Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 HDAC6 4件: Neutrophil extracellular trap formation 💬, Amyotrophic lateral sclerosis 💬, Alcoholism 💬, Viral carcinogenesis 💬 D06320 Vorinostat 3件: 19, 75, 96
2 HDAC5 5件: Apelin signaling pathway 💬, Neutrophil extracellular trap formation 💬, Alcoholism 💬, Viral carcinogenesis 💬, MicroRNAs in cancer 💬 D06320 Vorinostat 3件: 19, 75, 96
3 CRHR1 4件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Long-term depression 💬, Cushing syndrome 💬 D03592 Corticorelin ovine triflutate 1件: 75
4 CRHR1 4件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Long-term depression 💬, Cushing syndrome 💬 D03905 Corticorelin 2件: 75, 205
5 CRHR2 3件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cushing syndrome 💬 D03592 Corticorelin ovine triflutate 1件: 75
6 CRHR2 3件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cushing syndrome 💬 D03905 Corticorelin 2件: 75, 205
7 CYP11B1 4件: Steroid hormone biosynthesis 💬, Metabolic pathways 💬, Cortisol synthesis and secretion 💬, Cushing syndrome 💬 D00410 Metyrapone 2件: 75, 193
8 CYP11B1 4件: Steroid hormone biosynthesis 💬, Metabolic pathways 💬, Cortisol synthesis and secretion 💬, Cushing syndrome 💬 D05019 Metyrapone 2件: 75, 193
9 CYP11B2 3件: Steroid hormone biosynthesis 💬, Metabolic pathways 💬, Aldosterone synthesis and secretion 💬 D11061 Osilodrostat 1件: 75
10 CYP17A1 6件: Steroid hormone biosynthesis 💬, Metabolic pathways 💬, Ovarian steroidogenesis 💬, Prolactin signaling pathway 💬, Cortisol synthesis and secretion 💬, Cushing syndrome 💬 D00351 Ketoconazole 3件: 8, 13, 75
11 DPP4 1件: Protein digestion and absorption 💬 D08516 Sitagliptin 3件: 75, 233, 299
12 DRD2 8件: Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Alcoholism 💬 D00987 Cabergoline 3件: 6, 74, 75
13 AGTR1 16件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Apelin signaling pathway 💬, Renin-angiotensin system 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Cushing syndrome 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Diabetic cardiomyopathy 💬 D00400 Valsartan 7件: 57, 58, 66, 75, 218, 222, 224
14 EGFR 48件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, MAPK signaling pathway 💬, ErbB signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, Phospholipase D signaling pathway 💬, Endocytosis 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Adherens junction 💬, Gap junction 💬, JAK-STAT signaling pathway 💬, Regulation of actin cytoskeleton 💬, GnRH signaling pathway 💬, Estrogen signaling pathway 💬, Oxytocin signaling pathway 💬, Relaxin signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Cushing syndrome 💬, Epithelial cell signaling in Helicobacter pylori infection 💬, Shigellosis 💬, Hepatitis C 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Colorectal cancer 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Glioma 💬, Prostate cancer 💬, Melanoma 💬, Bladder cancer 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 D01977 Gefitinib 1件: 75
15 EGFR 48件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, MAPK signaling pathway 💬, ErbB signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, Phospholipase D signaling pathway 💬, Endocytosis 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Adherens junction 💬, Gap junction 💬, JAK-STAT signaling pathway 💬, Regulation of actin cytoskeleton 💬, GnRH signaling pathway 💬, Estrogen signaling pathway 💬, Oxytocin signaling pathway 💬, Relaxin signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Cushing syndrome 💬, Epithelial cell signaling in Helicobacter pylori infection 💬, Shigellosis 💬, Hepatitis C 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Colorectal cancer 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Glioma 💬, Prostate cancer 💬, Melanoma 💬, Bladder cancer 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 D04024 Lapatinib 3件: 34, 74, 75
16 EGFR 48件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, MAPK signaling pathway 💬, ErbB signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, Phospholipase D signaling pathway 💬, Endocytosis 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Adherens junction 💬, Gap junction 💬, JAK-STAT signaling pathway 💬, Regulation of actin cytoskeleton 💬, GnRH signaling pathway 💬, Estrogen signaling pathway 💬, Oxytocin signaling pathway 💬, Relaxin signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Cushing syndrome 💬, Epithelial cell signaling in Helicobacter pylori infection 💬, Shigellosis 💬, Hepatitis C 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Colorectal cancer 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Glioma 💬, Prostate cancer 💬, Melanoma 💬, Bladder cancer 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 D08108 Lapatinib 3件: 34, 74, 75
17 ERBB2 22件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, Platinum drug resistance 💬, MAPK signaling pathway 💬, ErbB signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Adherens junction 💬, Tight junction 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Prostate cancer 💬, Bladder cancer 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬 D04024 Lapatinib 3件: 34, 74, 75
18 ERBB2 22件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, Platinum drug resistance 💬, MAPK signaling pathway 💬, ErbB signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Adherens junction 💬, Tight junction 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Prostate cancer 💬, Bladder cancer 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬 D08108 Lapatinib 3件: 34, 74, 75
19 F8 1件: Complement and coagulation cascades 💬 D00291 Desmopressin 3件: 75, 225, 288
20 F8 1件: Complement and coagulation cascades 💬 D02235 Desmopressin 3件: 75, 225, 288
21 F10 1件: Complement and coagulation cascades 💬 D07086 Rivaroxaban 3件: 75, 91, 210
22 GABRA1 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00225 Alprazolam 2件: 8, 75
23 GABRA1 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00549 Propofol 10件: 6, 21, 22, 34, 46, 70, 75, 84, 98, 296
24 GABRA2 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00225 Alprazolam 2件: 8, 75
25 GABRA2 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00549 Propofol 10件: 6, 21, 22, 34, 46, 70, 75, 84, 98, 296
26 GABRA3 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00225 Alprazolam 2件: 8, 75
27 GABRA3 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00549 Propofol 10件: 6, 21, 22, 34, 46, 70, 75, 84, 98, 296
28 GABRA4 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00225 Alprazolam 2件: 8, 75
29 GABRA4 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00549 Propofol 10件: 6, 21, 22, 34, 46, 70, 75, 84, 98, 296
30 GABRA5 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00225 Alprazolam 2件: 8, 75
31 GABRA5 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00549 Propofol 10件: 6, 21, 22, 34, 46, 70, 75, 84, 98, 296
32 GABRA6 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00225 Alprazolam 2件: 8, 75
33 GABRA6 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Taste transduction 💬, Morphine addiction 💬, Nicotine addiction 💬 D00549 Propofol 10件: 6, 21, 22, 34, 46, 70, 75, 84, 98, 296
34 GABRB1 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00225 Alprazolam 2件: 8, 75
35 GABRB1 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00549 Propofol 10件: 6, 21, 22, 34, 46, 70, 75, 84, 98, 296
36 GABRB2 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00225 Alprazolam 2件: 8, 75
37 GABRB2 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00549 Propofol 10件: 6, 21, 22, 34, 46, 70, 75, 84, 98, 296
38 GABRB3 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00225 Alprazolam 2件: 8, 75
39 GABRB3 6件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, Serotonergic synapse 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00549 Propofol 10件: 6, 21, 22, 34, 46, 70, 75, 84, 98, 296
40 GABRD 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00225 Alprazolam 2件: 8, 75
41 GABRD 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00549 Propofol 10件: 6, 21, 22, 34, 46, 70, 75, 84, 98, 296
42 GABRE 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00225 Alprazolam 2件: 8, 75
43 GABRE 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00549 Propofol 10件: 6, 21, 22, 34, 46, 70, 75, 84, 98, 296
44 GABRG1 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00225 Alprazolam 2件: 8, 75
45 GABRG1 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00549 Propofol 10件: 6, 21, 22, 34, 46, 70, 75, 84, 98, 296
46 GABRG2 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00225 Alprazolam 2件: 8, 75
47 GABRG2 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00549 Propofol 10件: 6, 21, 22, 34, 46, 70, 75, 84, 98, 296
48 GABRG3 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00225 Alprazolam 2件: 8, 75
49 GABRG3 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00549 Propofol 10件: 6, 21, 22, 34, 46, 70, 75, 84, 98, 296
50 GABRP 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00225 Alprazolam 2件: 8, 75
51 GABRP 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00549 Propofol 10件: 6, 21, 22, 34, 46, 70, 75, 84, 98, 296
52 GHR 5件: Cytokine-cytokine receptor interaction 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Growth hormone synthesis, secretion and action 💬 D02691 Somatotropin 23件: 2, 3, 13, 19, 46, 65, 74, 75, 76, 78, 96, 107, 113, 187, 191, 193, 195, 236, 238, 265, 274, 276, 299
53 GLP1R 3件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Insulin secretion 💬 D06404 Liraglutide 3件: 6, 75, 193
54 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00088 Hydrocortisone 7件: 75, 78, 81, 83, 97, 98, 299
55 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00292 Dexamethasone 13件: 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
56 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00472 Prednisolone 18件: 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
57 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00585 Mifepristone 1件: 75
58 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00975 Dexamethasone 13件: 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
59 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00980 Prednisolone 18件: 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
60 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00981 Prednisolone 18件: 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
61 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00982 Prednisolone 18件: 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
62 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01239 Prednisolone 18件: 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
63 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01510 Dexamethasone 13件: 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
64 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01615 Dexamethasone 13件: 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
65 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01632 Dexamethasone 13件: 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
66 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01948 Dexamethasone 13件: 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
67 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D01998 Prednisolone 18件: 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
68 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D02156 Prednisolone 18件: 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
69 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D02174 Dexamethasone 13件: 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
70 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D02591 Dexamethasone 13件: 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
71 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D02592 Dexamethasone 13件: 75, 81, 84, 90, 96, 97, 162, 222, 235, 257, 283, 296, 299
72 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D03301 Prednisolone 18件: 75, 81, 84, 85, 95, 96, 97, 107, 113, 145, 162, 222, 269, 271, 296, 299, 300, 307
73 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D11336 Relacorilant 1件: 75
74 HDAC1 15件: Cell cycle 💬, Longevity regulating pathway - multiple species 💬, Notch signaling pathway 💬, Neutrophil extracellular trap formation 💬, Thyroid hormone signaling pathway 💬, Huntington disease 💬, Amphetamine addiction 💬, Alcoholism 💬, Human papillomavirus infection 💬, Epstein-Barr virus infection 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Viral carcinogenesis 💬, MicroRNAs in cancer 💬, Chronic myeloid leukemia 💬 D06320 Vorinostat 3件: 19, 75, 96
75 HDAC2 15件: Cell cycle 💬, Longevity regulating pathway - multiple species 💬, Notch signaling pathway 💬, Neutrophil extracellular trap formation 💬, Thyroid hormone signaling pathway 💬, Huntington disease 💬, Amphetamine addiction 💬, Alcoholism 💬, Human papillomavirus infection 💬, Epstein-Barr virus infection 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Viral carcinogenesis 💬, MicroRNAs in cancer 💬, Chronic myeloid leukemia 💬 D06320 Vorinostat 3件: 19, 75, 96
76 MC2R 5件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, Cushing syndrome 💬 D00146 Corticotropin 15件: 2, 13, 14, 46, 49, 50, 66, 75, 78, 81, 84, 145, 193, 205, 222
77 NR3C2 1件: Aldosterone-regulated sodium reabsorption 💬 D01115 Eplerenone 4件: 75, 113, 210, 215
78 HDAC7 3件: Neutrophil extracellular trap formation 💬, Alcoholism 💬, Viral carcinogenesis 💬 D06320 Vorinostat 3件: 19, 75, 96
79 PGR 5件: Oocyte meiosis 💬, Progesterone-mediated oocyte maturation 💬, Estrogen signaling pathway 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D00585 Mifepristone 1件: 75
80 PML 7件: Ubiquitin mediated proteolysis 💬, Endocytosis 💬, Influenza A 💬, Herpes simplex virus 1 infection 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Acute myeloid leukemia 💬 D00094 Tretinoin 6件: 2, 62, 63, 75, 94, 231
81 PPARG 11件: PPAR signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Osteoclast differentiation 💬, Thermogenesis 💬, Non-alcoholic fatty liver disease 💬, Huntington disease 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Thyroid cancer 💬, Lipid and atherosclerosis 💬 D00596 Rosiglitazone 5件: 46, 75, 97, 222, 265
82 PPARG 11件: PPAR signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Osteoclast differentiation 💬, Thermogenesis 💬, Non-alcoholic fatty liver disease 💬, Huntington disease 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Thyroid cancer 💬, Lipid and atherosclerosis 💬 D08491 Rosiglitazone 5件: 46, 75, 97, 222, 265
83 AVPR2 3件: Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vasopressin-regulated water reabsorption 💬 D00291 Desmopressin 6件: 6, 64, 72, 75, 225, 288
84 AVPR2 3件: Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vasopressin-regulated water reabsorption 💬 D02235 Desmopressin 6件: 6, 64, 72, 75, 225, 288
85 PRKAA1 20件: FoxO signaling pathway 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Apelin signaling pathway 💬, Tight junction 💬, Circadian rhythm 💬, Thermogenesis 💬, Insulin signaling pathway 💬, Adipocytokine signaling pathway 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, Alcoholic liver disease 💬, Hypertrophic cardiomyopathy 💬, Fluid shear stress and atherosclerosis 💬 D00944 Metformin 24件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
86 PRKAA1 20件: FoxO signaling pathway 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Apelin signaling pathway 💬, Tight junction 💬, Circadian rhythm 💬, Thermogenesis 💬, Insulin signaling pathway 💬, Adipocytokine signaling pathway 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, Alcoholic liver disease 💬, Hypertrophic cardiomyopathy 💬, Fluid shear stress and atherosclerosis 💬 D04966 Metformin 24件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
87 PRKAA2 20件: FoxO signaling pathway 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Apelin signaling pathway 💬, Tight junction 💬, Circadian rhythm 💬, Thermogenesis 💬, Insulin signaling pathway 💬, Adipocytokine signaling pathway 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, Alcoholic liver disease 💬, Hypertrophic cardiomyopathy 💬, Fluid shear stress and atherosclerosis 💬 D00944 Metformin 24件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
88 PRKAA2 20件: FoxO signaling pathway 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Apelin signaling pathway 💬, Tight junction 💬, Circadian rhythm 💬, Thermogenesis 💬, Insulin signaling pathway 💬, Adipocytokine signaling pathway 💬, Oxytocin signaling pathway 💬, Glucagon signaling pathway 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, Alcoholic liver disease 💬, Hypertrophic cardiomyopathy 💬, Fluid shear stress and atherosclerosis 💬 D04966 Metformin 24件: 2, 6, 8, 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 225, 233, 265, 285, 299, 301
89 HDAC8 3件: Neutrophil extracellular trap formation 💬, Alcoholism 💬, Viral carcinogenesis 💬 D06320 Vorinostat 3件: 19, 75, 96
90 GABRQ 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00225 Alprazolam 2件: 8, 75
91 GABRQ 5件: Neuroactive ligand-receptor interaction 💬, Retrograde endocannabinoid signaling 💬, GABAergic synapse 💬, Morphine addiction 💬, Nicotine addiction 💬 D00549 Propofol 10件: 6, 21, 22, 34, 46, 70, 75, 84, 98, 296
92 PRL 5件: Cytokine-cytokine receptor interaction 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Prolactin signaling pathway 💬 D00987 Cabergoline 3件: 6, 74, 75
93 RARA 5件: Th17 cell differentiation 💬, Estrogen signaling pathway 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Acute myeloid leukemia 💬 D00094 Tretinoin 6件: 2, 62, 63, 75, 94, 231
94 RARB 4件: Pathways in cancer 💬, Small cell lung cancer 💬, Non-small cell lung cancer 💬, Gastric cancer 💬 D00094 Tretinoin 6件: 2, 62, 63, 75, 94, 231
95 RXRA 17件: PPAR signaling pathway 💬, PI3K-Akt signaling pathway 💬, Th17 cell differentiation 💬, Thyroid hormone signaling pathway 💬, Adipocytokine signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Non-alcoholic fatty liver disease 💬, Bile secretion 💬, Hepatitis C 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Thyroid cancer 💬, Small cell lung cancer 💬, Non-small cell lung cancer 💬, Gastric cancer 💬, Lipid and atherosclerosis 💬 D03106 Bexarotene 2件: 13, 75
96 RXRB 13件: PPAR signaling pathway 💬, Th17 cell differentiation 💬, Thyroid hormone signaling pathway 💬, Adipocytokine signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Thyroid cancer 💬, Small cell lung cancer 💬, Non-small cell lung cancer 💬, Gastric cancer 💬, Lipid and atherosclerosis 💬 D03106 Bexarotene 2件: 13, 75
97 RXRG 13件: PPAR signaling pathway 💬, Th17 cell differentiation 💬, Thyroid hormone signaling pathway 💬, Adipocytokine signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Thyroid cancer 💬, Small cell lung cancer 💬, Non-small cell lung cancer 💬, Gastric cancer 💬, Lipid and atherosclerosis 💬 D03106 Bexarotene 2件: 13, 75
98 SSTR1 3件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Growth hormone synthesis, secretion and action 💬 D10147 Pasireotide 3件: 67, 74, 75
99 SSTR2 4件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Growth hormone synthesis, secretion and action 💬, Gastric acid secretion 💬 D00442 Octreotide 7件: 67, 75, 84, 85, 89, 193, 227
100 SSTR2 4件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Growth hormone synthesis, secretion and action 💬, Gastric acid secretion 💬 D06495 Octreotide 7件: 67, 75, 84, 85, 89, 193, 227
101 SSTR2 4件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Growth hormone synthesis, secretion and action 💬, Gastric acid secretion 💬 D10147 Pasireotide 3件: 67, 74, 75
102 SSTR3 2件: Neuroactive ligand-receptor interaction 💬, Growth hormone synthesis, secretion and action 💬 D10147 Pasireotide 3件: 67, 74, 75
103 SSTR5 3件: cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Growth hormone synthesis, secretion and action 💬 D10147 Pasireotide 3件: 67, 74, 75
104 VDR 5件: Parathyroid hormone synthesis, secretion and action 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Mineral absorption 💬, Tuberculosis 💬, Chemical carcinogenesis - receptor activation 💬 D00188 Cholecalciferol 25件: 6, 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 75, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299
105 HDAC11 3件: Neutrophil extracellular trap formation 💬, Alcoholism 💬, Viral carcinogenesis 💬 D06320 Vorinostat 3件: 19, 75, 96
106 HDAC10 3件: Neutrophil extracellular trap formation 💬, Alcoholism 💬, Viral carcinogenesis 💬 D06320 Vorinostat 3件: 19, 75, 96
107 PDE5A 3件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬 D02008 Tadalafil 7件: 6, 51, 75, 84, 86, 113, 210
108 HDAC3 4件: Neutrophil extracellular trap formation 💬, Thyroid hormone signaling pathway 💬, Alcoholism 💬, Viral carcinogenesis 💬 D06320 Vorinostat 3件: 19, 75, 96
109 HDAC9 3件: Neutrophil extracellular trap formation 💬, Alcoholism 💬, Viral carcinogenesis 💬 D06320 Vorinostat 3件: 19, 75, 96
110 HDAC4 5件: Apelin signaling pathway 💬, Neutrophil extracellular trap formation 💬, Alcoholism 💬, Viral carcinogenesis 💬, MicroRNAs in cancer 💬 D06320 Vorinostat 3件: 19, 75, 96