Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D00105 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299
2 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D01413 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299
3 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D01617 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299
4 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D01953 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299
5 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D04061 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299
6 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D04063 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299
7 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D04064 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299
8 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D04065 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299
9 ESR2 7件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, GnRH secretion 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D00105 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299
10 ESR2 7件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, GnRH secretion 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D01413 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299
11 ESR2 7件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, GnRH secretion 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D01617 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299
12 ESR2 7件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, GnRH secretion 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D01953 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299
13 ESR2 7件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, GnRH secretion 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D04061 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299
14 ESR2 7件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, GnRH secretion 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D04063 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299
15 ESR2 7件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, GnRH secretion 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D04064 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299
16 ESR2 7件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, GnRH secretion 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D04065 Estradiol 7件: 13, 46, 49, 65, 76, 226, 299
17 GHR 5件: Cytokine-cytokine receptor interaction 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Growth hormone synthesis, secretion and action 💬 D02691 Somatotropin 23件: 2, 3, 13, 19, 46, 65, 74, 75, 76, 78, 96, 107, 113, 187, 191, 193, 195, 236, 238, 265, 274, 276, 299
18 GNRHR 2件: Neuroactive ligand-receptor interaction 💬, GnRH signaling pathway 💬 D00988 Gonadorelin 1件: 76
19 GNRHR 2件: Neuroactive ligand-receptor interaction 💬, GnRH signaling pathway 💬 D00989 Leuprolide 5件: 1, 2, 3, 51, 76
20 GNRHR 2件: Neuroactive ligand-receptor interaction 💬, GnRH signaling pathway 💬 D02369 Histrelin 1件: 76
21 GNRHR 2件: Neuroactive ligand-receptor interaction 💬, GnRH signaling pathway 💬 D03267 Gonadorelin 1件: 76
22 GNRHR 2件: Neuroactive ligand-receptor interaction 💬, GnRH signaling pathway 💬 D04361 Gonadorelin 1件: 76
23 GNRHR 2件: Neuroactive ligand-receptor interaction 💬, GnRH signaling pathway 💬 D06247 Triptorelin 2件: 49, 76
24 GNRHR 2件: Neuroactive ligand-receptor interaction 💬, GnRH signaling pathway 💬 D08027 Gonadorelin 1件: 76
25 AR 4件: Oocyte meiosis 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Prostate cancer 💬 D00075 Testosterone 9件: 1, 2, 3, 13, 60, 76, 78, 113, 265
26 AR 4件: Oocyte meiosis 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Prostate cancer 💬 D00957 Testosterone 9件: 1, 2, 3, 13, 60, 76, 78, 113, 265
27 AR 4件: Oocyte meiosis 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Prostate cancer 💬 D00958 Testosterone 9件: 1, 2, 3, 13, 60, 76, 78, 113, 265
28 AR 4件: Oocyte meiosis 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Prostate cancer 💬 D00959 Testosterone 9件: 1, 2, 3, 13, 60, 76, 78, 113, 265
29 AR 4件: Oocyte meiosis 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Prostate cancer 💬 D06085 Testosterone 9件: 1, 2, 3, 13, 60, 76, 78, 113, 265
30 AR 4件: Oocyte meiosis 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Prostate cancer 💬 D06087 Testosterone 9件: 1, 2, 3, 13, 60, 76, 78, 113, 265
31 PGR 5件: Oocyte meiosis 💬, Progesterone-mediated oocyte maturation 💬, Estrogen signaling pathway 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D00066 Progesterone 1件: 76
32 PGR 5件: Oocyte meiosis 💬, Progesterone-mediated oocyte maturation 💬, Estrogen signaling pathway 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D00952 Megestrol acetate 1件: 76
33 PGR 5件: Oocyte meiosis 💬, Progesterone-mediated oocyte maturation 💬, Estrogen signaling pathway 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D08167 Megestrol acetate 1件: 76