Target Gene/Pathway(薬物標的遺伝子/パスウェイリスト)

e.g. "Sirolimus", "アダリムマブ", "MAP2K"

ABCDEFGH I JKLMNOPQRSTUVWXYZother

59 / 286 pathways

No. KEGG PATHWAY   💬 Info on mouse-over
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES
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KEGG DRUG
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DrugBank 指定難病告示番号
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1 Adrenergic signaling in cardiomyocytes 💬
5件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, SCN5A 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
2 Adrenergic signaling in cardiomyocytes 💬
1件: KCNQ1 💬 D09569 💬 Ezogabine 2件: 2, 144 💬
3 Adrenergic signaling in cardiomyocytes 💬
1件: SCN5A 💬 D00354 💬 Lamotrigine 5件: 13, 34, 38, 114, 144 💬
4 Adrenergic signaling in cardiomyocytes 💬
1件: SCN5A 💬 D05775 💬 Rufinamide 1件: 144 💬
5 Aldosterone synthesis and secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
6 Alzheimer disease 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
7 Amphetamine addiction 💬
6件: CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
8 Amphetamine addiction 💬
4件: GRIA1, GRIA2, GRIA3, GRIA4 💬 D08964 💬 Perampanel 3件: 2, 6, 144 💬
9 Amyotrophic lateral sclerosis 💬
2件: GRIA1, GRIA2 💬 D08964 💬 Perampanel 3件: 2, 6, 144 💬
10 Amyotrophic lateral sclerosis 💬
2件: GRIA1, GRIA2 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
11 Arrhythmogenic right ventricular cardiomyopathy 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
12 Bile secretion 💬
1件: CA2 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
13 Calcium signaling pathway 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
14 Calcium signaling pathway 💬
3件: HTR2A, HTR2B, HTR2C 💬 D07945 💬 Fenfluramine 3件: 140, 144, 145 💬
15 cAMP signaling pathway 💬
8件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
16 cAMP signaling pathway 💬
4件: GRIA1, GRIA2, GRIA3, GRIA4 💬 D08964 💬 Perampanel 3件: 2, 6, 144 💬
17 Carbohydrate digestion and absorption 💬
1件: CACNA1D 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
18 Cardiac muscle contraction 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
19 Cellular senescence 💬
1件: CACNA1D 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
20 cGMP-PKG signaling pathway 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
21 Cholinergic synapse 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
22 Cholinergic synapse 💬
5件: KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5 💬 D09569 💬 Ezogabine 2件: 2, 144 💬
23 Circadian entrainment 💬
6件: CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
24 Circadian entrainment 💬
4件: GRIA1, GRIA2, GRIA3, GRIA4 💬 D08964 💬 Perampanel 3件: 2, 6, 144 💬
25 Circadian entrainment 💬
2件: MTNR1A, MTNR1B 💬 D08170 💬 Melatonin 11件: 6, 8, 13, 46, 49, 90, 97, 144, 145, 149, 202 💬
26 Cocaine addiction 💬
1件: GRIA2 💬 D08964 💬 Perampanel 3件: 2, 6, 144 💬
27 Cocaine addiction 💬
1件: GRIA2 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
28 Collecting duct acid secretion 💬
1件: CA2 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
29 Cortisol synthesis and secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
30 Cushing syndrome 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
31 Dilated cardiomyopathy 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
32 Dopaminergic synapse 💬
7件: CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, SCN1A 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
33 Dopaminergic synapse 💬
4件: GRIA1, GRIA2, GRIA3, GRIA4 💬 D08964 💬 Perampanel 3件: 2, 6, 144 💬
34 Dopaminergic synapse 💬
1件: SCN1A 💬 D00354 💬 Lamotrigine 5件: 13, 34, 38, 114, 144 💬
35 Dopaminergic synapse 💬
1件: SCN1A 💬 D05775 💬 Rufinamide 1件: 144 💬
36 GABAergic synapse 💬
20件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
37 GABAergic synapse 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D01253 💬 Clobazam 2件: 140, 144 💬
38 Gap junction 💬
3件: HTR2A, HTR2B, HTR2C 💬 D07945 💬 Fenfluramine 3件: 140, 144, 145 💬
39 Gastric acid secretion 💬
1件: CA2 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
40 Gastric acid secretion 💬
1件: KCNQ1 💬 D09569 💬 Ezogabine 2件: 2, 144 💬
41 Glutamatergic synapse 💬
11件: CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
42 Glutamatergic synapse 💬
4件: GRIA1, GRIA2, GRIA3, GRIA4 💬 D08964 💬 Perampanel 3件: 2, 6, 144 💬
43 GnRH secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
44 GnRH signaling pathway 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
45 Growth hormone synthesis, secretion and action 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
46 Huntington disease 💬
4件: GRIA1, GRIA2, GRIA3, GRIA4 💬 D08964 💬 Perampanel 3件: 2, 6, 144 💬
47 Huntington disease 💬
4件: GRIA1, GRIA2, GRIA3, GRIA4 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
48 Hypertrophic cardiomyopathy 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
49 Inflammatory mediator regulation of TRP channels 💬
3件: HTR2A, HTR2B, HTR2C 💬 D07945 💬 Fenfluramine 3件: 140, 144, 145 💬
50 Insulin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
51 Long-term depression 💬
3件: GRIA1, GRIA2, GRIA3 💬 D08964 💬 Perampanel 3件: 2, 6, 144 💬
52 Long-term depression 💬
3件: GRIA1, GRIA2, GRIA3 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
53 Long-term potentiation 💬
3件: CACNA1C, GRIA1, GRIA2 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
54 Long-term potentiation 💬
2件: GRIA1, GRIA2 💬 D08964 💬 Perampanel 3件: 2, 6, 144 💬
55 MAPK signaling pathway 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
56 Metabolic pathways 💬
2件: CA2, CA4 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
57 Morphine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D01253 💬 Clobazam 2件: 140, 144 💬
58 Morphine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
59 Neuroactive ligand-receptor interaction 💬
2件: CNR1, CNR2 💬 D10915 💬 Cannabidiol 19件: 2, 6, 8, 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
60 Neuroactive ligand-receptor interaction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D01253 💬 Clobazam 2件: 140, 144 💬
61 Neuroactive ligand-receptor interaction 💬
25件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
62 Neuroactive ligand-receptor interaction 💬
4件: GRIA1, GRIA2, GRIA3, GRIA4 💬 D08964 💬 Perampanel 3件: 2, 6, 144 💬
63 Neuroactive ligand-receptor interaction 💬
3件: HTR2A, HTR2B, HTR2C 💬 D07945 💬 Fenfluramine 3件: 140, 144, 145 💬
64 Neuroactive ligand-receptor interaction 💬
2件: MTNR1A, MTNR1B 💬 D08170 💬 Melatonin 11件: 6, 8, 13, 46, 49, 90, 97, 144, 145, 149, 202 💬
65 Nicotine addiction 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D01253 💬 Clobazam 2件: 140, 144 💬
66 Nicotine addiction 💬
20件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
67 Nicotine addiction 💬
4件: GRIA1, GRIA2, GRIA3, GRIA4 💬 D08964 💬 Perampanel 3件: 2, 6, 144 💬
68 Nitrogen metabolism 💬
2件: CA2, CA4 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
69 Oxytocin signaling pathway 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
70 Pancreatic secretion 💬
1件: CA2 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
71 Pancreatic secretion 💬
1件: KCNQ1 💬 D09569 💬 Ezogabine 2件: 2, 144 💬
72 Pathways of neurodegeneration - multiple diseases 💬
8件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
73 Pathways of neurodegeneration - multiple diseases 💬
4件: GRIA1, GRIA2, GRIA3, GRIA4 💬 D08964 💬 Perampanel 3件: 2, 6, 144 💬
74 Prion disease 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
75 Protein digestion and absorption 💬
1件: KCNQ1 💬 D09569 💬 Ezogabine 2件: 2, 144 💬
76 Proximal tubule bicarbonate reclamation 💬
2件: CA2, CA4 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
77 Rap1 signaling pathway 💬
1件: CNR1 💬 D10915 💬 Cannabidiol 19件: 2, 6, 8, 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
78 Renin secretion 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
79 Retrograde endocannabinoid signaling 💬
24件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
80 Retrograde endocannabinoid signaling 💬
1件: CNR1 💬 D10915 💬 Cannabidiol 19件: 2, 6, 8, 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
81 Retrograde endocannabinoid signaling 💬
16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 D01253 💬 Clobazam 2件: 140, 144 💬
82 Retrograde endocannabinoid signaling 💬
4件: GRIA1, GRIA2, GRIA3, GRIA4 💬 D08964 💬 Perampanel 3件: 2, 6, 144 💬
83 Serotonergic synapse 💬
7件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRB1, GABRB2, GABRB3 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
84 Serotonergic synapse 💬
3件: GABRB1, GABRB2, GABRB3 💬 D01253 💬 Clobazam 2件: 140, 144 💬
85 Serotonergic synapse 💬
4件: HTR2A, HTR2B, HTR2C, SLC6A4 💬 D07945 💬 Fenfluramine 3件: 140, 144, 145 💬
86 Spinocerebellar ataxia 💬
3件: GRIA1, GRIA2, GRIA3 💬 D08964 💬 Perampanel 3件: 2, 6, 144 💬
87 Spinocerebellar ataxia 💬
3件: GRIA1, GRIA2, GRIA3 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
88 Synaptic vesicle cycle 💬
1件: SLC6A4 💬 D07945 💬 Fenfluramine 3件: 140, 144, 145 💬
89 Taste transduction 💬
10件: CACNA1C, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, SCN2A, SCN3A, SCN9A 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
90 Taste transduction 💬
6件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 D01253 💬 Clobazam 2件: 140, 144 💬
91 Taste transduction 💬
3件: SCN2A, SCN3A, SCN9A 💬 D00354 💬 Lamotrigine 5件: 13, 34, 38, 114, 144 💬
92 Taste transduction 💬
3件: SCN2A, SCN3A, SCN9A 💬 D05775 💬 Rufinamide 1件: 144 💬
93 Thermogenesis 💬
1件: CNR1 💬 D10915 💬 Cannabidiol 19件: 2, 6, 8, 13, 36, 46, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬
94 Tight junction 💬
1件: CACNA1D 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
95 Transcriptional misregulation in cancer 💬
1件: GRIA3 💬 D08964 💬 Perampanel 3件: 2, 6, 144 💬
96 Transcriptional misregulation in cancer 💬
1件: GRIA3 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
97 Type II diabetes mellitus 💬
2件: CACNA1C, CACNA1D 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
98 Vascular smooth muscle contraction 💬
4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S 💬 D00537 💬 Topiramate 5件: 6, 140, 144, 156, 193 💬
99 Vibrio cholerae infection 💬
1件: KCNQ1 💬 D09569 💬 Ezogabine 2件: 2, 144 💬