Target Gene/Pathway Pathway / Gene


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No. KEGG GENES KEGG PATHWAY KEGG DRUG DrugBank 指定難病告示番号
1 DRD1 💬 10件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Amphetamine addiction, Morphine addiction, Alcoholism Dopamine 💬 Dopamine 4件: 6, 7, 74, 299 💬
2 DRD2 💬 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism Cabergoline 💬 Cabergoline 3件: 6, 74, 75 💬
3 DRD2 💬 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism Bromocriptine 💬 Bromocriptine 2件: 6, 74 💬
4 DRD2 💬 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism Dopamine 💬 Dopamine 4件: 6, 7, 74, 299 💬
5 DRD2 💬 8件: Rap1 signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Gap junction, Dopaminergic synapse, Parkinson disease, Cocaine addiction, Alcoholism Ropinirole 💬 Ropinirole 4件: 2, 6, 74, 309 💬
6 DRD3 💬 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse Dopamine 💬 Dopamine 4件: 6, 7, 74, 299 💬
7 DRD3 💬 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse Ropinirole 💬 Ropinirole 4件: 2, 6, 74, 309 💬
8 DRD4 💬 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse Dopamine 💬 Dopamine 4件: 6, 7, 74, 299 💬
9 DRD4 💬 2件: Neuroactive ligand-receptor interaction, Dopaminergic synapse Ropinirole 💬 Ropinirole 4件: 2, 6, 74, 309 💬
10 DRD5 💬 4件: Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Dopaminergic synapse Dopamine 💬 Dopamine 4件: 6, 7, 74, 299 💬
11 EGFR 💬 48件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, MAPK signaling pathway, ErbB signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, HIF-1 signaling pathway, FoxO signaling pathway, Phospholipase D signaling pathway, Endocytosis, PI3K-Akt signaling pathway, Focal adhesion, Adherens junction, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, GnRH signaling pathway, Estrogen signaling pathway, Oxytocin signaling pathway, Relaxin signaling pathway, Parathyroid hormone synthesis, secretion and action, Cushing syndrome, Epithelial cell signaling in Helicobacter pylori infection, Shigellosis, Hepatitis C, Human cytomegalovirus infection, Human papillomavirus infection, Coronavirus disease - COVID-19, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Chemical carcinogenesis - receptor activation, Chemical carcinogenesis - reactive oxygen species, Colorectal cancer, Pancreatic cancer, Endometrial cancer, Glioma, Prostate cancer, Melanoma, Bladder cancer, Non-small cell lung cancer, Breast cancer, Hepatocellular carcinoma, Gastric cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer Lapatinib 💬 Lapatinib 3件: 34, 74, 75 💬
12 ERBB2 💬 22件: EGFR tyrosine kinase inhibitor resistance, Endocrine resistance, Platinum drug resistance, MAPK signaling pathway, ErbB signaling pathway, Calcium signaling pathway, HIF-1 signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Adherens junction, Tight junction, Pathways in cancer, Proteoglycans in cancer, MicroRNAs in cancer, Pancreatic cancer, Endometrial cancer, Prostate cancer, Bladder cancer, Non-small cell lung cancer, Breast cancer, Gastric cancer, Central carbon metabolism in cancer Lapatinib 💬 Lapatinib 3件: 34, 74, 75 💬
13 ESR1 💬 9件: Endocrine resistance, Estrogen signaling pathway, Prolactin signaling pathway, Thyroid hormone signaling pathway, Endocrine and other factor-regulated calcium reabsorption, Pathways in cancer, Proteoglycans in cancer, Chemical carcinogenesis - receptor activation, Breast cancer Clomifene 💬 Clomifene 1件: 74 💬
14 ESR2 💬 7件: Endocrine resistance, Estrogen signaling pathway, Prolactin signaling pathway, GnRH secretion, Pathways in cancer, Chemical carcinogenesis - receptor activation, Breast cancer Clomifene 💬 Clomifene 1件: 74 💬
15 PRL 💬 5件: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Prolactin signaling pathway Cabergoline 💬 Cabergoline 3件: 6, 74, 75 💬
16 PRL 💬 5件: Cytokine-cytokine receptor interaction, Neuroactive ligand-receptor interaction, PI3K-Akt signaling pathway, JAK-STAT signaling pathway, Prolactin signaling pathway Bromocriptine 💬 Bromocriptine 2件: 6, 74 💬
17 SSTR1 💬 3件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action Pasireotide 💬 Pasireotide 3件: 67, 74, 75 💬
18 SSTR2 💬 4件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action, Gastric acid secretion Pasireotide 💬 Pasireotide 3件: 67, 74, 75 💬
19 SSTR3 💬 2件: Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action Pasireotide 💬 Pasireotide 3件: 67, 74, 75 💬
20 SSTR5 💬 3件: cAMP signaling pathway, Neuroactive ligand-receptor interaction, Growth hormone synthesis, secretion and action Pasireotide 💬 Pasireotide 3件: 67, 74, 75 💬