Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 PARP2 2件: Base excision repair 💬, Apoptosis 💬 D09730 Olaparib 2件: 86, 285
2 CA5B 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D00218 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
3 CA5B 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D01196 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
4 CHRM1 8件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D02212 Ipratropium 2件: 6, 86
5 CHRM2 6件: Calcium signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, PI3K-Akt signaling pathway 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬 D02212 Ipratropium 2件: 6, 86
6 CHRM3 11件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Taste transduction 💬, Regulation of actin cytoskeleton 💬, Insulin secretion 💬, Salivary secretion 💬, Gastric acid secretion 💬, Pancreatic secretion 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D02212 Ipratropium 2件: 6, 86
7 CHRM4 3件: Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬 D02212 Ipratropium 2件: 6, 86
8 CHRM5 6件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Cholinergic synapse 💬, Regulation of actin cytoskeleton 💬, Alzheimer disease 💬, Pathways of neurodegeneration - multiple diseases 💬 D02212 Ipratropium 2件: 6, 86
9 PARP1 5件: Base excision repair 💬, NF-kappa B signaling pathway 💬, Apoptosis 💬, Necroptosis 💬, Diabetic cardiomyopathy 💬 D09730 Olaparib 2件: 86, 285
10 ADRA1D 6件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Salivary secretion 💬 D00255 Carvedilol 5件: 6, 57, 86, 113, 210
11 ADRA1D 6件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Salivary secretion 💬 D03415 Carvedilol 5件: 6, 57, 86, 113, 210
12 ADRA1B 6件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Salivary secretion 💬 D00255 Carvedilol 5件: 6, 57, 86, 113, 210
13 ADRA1B 6件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Salivary secretion 💬 D03415 Carvedilol 5件: 6, 57, 86, 113, 210
14 ADRA1A 7件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, AMPK signaling pathway 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Salivary secretion 💬 D00255 Carvedilol 5件: 6, 57, 86, 113, 210
15 ADRA1A 7件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, AMPK signaling pathway 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Salivary secretion 💬 D03415 Carvedilol 5件: 6, 57, 86, 113, 210
16 ADRB1 11件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Gap junction 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬, Dilated cardiomyopathy 💬 D00255 Carvedilol 5件: 6, 57, 86, 113, 210
17 ADRB1 11件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Gap junction 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬, Dilated cardiomyopathy 💬 D00634 Bisoprolol 3件: 67, 86, 113
18 ADRB1 11件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Gap junction 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬, Dilated cardiomyopathy 💬 D02342 Bisoprolol 3件: 67, 86, 113
19 ADRB1 11件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Gap junction 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬, Dilated cardiomyopathy 💬 D03415 Carvedilol 5件: 6, 57, 86, 113, 210
20 ADRB2 9件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬 D00255 Carvedilol 5件: 6, 57, 86, 113, 210
21 ADRB2 9件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬 D02147 Salbutamol 14件: 3, 11, 12, 13, 49, 85, 86, 89, 111, 113, 228, 231, 256, 299
22 ADRB2 9件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Regulation of lipolysis in adipocytes 💬, Renin secretion 💬, Salivary secretion 💬, Chemical carcinogenesis - receptor activation 💬 D03415 Carvedilol 5件: 6, 57, 86, 113, 210
23 CYP19A1 3件: Steroid hormone biosynthesis 💬, Metabolic pathways 💬, Ovarian steroidogenesis 💬 D00960 Anastrozole 3件: 78, 86, 193
24 ACE 6件: Renin-angiotensin system 💬, Renin secretion 💬, Chagas disease 💬, Coronavirus disease - COVID-19 💬, Hypertrophic cardiomyopathy 💬, Diabetic cardiomyopathy 💬 D00251 Captopril 8件: 6, 17, 46, 86, 96, 97, 107, 271
25 NQO1 7件: Ubiquinone and other terpenoid-quinone biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Pathways in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Hepatocellular carcinoma 💬, Fluid shear stress and atherosclerosis 💬 D00564 Warfarin 13件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
26 NQO1 7件: Ubiquinone and other terpenoid-quinone biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Pathways in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Hepatocellular carcinoma 💬, Fluid shear stress and atherosclerosis 💬 D01280 Warfarin 13件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
27 NQO1 7件: Ubiquinone and other terpenoid-quinone biosynthesis 💬, Metabolic pathways 💬, Biosynthesis of cofactors 💬, Pathways in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Hepatocellular carcinoma 💬, Fluid shear stress and atherosclerosis 💬 D08682 Warfarin 13件: 6, 8, 13, 19, 46, 49, 66, 85, 86, 88, 91, 96, 97
28 DRD2 8件: Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Alcoholism 💬 D01348 Terguride 2件: 51, 86
29 DRD2 8件: Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Alcoholism 💬 D01462 Lisuride 2件: 6, 86
30 DRD2 8件: Rap1 signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gap junction 💬, Dopaminergic synapse 💬, Parkinson disease 💬, Cocaine addiction 💬, Alcoholism 💬 D08132 Lisuride 2件: 6, 86
31 DRD3 2件: Neuroactive ligand-receptor interaction 💬, Dopaminergic synapse 💬 D01462 Lisuride 2件: 6, 86
32 DRD3 2件: Neuroactive ligand-receptor interaction 💬, Dopaminergic synapse 💬 D08132 Lisuride 2件: 6, 86
33 DRD4 2件: Neuroactive ligand-receptor interaction 💬, Dopaminergic synapse 💬 D01462 Lisuride 2件: 6, 86
34 DRD4 2件: Neuroactive ligand-receptor interaction 💬, Dopaminergic synapse 💬 D08132 Lisuride 2件: 6, 86
35 AGTR1 16件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Apelin signaling pathway 💬, Renin-angiotensin system 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Cushing syndrome 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Diabetic cardiomyopathy 💬 D00150 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224
36 AGTR1 16件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Phospholipase D signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Vascular smooth muscle contraction 💬, Apelin signaling pathway 💬, Renin-angiotensin system 💬, Renin secretion 💬, Aldosterone synthesis and secretion 💬, Cortisol synthesis and secretion 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Cushing syndrome 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Diabetic cardiomyopathy 💬 D02014 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224
37 AGTR2 3件: Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Renin-angiotensin system 💬 D00150 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224
38 AGTR2 3件: Neuroactive ligand-receptor interaction 💬, Adrenergic signaling in cardiomyocytes 💬, Renin-angiotensin system 💬 D02014 Angiotensin II 7件: 17, 19, 46, 66, 86, 222, 224
39 EDNRA 7件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vascular smooth muscle contraction 💬, Renin secretion 💬, Pathways in cancer 💬 D01227 Bosentan 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212
40 EDNRA 7件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vascular smooth muscle contraction 💬, Renin secretion 💬, Pathways in cancer 💬 D07077 Ambrisentan 7件: 51, 84, 85, 86, 88, 210, 211
41 EDNRA 7件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vascular smooth muscle contraction 💬, Renin secretion 💬, Pathways in cancer 💬 D07171 Sitaxentan 1件: 86
42 EDNRA 7件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vascular smooth muscle contraction 💬, Renin secretion 💬, Pathways in cancer 💬 D07538 Bosentan 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212
43 EDNRA 7件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, cAMP signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Vascular smooth muscle contraction 💬, Renin secretion 💬, Pathways in cancer 💬 D10135 Macitentan 5件: 51, 85, 86, 88, 210
44 EDNRB 6件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Melanogenesis 💬, Relaxin signaling pathway 💬, Pathways in cancer 💬 D01227 Bosentan 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212
45 EDNRB 6件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Melanogenesis 💬, Relaxin signaling pathway 💬, Pathways in cancer 💬 D07538 Bosentan 11件: 13, 41, 47, 51, 84, 85, 86, 88, 210, 211, 212
46 EDNRB 6件: Calcium signaling pathway 💬, cGMP-PKG signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Melanogenesis 💬, Relaxin signaling pathway 💬, Pathways in cancer 💬 D10135 Macitentan 5件: 51, 85, 86, 88, 210
47 EGFR 48件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, MAPK signaling pathway 💬, ErbB signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, Phospholipase D signaling pathway 💬, Endocytosis 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Adherens junction 💬, Gap junction 💬, JAK-STAT signaling pathway 💬, Regulation of actin cytoskeleton 💬, GnRH signaling pathway 💬, Estrogen signaling pathway 💬, Oxytocin signaling pathway 💬, Relaxin signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Cushing syndrome 💬, Epithelial cell signaling in Helicobacter pylori infection 💬, Shigellosis 💬, Hepatitis C 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Colorectal cancer 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Glioma 💬, Prostate cancer 💬, Melanoma 💬, Bladder cancer 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 D03455 Cetuximab 5件: 34, 51, 86, 89, 331
48 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D00966 Tamoxifen 4件: 2, 86, 113, 227
49 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D01161 Fulvestrant 2件: 49, 86
50 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D08409 Prasterone 6件: 49, 53, 83, 86, 96, 113
51 ESR1 9件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Endocrine and other factor-regulated calcium reabsorption 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D08559 Tamoxifen 4件: 2, 86, 113, 227
52 ESR2 7件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, GnRH secretion 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D00966 Tamoxifen 4件: 2, 86, 113, 227
53 ESR2 7件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, GnRH secretion 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D01161 Fulvestrant 2件: 49, 86
54 ESR2 7件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, GnRH secretion 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D08409 Prasterone 6件: 49, 53, 83, 86, 96, 113
55 ESR2 7件: Endocrine resistance 💬, Estrogen signaling pathway 💬, Prolactin signaling pathway 💬, GnRH secretion 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Breast cancer 💬 D08559 Tamoxifen 4件: 2, 86, 113, 227
56 FLT3 8件: MAPK signaling pathway 💬, Ras signaling pathway 💬, PI3K-Akt signaling pathway 💬, Hematopoietic cell lineage 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Acute myeloid leukemia 💬, Central carbon metabolism in cancer 💬 D06272 Sorafenib 2件: 34, 86
57 FLT3 8件: MAPK signaling pathway 💬, Ras signaling pathway 💬, PI3K-Akt signaling pathway 💬, Hematopoietic cell lineage 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Acute myeloid leukemia 💬, Central carbon metabolism in cancer 💬 D08524 Sorafenib 2件: 34, 86
58 FLT4 8件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Pathways in cancer 💬, Breast cancer 💬 D06272 Sorafenib 2件: 34, 86
59 FLT4 8件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Pathways in cancer 💬, Breast cancer 💬 D08524 Sorafenib 2件: 34, 86
60 CA14 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D00218 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
61 CA14 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D01196 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
62 MTOR 51件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, ErbB signaling pathway 💬, HIF-1 signaling pathway 💬, Phospholipase D signaling pathway 💬, Autophagy - other 💬, Autophagy - animal 💬, mTOR signaling pathway 💬, PI3K-Akt signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Longevity regulating pathway - multiple species 💬, Cellular senescence 💬, Apelin signaling pathway 💬, Neutrophil extracellular trap formation 💬, JAK-STAT signaling pathway 💬, Th17 cell differentiation 💬, Thermogenesis 💬, Insulin signaling pathway 💬, Thyroid hormone signaling pathway 💬, Adipocytokine signaling pathway 💬, Type II diabetes mellitus 💬, Insulin resistance 💬, Growth hormone synthesis, secretion and action 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Pathways of neurodegeneration - multiple diseases 💬, Shigellosis 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Herpes simplex virus 1 infection 💬, Human immunodeficiency virus 1 infection 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Colorectal cancer 💬, Pancreatic cancer 💬, Glioma 💬, Prostate cancer 💬, Acute myeloid leukemia 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬, Diabetic cardiomyopathy 💬 D00753 Sirolimus 41件: 2, 6, 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 127, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 285, 331
63 ABL1 11件: ErbB signaling pathway 💬, Ras signaling pathway 💬, Cell cycle 💬, Axon guidance 💬, Neurotrophin signaling pathway 💬, Pathogenic Escherichia coli infection 💬, Pathways in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Chronic myeloid leukemia 💬, Viral myocarditis 💬 D01441 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
64 ABL1 11件: ErbB signaling pathway 💬, Ras signaling pathway 💬, Cell cycle 💬, Axon guidance 💬, Neurotrophin signaling pathway 💬, Pathogenic Escherichia coli infection 💬, Pathways in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Chronic myeloid leukemia 💬, Viral myocarditis 💬 D08066 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
65 ABL1 11件: ErbB signaling pathway 💬, Ras signaling pathway 💬, Cell cycle 💬, Axon guidance 💬, Neurotrophin signaling pathway 💬, Pathogenic Escherichia coli infection 💬, Pathways in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - reactive oxygen species 💬, Chronic myeloid leukemia 💬, Viral myocarditis 💬 D08953 Nilotinib 5件: 6, 8, 34, 51, 86
66 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00407 Methylprednisolone 19件: 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
67 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00473 Prednisone 20件: 86, 95, 96, 97, 113, 127, 162, 164, 205, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331
68 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00751 Methylprednisolone 19件: 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
69 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00979 Methylprednisolone 19件: 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
70 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D05000 Methylprednisolone 19件: 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
71 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D05001 Methylprednisolone 19件: 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
72 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D05002 Methylprednisolone 19件: 86, 93, 95, 96, 97, 127, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296, 300
73 ANPEP 4件: Glutathione metabolism 💬, Metabolic pathways 💬, Renin-angiotensin system 💬, Hematopoietic cell lineage 💬 D00087 Ubenimex 1件: 86
74 GUCY1A2 11件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, Vascular smooth muscle contraction 💬, Gap junction 💬, Platelet activation 💬, Circadian entrainment 💬, Long-term depression 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Salivary secretion 💬 D09572 Riociguat 6件: 51, 84, 86, 88, 225, 299
75 GUCY1A1 11件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, Vascular smooth muscle contraction 💬, Gap junction 💬, Platelet activation 💬, Circadian entrainment 💬, Long-term depression 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Salivary secretion 💬 D09572 Riociguat 6件: 51, 84, 86, 88, 225, 299
76 GUCY1B1 11件: Purine metabolism 💬, Metabolic pathways 💬, cGMP-PKG signaling pathway 💬, Vascular smooth muscle contraction 💬, Gap junction 💬, Platelet activation 💬, Circadian entrainment 💬, Long-term depression 💬, Oxytocin signaling pathway 💬, Renin secretion 💬, Salivary secretion 💬 D09572 Riociguat 6件: 51, 84, 86, 88, 225, 299
77 HMGCR 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, AMPK signaling pathway 💬, Bile secretion 💬 D00434 Simvastatin 21件: 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
78 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D00300 Diphenhydramine 10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
79 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D00669 Diphenhydramine 10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
80 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D02419 Diphenhydramine 10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
81 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D03285 Diphenhydramine 10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
82 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D03360 Diphenhydramine 10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
83 HRH1 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Inflammatory mediator regulation of TRP channels 💬 D03854 Diphenhydramine 10件: 11, 13, 49, 51, 70, 86, 96, 222, 256, 300
84 HRH2 3件: Calcium signaling pathway 💬, Neuroactive ligand-receptor interaction 💬, Gastric acid secretion 💬 D00318 Famotidine 7件: 6, 46, 61, 86, 98, 107, 300
85 IL1R1 13件: MAPK signaling pathway 💬, Cytokine-cytokine receptor interaction 💬, NF-kappa B signaling pathway 💬, Osteoclast differentiation 💬, Hematopoietic cell lineage 💬, Th17 cell differentiation 💬, Inflammatory mediator regulation of TRP channels 💬, Pathogenic Escherichia coli infection 💬, Shigellosis 💬, Amoebiasis 💬, Human cytomegalovirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Fluid shear stress and atherosclerosis 💬 D02934 Anakinra 19件: 2, 13, 15, 19, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299
86 IL6R 12件: EGFR tyrosine kinase inhibitor resistance 💬, Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, HIF-1 signaling pathway 💬, PI3K-Akt signaling pathway 💬, JAK-STAT signaling pathway 💬, Hematopoietic cell lineage 💬, Th17 cell differentiation 💬, Non-alcoholic fatty liver disease 💬, Human cytomegalovirus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬 D02596 Tocilizumab 21件: 2, 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331
87 AR 4件: Oocyte meiosis 💬, Pathways in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Prostate cancer 💬 D08409 Prasterone 6件: 49, 53, 83, 86, 96, 113
88 CA13 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D00218 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
89 CA13 2件: Nitrogen metabolism 💬, Metabolic pathways 💬 D01196 Acetazolamide 8件: 13, 86, 90, 115, 154, 155, 225, 230
90 KDR 10件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, VEGF signaling pathway 💬, Focal adhesion 💬, Proteoglycans in cancer 💬, Fluid shear stress and atherosclerosis 💬 D06272 Sorafenib 2件: 34, 86
91 KDR 10件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, PI3K-Akt signaling pathway 💬, VEGF signaling pathway 💬, Focal adhesion 💬, Proteoglycans in cancer 💬, Fluid shear stress and atherosclerosis 💬 D08524 Sorafenib 2件: 34, 86
92 KIT 11件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Phospholipase D signaling pathway 💬, PI3K-Akt signaling pathway 💬, Hematopoietic cell lineage 💬, Melanogenesis 💬, Pathways in cancer 💬, Acute myeloid leukemia 💬, Breast cancer 💬, Central carbon metabolism in cancer 💬 D01441 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
93 KIT 11件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Phospholipase D signaling pathway 💬, PI3K-Akt signaling pathway 💬, Hematopoietic cell lineage 💬, Melanogenesis 💬, Pathways in cancer 💬, Acute myeloid leukemia 💬, Breast cancer 💬, Central carbon metabolism in cancer 💬 D06272 Sorafenib 2件: 34, 86
94 KIT 11件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Phospholipase D signaling pathway 💬, PI3K-Akt signaling pathway 💬, Hematopoietic cell lineage 💬, Melanogenesis 💬, Pathways in cancer 💬, Acute myeloid leukemia 💬, Breast cancer 💬, Central carbon metabolism in cancer 💬 D08066 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
95 KIT 11件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Phospholipase D signaling pathway 💬, PI3K-Akt signaling pathway 💬, Hematopoietic cell lineage 💬, Melanogenesis 💬, Pathways in cancer 💬, Acute myeloid leukemia 💬, Breast cancer 💬, Central carbon metabolism in cancer 💬 D08524 Sorafenib 2件: 34, 86
96 KIT 11件: MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Phospholipase D signaling pathway 💬, PI3K-Akt signaling pathway 💬, Hematopoietic cell lineage 💬, Melanogenesis 💬, Pathways in cancer 💬, Acute myeloid leukemia 💬, Breast cancer 💬, Central carbon metabolism in cancer 💬 D08953 Nilotinib 5件: 6, 8, 34, 51, 86
97 MAP3K5 20件: Platinum drug resistance 💬, MAPK signaling pathway 💬, Sphingolipid signaling pathway 💬, Protein processing in endoplasmic reticulum 💬, Apoptosis 💬, Tight junction 💬, TNF signaling pathway 💬, Thermogenesis 💬, Neurotrophin signaling pathway 💬, Non-alcoholic fatty liver disease 💬, Alcoholic liver disease 💬, Alzheimer disease 💬, Parkinson disease 💬, Amyotrophic lateral sclerosis 💬, Huntington disease 💬, Spinocerebellar ataxia 💬, Pathways of neurodegeneration - multiple diseases 💬, Chemical carcinogenesis - reactive oxygen species 💬, Lipid and atherosclerosis 💬, Fluid shear stress and atherosclerosis 💬 D10988 Selonsertib 1件: 86
98 NR3C2 1件: Aldosterone-regulated sodium reabsorption 💬 D00443 Spironolactone 5件: 86, 113, 210, 218, 225
99 ATP4A 4件: Oxidative phosphorylation 💬, Metabolic pathways 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬 D01984 Esomeprazole 8件: 13, 46, 86, 98, 107, 113, 298, 299
100 ATP4A 4件: Oxidative phosphorylation 💬, Metabolic pathways 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬 D04056 Esomeprazole 8件: 13, 46, 86, 98, 107, 113, 298, 299
101 ATP4A 4件: Oxidative phosphorylation 💬, Metabolic pathways 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬 D07917 Esomeprazole 8件: 13, 46, 86, 98, 107, 113, 298, 299
102 ATP4A 4件: Oxidative phosphorylation 💬, Metabolic pathways 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬 D09339 Esomeprazole 8件: 13, 46, 86, 98, 107, 113, 298, 299
103 ATP4B 4件: Oxidative phosphorylation 💬, Metabolic pathways 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬 D01984 Esomeprazole 8件: 13, 46, 86, 98, 107, 113, 298, 299
104 ATP4B 4件: Oxidative phosphorylation 💬, Metabolic pathways 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬 D04056 Esomeprazole 8件: 13, 46, 86, 98, 107, 113, 298, 299
105 ATP4B 4件: Oxidative phosphorylation 💬, Metabolic pathways 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬 D07917 Esomeprazole 8件: 13, 46, 86, 98, 107, 113, 298, 299
106 ATP4B 4件: Oxidative phosphorylation 💬, Metabolic pathways 💬, Collecting duct acid secretion 💬, Gastric acid secretion 💬 D09339 Esomeprazole 8件: 13, 46, 86, 98, 107, 113, 298, 299
107 OPRM1 3件: Neuroactive ligand-receptor interaction 💬, Estrogen signaling pathway 💬, Morphine addiction 💬 D00842 Morphine 6件: 36, 46, 70, 85, 86, 298
108 OPRM1 3件: Neuroactive ligand-receptor interaction 💬, Estrogen signaling pathway 💬, Morphine addiction 💬 D02271 Morphine 6件: 36, 46, 70, 85, 86, 298
109 OPRM1 3件: Neuroactive ligand-receptor interaction 💬, Estrogen signaling pathway 💬, Morphine addiction 💬 D08233 Morphine 6件: 36, 46, 70, 85, 86, 298
110 PDGFRA 20件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, Phospholipase D signaling pathway 💬, Endocytosis 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Gap junction 💬, JAK-STAT signaling pathway 💬, Regulation of actin cytoskeleton 💬, Human cytomegalovirus infection 💬, Pathways in cancer 💬, MicroRNAs in cancer 💬, Glioma 💬, Prostate cancer 💬, Melanoma 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬 D01441 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162
111 PDGFRA 20件: EGFR tyrosine kinase inhibitor resistance 💬, MAPK signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬,