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KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
指定難病告示番号
1
CCR5
💬
1. CCR5
×
Name
Full Name
CCR5
C-C motif chemokine receptor 5
11件:
Viral life cycle - HIV-1
Viral life cycle - HIV-1
,
Virion - Human immunodeficiency virus
,
Cytokine-cytokine receptor interaction
,
Viral protein interaction with cytokine and cytokine receptor
,
Chemokine signaling pathway
,
Endocytosis
,
Toxoplasmosis
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Human immunodeficiency virus 1 infection
,
Viral carcinogenesis
11件:
Viral life cycle - HIV-1
,
Virion - Human immunodeficiency virus
,
Cytokine-cytokine receptor int
...
Cenicriviroc
Cenicriviroc
💬
1. CCR5
×
Name
Other Names
Cenicriviroc
Cenicriviroc (USAN/INN)
セニクリビロック
Cenicriviroc
1件:
94
94
💬
1. CCR5
×
告示番号
日本語名
英語名
94
原発性硬化性胆管炎
Primary sclerosing cholangitis
2
EGFR
💬
2. EGFR
×
Name
Full Name
EGFR
epidermal growth factor receptor
48件:
EGFR tyrosine kinase inhibitor resistance
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB signaling pathway
,
Ras signaling pathway
,
Rap1 signaling pathway
,
Calcium signaling pathway
,
HIF-1 signaling pathway
,
FoxO signaling pathway
,
Phospholipase D signaling pathway
,
Endocytosis
,
PI3K-Akt signaling pathway
,
Focal adhesion
,
Adherens junction
,
Gap junction
,
JAK-STAT signaling pathway
,
Regulation of actin cytoskeleton
,
GnRH signaling pathway
,
Estrogen signaling pathway
,
Oxytocin signaling pathway
,
Relaxin signaling pathway
,
Parathyroid hormone synthesis, secretion and action
,
Cushing syndrome
,
Epithelial cell signaling in Helicobacter pylori infection
,
Shigellosis
,
Hepatitis C
,
Human cytomegalovirus infection
,
Human papillomavirus infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Proteoglycans in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Chemical carcinogenesis - reactive oxygen species
,
Colorectal cancer
,
Pancreatic cancer
,
Endometrial cancer
,
Glioma
,
Prostate cancer
,
Melanoma
,
Bladder cancer
,
Non-small cell lung cancer
,
Breast cancer
,
Hepatocellular carcinoma
,
Gastric cancer
,
Central carbon metabolism in cancer
,
Choline metabolism in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
48件:
EGFR tyrosine kinase inhibitor resistance
,
Endocrine resistance
,
MAPK signaling pathway
,
ErbB s
...
Erlotinib
Erlotinib
💬
2. EGFR
×
Name
Other Names
Erlotinib
Erlotinib (INN)
エルロチニブ
Erlotinib
1件:
94
94
💬
2. EGFR
×
告示番号
日本語名
英語名
94
原発性硬化性胆管炎
Primary sclerosing cholangitis
3
NR3C1
💬
3. NR3C1
×
Name
Full Name
NR3C1
nuclear receptor subfamily 3 group C member 1
1件:
Neuroactive ligand-receptor interaction
Neuroactive ligand-receptor interaction
Budesonide
Budesonide
💬
3. NR3C1
×
Name
Other Names
Budesonide
Budesonide (JP18/USP/INN)
Entocort EC (TN)
Pulmicort (TN)
Rhinocort (TN)
Uceris (TN)
ORTIKOS
PULMICORT RESPULES
TARPEYO
BUDESONIDE INHALATION
BUDESONIDE INHALATION SUSPENSION
ブデソニド
ゼンタコート
パルミコート
レクタブル
Budesonide
9件:
66
66
,
93
,
94
,
95
,
96
,
97
,
98
,
228
,
299
💬
3. NR3C1
×
告示番号
日本語名
英語名
66
IgA腎症
IgA nephropathy
93
原発性胆汁性胆管炎
Primary biliary cholangitis
94
原発性硬化性胆管炎
Primary sclerosing cholangitis
95
自己免疫性肝炎
Autoimmune hepatitis
96
クローン病;回腸末端炎
Crohn disease
97
潰瘍性大腸炎
Ulcerative colitis
98
好酸球性消化管疾患
Eosinophilic gastrointestinal disease
228
閉塞性細気管支炎
Bronchiolitis obliterans
299
嚢胞性線維症;膵囊胞線維症
Cystic fibrosis
4
HMGCR
💬
4. HMGCR
×
Name
Full Name
HMGCR
3-hydroxy-3-methylglutaryl-CoA reductase
4件:
Terpenoid backbone biosynthesis
Terpenoid backbone biosynthesis
,
Metabolic pathways
,
AMPK signaling pathway
,
Bile secretion
Simvastatin
Simvastatin
💬
4. HMGCR
×
Name
Other Names
Simvastatin
Simvastatin (JP18/USP/INN)
MK-733
Zocor (TN)
FLOLIPID
シンバスタチン
リポバス
Simvastatin
21件:
6
6
,
13
,
15
,
34
,
46
,
49
,
51
,
66
,
79
,
86
,
89
,
94
,
158
,
160
,
162
,
195
,
265
,
288
,
298
,
299
,
310
💬
4. HMGCR
×
告示番号
日本語名
英語名
6
パーキンソン病
Parkinson disease
13
多発性硬化症/視神経脊髄炎
Multiple sclerosis/Neuromyelitis optica
15
封入体筋炎
Inclusion body myositis
34
神経線維腫症
Neurofibromatosis
46
悪性関節リウマチ
Malignant rheumatoid arthritis
49
全身性エリテマトーデス
Systemic lupus erythematosus
51
全身性強皮症
Scleroderma
66
IgA腎症
IgA nephropathy
79
家族性高コレステロール血症(ホモ接合体)
Homozygous familial hypercholesterolemia
86
肺動脈性肺高血圧症
Pulmonary arterial hypertension
89
リンパ脈管筋腫症
Lymphangioleiomyomatosis
94
原発性硬化性胆管炎
Primary sclerosing cholangitis
158
結節性硬化症
Tuberous sclerosis
160
先天性魚鱗癬
Congenital ichthyosis
162
類天疱瘡(後天性表皮水疱症を含む。)
Pemphigoid
195
ヌーナン症候群
Noonan syndrome
265
脂肪萎縮症
Lipodystrophy
288
自己免疫性後天性凝固因子欠乏症
Autoimmune acquired coagulation factor deficiency
298
遺伝性膵炎
Hereditary pancreatitis
299
嚢胞性線維症;膵囊胞線維症
Cystic fibrosis
310
先天異常症候群
Congenital anomalies syndrome
5
IMPDH1
💬
5. IMPDH1
×
Name
Full Name
IMPDH1
inosine monophosphate dehydrogenase 1
4件:
Purine metabolism
Purine metabolism
,
Drug metabolism - other enzymes
,
Metabolic pathways
,
Nucleotide metabolism
Mizoribine
Mizoribine
💬
5. IMPDH1
×
Name
Other Names
Mizoribine
Mizoribine (JP18/INN)
Bredinin (TN)
ミゾリビン
ブレディニン
Mizoribine
8件:
46
46
,
49
,
51
,
53
,
66
,
94
,
222
,
224
💬
5. IMPDH1
×
告示番号
日本語名
英語名
46
悪性関節リウマチ
Malignant rheumatoid arthritis
49
全身性エリテマトーデス
Systemic lupus erythematosus
51
全身性強皮症
Scleroderma
53
シェーグレン症候群
Sjogren syndrome
66
IgA腎症
IgA nephropathy
94
原発性硬化性胆管炎
Primary sclerosing cholangitis
222
一次性ネフローゼ症候群
Primary nephrotic syndrome
224
紫斑病性腎炎
Purpura nephritis
6
IMPDH2
💬
6. IMPDH2
×
Name
Full Name
IMPDH2
inosine monophosphate dehydrogenase 2
4件:
Purine metabolism
Purine metabolism
,
Drug metabolism - other enzymes
,
Metabolic pathways
,
Nucleotide metabolism
Mizoribine
Mizoribine
💬
6. IMPDH2
×
Name
Other Names
Mizoribine
Mizoribine (JP18/INN)
Bredinin (TN)
ミゾリビン
ブレディニン
Mizoribine
8件:
46
46
,
49
,
51
,
53
,
66
,
94
,
222
,
224
💬
6. IMPDH2
×
告示番号
日本語名
英語名
46
悪性関節リウマチ
Malignant rheumatoid arthritis
49
全身性エリテマトーデス
Systemic lupus erythematosus
51
全身性強皮症
Scleroderma
53
シェーグレン症候群
Sjogren syndrome
66
IgA腎症
IgA nephropathy
94
原発性硬化性胆管炎
Primary sclerosing cholangitis
222
一次性ネフローゼ症候群
Primary nephrotic syndrome
224
紫斑病性腎炎
Purpura nephritis
7
ITGA4
💬
7. ITGA4
×
Name
Full Name
ITGA4
integrin subunit alpha 4
14件:
PI3K-Akt signaling pathway
PI3K-Akt signaling pathway
,
Focal adhesion
,
ECM-receptor interaction
,
Cell adhesion molecules
,
Hematopoietic cell lineage
,
Leukocyte transendothelial migration
,
Intestinal immune network for IgA production
,
Regulation of actin cytoskeleton
,
Yersinia infection
,
Leishmaniasis
,
Human papillomavirus infection
,
Hypertrophic cardiomyopathy
,
Arrhythmogenic right ventricular cardiomyopathy
,
Dilated cardiomyopathy
14件:
PI3K-Akt signaling pathway
,
Focal adhesion
,
ECM-receptor interaction
,
Cell adhesion molecules
, ...
Vedolizumab
Vedolizumab
💬
7. ITGA4
×
Name
Other Names
Vedolizumab
Vedolizumab (USAN)
Vedolizumab (genetical recombination) (JAN)
Entyvio (TN)
ベドリズマブ
エンタイビオ
Vedolizumab
3件:
94
94
,
96
,
97
💬
7. ITGA4
×
告示番号
日本語名
英語名
94
原発性硬化性胆管炎
Primary sclerosing cholangitis
96
クローン病;回腸末端炎
Crohn disease
97
潰瘍性大腸炎
Ulcerative colitis
8
ITGB7
💬
8. ITGB7
×
Name
Full Name
ITGB7
integrin subunit beta 7
11件:
PI3K-Akt signaling pathway
PI3K-Akt signaling pathway
,
Focal adhesion
,
ECM-receptor interaction
,
Cell adhesion molecules
,
Intestinal immune network for IgA production
,
Regulation of actin cytoskeleton
,
Human papillomavirus infection
,
Transcriptional misregulation in cancer
,
Hypertrophic cardiomyopathy
,
Arrhythmogenic right ventricular cardiomyopathy
,
Dilated cardiomyopathy
11件:
PI3K-Akt signaling pathway
,
Focal adhesion
,
ECM-receptor interaction
,
Cell adhesion molecules
, ...
Vedolizumab
Vedolizumab
💬
8. ITGB7
×
Name
Other Names
Vedolizumab
Vedolizumab (USAN)
Vedolizumab (genetical recombination) (JAN)
Entyvio (TN)
ベドリズマブ
エンタイビオ
Vedolizumab
3件:
94
94
,
96
,
97
💬
8. ITGB7
×
告示番号
日本語名
英語名
94
原発性硬化性胆管炎
Primary sclerosing cholangitis
96
クローン病;回腸末端炎
Crohn disease
97
潰瘍性大腸炎
Ulcerative colitis
9
PML
💬
9. PML
×
Name
Full Name
PML
PML nuclear body scaffold
7件:
Ubiquitin mediated proteolysis
Ubiquitin mediated proteolysis
,
Endocytosis
,
Influenza A
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
Transcriptional misregulation in cancer
,
Acute myeloid leukemia
7件:
Ubiquitin mediated proteolysis
,
Endocytosis
,
Influenza A
,
Herpes simplex virus 1 infection
,
Path
...
Tretinoin
Tretinoin
💬
9. PML
×
Name
Other Names
Tretinoin
Tretinoin (JAN/USP/INN)
Avita (TN)
Renova (TN)
Retin A (TN)
Tretinoin (TN)
ALTRENO
ATRALIN
RETIN-A
RETIN-A MICRO
TRETINOIN CREAM
トレチノイン
ベサノイド
Tretinoin
6件:
2
2
,
62
,
63
,
75
,
94
,
231
💬
9. PML
×
告示番号
日本語名
英語名
2
筋萎縮性側索硬化症
Amyotrophic lateral sclerosis
62
発作性夜間ヘモグロビン尿症
Paroxysmal nocturnal hemoglobinuria
63
特発性血小板減少性紫斑病;一次性免疫性血小板減少症
Idiopathic thrombocytopenic purpura
75
クッシング病
Cushing disease
94
原発性硬化性胆管炎
Primary sclerosing cholangitis
231
α1−アンチトリプシン欠乏症
Alpha-1-antitrypsin deficiency
10
PPARA
💬
10. PPARA
×
Name
Full Name
PPARA
peroxisome proliferator activated receptor alpha
10件:
PPAR signaling pathway
PPAR signaling pathway
,
cAMP signaling pathway
,
Adipocytokine signaling pathway
,
Glucagon signaling pathway
,
Insulin resistance
,
Non-alcoholic fatty liver disease
,
Alcoholic liver disease
,
Hepatitis C
,
Chemical carcinogenesis - receptor activation
,
Diabetic cardiomyopathy
10件:
PPAR signaling pathway
,
cAMP signaling pathway
,
Adipocytokine signaling pathway
,
Glucagon signa
...
Fenofibrate
Fenofibrate
💬
10. PPARA
×
Name
Other Names
Fenofibrate
Fenofibrate (JP18/USP/INN)
Antara (TN)
Lipantil (TN)
Lipofen (TN)
Tricor (TN)
Triglide (TN)
FENOGLIDE
フェノフィブラート
トライコア
リピディル
Fenofibrate
6件:
8
8
,
79
,
93
,
94
,
97
,
265
💬
10. PPARA
×
告示番号
日本語名
英語名
8
ハンチントン病
Huntington disease
79
家族性高コレステロール血症(ホモ接合体)
Homozygous familial hypercholesterolemia
93
原発性胆汁性胆管炎
Primary biliary cholangitis
94
原発性硬化性胆管炎
Primary sclerosing cholangitis
97
潰瘍性大腸炎
Ulcerative colitis
265
脂肪萎縮症
Lipodystrophy