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KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
指定難病告示番号
1
MAPK14
💬
1. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
62件:
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
62件:
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Losmapimod
Losmapimod
💬
1. MAPK14
×
Name
Other Names
Losmapimod
Losmapimod (USAN/INN)
ロスマピモド
Losmapimod
2件:
113
113
,
222
💬
1. MAPK14
×
告示番号
日本語名
英語名
113
筋ジストロフィー
Muscular dystrophy
222
一次性ネフローゼ症候群
Primary nephrotic syndrome
2
MAPK14
💬
2. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
62件:
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
62件:
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Neflamapimod
Neflamapimod
💬
2. MAPK14
×
Name
Other Names
Neflamapimod
Neflamapimod (USAN)
ネフラマピモド
Neflamapimod
1件:
8
8
💬
2. MAPK14
×
告示番号
日本語名
英語名
8
ハンチントン病
Huntington disease
3
IFNG
💬
3. IFNG
×
Name
Full Name
IFNG
interferon gamma
32件:
Proteasome
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Antigen processing and presentation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Type I diabetes mellitus
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis C
,
Influenza A
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
,
Systemic lupus erythematosus
,
Rheumatoid arthritis
,
Allograft rejection
,
Graft-versus-host disease
,
Fluid shear stress and atherosclerosis
32件:
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-b
...
Fontolizumab
Fontolizumab
💬
3. IFNG
×
Name
Other Names
Fontolizumab
Fontolizumab (USAN/INN)
フォントリズマブ
Fontolizumab
1件:
46
46
💬
3. IFNG
×
告示番号
日本語名
英語名
46
悪性関節リウマチ
Malignant rheumatoid arthritis
4
IFNG
💬
4. IFNG
×
Name
Full Name
IFNG
interferon gamma
32件:
Proteasome
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Antigen processing and presentation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Type I diabetes mellitus
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis C
,
Influenza A
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
,
Systemic lupus erythematosus
,
Rheumatoid arthritis
,
Allograft rejection
,
Graft-versus-host disease
,
Fluid shear stress and atherosclerosis
32件:
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-b
...
Emapalumab
Emapalumab
💬
4. IFNG
×
Name
Other Names
Emapalumab
Emapalumab (USAN/INN)
Emapalumab (genetical recombination) (JAN)
Emapalumab-lzsg
Gamifant (TN)
エマパルマブ
Emapalumab
3件:
49
49
,
65
,
107
💬
4. IFNG
×
告示番号
日本語名
英語名
49
全身性エリテマトーデス
Systemic lupus erythematosus
65
原発性免疫不全症候群
Primary immunodeficiency
107
若年性特発性関節炎
Juvenile idiopathic arthritis
5
IFNGR1
💬
5. IFNGR1
×
Name
Full Name
IFNGR1
interferon gamma receptor 1
18件:
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Influenza A
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
18件:
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
Osteoclast differ
...
Interferon gamma-1b
Interferon gamma-1b
💬
5. IFNGR1
×
Name
Other Names
Interferon gamma-1b
Interferon gamma-1b (USAN/INN)
Actimmune (TN)
インターフェロンガンマ-1b
Interferon gamma-1b
7件:
18
18
,
65
,
85
,
228
,
299
,
301
,
326
💬
5. IFNGR1
×
告示番号
日本語名
英語名
18
脊髄小脳変性症（多系統萎縮症を除く。）
Spinocerebellar degeneration
65
原発性免疫不全症候群
Primary immunodeficiency
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
228
閉塞性細気管支炎
Bronchiolitis obliterans
299
嚢胞性線維症;膵囊胞線維症
Cystic fibrosis
301
黄斑ジストロフィー
Macular dystrophy
326
大理石骨病
Osteopetrosis
6
IFNGR2
💬
6. IFNGR2
×
Name
Full Name
IFNGR2
interferon gamma receptor 2
17件:
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Influenza A
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
17件:
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
Osteoclast differ
...
Interferon gamma-1b
Interferon gamma-1b
💬
6. IFNGR2
×
Name
Other Names
Interferon gamma-1b
Interferon gamma-1b (USAN/INN)
Actimmune (TN)
インターフェロンガンマ-1b
Interferon gamma-1b
7件:
18
18
,
65
,
85
,
228
,
299
,
301
,
326
💬
6. IFNGR2
×
告示番号
日本語名
英語名
18
脊髄小脳変性症（多系統萎縮症を除く。）
Spinocerebellar degeneration
65
原発性免疫不全症候群
Primary immunodeficiency
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
228
閉塞性細気管支炎
Bronchiolitis obliterans
299
嚢胞性線維症;膵囊胞線維症
Cystic fibrosis
301
黄斑ジストロフィー
Macular dystrophy
326
大理石骨病
Osteopetrosis
7
IL1A
💬
7. IL1A
×
Name
Full Name
IL1A
interleukin 1 alpha
21件:
MAPK signaling pathway
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
Necroptosis
,
Cellular senescence
,
Osteoclast differentiation
,
Hematopoietic cell lineage
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Type I diabetes mellitus
,
Alzheimer disease
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Pertussis
,
Leishmaniasis
,
Tuberculosis
,
Measles
,
Influenza A
,
Inflammatory bowel disease
,
Rheumatoid arthritis
,
Graft-versus-host disease
,
Fluid shear stress and atherosclerosis
21件:
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
Necroptosis
,
Cellular senescenc
...
Pirfenidone
Pirfenidone
💬
7. IL1A
×
Name
Other Names
Pirfenidone
Pirfenidone (JAN/USAN/INN)
Esbriet (TN)
ピルフェニドン
ピレスパ
Pirfenidone
11件:
13
13
,
34
,
46
,
50
,
51
,
58
,
84
,
85
,
164
,
222
,
228
💬
7. IL1A
×
告示番号
日本語名
英語名
13
多発性硬化症／視神経脊髄炎
Multiple sclerosis/Neuromyelitis optica
34
神経線維腫症
Neurofibromatosis
46
悪性関節リウマチ
Malignant rheumatoid arthritis
50
皮膚筋炎／多発性筋炎
Dermatomyositis
51
全身性強皮症
Scleroderma
58
肥大型心筋症
Hypertrophic cardiomyopathy
84
サルコイドーシス
Sarcoidosis
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
164
眼皮膚白皮症
Oculocutaneous albinism
222
一次性ネフローゼ症候群
Primary nephrotic syndrome
228
閉塞性細気管支炎
Bronchiolitis obliterans
8
IL1A
💬
8. IL1A
×
Name
Full Name
IL1A
interleukin 1 alpha
21件:
MAPK signaling pathway
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
Necroptosis
,
Cellular senescence
,
Osteoclast differentiation
,
Hematopoietic cell lineage
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Type I diabetes mellitus
,
Alzheimer disease
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Pertussis
,
Leishmaniasis
,
Tuberculosis
,
Measles
,
Influenza A
,
Inflammatory bowel disease
,
Rheumatoid arthritis
,
Graft-versus-host disease
,
Fluid shear stress and atherosclerosis
21件:
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
Necroptosis
,
Cellular senescenc
...
Rilonacept
Rilonacept
💬
8. IL1A
×
Name
Other Names
Rilonacept
Rilonacept (USAN/INN)
Arcalyst (TN)
リロナセプト
Rilonacept
4件:
51
51
,
106
,
107
,
266
💬
8. IL1A
×
告示番号
日本語名
英語名
51
全身性強皮症
Scleroderma
106
クリオピリン関連周期熱症候群
Cryopyrin-associated periodic syndrome
107
若年性特発性関節炎
Juvenile idiopathic arthritis
266
家族性地中海熱
Familial mediterranean fever
9
IL1A
💬
9. IL1A
×
Name
Full Name
IL1A
interleukin 1 alpha
21件:
MAPK signaling pathway
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
Necroptosis
,
Cellular senescence
,
Osteoclast differentiation
,
Hematopoietic cell lineage
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Type I diabetes mellitus
,
Alzheimer disease
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Pertussis
,
Leishmaniasis
,
Tuberculosis
,
Measles
,
Influenza A
,
Inflammatory bowel disease
,
Rheumatoid arthritis
,
Graft-versus-host disease
,
Fluid shear stress and atherosclerosis
21件:
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
Necroptosis
,
Cellular senescenc
...
Bermekimab
Bermekimab
💬
9. IL1A
×
Name
Other Names
Bermekimab
Bermekimab (USAN)
ベルメキマブ
Bermekimab
1件:
51
51
💬
9. IL1A
×
告示番号
日本語名
英語名
51
全身性強皮症
Scleroderma
10
IL1B
💬
10. IL1B
×
Name
Full Name
IL1B
interleukin 1 beta
44件:
Antifolate resistance
Antifolate resistance
,
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
NF-kappa B signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
Cytosolic DNA-sensing pathway
,
C-type lectin receptor signaling pathway
,
Hematopoietic cell lineage
,
IL-17 signaling pathway
,
Th17 cell differentiation
,
TNF signaling pathway
,
Inflammatory mediator regulation of TRP channels
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Alcoholic liver disease
,
Type I diabetes mellitus
,
Alzheimer disease
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Legionellosis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Amoebiasis
,
Tuberculosis
,
Measles
,
Human cytomegalovirus infection
,
Influenza A
,
Herpes simplex virus 1 infection
,
Coronavirus disease - COVID-19
,
Inflammatory bowel disease
,
Rheumatoid arthritis
,
Graft-versus-host disease
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
44件:
Antifolate resistance
,
MAPK signaling pathway
,
Cytokine-cytokine receptor interaction
,
NF-kappa
...
Pirfenidone
Pirfenidone
💬
10. IL1B
×
Name
Other Names
Pirfenidone
Pirfenidone (JAN/USAN/INN)
Esbriet (TN)
ピルフェニドン
ピレスパ
Pirfenidone
11件:
13
13
,
34
,
46
,
50
,
51
,
58
,
84
,
85
,
164
,
222
,
228
💬
10. IL1B
×
告示番号
日本語名
英語名
13
多発性硬化症／視神経脊髄炎
Multiple sclerosis/Neuromyelitis optica
34
神経線維腫症
Neurofibromatosis
46
悪性関節リウマチ
Malignant rheumatoid arthritis
50
皮膚筋炎／多発性筋炎
Dermatomyositis
51
全身性強皮症
Scleroderma
58
肥大型心筋症
Hypertrophic cardiomyopathy
84
サルコイドーシス
Sarcoidosis
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
164
眼皮膚白皮症
Oculocutaneous albinism
222
一次性ネフローゼ症候群
Primary nephrotic syndrome
228
閉塞性細気管支炎
Bronchiolitis obliterans