cancer, Non-small cell lung cancer, Gastric cancer Tretinoin 💬 Tretinoin 6件: 2, 62, 63, 75, 94, 231 💬
52 BTK 💬 7件: NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Epstein-Barr virus infection, Primary immunodeficiency Zanubrutinib 💬 Zanubrutinib 5件: 13, 63, 222, 300, 331 💬
53 BTK 💬 7件: NF-kappa B signaling pathway, Osteoclast differentiation, Platelet activation, B cell receptor signaling pathway, Fc epsilon RI signaling pathway, Epstein-Barr virus infection, Primary immunodeficiency Orelabrutinib 💬 Orelabrutinib 4件: 13, 49, 61, 63 💬
54 PDE8B 💬 5件: Purine metabolism, Metabolic pathways, Cortisol synthesis and secretion, Cushing syndrome, Morphine addiction Aminophylline 💬 Aminophylline 1件: 63 💬
55 MS4A1 💬 1件: Hematopoietic cell lineage Rituximab 💬 Rituximab 48件: 11, 13, 14, 19, 26, 35, 36, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 52, 53, 55, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331 💬
56 CD38 💬 7件: Nicotinate and nicotinamide metabolism, Metabolic pathways, Calcium signaling pathway, Hematopoietic cell lineage, Oxytocin signaling pathway, Salivary secretion, Pancreatic secretion Daratumumab 💬 Daratumumab 5件: 13, 28, 48, 49, 63 💬
57 CD38 💬 7件: Nicotinate and nicotinamide metabolism, Metabolic pathways, Calcium signaling pathway, Hematopoietic cell lineage, Oxytocin signaling pathway, Salivary secretion, Pancreatic secretion Mezagitamab 💬 Mezagitamab 2件: 63, 66 💬
58 CD40LG 💬 14件: Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Cell adhesion molecules, T cell receptor signaling pathway, Intestinal immune network for IgA production, Malaria, Toxoplasmosis, Asthma, Autoimmune thyroid disease, Systemic lupus erythematosus, Allograft rejection, Primary immunodeficiency, Viral myocarditis, Lipid and atherosclerosis Toralizumab 💬 Toralizumab 1件: 63 💬