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 Target Gene/Pathway(薬物標的遺伝子/パスウェイリスト) 

   e.g. "Sirolimus", "アダリムマブ", "MAP2K"    Synonyms (Drugs) were also searched for.

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29 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY
 On map, Yellow: Drug target, Red: Disease-related 
 KEGG GENES  KEGG DRUG  DrugBank   指定難病告示番号
 1  ABC transporters 
 1 gene, 1 drug (DrugBank) and 1 disease shown 
 1件: ABCC8   D00418   Minoxidil   1件: 179 
 2  Adrenergic signaling in cardiomyocytes 
 1 gene, 1 drug (DrugBank) and 18 diseases shown 
 1件: AGTR1   D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 3  AGE-RAGE signaling pathway in diabetic complications 
 1 gene, 1 drug (DrugBank) and 18 diseases shown 
 1件: AGTR1   D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 4  Alcoholism 
 2 genes, 2 drugs (DrugBank) and 10 diseases shown 
 1件: DRD2   D00426   Risperidone   5件: 8, 156, 179, 187, 206 
 1件: SLC6A3   D01296   Methylphenidate   7件: 6, 13, 34, 84, 113, 179, 206 
 D04999 
 5  Aldosterone synthesis and secretion 
 1 gene, 1 drug (DrugBank) and 18 diseases shown 
 1件: AGTR1   D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 6  Amphetamine addiction 
 1 gene, 1 drug (DrugBank) and 7 diseases shown 
 1件: SLC6A3   D01296   Methylphenidate   7件: 6, 13, 34, 84, 113, 179, 206 
 D04999 
 7  Apelin signaling pathway 
 1 gene, 1 drug (DrugBank) and 18 diseases shown 
 1件: AGTR1   D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 8  Calcium signaling pathway 
 2 genes, 2 drugs (DrugBank) and 22 diseases shown 
 1件: AGTR1   D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 1件: HTR2A   D00426   Risperidone   5件: 8, 156, 179, 187, 206 
 9  cAMP signaling pathway 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 
 1件: DRD2   D00426   Risperidone   5件: 8, 156, 179, 187, 206 
 10  cGMP-PKG signaling pathway 
 1 gene, 1 drug (DrugBank) and 18 diseases shown 
 1件: AGTR1   D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 11  Cocaine addiction 
 2 genes, 2 drugs (DrugBank) and 10 diseases shown 
 1件: DRD2   D00426   Risperidone   5件: 8, 156, 179, 187, 206 
 1件: SLC6A3   D01296   Methylphenidate   7件: 6, 13, 34, 84, 113, 179, 206 
 D04999 
 12  Cortisol synthesis and secretion 
 1 gene, 1 drug (DrugBank) and 18 diseases shown 
 1件: AGTR1   D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 13  Cushing syndrome 
 1 gene, 1 drug (DrugBank) and 18 diseases shown 
 1件: AGTR1   D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 14  Dopaminergic synapse 
 2 genes, 2 drugs (DrugBank) and 10 diseases shown 
 1件: DRD2   D00426   Risperidone   5件: 8, 156, 179, 187, 206 
 1件: SLC6A3   D01296   Methylphenidate   7件: 6, 13, 34, 84, 113, 179, 206 
 D04999 
 15  Gap junction 
 2 genes, 1 drug (DrugBank) and 5 diseases shown 
 2件: DRD2, HTR2A   D00426   Risperidone   5件: 8, 156, 179, 187, 206 
 16  GnRH secretion 
 1 gene, 1 drug (DrugBank) and 1 disease shown 
 1件: KCNJ11   D00418   Minoxidil   1件: 179 
 17  Inflammatory mediator regulation of TRP channels 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 
 1件: HTR2A   D00426   Risperidone   5件: 8, 156, 179, 187, 206 
 18  Insulin secretion 
 2 genes, 1 drug (DrugBank) and 1 disease shown 
 2件: ABCC8, KCNJ11   D00418   Minoxidil   1件: 179 
 19  Neuroactive ligand-receptor interaction 
 3 genes, 2 drugs (DrugBank) and 22 diseases shown 
 1件: AGTR1   D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 2件: DRD2, HTR2A   D00426   Risperidone   5件: 8, 156, 179, 187, 206 
 20  Parkinson disease 
 2 genes, 2 drugs (DrugBank) and 10 diseases shown 
 1件: DRD2   D00426   Risperidone   5件: 8, 156, 179, 187, 206 
 1件: SLC6A3   D01296   Methylphenidate   7件: 6, 13, 34, 84, 113, 179, 206 
 D04999 
 21  Pathways in cancer 
 1 gene, 1 drug (DrugBank) and 18 diseases shown 
 1件: AGTR1   D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 22  Phospholipase D signaling pathway 
 1 gene, 1 drug (DrugBank) and 18 diseases shown 
 1件: AGTR1   D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 23  Rap1 signaling pathway 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 
 1件: DRD2   D00426   Risperidone   5件: 8, 156, 179, 187, 206 
 24  Renin secretion 
 1 gene, 1 drug (DrugBank) and 18 diseases shown 
 1件: AGTR1   D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 25  Renin-angiotensin system 
 1 gene, 1 drug (DrugBank) and 18 diseases shown 
 1件: AGTR1   D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 
 26  Serotonergic synapse 
 2 genes, 2 drugs (DrugBank) and 9 diseases shown 
 1件: HTR2A   D00426   Risperidone   5件: 8, 156, 179, 187, 206 
 1件: SLC6A4   D00326   Fluoxetine   6件: 13, 17, 78, 86, 179, 206 
 D00823 
 27  Synaptic vesicle cycle 
 3 genes, 2 drugs (DrugBank) and 10 diseases shown 
 2件: SLC6A2, SLC6A3   D01296   Methylphenidate   7件: 6, 13, 34, 84, 113, 179, 206 
 D04999 
 1件: SLC6A4   D00326   Fluoxetine   6件: 13, 17, 78, 86, 179, 206 
 D00823 
 28  Type II diabetes mellitus 
 2 genes, 1 drug (DrugBank) and 1 disease shown 
 2件: ABCC8, KCNJ11   D00418   Minoxidil   1件: 179 
 29  Vascular smooth muscle contraction 
 1 gene, 1 drug (DrugBank) and 18 diseases shown 
 1件: AGTR1   D00357   Losartan   18件: 13, 17, 19, 46, 58, 66, 67, 85, 96, 97, 98, 113, 164, 167, 179, 215, 222, 299 
 D08146 

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