Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 DRD1 10件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Morphine addiction 💬, Alcoholism 💬 D00633 Dopamine 4件: 6, 7, 74, 299
2 DRD1 10件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Amphetamine addiction 💬, Morphine addiction 💬, Alcoholism 💬 D07870 Dopamine 4件: 6, 7, 74, 299
3 DRD2 8件: Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Alcoholism 💬 D00633 Dopamine 4件: 6, 7, 74, 299
4 DRD2 8件: Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Alcoholism 💬 D00780 Bromocriptine 2件: 6, 74
5 DRD2 8件: Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Alcoholism 💬 D00784 Ropinirole 4件: 2, 6, 74, 309
6 DRD2 8件: Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Alcoholism 💬 D00987 Cabergoline 3件: 6, 74, 75
7 DRD2 8件: Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Alcoholism 💬 D03165 Bromocriptine 2件: 6, 74
8 DRD2 8件: Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Alcoholism 💬 D07870 Dopamine 4件: 6, 7, 74, 299
9 DRD2 8件: Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Alcoholism 💬 D08489 Ropinirole 4件: 2, 6, 74, 309
10 DRD3 2件: Neuroactive ligand-receptor interaction 💬, Dopaminergic synapse 💬 D00633 Dopamine 4件: 6, 7, 74, 299
11 DRD3 2件: Neuroactive ligand-receptor interaction 💬, Dopaminergic synapse 💬 D00784 Ropinirole 4件: 2, 6, 74, 309
12 DRD3 2件: Neuroactive ligand-receptor interaction 💬, Dopaminergic synapse 💬 D07870 Dopamine 4件: 6, 7, 74, 299
13 DRD3 2件: Neuroactive ligand-receptor interaction 💬, Dopaminergic synapse 💬 D08489 Ropinirole 4件: 2, 6, 74, 309
14 DRD4 2件: Neuroactive ligand-receptor interaction 💬, Dopaminergic synapse 💬 D00633 Dopamine 4件: 6, 7, 74, 299
15 DRD4 2件: Neuroactive ligand-receptor interaction 💬, Dopaminergic synapse 💬 D00784 Ropinirole 4件: 2, 6, 74, 309
16 DRD4 2件: Neuroactive ligand-receptor interaction 💬, Dopaminergic synapse 💬 D07870 Dopamine 4件: 6, 7, 74, 299
17 DRD4 2件: Neuroactive ligand-receptor interaction 💬, Dopaminergic synapse 💬 D08489 Ropinirole 4件: 2, 6, 74, 309
18 DRD5 4件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Dopaminergic synapse 💬 D00633 Dopamine 4件: 6, 7, 74, 299
19 DRD5 4件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Dopaminergic synapse 💬 D07870 Dopamine 4件: 6, 7, 74, 299
20 EGFR 48件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, MAPK signaling pathway 💬, ErbB signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, Phospholipase D signaling pathway 💬, Endocytosis 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Adherens junction 💬, Gap junction 💬, JAK-STAT signaling pathway 💬, Regulation of actin cytoskeleton 💬, GnRH signaling pathway 💬, Estrogen signaling pathway 💬, Oxytocin signaling pathway 💬, Relaxin signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Cushing syndrome 💬, Epithelial cell signaling in Helicobacter pylori infection 💬, Shigellosis 💬, Hepatitis C 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Colorectal cancer 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Glioma 💬, Prostate cancer 💬, Melanoma 💬, Bladder cancer 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 D04024 Lapatinib 3件: 34, 74, 75
21 EGFR 48件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, MAPK signaling pathway 💬, ErbB signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, Phospholipase D signaling pathway 💬, Endocytosis 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Adherens junction 💬, Gap junction 💬, JAK-STAT signaling pathway 💬, Regulation of actin cytoskeleton 💬, GnRH signaling pathway 💬, Estrogen signaling pathway 💬, Oxytocin signaling pathway 💬, Relaxin signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Cushing syndrome 💬, Epithelial cell signaling in Helicobacter pylori infection 💬, Shigellosis 💬, Hepatitis C 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Colorectal cancer 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Glioma 💬, Prostate cancer 💬, Melanoma 💬, Bladder cancer 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 D08108 Lapatinib 3件: 34, 74, 75
22 ERBB2 22件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, Platinum drug resistance 💬, MAPK signaling pathway 💬, ErbB signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Adherens junction 💬, Tight junction 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Prostate cancer 💬, Bladder cancer 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬 D04024 Lapatinib 3件: 34, 74, 75
23 ERBB2 22件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, Platinum drug resistance 💬, MAPK signaling pathway 💬, ErbB signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Adherens junction 💬, Tight junction 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Prostate cancer 💬, Bladder cancer 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬 D08108 Lapatinib 3件: 34, 74, 75
24 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D00962 Clomifene 1件: 74
25 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D07726 Clomifene 1件: 74
26 ESR2 7件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, GnRH secretion 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D00962 Clomifene 1件: 74
27 ESR2 7件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, GnRH secretion 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D07726 Clomifene 1件: 74
28 GHR 5件: Cytokine-cytokine receptor interaction 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Growth hormone synthesis, secretion and action 💬 D02691 Somatotropin 23件: 2, 3, 13, 19, 46, 65, 74, 75, 76, 78, 96, 107, 113, 187, 191, 193, 195, 236, 238, 265, 274, 276, 299
29 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00292 Dexamethasone 14件: 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
30 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00975 Dexamethasone 14件: 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
31 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01510 Dexamethasone 14件: 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
32 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01615 Dexamethasone 14件: 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
33 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01632 Dexamethasone 14件: 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
34 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01948 Dexamethasone 14件: 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
35 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D02174 Dexamethasone 14件: 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
36 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D02591 Dexamethasone 14件: 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
37 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D02592 Dexamethasone 14件: 74, 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
38 PRL 5件: Cytokine-cytokine receptor interaction 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Prolactin signaling pathway 💬 D00780 Bromocriptine 2件: 6, 74
39 PRL 5件: Cytokine-cytokine receptor interaction 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Prolactin signaling pathway 💬 D00987 Cabergoline 3件: 6, 74, 75
40 PRL 5件: Cytokine-cytokine receptor interaction 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Prolactin signaling pathway 💬 D03165 Bromocriptine 2件: 6, 74
41 SSTR1 3件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Growth hormone synthesis, secretion and action 💬 D10147 Pasireotide 3件: 67, 74, 75
42 SSTR2 4件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Growth hormone synthesis, secretion and action 💬, Gastric acid secretion 💬 D10147 Pasireotide 3件: 67, 74, 75
43 SSTR3 2件: Neuroactive ligand-receptor interaction 💬, Growth hormone synthesis, secretion and action 💬 D10147 Pasireotide 3件: 67, 74, 75
44 SSTR5 3件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Growth hormone synthesis, secretion and action 💬 D10147 Pasireotide 3件: 67, 74, 75