Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 ADRA1D 6件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Salivary secretion 💬 D00608 Doxazosin 2件: 57, 67
2 ADRA1D 6件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Salivary secretion 💬 D07874 Doxazosin 2件: 57, 67
3 ADRA1B 6件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Salivary secretion 💬 D00608 Doxazosin 2件: 57, 67
4 ADRA1B 6件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Salivary secretion 💬 D07874 Doxazosin 2件: 57, 67
5 ADRA1A 7件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, AMPK signaling pathway 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Salivary secretion 💬 D00608 Doxazosin 2件: 57, 67
6 ADRA1A 7件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, AMPK signaling pathway 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Salivary secretion 💬 D07874 Doxazosin 2件: 57, 67
7 ADRB1 11件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Gap junction 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬, Dilated cardiomyopathy 💬 D00634 Bisoprolol 3件: 67, 86, 113
8 ADRB1 11件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Gap junction 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬, Dilated cardiomyopathy 💬 D02342 Bisoprolol 3件: 67, 86, 113
9 ACE 6件: Renin-angiotensin system 💬, Renin secretion 💬, Chagas disease 💬, Coronavirus disease - COVID-19 💬, Hypertrophic cardiomyopathy 💬, Diabetic cardiomyopathy 💬 D00362 Lisinopril 7件: 19, 46, 49, 66, 67, 113, 222
10 ACE 6件: Renin-angiotensin system 💬, Renin secretion 💬, Chagas disease 💬, Coronavirus disease - COVID-19 💬, Hypertrophic cardiomyopathy 💬, Diabetic cardiomyopathy 💬 D00421 Ramipril 7件: 46, 49, 66, 67, 113, 218, 257
11 ACE 6件: Renin-angiotensin system 💬, Renin secretion 💬, Chagas disease 💬, Coronavirus disease - COVID-19 💬, Hypertrophic cardiomyopathy 💬, Diabetic cardiomyopathy 💬 D08068 Imidapril 1件: 67
12 ACE 6件: Renin-angiotensin system 💬, Renin secretion 💬, Chagas disease 💬, Coronavirus disease - COVID-19 💬, Hypertrophic cardiomyopathy 💬, Diabetic cardiomyopathy 💬 D08131 Lisinopril 7件: 19, 46, 49, 66, 67, 113, 222
13 AGTR1 16件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Apelin signaling pathway 💬, Renin-angiotensin system 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Cushing syndrome 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Diabetic cardiomyopathy 💬 D00357 Losartan 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299
14 AGTR1 16件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Apelin signaling pathway 💬, Renin-angiotensin system 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Cushing syndrome 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Diabetic cardiomyopathy 💬 D00522 Candesartan cilexetil 1件: 67
15 AGTR1 16件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Apelin signaling pathway 💬, Renin-angiotensin system 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Cushing syndrome 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Diabetic cardiomyopathy 💬 D00522 Candesartan 2件: 58, 67
16 AGTR1 16件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Apelin signaling pathway 💬, Renin-angiotensin system 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Cushing syndrome 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Diabetic cardiomyopathy 💬 D00626 Candesartan cilexetil 1件: 67
17 AGTR1 16件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Apelin signaling pathway 💬, Renin-angiotensin system 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Cushing syndrome 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Diabetic cardiomyopathy 💬 D00627 Telmisartan 2件: 66, 67
18 AGTR1 16件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Apelin signaling pathway 💬, Renin-angiotensin system 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Cushing syndrome 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Diabetic cardiomyopathy 💬 D08146 Losartan 18件: 17, 19, 36, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299
19 EGFR 48件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, MAPK signaling pathway 💬, ErbB signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, Phospholipase D signaling pathway 💬, Endocytosis 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Adherens junction 💬, Gap junction 💬, JAK-STAT signaling pathway 💬, Regulation of actin cytoskeleton 💬, GnRH signaling pathway 💬, Estrogen signaling pathway 💬, Oxytocin signaling pathway 💬, Relaxin signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Cushing syndrome 💬, Epithelial cell signaling in Helicobacter pylori infection 💬, Shigellosis 💬, Hepatitis C 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Colorectal cancer 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Glioma 💬, Prostate cancer 💬, Melanoma 💬, Bladder cancer 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 D11772 Tesevatinib 1件: 67
20 EPHB4 1件: Axon guidance 💬 D11772 Tesevatinib 1件: 67
21 ERBB2 22件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, Platinum drug resistance 💬, MAPK signaling pathway 💬, ErbB signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Adherens junction 💬, Tight junction 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Prostate cancer 💬, Bladder cancer 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬 D11772 Tesevatinib 1件: 67
22 FLT4 8件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Pathways in cancer 💬, Breast cancer 💬 D11772 Tesevatinib 1件: 67
23 MTOR 51件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, ErbB signaling pathway 💬, HIF-1 signaling pathway 💬, Phospholipase D signaling pathway 💬, Autophagy - other 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Cellular senescence 💬, Apelin signaling pathway 💬, Neutrophil extracellular trap formation 💬, JAK-STAT signaling pathway 💬, Th17 cell differentiation 💬, Thermogenesis 💬, Insulin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Adipocytokine signaling pathway 💬, Type II diabetes mellitus 💬, Insulin resistance 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Pathways of neurodegeneration - multiple diseases 💬, Shigellosis 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Human immunodeficiency virus 1 infection 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Colorectal cancer 💬, Pancreatic cancer 💬, Glioma 💬, Prostate cancer 💬, Acute myeloid leukemia 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Diabetic cardiomyopathy 💬 D00753 Sirolimus 41件: 2, 6, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331
24 MTOR 51件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, ErbB signaling pathway 💬, HIF-1 signaling pathway 💬, Phospholipase D signaling pathway 💬, Autophagy - other 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Cellular senescence 💬, Apelin signaling pathway 💬, Neutrophil extracellular trap formation 💬, JAK-STAT signaling pathway 💬, Th17 cell differentiation 💬, Thermogenesis 💬, Insulin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Adipocytokine signaling pathway 💬, Type II diabetes mellitus 💬, Insulin resistance 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Pathways of neurodegeneration - multiple diseases 💬, Shigellosis 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Human immunodeficiency virus 1 infection 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Colorectal cancer 💬, Pancreatic cancer 💬, Glioma 💬, Prostate cancer 💬, Acute myeloid leukemia 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Diabetic cardiomyopathy 💬 D02714 Everolimus 9件: 34, 67, 89, 96, 137, 157, 158, 228, 277
25 ABL1 11件: ErbB signaling pathway 💬, Ras signaling pathway 💬, Cell cycle 💬, Axon guidance 💬, Neurotrophin signaling pathway 💬, Pathogenic Escherichia coli infection 💬, Pathways in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Chronic myeloid leukemia 💬, Viral myocarditis 💬 D03252 Bosutinib 2件: 2, 67
26 HMGCR 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, AMPK signaling pathway 💬, Bile secretion 💬 D00893 Pravastatin 9件: 13, 46, 49, 67, 79, 96, 164, 265, 333
27 HMGCR 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, AMPK signaling pathway 💬, Bile secretion 💬 D08410 Pravastatin 9件: 13, 46, 49, 67, 79, 96, 164, 265, 333
28 KDR 10件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, VEGF signaling pathway 💬, Focal adhesion 💬, Proteoglycans in cancer 💬, Fluid shear stress and atherosclerosis 💬 D11772 Tesevatinib 1件: 67
29 NR3C2 1件: Aldosterone-regulated sodium reabsorption 💬 D00443 Spironolactone 6件: 67, 86, 113, 210, 218, 225
30 PPARG 11件: PPAR signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Osteoclast differentiation 💬, Thermogenesis 💬, Non-alcoholic fatty liver disease 💬, Huntington disease 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Thyroid cancer 💬, Lipid and atherosclerosis 💬 D00945 Pioglitazone 17件: 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299
31 PPARG 11件: PPAR signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Osteoclast differentiation 💬, Thermogenesis 💬, Non-alcoholic fatty liver disease 💬, Huntington disease 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Thyroid cancer 💬, Lipid and atherosclerosis 💬 D08378 Pioglitazone 17件: 2, 6, 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299
32 AVPR2 3件: Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vasopressin-regulated water reabsorption 💬 D01213 Tolvaptan 3件: 67, 72, 225
33 AVPR2 3件: Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vasopressin-regulated water reabsorption 💬 D04752 Lixivaptan 1件: 67
34 PRKAA1 20件: FoxO signaling pathway 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Apelin signaling pathway 💬, Tight junction 💬, Circadian rhythm 💬, Thermogenesis 💬, Insulin signaling pathway 💬, Adipocytokine signaling pathway 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, Alcoholic liver disease 💬, Hypertrophic cardiomyopathy 💬, Fluid shear stress and atherosclerosis 💬 D00944 Metformin 24件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
35 PRKAA1 20件: FoxO signaling pathway 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Apelin signaling pathway 💬, Tight junction 💬, Circadian rhythm 💬, Thermogenesis 💬, Insulin signaling pathway 💬, Adipocytokine signaling pathway 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, Alcoholic liver disease 💬, Hypertrophic cardiomyopathy 💬, Fluid shear stress and atherosclerosis 💬 D04966 Metformin 24件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
36 PRKAA2 20件: FoxO signaling pathway 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Apelin signaling pathway 💬, Tight junction 💬, Circadian rhythm 💬, Thermogenesis 💬, Insulin signaling pathway 💬, Adipocytokine signaling pathway 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, Alcoholic liver disease 💬, Hypertrophic cardiomyopathy 💬, Fluid shear stress and atherosclerosis 💬 D00944 Metformin 24件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
37 PRKAA2 20件: FoxO signaling pathway 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Apelin signaling pathway 💬, Tight junction 💬, Circadian rhythm 💬, Thermogenesis 💬, Insulin signaling pathway 💬, Adipocytokine signaling pathway 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, Alcoholic liver disease 💬, Hypertrophic cardiomyopathy 💬, Fluid shear stress and atherosclerosis 💬 D04966 Metformin 24件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
38 SCNN1A 2件: Taste transduction 💬, Aldosterone-regulated sodium reabsorption 💬 D00649 Amiloride 4件: 13, 67, 225, 299
39 SCNN1A 2件: Taste transduction 💬, Aldosterone-regulated sodium reabsorption 💬 D07447 Amiloride 4件: 13, 67, 225, 299
40 SCNN1B 2件: Taste transduction 💬, Aldosterone-regulated sodium reabsorption 💬 D00649 Amiloride 4件: 13, 67, 225, 299
41 SCNN1B 2件: Taste transduction 💬, Aldosterone-regulated sodium reabsorption 💬 D07447 Amiloride 4件: 13, 67, 225, 299
42 SCNN1G 2件: Taste transduction 💬, Aldosterone-regulated sodium reabsorption 💬 D00649 Amiloride 4件: 13, 67, 225, 299
43 SCNN1G 2件: Taste transduction 💬, Aldosterone-regulated sodium reabsorption 💬 D07447 Amiloride 4件: 13, 67, 225, 299
44 SRC 42件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, ErbB signaling pathway 💬, Rap1 signaling pathway 💬, Chemokine signaling pathway 💬, Mitophagy - animal 💬, Endocytosis 💬, Axon guidance 💬, VEGF signaling pathway 💬, Focal adhesion 💬, Adherens junction 💬, Tight junction 💬, Gap junction 💬, Platelet activation 💬, Neutrophil extracellular trap formation 💬, C-type lectin receptor signaling pathway 💬, GABAergic synapse 💬, Inflammatory mediator regulation of TRP channels 💬, Regulation of actin cytoskeleton 💬, GnRH signaling pathway 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Oxytocin signaling pathway 💬, Relaxin signaling pathway 💬, Bacterial invasion of epithelial cells 💬, Epithelial cell signaling in Helicobacter pylori infection 💬, Pathogenic Escherichia coli infection 💬, Shigellosis 💬, Yersinia infection 💬, Tuberculosis 💬, Hepatitis B 💬, Human cytomegalovirus infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Viral carcinogenesis 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Bladder cancer 💬, Lipid and atherosclerosis 💬, Fluid shear stress and atherosclerosis 💬 D03252 Bosutinib 2件: 2, 67
45 SSTR1 3件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Growth hormone synthesis, secretion and action 💬 D07431 Somatostatin 2件: 67, 78
46 SSTR1 3件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Growth hormone synthesis, secretion and action 💬 D10147 Pasireotide 3件: 67, 74, 75
47 SSTR2 4件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Growth hormone synthesis, secretion and action 💬, Gastric acid secretion 💬 D00442 Octreotide 7件: 67, 75, 84, 85, 89, 193, 227
48 SSTR2 4件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Growth hormone synthesis, secretion and action 💬, Gastric acid secretion 💬 D06495 Octreotide 7件: 67, 75, 84, 85, 89, 193, 227
49 SSTR2 4件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Growth hormone synthesis, secretion and action 💬, Gastric acid secretion 💬 D07431 Somatostatin 2件: 67, 78
50 SSTR2 4件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Growth hormone synthesis, secretion and action 💬, Gastric acid secretion 💬 D10147 Pasireotide 3件: 67, 74, 75
51 SSTR3 2件: Neuroactive ligand-receptor interaction 💬, Growth hormone synthesis, secretion and action 💬 D07431 Somatostatin 2件: 67, 78
52 SSTR3 2件: Neuroactive ligand-receptor interaction 💬, Growth hormone synthesis, secretion and action 💬 D10147 Pasireotide 3件: 67, 74, 75
53 SSTR4 1件: Neuroactive ligand-receptor interaction 💬 D07431 Somatostatin 2件: 67, 78
54 SSTR5 3件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Growth hormone synthesis, secretion and action 💬 D07431 Somatostatin 2件: 67, 78
55 SSTR5 3件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Growth hormone synthesis, secretion and action 💬 D10147 Pasireotide 3件: 67, 74, 75
56 UGCG 2件: Sphingolipid metabolism 💬, Metabolic pathways 💬 D11633 Venglustat 3件: 6, 19, 67
57 CACNA1B 15件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, Synaptic vesicle cycle 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Dopaminergic synapse 💬, Type II diabetes mellitus 💬, Huntington disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Morphine addiction 💬, Nicotine addiction 💬, Chemical carcinogenesis - receptor activation 💬 D01173 Cilnidipine 1件: 67
58 CACNA1C 34件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Dopaminergic synapse 💬, Taste transduction 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Type II diabetes mellitus 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D00615 Amlodipine 4件: 13, 51, 67, 298
59 CACNA1C 34件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Dopaminergic synapse 💬, Taste transduction 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Type II diabetes mellitus 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D01173 Cilnidipine 1件: 67
60 CACNA1C 34件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Dopaminergic synapse 💬, Taste transduction 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Type II diabetes mellitus 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D02914 Amlodipine 4件: 13, 51, 67, 298
61 CACNA1C 34件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Circadian entrainment 💬, Long-term potentiation 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Dopaminergic synapse 💬, Taste transduction 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Type II diabetes mellitus 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D07450 Amlodipine 4件: 13, 51, 67, 298
62 CACNA1D 35件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cellular senescence 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Tight junction 💬, Circadian entrainment 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Dopaminergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Type II diabetes mellitus 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Carbohydrate digestion and absorption 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D00615 Amlodipine 4件: 13, 51, 67, 298
63 CACNA1D 35件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cellular senescence 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Tight junction 💬, Circadian entrainment 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Dopaminergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Type II diabetes mellitus 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Carbohydrate digestion and absorption 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D01173 Cilnidipine 1件: 67
64 CACNA1D 35件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cellular senescence 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Tight junction 💬, Circadian entrainment 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Dopaminergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Type II diabetes mellitus 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Carbohydrate digestion and absorption 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D02914 Amlodipine 4件: 13, 51, 67, 298
65 CACNA1D 35件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cellular senescence 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Tight junction 💬, Circadian entrainment 💬, Retrograde endocannabinoid signaling 💬, Glutamatergic synapse 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Dopaminergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Type II diabetes mellitus 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Carbohydrate digestion and absorption 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Amphetamine addiction 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D07450 Amlodipine 4件: 13, 51, 67, 298
66 CACNA1F 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D00615 Amlodipine 4件: 13, 51, 67, 298
67 CACNA1F 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D01173 Cilnidipine 1件: 67
68 CACNA1F 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D02914 Amlodipine 4件: 13, 51, 67, 298
69 CACNA1F 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D07450 Amlodipine 4件: 13, 51, 67, 298
70 CACNA1S 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D00615 Amlodipine 4件: 13, 51, 67, 298
71 CACNA1S 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D01173 Cilnidipine 1件: 67
72 CACNA1S 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D02914 Amlodipine 4件: 13, 51, 67, 298
73 CACNA1S 27件: MAPK signaling pathway 💬, Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Cardiac muscle contraction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Retrograde endocannabinoid signaling 💬, Cholinergic synapse 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Insulin secretion 💬, GnRH signaling pathway 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, GnRH secretion 💬, Cushing syndrome 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - receptor activation 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D07450 Amlodipine 4件: 13, 51, 67, 298
74 TAS1R2 2件: Taste transduction 💬, Carbohydrate digestion and absorption 💬 D02381 Aspartame 5件: 6, 13, 67, 86, 230
75 TAS1R3 2件: Taste transduction 💬, Carbohydrate digestion and absorption 💬 D02381 Aspartame 5件: 6, 13, 67, 86, 230
76 AOC3 5件: Glycine, serine and threonine metabolism 💬, Tyrosine metabolism 💬, Phenylalanine metabolism 💬, beta-Alanine metabolism 💬, Metabolic pathways 💬 D08044 Hydralazine 1件: 67
77 NR1H4 1件: Bile secretion 💬 D00734 Ursodeoxycholic acid 10件: 67, 84, 93, 94, 95, 96, 97, 234, 296, 299