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KEGG GENES
KEGG PATHWAY
KEGG DRUG
DrugBank
指定難病告示番号
1
CCR5
💬
1. CCR5
×
Name
Full Name
CCR5
C-C motif chemokine receptor 5
11件:
Viral life cycle - HIV-1
Viral life cycle - HIV-1
,
Virion - Human immunodeficiency virus
,
Cytokine-cytokine receptor interaction
,
Viral protein interaction with cytokine and cytokine receptor
,
Chemokine signaling pathway
,
Endocytosis
,
Toxoplasmosis
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Human immunodeficiency virus 1 infection
,
Viral carcinogenesis
11件:
Viral life cycle - HIV-1
,
Virion - Human immunodeficiency virus
,
Cytokine-cytokine receptor int
...
Maraviroc
Maraviroc
💬
1. CCR5
×
Name
Other Names
Maraviroc
Maraviroc (JAN/INN)
Selzentry (TN)
マラビロク
マラビロック
シーエルセントリ
Maraviroc
2件:
46
46
,
84
💬
1. CCR5
×
告示番号
日本語名
英語名
46
悪性関節リウマチ
Malignant rheumatoid arthritis
84
サルコイドーシス
Sarcoidosis
2
CCR5
💬
2. CCR5
×
Name
Full Name
CCR5
C-C motif chemokine receptor 5
11件:
Viral life cycle - HIV-1
Viral life cycle - HIV-1
,
Virion - Human immunodeficiency virus
,
Cytokine-cytokine receptor interaction
,
Viral protein interaction with cytokine and cytokine receptor
,
Chemokine signaling pathway
,
Endocytosis
,
Toxoplasmosis
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Human immunodeficiency virus 1 infection
,
Viral carcinogenesis
11件:
Viral life cycle - HIV-1
,
Virion - Human immunodeficiency virus
,
Cytokine-cytokine receptor int
...
Cenicriviroc
Cenicriviroc
💬
2. CCR5
×
Name
Other Names
Cenicriviroc
Cenicriviroc (USAN/INN)
セニクリビロック
Cenicriviroc
1件:
94
94
💬
2. CCR5
×
告示番号
日本語名
英語名
94
原発性硬化性胆管炎
Primary sclerosing cholangitis
3
MAPK14
💬
3. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
62件:
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
62件:
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Losmapimod
Losmapimod
💬
3. MAPK14
×
Name
Other Names
Losmapimod
Losmapimod (USAN/INN)
ロスマピモド
Losmapimod
2件:
113
113
,
222
💬
3. MAPK14
×
告示番号
日本語名
英語名
113
筋ジストロフィー
Muscular dystrophy
222
一次性ネフローゼ症候群
Primary nephrotic syndrome
4
MAPK14
💬
4. MAPK14
×
Name
Full Name
MAPK14
mitogen-activated protein kinase 14
62件:
Endocrine resistance
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
Sphingolipid signaling pathway
,
Oocyte meiosis
,
Cellular senescence
,
Adrenergic signaling in cardiomyocytes
,
VEGF signaling pathway
,
Osteoclast differentiation
,
Signaling pathways regulating pluripotency of stem cells
,
Platelet activation
,
Neutrophil extracellular trap formation
,
Toll-like receptor signaling pathway
,
NOD-like receptor signaling pathway
,
RIG-I-like receptor signaling pathway
,
C-type lectin receptor signaling pathway
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Fc epsilon RI signaling pathway
,
TNF signaling pathway
,
Leukocyte transendothelial migration
,
Thermogenesis
,
Neurotrophin signaling pathway
,
Retrograde endocannabinoid signaling
,
Dopaminergic synapse
,
Inflammatory mediator regulation of TRP channels
,
GnRH signaling pathway
,
Progesterone-mediated oocyte maturation
,
Prolactin signaling pathway
,
Relaxin signaling pathway
,
Non-alcoholic fatty liver disease
,
AGE-RAGE signaling pathway in diabetic complications
,
Growth hormone synthesis, secretion and action
,
Alcoholic liver disease
,
Amyotrophic lateral sclerosis
,
Prion disease
,
Pathways of neurodegeneration - multiple diseases
,
Epithelial cell signaling in Helicobacter pylori infection
,
Pathogenic Escherichia coli infection
,
Shigellosis
,
Salmonella infection
,
Pertussis
,
Yersinia infection
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Hepatitis B
,
Human cytomegalovirus infection
,
Kaposi sarcoma-associated herpesvirus infection
,
Epstein-Barr virus infection
,
Human immunodeficiency virus 1 infection
,
Coronavirus disease - COVID-19
,
Proteoglycans in cancer
,
Chemical carcinogenesis - reactive oxygen species
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Diabetic cardiomyopathy
,
Lipid and atherosclerosis
,
Fluid shear stress and atherosclerosis
62件:
Endocrine resistance
,
MAPK signaling pathway
,
Rap1 signaling pathway
,
FoxO signaling pathway
,
S
...
Neflamapimod
Neflamapimod
💬
4. MAPK14
×
Name
Other Names
Neflamapimod
Neflamapimod (USAN)
ネフラマピモド
Neflamapimod
1件:
8
8
💬
4. MAPK14
×
告示番号
日本語名
英語名
8
ハンチントン病
Huntington disease
5
ALOX5
💬
5. ALOX5
×
Name
Full Name
ALOX5
arachidonate 5-lipoxygenase
6件:
Arachidonic acid metabolism
Arachidonic acid metabolism
,
Metabolic pathways
,
Fc epsilon RI signaling pathway
,
Serotonergic synapse
,
Ovarian steroidogenesis
,
Toxoplasmosis
6件:
Arachidonic acid metabolism
,
Metabolic pathways
,
Fc epsilon RI signaling pathway
,
Serotonergic s
...
Zileuton
Zileuton
💬
5. ALOX5
×
Name
Other Names
Zileuton
Zileuton (USP/INN)
Zyflo (TN)
ジロートン
Zileuton
3件:
85
85
,
160
,
164
💬
5. ALOX5
×
告示番号
日本語名
英語名
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
160
先天性魚鱗癬
Congenital ichthyosis
164
眼皮膚白皮症
Oculocutaneous albinism
6
ALOX5
💬
6. ALOX5
×
Name
Full Name
ALOX5
arachidonate 5-lipoxygenase
6件:
Arachidonic acid metabolism
Arachidonic acid metabolism
,
Metabolic pathways
,
Fc epsilon RI signaling pathway
,
Serotonergic synapse
,
Ovarian steroidogenesis
,
Toxoplasmosis
6件:
Arachidonic acid metabolism
,
Metabolic pathways
,
Fc epsilon RI signaling pathway
,
Serotonergic s
...
Oxatomide
Oxatomide
💬
6. ALOX5
×
Name
Other Names
Oxatomide
Oxatomide (JAN/USAN/INN)
Celtect (TN)
オキサトミド
Oxatomide
1件:
113
113
💬
6. ALOX5
×
告示番号
日本語名
英語名
113
筋ジストロフィー
Muscular dystrophy
7
IFNG
💬
7. IFNG
×
Name
Full Name
IFNG
interferon gamma
32件:
Proteasome
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Antigen processing and presentation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Type I diabetes mellitus
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis C
,
Influenza A
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
,
Systemic lupus erythematosus
,
Rheumatoid arthritis
,
Allograft rejection
,
Graft-versus-host disease
,
Fluid shear stress and atherosclerosis
32件:
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-b
...
Fontolizumab
Fontolizumab
💬
7. IFNG
×
Name
Other Names
Fontolizumab
Fontolizumab (USAN/INN)
フォントリズマブ
Fontolizumab
1件:
46
46
💬
7. IFNG
×
告示番号
日本語名
英語名
46
悪性関節リウマチ
Malignant rheumatoid arthritis
8
IFNG
💬
8. IFNG
×
Name
Full Name
IFNG
interferon gamma
32件:
Proteasome
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-beta signaling pathway
,
Osteoclast differentiation
,
Antigen processing and presentation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
IL-17 signaling pathway
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
T cell receptor signaling pathway
,
Type I diabetes mellitus
,
Leishmaniasis
,
Chagas disease
,
African trypanosomiasis
,
Malaria
,
Toxoplasmosis
,
Amoebiasis
,
Tuberculosis
,
Hepatitis C
,
Influenza A
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
,
Systemic lupus erythematosus
,
Rheumatoid arthritis
,
Allograft rejection
,
Graft-versus-host disease
,
Fluid shear stress and atherosclerosis
32件:
Proteasome
,
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
TGF-b
...
Emapalumab
Emapalumab
💬
8. IFNG
×
Name
Other Names
Emapalumab
Emapalumab (USAN/INN)
Emapalumab (genetical recombination) (JAN)
Emapalumab-lzsg
Gamifant (TN)
エマパルマブ
Emapalumab
3件:
49
49
,
65
,
107
💬
8. IFNG
×
告示番号
日本語名
英語名
49
全身性エリテマトーデス
Systemic lupus erythematosus
65
原発性免疫不全症候群
Primary immunodeficiency
107
若年性特発性関節炎
Juvenile idiopathic arthritis
9
IFNGR1
💬
9. IFNGR1
×
Name
Full Name
IFNGR1
interferon gamma receptor 1
18件:
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Influenza A
,
Kaposi sarcoma-associated herpesvirus infection
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
18件:
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
Osteoclast differ
...
Interferon gamma-1b
Interferon gamma-1b
💬
9. IFNGR1
×
Name
Other Names
Interferon gamma-1b
Interferon gamma-1b (USAN/INN)
Actimmune (TN)
インターフェロンガンマ-1b
Interferon gamma-1b
7件:
18
18
,
65
,
85
,
228
,
299
,
301
,
326
💬
9. IFNGR1
×
告示番号
日本語名
英語名
18
脊髄小脳変性症（多系統萎縮症を除く。）
Spinocerebellar degeneration
65
原発性免疫不全症候群
Primary immunodeficiency
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
228
閉塞性細気管支炎
Bronchiolitis obliterans
299
嚢胞性線維症;膵囊胞線維症
Cystic fibrosis
301
黄斑ジストロフィー
Macular dystrophy
326
大理石骨病
Osteopetrosis
10
IFNGR2
💬
10. IFNGR2
×
Name
Full Name
IFNGR2
interferon gamma receptor 2
17件:
Cytokine-cytokine receptor interaction
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
Osteoclast differentiation
,
JAK-STAT signaling pathway
,
Natural killer cell mediated cytotoxicity
,
Th1 and Th2 cell differentiation
,
Th17 cell differentiation
,
Leishmaniasis
,
Chagas disease
,
Toxoplasmosis
,
Tuberculosis
,
Influenza A
,
Herpes simplex virus 1 infection
,
Pathways in cancer
,
PD-L1 expression and PD-1 checkpoint pathway in cancer
,
Inflammatory bowel disease
17件:
Cytokine-cytokine receptor interaction
,
HIF-1 signaling pathway
,
Necroptosis
,
Osteoclast differ
...
Interferon gamma-1b
Interferon gamma-1b
💬
10. IFNGR2
×
Name
Other Names
Interferon gamma-1b
Interferon gamma-1b (USAN/INN)
Actimmune (TN)
インターフェロンガンマ-1b
Interferon gamma-1b
7件:
18
18
,
65
,
85
,
228
,
299
,
301
,
326
💬
10. IFNGR2
×
告示番号
日本語名
英語名
18
脊髄小脳変性症（多系統萎縮症を除く。）
Spinocerebellar degeneration
65
原発性免疫不全症候群
Primary immunodeficiency
85
特発性間質性肺炎
Idiopathic interstitial pneumonia
228
閉塞性細気管支炎
Bronchiolitis obliterans
299
嚢胞性線維症;膵囊胞線維症
Cystic fibrosis
301
黄斑ジストロフィー
Macular dystrophy
326
大理石骨病
Osteopetrosis