Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Adherens junction 💬
1件: IGF1R 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
2 Adherens junction 💬
1件: IGF1R 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
3 Adrenergic signaling in cardiomyocytes 💬
1件: ADRB1 💬 D07660 💬 Celiprolol 1件: 168 💬
4 Adrenergic signaling in cardiomyocytes 💬
1件: AGTR1 💬 D00523 💬 Irbesartan 4件: 66, 167, 168, 222 💬
5 Adrenergic signaling in cardiomyocytes 💬
1件: SCN5A 💬 D01450 💬 Bupivacaine 8件: 46, 51, 53, 70, 96, 168, 226, 298 💬
6 Adrenergic signaling in cardiomyocytes 💬
1件: SCN5A 💬 D07552 💬 Bupivacaine 8件: 46, 51, 53, 70, 96, 168, 226, 298 💬
7 Adrenergic signaling in cardiomyocytes 💬
1件: SCN5A 💬 D00358 💬 Lidocaine 13件:  6 , 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256 💬
8 Adrenergic signaling in cardiomyocytes 💬
1件: SCN5A 💬 D02086 💬 Lidocaine 13件:  6 , 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256 💬
9 Adrenergic signaling in cardiomyocytes 💬
1件: SCN5A 💬 D08127 💬 Lidocaine 13件:  6 , 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256 💬
10 AGE-RAGE signaling pathway in diabetic complications 💬
1件: AGTR1 💬 D00523 💬 Irbesartan 4件: 66, 167, 168, 222 💬
11 Aldosterone synthesis and secretion 💬
1件: AGTR1 💬 D00523 💬 Irbesartan 4件: 66, 167, 168, 222 💬
12 AMPK signaling pathway 💬
1件: IGF1R 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
13 AMPK signaling pathway 💬
1件: IGF1R 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
14 Apelin signaling pathway 💬
1件: AGTR1 💬 D00523 💬 Irbesartan 4件: 66, 167, 168, 222 💬
15 Autophagy - animal 💬
1件: IGF1R 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
16 Autophagy - animal 💬
1件: IGF1R 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
17 Breast cancer 💬
1件: IGF1R 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
18 Breast cancer 💬
1件: IGF1R 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
19 Calcium signaling pathway 💬
1件: ADRB1 💬 D07660 💬 Celiprolol 1件: 168 💬
20 Calcium signaling pathway 💬
1件: AGTR1 💬 D00523 💬 Irbesartan 4件: 66, 167, 168, 222 💬
21 cAMP signaling pathway 💬
1件: ADRB1 💬 D07660 💬 Celiprolol 1件: 168 💬
22 cGMP-PKG signaling pathway 💬
1件: ADRB1 💬 D07660 💬 Celiprolol 1件: 168 💬
23 cGMP-PKG signaling pathway 💬
1件: AGTR1 💬 D00523 💬 Irbesartan 4件: 66, 167, 168, 222 💬
24 Chemical carcinogenesis - receptor activation 💬
1件: ADRB1 💬 D07660 💬 Celiprolol 1件: 168 💬
25 Coronavirus disease - COVID-19 💬
1件: AGTR1 💬 D00523 💬 Irbesartan 4件: 66, 167, 168, 222 💬
26 Cortisol synthesis and secretion 💬
1件: AGTR1 💬 D00523 💬 Irbesartan 4件: 66, 167, 168, 222 💬
27 Cushing syndrome 💬
1件: AGTR1 💬 D00523 💬 Irbesartan 4件: 66, 167, 168, 222 💬
28 Cytokine-cytokine receptor interaction 💬
1件: GHR 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
29 Cytokine-cytokine receptor interaction 💬
1件: GHR 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
30 Diabetic cardiomyopathy 💬
1件: AGTR1 💬 D00523 💬 Irbesartan 4件: 66, 167, 168, 222 💬
31 Dilated cardiomyopathy 💬
1件: ADRB1 💬 D07660 💬 Celiprolol 1件: 168 💬
32 Dopaminergic synapse 💬
1件: SCN1A 💬 D01450 💬 Bupivacaine 8件: 46, 51, 53, 70, 96, 168, 226, 298 💬
33 Dopaminergic synapse 💬
1件: SCN1A 💬 D07552 💬 Bupivacaine 8件: 46, 51, 53, 70, 96, 168, 226, 298 💬
34 Dopaminergic synapse 💬
1件: SCN1A 💬 D00358 💬 Lidocaine 13件:  6 , 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256 💬
35 Dopaminergic synapse 💬
1件: SCN1A 💬 D02086 💬 Lidocaine 13件:  6 , 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256 💬
36 Dopaminergic synapse 💬
1件: SCN1A 💬 D08127 💬 Lidocaine 13件:  6 , 13, 34, 46, 51, 70, 84, 86, 107, 168, 226, 231, 256 💬
37 EGFR tyrosine kinase inhibitor resistance 💬
1件: IGF1R 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
38 EGFR tyrosine kinase inhibitor resistance 💬
1件: IGF1R 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
39 Endocrine resistance 💬
1件: IGF1R 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
40 Endocrine resistance 💬
1件: IGF1R 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
41 Endocytosis 💬
1件: IGF1R 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
42 Endocytosis 💬
1件: IGF1R 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
43 Focal adhesion 💬
1件: IGF1R 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
44 Focal adhesion 💬
1件: IGF1R 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
45 FoxO signaling pathway 💬
1件: IGF1R 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
46 FoxO signaling pathway 💬
1件: IGF1R 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
47 Gap junction 💬
1件: ADRB1 💬 D07660 💬 Celiprolol 1件: 168 💬
48 Glioma 💬
1件: IGF1R 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
49 Glioma 💬
1件: IGF1R 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
50 Growth hormone synthesis, secretion and action 💬
1件: GHR 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
51 Growth hormone synthesis, secretion and action 💬
1件: GHR 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
52 Hepatocellular carcinoma 💬
1件: IGF1R 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
53 Hepatocellular carcinoma 💬
1件: IGF1R 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
54 HIF-1 signaling pathway 💬
1件: IGF1R 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
55 HIF-1 signaling pathway 💬
1件: IGF1R 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
56 JAK-STAT signaling pathway 💬
1件: GHR 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
57 JAK-STAT signaling pathway 💬
1件: GHR 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
58 Long-term depression 💬
1件: IGF1R 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
59 Long-term depression 💬
1件: IGF1R 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
60 Longevity regulating pathway 💬
1件: IGF1R 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
61 Longevity regulating pathway 💬
1件: IGF1R 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
62 Longevity regulating pathway - multiple species 💬
1件: IGF1R 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
63 Longevity regulating pathway - multiple species 💬
1件: IGF1R 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
64 MAPK signaling pathway 💬
1件: IGF1R 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
65 MAPK signaling pathway 💬
1件: IGF1R 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
66 Melanoma 💬
1件: IGF1R 💬 D03297 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
67 Melanoma 💬
1件: IGF1R 💬 D04870 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬
68