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 Target Gene/Pathway(薬物標的遺伝子/パスウェイリスト) 

   e.g. "Sirolimus", "アダリムマブ", "MAP2K"    Synonyms (Drugs) were also searched for.

A B C D E F G H  I  J K L M N O P Q R S T U V W X Y Z other

80 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY
 On map, Yellow: Drug target, Red: Disease-related 
 KEGG GENES  KEGG DRUG  DrugBank   指定難病告示番号
 1  Adrenergic signaling in cardiomyocytes 
 5 genes, 2 drugs (DrugBank) and 13 diseases shown 
 5件: ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2   D00124   Ephedrine   1件: 11 
 1件: ADRB2   D02147   Salbutamol   13件: 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 2  Allograft rejection 
 2 genes, 1 drug (DrugBank) and 24 diseases shown 
 2件: CD80, CD86   D03203   Abatacept   24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 3  Alzheimer disease 
 5 genes, 2 drugs (DrugBank) and 55 diseases shown 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 4  Amphetamine addiction 
 5 genes, 2 drugs (DrugBank) and 55 diseases shown 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 5  AMPK signaling pathway 
 1 gene, 1 drug (DrugBank) and 1 disease shown 
 1件: ADRA1A   D00124   Ephedrine   1件: 11 
 6  Amyotrophic lateral sclerosis (ALS) 
 5 genes, 2 drugs (DrugBank) and 55 diseases shown 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 7  Antifolate resistance 
 2 genes, 1 drug (DrugBank) and 33 diseases shown 
 2件: DHFR, DHFR2   D00142   Methotrexate   33件: 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 8  Autoimmune thyroid disease 
 2 genes, 1 drug (DrugBank) and 24 diseases shown 
 2件: CD80, CD86   D03203   Abatacept   24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 9  Axon guidance 
 5 genes, 2 drugs (DrugBank) and 55 diseases shown 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 10  B cell receptor signaling pathway 
 5 genes, 2 drugs (DrugBank) and 55 diseases shown 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 11  C-type lectin receptor signaling pathway 
 5 genes, 2 drugs (DrugBank) and 55 diseases shown 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 12  Calcium signaling pathway 
 11 genes, 4 drugs (DrugBank) and 60 diseases shown 
 6件: ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3   D00124   Ephedrine   1件: 11 
 1件: ADRB2   D02147   Salbutamol   13件: 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 13  cAMP signaling pathway 
 2 genes, 2 drugs (DrugBank) and 13 diseases shown 
 2件: ADRB1, ADRB2   D00124   Ephedrine   1件: 11 
 1件: ADRB2   D02147   Salbutamol   13件: 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 14  Cell adhesion molecules (CAMs) 
 3 genes, 2 drugs (DrugBank) and 27 diseases shown 
 2件: CD80, CD86   D03203   Abatacept   24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 1件: ITGAL   D03959   Efalizumab   9件: 11, 13, 37, 46, 49, 53, 61, 95, 96 
 15  Cellular senescence 
 5 genes, 2 drugs (DrugBank) and 55 diseases shown 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 16  cGMP-PKG signaling pathway 
 14 genes, 4 drugs (DrugBank) and 60 diseases shown 
 9件: ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3   D00124   Ephedrine   1件: 11 
 1件: ADRB2   D02147   Salbutamol   13件: 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 17  Cholinergic synapse 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 
 1件: ACHE   D00487   Pyridostigmine   4件: 3, 6, 11, 256 
 18  Complement and coagulation cascades 
 1 gene, 2 drugs (DrugBank) and 7 diseases shown 
 1件: C5   D03940   Eculizumab   7件: 11, 13, 14, 62, 109, 222, 223 
 D11054   Ravulizumab   3件: 11, 62, 109 
 19  Cortisol synthesis and secretion 
 1 gene, 1 drug (DrugBank) and 3 diseases shown 
 1件: KCNA4   D10228   Amifampridine   3件: 3, 11, 12 
 20  Cushing syndrome 
 1 gene, 1 drug (DrugBank) and 3 diseases shown 
 1件: KCNA4   D10228   Amifampridine   3件: 3, 11, 12 
 21  Cytokine-cytokine receptor interaction 
 2 genes, 2 drugs (DrugBank) and 9 diseases shown 
 1件: CSF2RA   D05712   Regramostim   4件: 11, 46, 51, 229 
 1件: TNFSF13B   D03068   Belimumab   8件: 11, 43, 44, 46, 49, 51, 53, 222 
 22  Dilated cardiomyopathy (DCM) 
 1 gene, 1 drug (DrugBank) and 1 disease shown 
 1件: ADRB1   D00124   Ephedrine   1件: 11 
 23  Dopaminergic synapse 
 3 genes, 2 drugs (DrugBank) and 55 diseases shown 
 3件: PPP3CA, PPP3CB, PPP3CC   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 24  Drug metabolism - other enzymes 
 2 genes, 2 drugs (DrugBank) and 34 diseases shown 
 2件: IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   32件: 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   34件: 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 25  Epstein-Barr virus infection 
 1 gene, 1 drug (DrugBank) and 9 diseases shown 
 1件: ITGAL   D03959   Efalizumab   9件: 11, 13, 37, 46, 49, 53, 61, 95, 96 
 26  Folate biosynthesis 
 2 genes, 1 drug (DrugBank) and 33 diseases shown 
 2件: DHFR, DHFR2   D00142   Methotrexate   33件: 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 27  Gap junction 
 1 gene, 1 drug (DrugBank) and 1 disease shown 
 1件: ADRB1   D00124   Ephedrine   1件: 11 
 28  Glucagon signaling pathway 
 5 genes, 2 drugs (DrugBank) and 55 diseases shown 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 29  Glutamatergic synapse 
 5 genes, 2 drugs (DrugBank) and 55 diseases shown 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 30  Glycerophospholipid metabolism 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 
 1件: ACHE   D00487   Pyridostigmine   4件: 3, 6, 11, 256 
 31  Graft-versus-host disease 
 2 genes, 1 drug (DrugBank) and 24 diseases shown 
 2件: CD80, CD86   D03203   Abatacept   24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 32  Hematopoietic cell lineage 
 2 genes, 2 drugs (DrugBank) and 42 diseases shown 
 1件: CSF2RA   D05712   Regramostim   4件: 11, 46, 51, 229 
 1件: MS4A1   D02994   Rituximab   42件: 11, 13, 14, 17, 35, 36, 43, 44, 45, 46, 49, 50, 51, 52, 53, 56, 60, 61, 63, 64, 65, 66, 83, 84, 85, 86, 93, 94, 96, 97, 162, 222, 223, 229, 256, 271, 283, 284, 285, 288, 300, 331 
 33  Herpes simplex virus 1 infection 
 1 gene, 2 drugs (DrugBank) and 7 diseases shown 
 1件: C5   D03940   Eculizumab   7件: 11, 13, 14, 62, 109, 222, 223 
 D11054   Ravulizumab   3件: 11, 62, 109 
 34  Human cytomegalovirus infection 
 5 genes, 2 drugs (DrugBank) and 55 diseases shown 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 35  Human immunodeficiency virus 1 infection 
 5 genes, 2 drugs (DrugBank) and 55 diseases shown 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 36  Human T-cell leukemia virus 1 infection 
 6 genes, 3 drugs (DrugBank) and 56 diseases shown 
 1件: ITGAL   D03959   Efalizumab   9件: 11, 13, 37, 46, 49, 53, 61, 95, 96 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 37  Intestinal immune network for IgA production 
 3 genes, 2 drugs (DrugBank) and 25 diseases shown 
 2件: CD80, CD86   D03203   Abatacept   24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 1件: TNFSF13B   D03068   Belimumab   8件: 11, 43, 44, 46, 49, 51, 53, 222 
 38  JAK-STAT signaling pathway 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 
 1件: CSF2RA   D05712   Regramostim   4件: 11, 46, 51, 229 
 39  Kaposi sarcoma-associated herpesvirus infection 
 6 genes, 3 drugs (DrugBank) and 61 diseases shown 
 1件: CD86   D03203   Abatacept   24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 40  Leukocyte transendothelial migration 
 1 gene, 1 drug (DrugBank) and 9 diseases shown 
 1件: ITGAL   D03959   Efalizumab   9件: 11, 13, 37, 46, 49, 53, 61, 95, 96 
 41  Long-term potentiation 
 5 genes, 2 drugs (DrugBank) and 55 diseases shown 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 42  Malaria 
 1 gene, 1 drug (DrugBank) and 9 diseases shown 
 1件: ITGAL   D03959   Efalizumab   9件: 11, 13, 37, 46, 49, 53, 61, 95, 96 
 43  MAPK signaling pathway 
 5 genes, 2 drugs (DrugBank) and 55 diseases shown 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 44  Metabolic pathways 
 5 genes, 4 drugs (DrugBank) and 49 diseases shown 
 2件: DHFR, DHFR2   D00142   Methotrexate   33件: 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 1件: DHODH   D00749   Leflunomide   10件: 11, 40, 46, 49, 53, 66, 162, 224, 271, 300 
 2件: IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   32件: 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   34件: 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 45  Natural killer cell mediated cytotoxicity 
 6 genes, 3 drugs (DrugBank) and 56 diseases shown 
 1件: ITGAL   D03959   Efalizumab   9件: 11, 13, 37, 46, 49, 53, 61, 95, 96 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 46  Neuroactive ligand-receptor interaction 
 11 genes, 6 drugs (DrugBank) and 61 diseases shown 
 9件: ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3   D00124   Ephedrine   1件: 11 
 1件: ADRB2   D02147   Salbutamol   13件: 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 1件: C5   D03940   Eculizumab   7件: 11, 13, 14, 62, 109, 222, 223 
 D11054   Ravulizumab   3件: 11, 62, 109 
 1件: NR3C1   D00472   Prednisolone   38件: 11, 13, 25, 26, 35, 38, 39, 41, 43, 44, 45, 46, 49, 50, 51, 56, 60, 61, 63, 64, 65, 66, 75, 81, 84, 85, 95, 96, 97, 113, 145, 162, 222, 269, 271, 296, 299, 300 
 D00980 
 D00981 
 D00982 
 D01239 
 D01998 
 D02156 
 D03301 
 D00473   Prednisone   44件: 2, 11, 13, 14, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 81, 84, 85, 86, 95, 96, 97, 113, 145, 162, 164, 222, 224, 228, 251, 283, 284, 285, 288, 299, 300, 331 
 47  NF-kappa B signaling pathway 
 1 gene, 1 drug (DrugBank) and 8 diseases shown 
 1件: TNFSF13B   D03068   Belimumab   8件: 11, 43, 44, 46, 49, 51, 53, 222 
 48  One carbon pool by folate 
 2 genes, 1 drug (DrugBank) and 33 diseases shown 
 2件: DHFR, DHFR2   D00142   Methotrexate   33件: 11, 13, 19, 34, 35, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 55, 56, 60, 62, 65, 84, 93, 96, 97, 162, 164, 172, 256, 271, 284, 285, 326, 331 
 D02115 
 49  Oocyte meiosis 
 5 genes, 2 drugs (DrugBank) and 55 diseases shown 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 50  Osteoclast differentiation 
 5 genes, 2 drugs (DrugBank) and 55 diseases shown 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 51  Oxytocin signaling pathway 
 5 genes, 2 drugs (DrugBank) and 55 diseases shown 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 52  Pathways in cancer 
 1 gene, 1 drug (DrugBank) and 4 diseases shown 
 1件: CSF2RA   D05712   Regramostim   4件: 11, 46, 51, 229 
 53  PD-L1 expression and PD-1 checkpoint pathway in cancer 
 5 genes, 2 drugs (DrugBank) and 55 diseases shown 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 54  Pertussis 
 1 gene, 2 drugs (DrugBank) and 7 diseases shown 
 1件: C5   D03940   Eculizumab   7件: 11, 13, 14, 62, 109, 222, 223 
 D11054   Ravulizumab   3件: 11, 62, 109 
 55  Platinum drug resistance 
 2 genes, 2 drugs (DrugBank) and 11 diseases shown 
 2件: TOP2A, TOP2B   D00125   Etoposide   11件: 11, 13, 14, 26, 28, 34, 60, 65, 85, 164, 331 
 D04107 
 D05522   Pixantrone   2件: 11, 13 
 56  Prion diseases 
 1 gene, 2 drugs (DrugBank) and 7 diseases shown 
 1件: C5   D03940   Eculizumab   7件: 11, 13, 14, 62, 109, 222, 223 
 D11054   Ravulizumab   3件: 11, 62, 109 
 57  Proteasome 
 1 gene, 1 drug (DrugBank) and 13 diseases shown 
 1件: PSMB5   D03150   Bortezomib   13件: 11, 26, 28, 46, 49, 51, 61, 63, 66, 228, 256, 288, 331 
 58  Purine metabolism 
 2 genes, 2 drugs (DrugBank) and 34 diseases shown 
 2件: IMPDH1, IMPDH2   D00752   Mycophenolate mofetil   32件: 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 85, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 
 D05094 
 D05095 
 D05096   Mycophenolic acid   34件: 2, 11, 13, 14, 19, 20, 28, 35, 36, 42, 43, 45, 49, 51, 53, 60, 62, 65, 66, 84, 85, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 
 59  Pyrimidine metabolism 
 1 gene, 1 drug (DrugBank) and 10 diseases shown 
 1件: DHODH   D00749   Leflunomide   10件: 11, 40, 46, 49, 53, 66, 162, 224, 271, 300 
 60  Rap1 signaling pathway 
 1 gene, 1 drug (DrugBank) and 9 diseases shown 
 1件: ITGAL   D03959   Efalizumab   9件: 11, 13, 37, 46, 49, 53, 61, 95, 96 
 61  Regulation of actin cytoskeleton 
 1 gene, 1 drug (DrugBank) and 9 diseases shown 
 1件: ITGAL   D03959   Efalizumab   9件: 11, 13, 37, 46, 49, 53, 61, 95, 96 
 62  Regulation of lipolysis in adipocytes 
 3 genes, 2 drugs (DrugBank) and 13 diseases shown 
 3件: ADRB1, ADRB2, ADRB3   D00124   Ephedrine   1件: 11 
 1件: ADRB2   D02147   Salbutamol   13件: 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 63  Renin secretion 
 8 genes, 4 drugs (DrugBank) and 60 diseases shown 
 3件: ADRB1, ADRB2, ADRB3   D00124   Ephedrine   1件: 11 
 1件: ADRB2   D02147   Salbutamol   13件: 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 64  Rheumatoid arthritis 
 4 genes, 3 drugs (DrugBank) and 28 diseases shown 
 2件: CD80, CD86   D03203   Abatacept   24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 1件: ITGAL   D03959   Efalizumab   9件: 11, 13, 37, 46, 49, 53, 61, 95, 96 
 1件: TNFSF13B   D03068   Belimumab   8件: 11, 43, 44, 46, 49, 51, 53, 222 
 65  Salivary secretion 
 6 genes, 2 drugs (DrugBank) and 13 diseases shown 
 6件: ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3   D00124   Ephedrine   1件: 11 
 1件: ADRB2   D02147   Salbutamol   13件: 3, 11, 12, 13, 49, 85, 86, 89, 113, 228, 231, 256, 299 
 66  Serotonergic synapse 
 1 gene, 1 drug (DrugBank) and 3 diseases shown 
 1件: KCND2   D10228   Amifampridine   3件: 3, 11, 12 
 67  Staphylococcus aureus infection 
 2 genes, 3 drugs (DrugBank) and 14 diseases shown 
 1件: C5   D03940   Eculizumab   7件: 11, 13, 14, 62, 109, 222, 223 
 D11054   Ravulizumab   3件: 11, 62, 109 
 1件: ITGAL   D03959   Efalizumab   9件: 11, 13, 37, 46, 49, 53, 61, 95, 96 
 68  Systemic lupus erythematosus 
 3 genes, 3 drugs (DrugBank) and 28 diseases shown 
 1件: C5   D03940   Eculizumab   7件: 11, 13, 14, 62, 109, 222, 223 
 D11054   Ravulizumab   3件: 11, 62, 109 
 2件: CD80, CD86   D03203   Abatacept   24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 69  T cell receptor signaling pathway 
 5 genes, 2 drugs (DrugBank) and 55 diseases shown 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 70  Th1 and Th2 cell differentiation 
 5 genes, 2 drugs (DrugBank) and 55 diseases shown 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 71  Th17 cell differentiation 
 5 genes, 2 drugs (DrugBank) and 55 diseases shown 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 72  Thermogenesis 
 1 gene, 1 drug (DrugBank) and 1 disease shown 
 1件: ADRB3   D00124   Ephedrine   1件: 11 
 73  Toll-like receptor signaling pathway 
 2 genes, 1 drug (DrugBank) and 24 diseases shown 
 2件: CD80, CD86   D03203   Abatacept   24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 74  Transcriptional misregulation in cancer 
 1 gene, 1 drug (DrugBank) and 24 diseases shown 
 1件: CD86   D03203   Abatacept   24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 75  Tuberculosis 
 5 genes, 2 drugs (DrugBank) and 55 diseases shown 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 76  Type I diabetes mellitus 
 2 genes, 1 drug (DrugBank) and 24 diseases shown 
 2件: CD80, CD86   D03203   Abatacept   24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 77  Vascular smooth muscle contraction 
 3 genes, 1 drug (DrugBank) and 1 disease shown 
 3件: ADRA1A, ADRA1B, ADRA1D   D00124   Ephedrine   1件: 11 
 78  VEGF signaling pathway 
 5 genes, 2 drugs (DrugBank) and 55 diseases shown 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 
 79  Viral myocarditis 
 3 genes, 2 drugs (DrugBank) and 27 diseases shown 
 2件: CD80, CD86   D03203   Abatacept   24件: 11, 13, 19, 41, 44, 46, 49, 50, 51, 53, 55, 60, 65, 84, 93, 96, 97, 107, 164, 222, 271, 284, 285, 300 
 1件: ITGAL   D03959   Efalizumab   9件: 11, 13, 37, 46, 49, 53, 61, 95, 96 
 80  Wnt signaling pathway 
 5 genes, 2 drugs (DrugBank) and 55 diseases shown 
 5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2   D00184   Ciclosporin   44件: 11, 14, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 95, 97, 113, 162, 164, 222, 223, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 
 D00107   Tacrolimus   30件: 2, 11, 13, 36, 46, 49, 50, 51, 53, 60, 61, 62, 65, 66, 85, 86, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 228, 283, 284, 299 
 D08556 

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