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 Target Gene/Pathway(薬物標的遺伝子/パスウェイリスト) 

   e.g. "Sirolimus", "アダリムマブ", "MAP2K"    Synonyms (Drugs) were also searched for.

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55 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY
 On map, Yellow: Drug target, Red: Disease-related 
 KEGG GENES  KEGG DRUG  DrugBank   指定難病告示番号
 1  Adrenergic signaling in cardiomyocytes 
 6 genes, 3 drugs (DrugBank) and 6 diseases shown 
 5件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, SCN5A   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 1件: KCNQ1   D09569   Ezogabine   2件: 2, 144 
 1件: SCN5A   D05775   Rufinamide   1件: 144 
 2  Aldosterone synthesis and secretion 
 4 genes, 1 drug (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 3  Alzheimer disease 
 4 genes, 1 drug (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 4  Amphetamine addiction 
 6 genes, 2 drugs (DrugBank) and 6 diseases shown 
 6件: CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 4件: GRIA1, GRIA2, GRIA3, GRIA4   D08964   Perampanel   3件: 2, 6, 144 
 5  Amyotrophic lateral sclerosis (ALS) 
 2 genes, 2 drugs (DrugBank) and 6 diseases shown 
 2件: GRIA1, GRIA2   D08964   Perampanel   3件: 2, 6, 144 
 D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 6  Arrhythmogenic right ventricular cardiomyopathy (ARVC) 
 4 genes, 1 drug (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 7  Bile secretion 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 
 1件: CA2   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 8  Calcium signaling pathway 
 7 genes, 2 drugs (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 3件: HTR2A, HTR2B, HTR2C   D04148   Fenfluramine   2件: 140, 144 
 D07945 
 9  cAMP signaling pathway 
 8 genes, 2 drugs (DrugBank) and 6 diseases shown 
 8件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 4件: GRIA1, GRIA2, GRIA3, GRIA4   D08964   Perampanel   3件: 2, 6, 144 
 10  Carbohydrate digestion and absorption 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 
 1件: CACNA1D   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 11  Cardiac muscle contraction 
 4 genes, 1 drug (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 12  Cellular senescence 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 
 1件: CACNA1D   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 13  cGMP-PKG signaling pathway 
 4 genes, 1 drug (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 14  Cholinergic synapse 
 9 genes, 2 drugs (DrugBank) and 6 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 5件: KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5   D09569   Ezogabine   2件: 2, 144 
 15  Circadian entrainment 
 8 genes, 3 drugs (DrugBank) and 12 diseases shown 
 6件: CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 4件: GRIA1, GRIA2, GRIA3, GRIA4   D08964   Perampanel   3件: 2, 6, 144 
 2件: MTNR1A, MTNR1B   D08170   Melatonin   8件: 6, 13, 46, 49, 90, 97, 144, 202 
 16  Cocaine addiction 
 1 gene, 2 drugs (DrugBank) and 6 diseases shown 
 1件: GRIA2   D08964   Perampanel   3件: 2, 6, 144 
 D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 17  Collecting duct acid secretion 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 
 1件: CA2   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 18  Cortisol synthesis and secretion 
 4 genes, 1 drug (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 19  Cushing syndrome 
 4 genes, 1 drug (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 20  Dilated cardiomyopathy (DCM) 
 4 genes, 1 drug (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 21  Dopaminergic synapse 
 7 genes, 3 drugs (DrugBank) and 6 diseases shown 
 7件: CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, SCN1A   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 4件: GRIA1, GRIA2, GRIA3, GRIA4   D08964   Perampanel   3件: 2, 6, 144 
 1件: SCN1A   D05775   Rufinamide   1件: 144 
 22  GABAergic synapse 
 20 genes, 2 drugs (DrugBank) and 5 diseases shown 
 20件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D01253   Clobazam   2件: 140, 144 
 23  Gap junction 
 3 genes, 1 drug (DrugBank) and 2 diseases shown 
 3件: HTR2A, HTR2B, HTR2C   D04148   Fenfluramine   2件: 140, 144 
 D07945 
 24  Gastric acid secretion 
 2 genes, 2 drugs (DrugBank) and 6 diseases shown 
 1件: CA2   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 1件: KCNQ1   D09569   Ezogabine   2件: 2, 144 
 25  Glutamatergic synapse 
 11 genes, 2 drugs (DrugBank) and 6 diseases shown 
 11件: CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 4件: GRIA1, GRIA2, GRIA3, GRIA4   D08964   Perampanel   3件: 2, 6, 144 
 26  GnRH secretion 
 4 genes, 1 drug (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 27  GnRH signaling pathway 
 4 genes, 1 drug (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 28  Growth hormone synthesis, secretion and action 
 4 genes, 1 drug (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 29  Hypertrophic cardiomyopathy (HCM) 
 4 genes, 1 drug (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 30  Inflammatory mediator regulation of TRP channels 
 3 genes, 1 drug (DrugBank) and 2 diseases shown 
 3件: HTR2A, HTR2B, HTR2C   D04148   Fenfluramine   2件: 140, 144 
 D07945 
 31  Insulin secretion 
 4 genes, 1 drug (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 32  Long-term depression 
 3 genes, 2 drugs (DrugBank) and 6 diseases shown 
 3件: GRIA1, GRIA2, GRIA3   D08964   Perampanel   3件: 2, 6, 144 
 D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 33  Long-term potentiation 
 3 genes, 2 drugs (DrugBank) and 6 diseases shown 
 3件: CACNA1C, GRIA1, GRIA2   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 2件: GRIA1, GRIA2   D08964   Perampanel   3件: 2, 6, 144 
 34  MAPK signaling pathway 
 4 genes, 1 drug (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 35  Metabolic pathways 
 2 genes, 1 drug (DrugBank) and 5 diseases shown 
 2件: CA2, CA4   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 36  Morphine addiction 
 16 genes, 2 drugs (DrugBank) and 5 diseases shown 
 16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D01253   Clobazam   2件: 140, 144 
 D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 37  Neuroactive ligand-receptor interaction 
 32 genes, 6 drugs (DrugBank) and 18 diseases shown 
 2件: CNR1, CNR2   D10915   Cannabidiol   14件: 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D01253   Clobazam   2件: 140, 144 
 25件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 4件: GRIA1, GRIA2, GRIA3, GRIA4   D08964   Perampanel   3件: 2, 6, 144 
 3件: HTR2A, HTR2B, HTR2C   D04148   Fenfluramine   2件: 140, 144 
 D07945 
 2件: MTNR1A, MTNR1B   D08170   Melatonin   8件: 6, 13, 46, 49, 90, 97, 144, 202 
 38  Nicotine addiction 
 20 genes, 3 drugs (DrugBank) and 6 diseases shown 
 16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D01253   Clobazam   2件: 140, 144 
 20件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 4件: GRIA1, GRIA2, GRIA3, GRIA4   D08964   Perampanel   3件: 2, 6, 144 
 39  Nitrogen metabolism 
 2 genes, 1 drug (DrugBank) and 5 diseases shown 
 2件: CA2, CA4   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 40  Oxytocin signaling pathway 
 4 genes, 1 drug (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 41  Pancreatic secretion 
 2 genes, 2 drugs (DrugBank) and 6 diseases shown 
 1件: CA2   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 1件: KCNQ1   D09569   Ezogabine   2件: 2, 144 
 42  Protein digestion and absorption 
 1 gene, 1 drug (DrugBank) and 2 diseases shown 
 1件: KCNQ1   D09569   Ezogabine   2件: 2, 144 
 43  Proximal tubule bicarbonate reclamation 
 2 genes, 1 drug (DrugBank) and 5 diseases shown 
 2件: CA2, CA4   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 44  Rap1 signaling pathway 
 1 gene, 1 drug (DrugBank) and 14 diseases shown 
 1件: CNR1   D10915   Cannabidiol   14件: 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 45  Renin secretion 
 4 genes, 1 drug (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 46  Retrograde endocannabinoid signaling 
 25 genes, 4 drugs (DrugBank) and 15 diseases shown 
 24件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 1件: CNR1   D10915   Cannabidiol   14件: 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D01253   Clobazam   2件: 140, 144 
 4件: GRIA1, GRIA2, GRIA3, GRIA4   D08964   Perampanel   3件: 2, 6, 144 
 47  Serotonergic synapse 
 11 genes, 3 drugs (DrugBank) and 5 diseases shown 
 7件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRB1, GABRB2, GABRB3   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 3件: GABRB1, GABRB2, GABRB3   D01253   Clobazam   2件: 140, 144 
 4件: HTR2A, HTR2B, HTR2C, SLC6A4   D04148   Fenfluramine   2件: 140, 144 
 D07945 
 48  Synaptic vesicle cycle 
 1 gene, 1 drug (DrugBank) and 2 diseases shown 
 1件: SLC6A4   D04148   Fenfluramine   2件: 140, 144 
 D07945 
 49  Taste transduction 
 10 genes, 3 drugs (DrugBank) and 5 diseases shown 
 10件: CACNA1C, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, SCN2A, SCN3A, SCN9A   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 6件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6   D01253   Clobazam   2件: 140, 144 
 3件: SCN2A, SCN3A, SCN9A   D05775   Rufinamide   1件: 144 
 50  Thermogenesis 
 1 gene, 1 drug (DrugBank) and 14 diseases shown 
 1件: CNR1   D10915   Cannabidiol   14件: 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 51  Tight junction 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 
 1件: CACNA1D   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 52  Transcriptional misregulation in cancer 
 1 gene, 2 drugs (DrugBank) and 6 diseases shown 
 1件: GRIA3   D08964   Perampanel   3件: 2, 6, 144 
 D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 53  Type II diabetes mellitus 
 2 genes, 1 drug (DrugBank) and 5 diseases shown 
 2件: CACNA1C, CACNA1D   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 54  Vascular smooth muscle contraction 
 4 genes, 1 drug (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 55  Vibrio cholerae infection 
 1 gene, 1 drug (DrugBank) and 2 diseases shown 
 1件: KCNQ1   D09569   Ezogabine   2件: 2, 144 

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