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 Target Gene/Pathway(薬物標的遺伝子/パスウェイリスト) 

   e.g. "Sirolimus", "アダリムマブ", "MAP2K"    Synonyms (Drugs) were also searched for.

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59 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY
 On map, Yellow: Drug target, Red: Disease-related 
 KEGG GENES  KEGG DRUG  DrugBank   指定難病告示番号
 1  ABC transporters 
 1 gene, 1 drug (DrugBank) and 1 disease shown 
 1件: ABCC8   D00294   Diazoxide   1件: 193 
 2  Adrenergic signaling in cardiomyocytes 
 6 genes, 2 drugs (DrugBank) and 11 diseases shown 
 1件: ADRB1   D00601   Metoprolol   7件: 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 5件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, SCN5A   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 3  Aldosterone synthesis and secretion 
 5 genes, 2 drugs (DrugBank) and 16 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 1件: MC2R   D00146   Corticotropin   12件: 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 4  Alzheimer disease 
 4 genes, 1 drug (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 5  Amphetamine addiction 
 6 genes, 1 drug (DrugBank) and 5 diseases shown 
 6件: CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 6  Amyotrophic lateral sclerosis (ALS) 
 2 genes, 1 drug (DrugBank) and 5 diseases shown 
 2件: GRIA1, GRIA2   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 7  Arrhythmogenic right ventricular cardiomyopathy (ARVC) 
 4 genes, 1 drug (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 8  Bile secretion 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 
 1件: CA2   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 9  Calcium signaling pathway 
 6 genes, 4 drugs (DrugBank) and 13 diseases shown 
 1件: ADRB1   D00601   Metoprolol   7件: 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 1件: OXTR   D07229   Carbetocin   1件: 193 
 D00089   Oxytocin   4件: 127, 193, 206, 226 
 10  cAMP signaling pathway 
 13 genes, 8 drugs (DrugBank) and 29 diseases shown 
 1件: ADRB1   D00601   Metoprolol   7件: 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 8件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GRIA1, GRIA2, GRIA3, GRIA4   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 1件: GLP1R   D04121   Exenatide   3件: 6, 193, 233 
 D06404   Liraglutide   3件: 6, 75, 193 
 1件: MC2R   D00146   Corticotropin   12件: 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 1件: OXTR   D07229   Carbetocin   1件: 193 
 D00089   Oxytocin   4件: 127, 193, 206, 226 
 1件: SSTR2   D00442   Octreotide   8件: 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 11  Carbohydrate digestion and absorption 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 
 1件: CACNA1D   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 12  Cardiac muscle contraction 
 4 genes, 1 drug (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 13  Cellular senescence 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 
 1件: CACNA1D   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 14  cGMP-PKG signaling pathway 
 6 genes, 3 drugs (DrugBank) and 11 diseases shown 
 1件: ADRA2A   D00606   Guanfacine   1件: 193 
 D08031 
 1件: ADRB1   D00601   Metoprolol   7件: 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 15  Cholinergic synapse 
 4 genes, 1 drug (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 16  Circadian entrainment 
 6 genes, 1 drug (DrugBank) and 5 diseases shown 
 6件: CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 17  Cocaine addiction 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 
 1件: GRIA2   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 18  Collecting duct acid secretion 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 
 1件: CA2   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 19  Cortisol synthesis and secretion 
 6 genes, 3 drugs (DrugBank) and 16 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 1件: CYP11B1   D00410   Metyrapone   2件: 75, 193 
 D05019 
 1件: MC2R   D00146   Corticotropin   12件: 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 20  Cushing syndrome 
 6 genes, 3 drugs (DrugBank) and 16 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 1件: CYP11B1   D00410   Metyrapone   2件: 75, 193 
 D05019 
 1件: MC2R   D00146   Corticotropin   12件: 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 21  Cytokine-cytokine receptor interaction 
 1 gene, 1 drug (DrugBank) and 18 diseases shown 
 1件: GHR   D02691   Somatotropin   18件: 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 22  Dilated cardiomyopathy (DCM) 
 5 genes, 2 drugs (DrugBank) and 11 diseases shown 
 1件: ADRB1   D00601   Metoprolol   7件: 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 23  Dopaminergic synapse 
 7 genes, 1 drug (DrugBank) and 5 diseases shown 
 7件: CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, SCN1A   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 24  GABAergic synapse 
 20 genes, 1 drug (DrugBank) and 5 diseases shown 
 20件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 25  Gap junction 
 1 gene, 1 drug (DrugBank) and 7 diseases shown 
 1件: ADRB1   D00601   Metoprolol   7件: 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 26  Gastric acid secretion 
 2 genes, 2 drugs (DrugBank) and 12 diseases shown 
 1件: CA2   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 1件: SSTR2   D00442   Octreotide   8件: 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 27  Glutamatergic synapse 
 11 genes, 1 drug (DrugBank) and 5 diseases shown 
 11件: CACNA1C, CACNA1D, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 28  GnRH secretion 
 5 genes, 2 drugs (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 1件: KCNJ11   D00294   Diazoxide   1件: 193 
 29  GnRH signaling pathway 
 4 genes, 1 drug (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 30  Growth hormone synthesis, secretion and action 
 6 genes, 3 drugs (DrugBank) and 27 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 1件: GHR   D02691   Somatotropin   18件: 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 1件: SSTR2   D00442   Octreotide   8件: 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 31  Hypertrophic cardiomyopathy (HCM) 
 4 genes, 1 drug (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 32  Insulin secretion 
 7 genes, 4 drugs (DrugBank) and 7 diseases shown 
 2件: ABCC8, KCNJ11   D00294   Diazoxide   1件: 193 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 1件: GLP1R   D04121   Exenatide   3件: 6, 193, 233 
 D06404   Liraglutide   3件: 6, 75, 193 
 33  JAK-STAT signaling pathway 
 1 gene, 1 drug (DrugBank) and 18 diseases shown 
 1件: GHR   D02691   Somatotropin   18件: 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 34  Long-term depression 
 3 genes, 1 drug (DrugBank) and 5 diseases shown 
 3件: GRIA1, GRIA2, GRIA3   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 35  Long-term potentiation 
 3 genes, 1 drug (DrugBank) and 5 diseases shown 
 3件: CACNA1C, GRIA1, GRIA2   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 36  MAPK signaling pathway 
 4 genes, 1 drug (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 37  Metabolic pathways 
 4 genes, 3 drugs (DrugBank) and 8 diseases shown 
 2件: CA2, CA4   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 1件: CYP11B1   D00410   Metyrapone   2件: 75, 193 
 D05019 
 1件: CYP19A1   D00960   Anastrozole   3件: 78, 86, 193 
 38  Morphine addiction 
 16 genes, 1 drug (DrugBank) and 5 diseases shown 
 16件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 39  Neuroactive ligand-receptor interaction 
 34 genes, 12 drugs (DrugBank) and 44 diseases shown 
 1件: ADRA2A   D00606   Guanfacine   1件: 193 
 D08031 
 1件: ADRB1   D00601   Metoprolol   7件: 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 1件: CNR1   D05731   Rimonabant   1件: 193 
 2件: CNR1, CNR2   D10915   Cannabidiol   14件: 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 25件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 1件: GHR   D02691   Somatotropin   18件: 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 1件: GLP1R   D04121   Exenatide   3件: 6, 193, 233 
 D06404   Liraglutide   3件: 6, 75, 193 
 1件: MC2R   D00146   Corticotropin   12件: 2, 13, 46, 49, 50, 66, 75, 78, 84, 145, 193, 222 
 1件: OXTR   D07229   Carbetocin   1件: 193 
 D00089   Oxytocin   4件: 127, 193, 206, 226 
 1件: SSTR2   D00442   Octreotide   8件: 67, 75, 84, 85, 89, 96, 193, 227 
 D06495 
 40  Nicotine addiction 
 20 genes, 1 drug (DrugBank) and 5 diseases shown 
 20件: GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 41  Nitrogen metabolism 
 2 genes, 1 drug (DrugBank) and 5 diseases shown 
 2件: CA2, CA4   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 42  Ovarian steroidogenesis 
 1 gene, 1 drug (DrugBank) and 3 diseases shown 
 1件: CYP19A1   D00960   Anastrozole   3件: 78, 86, 193 
 43  Oxytocin signaling pathway 
 5 genes, 3 drugs (DrugBank) and 8 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 1件: OXTR   D07229   Carbetocin   1件: 193 
 D00089   Oxytocin   4件: 127, 193, 206, 226 
 44  Pancreatic secretion 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 
 1件: CA2   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 45  PI3K-Akt signaling pathway 
 1 gene, 1 drug (DrugBank) and 18 diseases shown 
 1件: GHR   D02691   Somatotropin   18件: 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 46  Proximal tubule bicarbonate reclamation 
 2 genes, 1 drug (DrugBank) and 5 diseases shown 
 2件: CA2, CA4   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 47  Rap1 signaling pathway 
 1 gene, 2 drugs (DrugBank) and 14 diseases shown 
 1件: CNR1   D10915   Cannabidiol   14件: 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 D05731   Rimonabant   1件: 193 
 48  Regulation of lipolysis in adipocytes 
 1 gene, 1 drug (DrugBank) and 7 diseases shown 
 1件: ADRB1   D00601   Metoprolol   7件: 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 49  Renin secretion 
 5 genes, 2 drugs (DrugBank) and 11 diseases shown 
 1件: ADRB1   D00601   Metoprolol   7件: 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 50  Retrograde endocannabinoid signaling 
 25 genes, 3 drugs (DrugBank) and 15 diseases shown 
 24件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GRIA1, GRIA2, GRIA3, GRIA4   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 1件: CNR1   D10915   Cannabidiol   14件: 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 D05731   Rimonabant   1件: 193 
 51  Salivary secretion 
 1 gene, 1 drug (DrugBank) and 7 diseases shown 
 1件: ADRB1   D00601   Metoprolol   7件: 17, 57, 58, 66, 113, 193, 226 
 D02358 
 D05011 
 52  Serotonergic synapse 
 7 genes, 1 drug (DrugBank) and 5 diseases shown 
 7件: CACNA1C, CACNA1D, CACNA1F, CACNA1S, GABRB1, GABRB2, GABRB3   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 53  Steroid hormone biosynthesis 
 2 genes, 2 drugs (DrugBank) and 4 diseases shown 
 1件: CYP11B1   D00410   Metyrapone   2件: 75, 193 
 D05019 
 1件: CYP19A1   D00960   Anastrozole   3件: 78, 86, 193 
 54  Taste transduction 
 10 genes, 1 drug (DrugBank) and 5 diseases shown 
 10件: CACNA1C, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, SCN2A, SCN3A, SCN9A   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 55  Thermogenesis 
 1 gene, 2 drugs (DrugBank) and 14 diseases shown 
 1件: CNR1   D10915   Cannabidiol   14件: 2, 6, 13, 46, 95, 96, 97, 140, 144, 145, 157, 158, 193, 271 
 D05731   Rimonabant   1件: 193 
 56  Tight junction 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 
 1件: CACNA1D   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 57  Transcriptional misregulation in cancer 
 1 gene, 1 drug (DrugBank) and 5 diseases shown 
 1件: GRIA3   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 58  Type II diabetes mellitus 
 4 genes, 2 drugs (DrugBank) and 5 diseases shown 
 2件: ABCC8, KCNJ11   D00294   Diazoxide   1件: 193 
 2件: CACNA1C, CACNA1D   D00537   Topiramate   5件: 6, 140, 144, 156, 193 
 59  Vascular smooth muscle contraction 
 4 genes, 1 drug (DrugBank) and 5 diseases shown 
 4件: CACNA1C, CACNA1D, CACNA1F, CACNA1S   D00537   Topiramate   5件: 6, 140, 144, 156, 193 

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