Target Gene/Pathway PATHWAY / GENE


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No. KEGG GENES KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG DRUG DrugBank 指定難病告示番号
1 CCR5 9件: Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, Chemokine signaling pathway 💬, Endocytosis 💬, Toxoplasmosis 💬, Human cytomegalovirus infection 💬, Kaposi sarcoma-associated herpesvirus infection 💬, Human immunodeficiency virus 1 infection 💬, Viral carcinogenesis 💬 D09878 Cenicriviroc 1件: 94
2 EGFR 48件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, MAPK signaling pathway 💬, ErbB signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, Phospholipase D signaling pathway 💬, Endocytosis 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Adherens junction 💬, Gap junction 💬, JAK-STAT signaling pathway 💬, Regulation of actin cytoskeleton 💬, GnRH signaling pathway 💬, Estrogen signaling pathway 💬, Oxytocin signaling pathway 💬, Relaxin signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Cushing syndrome 💬, Epithelial cell signaling in Helicobacter pylori infection 💬, Shigellosis 💬, Hepatitis C 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Colorectal cancer 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Glioma 💬, Prostate cancer 💬, Melanoma 💬, Bladder cancer 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 D04023 Erlotinib 1件: 94
3 EGFR 48件: EGFR tyrosine kinase inhibitor resistance 💬, Endocrine resistance 💬, MAPK signaling pathway 💬, ErbB signaling pathway 💬, Ras signaling pathway 💬, Rap1 signaling pathway 💬, Calcium signaling pathway 💬, HIF-1 signaling pathway 💬, FoxO signaling pathway 💬, Phospholipase D signaling pathway 💬, Endocytosis 💬, PI3K-Akt signaling pathway 💬, Focal adhesion 💬, Adherens junction 💬, Gap junction 💬, JAK-STAT signaling pathway 💬, Regulation of actin cytoskeleton 💬, GnRH signaling pathway 💬, Estrogen signaling pathway 💬, Oxytocin signaling pathway 💬, Relaxin signaling pathway 💬, Parathyroid hormone synthesis, secretion and action 💬, Cushing syndrome 💬, Epithelial cell signaling in Helicobacter pylori infection 💬, Shigellosis 💬, Hepatitis C 💬, Human cytomegalovirus infection 💬, Human papillomavirus infection 💬, Coronavirus disease - COVID-19 💬, Pathways in cancer 💬, Proteoglycans in cancer 💬, MicroRNAs in cancer 💬, Chemical carcinogenesis - receptor activation 💬, Chemical carcinogenesis - reactive oxygen species 💬, Colorectal cancer 💬, Pancreatic cancer 💬, Endometrial cancer 💬, Glioma 💬, Prostate cancer 💬, Melanoma 💬, Bladder cancer 💬, Non-small cell lung cancer 💬, Breast cancer 💬, Hepatocellular carcinoma 💬, Gastric cancer 💬, Central carbon metabolism in cancer 💬, Choline metabolism in cancer 💬, PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 D07907 Erlotinib 1件: 94
4 NR3C1 1件: Neuroactive ligand-receptor interaction 💬 D00246 Budesonide 7件: 94, 95, 96, 97, 98, 228, 299
5 HMGCR 4件: Terpenoid backbone biosynthesis 💬, Metabolic pathways 💬, AMPK signaling pathway 💬, Bile secretion 💬 D00434 Simvastatin 21件: 6, 13, 15, 34, 46, 49, 51, 66, 79, 86, 89, 94, 158, 160, 162, 195, 265, 288, 298, 299, 310
6 IMPDH1 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D01392 Mizoribine 8件: 46, 49, 51, 53, 66, 94, 222, 224
7 IMPDH2 3件: Purine metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D01392 Mizoribine 8件: 46, 49, 51, 53, 66, 94, 222, 224
8 ITGA4 14件: PI3K-Akt signaling pathway 💬, Focal adhesion 💬, ECM-receptor interaction 💬, Cell adhesion molecules 💬, Hematopoietic cell lineage 💬, Leukocyte transendothelial migration 💬, Intestinal immune network for IgA production 💬, Regulation of actin cytoskeleton 💬, Yersinia infection 💬, Leishmaniasis 💬, Human papillomavirus infection 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D08083 Vedolizumab 3件: 94, 96, 97
9 ITGB7 11件: PI3K-Akt signaling pathway 💬, Focal adhesion 💬, ECM-receptor interaction 💬, Cell adhesion molecules 💬, Intestinal immune network for IgA production 💬, Regulation of actin cytoskeleton 💬, Human papillomavirus infection 💬, Transcriptional misregulation in cancer 💬, Hypertrophic cardiomyopathy 💬, Arrhythmogenic right ventricular cardiomyopathy 💬, Dilated cardiomyopathy 💬 D08083 Vedolizumab 3件: 94, 96, 97
10 PML 7件: Ubiquitin mediated proteolysis 💬, Endocytosis 💬, Influenza A 💬, Herpes simplex virus 1 infection 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Acute myeloid leukemia 💬 D00094 Tretinoin 6件: 2, 62, 63, 75, 94, 231
11 PPARA 10件: PPAR signaling pathway 💬, cAMP signaling pathway 💬, Adipocytokine signaling pathway 💬, Glucagon signaling pathway 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, Alcoholic liver disease 💬, Hepatitis C 💬, Chemical carcinogenesis - receptor activation 💬, Diabetic cardiomyopathy 💬 D00565 Fenofibrate 5件: 8, 79, 93, 94, 265
12 PPARA 10件: PPAR signaling pathway 💬, cAMP signaling pathway 💬, Adipocytokine signaling pathway 💬, Glucagon signaling pathway 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, Alcoholic liver disease 💬, Hepatitis C 💬, Chemical carcinogenesis - receptor activation 💬, Diabetic cardiomyopathy 💬 D01366 Bezafibrate 7件: 20, 93, 94, 160, 296, 316, 324
13 PPARG 11件: PPAR signaling pathway 💬, AMPK signaling pathway 💬, Longevity regulating pathway 💬, Osteoclast differentiation 💬, Thermogenesis 💬, Non-alcoholic fatty liver disease 💬, Huntington disease 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Thyroid cancer 💬, Lipid and atherosclerosis 💬 D11256 Seladelpar 2件: 93, 94
14 RARA 5件: Th17 cell differentiation 💬, Estrogen signaling pathway 💬, Pathways in cancer 💬, Transcriptional misregulation in cancer 💬, Acute myeloid leukemia 💬 D00094 Tretinoin 6件: 2, 62, 63, 75, 94, 231
15 RARB 4件: Pathways in cancer 💬, Small cell lung cancer 💬, Non-small cell lung cancer 💬, Gastric cancer 💬 D00094 Tretinoin 6件: 2, 62, 63, 75, 94, 231
16 RRM1 5件: Purine metabolism 💬, Pyrimidine metabolism 💬, Glutathione metabolism 💬, Drug metabolism - other enzymes 💬, Metabolic pathways 💬 D01370 Cladribine 3件: 11, 13, 94
17 TNF 67件: Antifolate resistance 💬, MAPK signaling pathway 💬, Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, NF-kappa B signaling pathway 💬, Sphingolipid signaling pathway 💬, mTOR signaling pathway 💬, Apoptosis 💬, Necroptosis 💬, TGF-beta signaling pathway 💬, Osteoclast differentiation 💬, Antigen processing and presentation 💬, Toll-like receptor signaling pathway 💬, NOD-like receptor signaling pathway 💬, RIG-I-like receptor signaling pathway 💬, C-type lectin receptor signaling pathway 💬, Hematopoietic cell lineage 💬, Natural killer cell mediated cytotoxicity 💬, IL-17 signaling pathway 💬, T cell receptor signaling pathway 💬, Fc epsilon RI signaling pathway 💬, TNF signaling pathway 💬, Adipocytokine signaling pathway 💬, Type II diabetes mellitus 💬, Insulin resistance 💬, Non-alcoholic fatty liver disease 💬, AGE-RAGE signaling pathway in diabetic complications 💬, Alcoholic liver disease 💬, Type I diabetes mellitus 💬, Alzheimer disease 💬, Amyotrophic lateral sclerosis 💬, Prion disease 💬, Pathways of neurodegeneration - multiple diseases 💬, Pathogenic Escherichia coli infection 💬, Shigellosis 💬, Salmonella infection 💬, Pertussis 💬, Legionellosis 💬, Yersinia infection 💬, Leishmaniasis 💬, Chagas disease 💬, African trypanosomiasis 💬, Malaria 💬, Toxoplasmosis 💬, Amoebiasis 💬, Tuberculosis 💬, Hepatitis C 💬, Hepatitis B 💬, Human cytomegalovirus infection 💬, Influenza A 💬, Human papillomavirus infection 💬, Human T-cell leukemia virus 1 infection 💬, Herpes simplex virus 1 infection 💬, Epstein-Barr virus infection 💬, Human immunodeficiency virus 1 infection 💬, Coronavirus disease - COVID-19 💬, Proteoglycans in cancer 💬, Asthma 💬, Inflammatory bowel disease 💬, Systemic lupus erythematosus 💬, Rheumatoid arthritis 💬, Allograft rejection 💬, Graft-versus-host disease 💬, Hypertrophic cardiomyopathy 💬, Dilated cardiomyopathy 💬, Lipid and atherosclerosis 💬, Fluid shear stress and atherosclerosis 💬 D00754 Thalidomide 20件: 2, 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331
18 CCR2 3件: Cytokine-cytokine receptor interaction 💬, Viral protein interaction with cytokine and cytokine receptor 💬, Chemokine signaling pathway 💬 D09878 Cenicriviroc 1件: 94
19 TYMS 4件: Pyrimidine metabolism 💬, One carbon pool by folate 💬, Metabolic pathways 💬, Antifolate resistance 💬 D01223 Capecitabine 1件: 94
20 MS4A1 1件: Hematopoietic cell lineage 💬 D02994 Rituximab 17件: 94, 96, 97, 127, 162, 222, 229, 256, 271, 274, 283, 284, 285, 288, 296, 300, 331
21 NR1H4 1件: Bile secretion 💬 D00734 Ursodeoxycholic acid 7件: 94, 95, 96, 97, 234, 296, 299