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KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
指定難病告示番号
1
MAPK14
💬
1. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
62件:
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
62件:
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Losmapimod
Losmapimod
💬
1. MAPK14
×
Name
Other Names
Losmapimod
Losmapimod (USAN/INN)
ロスマピモド
Losmapimod
2件:
113
113
,
222
💬
1. MAPK14
×
告示番号
日本語名
英語名
113
筋ジストロフィー
Muscular dystrophy
222
一次性ネフローゼ症候群
Primary nephrotic syndrome
2
MAPK14
💬
2. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
62件:
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
62件:
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Neflamapimod
Neflamapimod
💬
2. MAPK14
×
Name
Other Names
Neflamapimod
Neflamapimod (USAN)
ネフラマピモド
Neflamapimod
1件:
8
8
💬
2. MAPK14
×
告示番号
日本語名
英語名
8
ハンチントン病
Huntington disease
3
ABL1
💬
3. ABL1
×
Name
Full Name
ABL1
ABL proto-oncogene 1, non-receptor tyrosine kinase
11件:
ErbB signaling pathway
ErbB signaling pathway
,
Ras signaling pathway
,
Cell cycle
,
Axon guidance
,
Neurotrophin signaling pathway
,
Pathogenic Escherichia coli infection
,
Pathways in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
Chronic myeloid leukemia
,
Viral myocarditis
11件:
ErbB signaling pathway
,
Ras signaling pathway
,
Cell cycle
,
Axon guidance
,
Neurotrophin signalin
...
Bosutinib
Bosutinib
💬
3. ABL1
×
Name
Other Names
Bosutinib
Bosutinib (USAN)
ボスチニブ
Bosutinib
2件:
2
2
,
67
💬
3. ABL1
×
告示番号
日本語名
英語名
2
筋萎縮性側索硬化症
Amyotrophic lateral sclerosis
67
多発性嚢胞腎
Polycystic kidney disease
4
ABL1
💬
4. ABL1
×
Name
Full Name
ABL1
ABL proto-oncogene 1, non-receptor tyrosine kinase
11件:
ErbB signaling pathway
ErbB signaling pathway
,
Ras signaling pathway
,
Cell cycle
,
Axon guidance
,
Neurotrophin signaling pathway
,
Pathogenic Escherichia coli infection
,
Pathways in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
Chronic myeloid leukemia
,
Viral myocarditis
11件:
ErbB signaling pathway
,
Ras signaling pathway
,
Cell cycle
,
Axon guidance
,
Neurotrophin signalin
...
Dasatinib
Dasatinib
💬
4. ABL1
×
Name
Other Names
Dasatinib
Dasatinib (JAN/INN)
ダサチニブ
Dasatinib
2件:
51
51
,
85
💬
4. ABL1
×
告示番号
日本語名
英語名
51
全身性強皮症
Scleroderma
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
5
ABL1
💬
5. ABL1
×
Name
Full Name
ABL1
ABL proto-oncogene 1, non-receptor tyrosine kinase
11件:
ErbB signaling pathway
ErbB signaling pathway
,
Ras signaling pathway
,
Cell cycle
,
Axon guidance
,
Neurotrophin signaling pathway
,
Pathogenic Escherichia coli infection
,
Pathways in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
Chronic myeloid leukemia
,
Viral myocarditis
11件:
ErbB signaling pathway
,
Ras signaling pathway
,
Cell cycle
,
Axon guidance
,
Neurotrophin signalin
...
Dasatinib
Dasatinib
💬
5. ABL1
×
Name
Other Names
Dasatinib
Dasatinib (USAN)
Dasatinib hydrate (JAN)
Sprycel (TN)
ダサチニブ水和物
スプリセル
Dasatinib
2件:
51
51
,
85
💬
5. ABL1
×
告示番号
日本語名
英語名
51
全身性強皮症
Scleroderma
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
6
ABL1
💬
6. ABL1
×
Name
Full Name
ABL1
ABL proto-oncogene 1, non-receptor tyrosine kinase
11件:
ErbB signaling pathway
ErbB signaling pathway
,
Ras signaling pathway
,
Cell cycle
,
Axon guidance
,
Neurotrophin signaling pathway
,
Pathogenic Escherichia coli infection
,
Pathways in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
Chronic myeloid leukemia
,
Viral myocarditis
11件:
ErbB signaling pathway
,
Ras signaling pathway
,
Cell cycle
,
Axon guidance
,
Neurotrophin signalin
...
Imatinib
Imatinib
💬
6. ABL1
×
Name
Other Names
Imatinib
Imatinib (INN)
Glamox (TN)
イマチニブ
Imatinib
12件:
13
13
,
28
,
34
,
35
,
46
,
51
,
85
,
86
,
87
,
88
,
89
,
162
💬
6. ABL1
×
告示番号
日本語名
英語名
13
多発性硬化症／視神経脊髄炎
Multiple sclerosis/Neuromyelitis optica
28
全身性アミロイドーシス
Systemic amyloidosis
34
神経線維腫症
Neurofibromatosis
35
天疱瘡
Pemphigus
46
悪性関節リウマチ
Malignant rheumatoid arthritis
51
全身性強皮症
Scleroderma
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
86
肺動脈性肺高血圧症
Pulmonary arterial hypertension
87
肺静脈閉塞症／肺毛細血管腫症
Pulmonary veno-occlusive disease
88
慢性血栓塞栓性肺高血圧症;特発性慢性肺血栓塞栓症（肺高血圧型）
Chronic thromboembolic pulmonary hypertension
89
リンパ脈管筋腫症
Lymphangioleiomyomatosis
162
類天疱瘡（後天性表皮水疱症を含む。）
Pemphigoid
7
ABL1
💬
7. ABL1
×
Name
Full Name
ABL1
ABL proto-oncogene 1, non-receptor tyrosine kinase
11件:
ErbB signaling pathway
ErbB signaling pathway
,
Ras signaling pathway
,
Cell cycle
,
Axon guidance
,
Neurotrophin signaling pathway
,
Pathogenic Escherichia coli infection
,
Pathways in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
Chronic myeloid leukemia
,
Viral myocarditis
11件:
ErbB signaling pathway
,
Ras signaling pathway
,
Cell cycle
,
Axon guidance
,
Neurotrophin signalin
...
Nilotinib
Nilotinib
💬
7. ABL1
×
Name
Other Names
Nilotinib
Nilotinib (USAN/INN)
ニロチニブ
Nilotinib
5件:
6
6
,
8
,
34
,
51
,
86
💬
7. ABL1
×
告示番号
日本語名
英語名
6
パーキンソン病
Parkinson disease
8
ハンチントン病
Huntington disease
34
神経線維腫症
Neurofibromatosis
51
全身性強皮症
Scleroderma
86
肺動脈性肺高血圧症
Pulmonary arterial hypertension
8
ABL1
💬
8. ABL1
×
Name
Full Name
ABL1
ABL proto-oncogene 1, non-receptor tyrosine kinase
11件:
ErbB signaling pathway
ErbB signaling pathway
,
Ras signaling pathway
,
Cell cycle
,
Axon guidance
,
Neurotrophin signaling pathway
,
Pathogenic Escherichia coli infection
,
Pathways in cancer
,
MicroRNAs in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
Chronic myeloid leukemia
,
Viral myocarditis
11件:
ErbB signaling pathway
,
Ras signaling pathway
,
Cell cycle
,
Axon guidance
,
Neurotrophin signalin
...
Saracatinib
Saracatinib
💬
8. ABL1
×
Name
Other Names
Saracatinib
Saracatinib (USAN/INN)
サラカチニブ
Saracatinib
3件:
6
6
,
89
,
272
💬
8. ABL1
×
告示番号
日本語名
英語名
6
パーキンソン病
Parkinson disease
89
リンパ脈管筋腫症
Lymphangioleiomyomatosis
272
進行性骨化性線維異形成症
Fibrodysplasia ossificans progressiva
9
MAP3K5
💬
9. MAP3K5
×
Name
Full Name
MAP3K5
mitogen-activated protein kinase kinase kinase 5
20件:
Platinum drug resistance
Platinum drug resistance
,
MAPK signaling pathway
,
Sphingolipid signaling pathway
,
Protein processing in endoplasmic reticulum
,
Apoptosis
,
Tight junction
,
TNF signaling pathway
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Non-alcoholic fatty liver disease
,
Alcoholic liver disease
,
Alzheimer disease
,
Parkinson disease
,
Amyotrophic lateral sclerosis
,
Huntington disease
,
Spinocerebellar ataxia
,
Pathways of neurodegeneration - multiple diseases
,
Chemical carcinogenesis - reactive oxygen species
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
20件:
Platinum drug resistance
,
MAPK signaling pathway
,
Sphingolipid signaling pathway
,
Protein proce
...
Selonsertib
Selonsertib
💬
9. MAP3K5
×
Name
Other Names
Selonsertib
Selonsertib (JAN/USAN/INN)
セロンセルチブ
Selonsertib
1件:
86
86
💬
9. MAP3K5
×
告示番号
日本語名
英語名
86
肺動脈性肺高血圧症
Pulmonary arterial hypertension
10
NFKB1
💬
10. NFKB1
×
Name
Full Name
NFKB1
nuclear factor kappa B subunit 1
76件:
Antifolate resistance
Antifolate resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
cAMP signaling pathway
,
Chemokine signaling pathway
,
NF-kappa B signaling pathway
,
HIF-1 signaling pathway
,
Sphingolipid signaling pathway
,
PI3K-Akt signaling pathway
,
Apoptosis
,
Longevity regulating pathway
,
Cellular senescence
,
Osteoclast differentiation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
Cytosolic DNA-sensing pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
B cell receptor signaling pathway
,
TNF signaling pathway
,
Neurotrophin signaling pathway
,
Prolactin signaling pathway
,
Adipocytokine signaling pathway
,
Relaxin signaling pathway
,
Insulin resistance
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Alcoholic liver disease
,
Alzheimer disease
,
Pathways of neurodegeneration - multiple diseases
,
Cocaine addiction
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Legionellosis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis C
,
Hepatitis B
,
Measles
,
Human cytomegalovirus infection
,
Influenza A
,
Human papillomavirus infection
,
Human T-cell leukemia virus 1 infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Pathways in cancer
,
Transcriptional misregulation in cancer
,
Viral carcinogenesis
,
MicroRNAs in cancer
,
Chemical carcinogenesis - receptor activation
,
Chemical carcinogenesis - reactive oxygen species
,
Pancreatic cancer
,
Prostate cancer
,
Chronic myeloid leukemia
,
Acute myeloid leukemia
,
Small cell lung cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
76件:
Antifolate resistance
,
MAPK signaling pathway
,
Ras signaling pathway
,
cAMP signaling pathway
,
C
...
Iguratimod
Iguratimod
💬
10. NFKB1
×
Name
Other Names
Iguratimod
Iguratimod (JAN/INN)
イグラチモド
ケアラム
Iguratimod
5件:
46
46
,
51
,
53
,
271
,
300
💬
10. NFKB1
×
告示番号
日本語名
英語名
46
悪性関節リウマチ
Malignant rheumatoid arthritis
51
全身性強皮症
Scleroderma
53
シェーグレン症候群
Sjogren syndrome
271
強直性脊椎炎
Ankylosing spondylitis
300
IgG4関連疾患
IgG4-related disease