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 Target Gene/Pathway(薬物標的遺伝子/パスウェイリスト) 

   e.g. "Sirolimus", "アダリムマブ", "MAP2K"    Synonyms (Drugs) were also searched for.

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28 / 275 pathways found* Show info (disease name, etc.) on mouse-over.
 No.   KEGG PATHWAY
 On map, Yellow: Drug target, Red: Disease-related 
 KEGG GENES  KEGG DRUG  DrugBank   指定難病告示番号
 1  Alcoholism 
 2 genes, 1 drug (DrugBank) and 2 diseases shown 
 1件: ADORA2A   D02017   Theophylline   2件: 236, 299 
 1件: ADORA2B   D00371   Theophylline   2件: 236, 299 
 D01712 
 D06103 
 D06104 
 2  Aldosterone synthesis and secretion 
 1 gene, 1 drug (DrugBank) and 2 diseases shown 
 1件: PDE2A   D00371   Theophylline   2件: 236, 299 
 D01712 
 D02017 
 D06103 
 D06104 
 3  Apelin signaling pathway 
 1 gene, 1 drug (DrugBank) and 2 diseases shown 
 1件: PDE3B   D00371   Theophylline   2件: 236, 299 
 D01712 
 D02017 
 D06103 
 D06104 
 4  Calcium signaling pathway 
 5 genes, 1 drug (DrugBank) and 2 diseases shown 
 4件: ADORA2A, PDE1A, PDE1B, PDE1C   D02017   Theophylline   2件: 236, 299 
 4件: ADORA2B, PDE1A, PDE1B, PDE1C   D00371   Theophylline   2件: 236, 299 
 D01712 
 D06103 
 D06104 
 5  cAMP signaling pathway 
 9 genes, 1 drug (DrugBank) and 2 diseases shown 
 9件: ADORA1, ADORA2A, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D   D02017   Theophylline   2件: 236, 299 
 8件: ADORA1, PDE10A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D   D00371   Theophylline   2件: 236, 299 
 D01712 
 D06103 
 D06104 
 6  cGMP-PKG signaling pathway 
 4 genes, 1 drug (DrugBank) and 2 diseases shown 
 4件: ADORA1, PDE2A, PDE3A, PDE3B   D00371   Theophylline   2件: 236, 299 
 D01712 
 D02017 
 D06103 
 D06104 
 7  Cortisol synthesis and secretion 
 2 genes, 1 drug (DrugBank) and 2 diseases shown 
 2件: PDE8A, PDE8B   D00371   Theophylline   2件: 236, 299 
 D01712 
 D02017 
 D06103 
 D06104 
 8  Cushing syndrome 
 3 genes, 1 drug (DrugBank) and 2 diseases shown 
 3件: PDE11A, PDE8A, PDE8B   D00371   Theophylline   2件: 236, 299 
 D01712 
 D02017 
 D06103 
 D06104 
 9  Cytokine-cytokine receptor interaction 
 1 gene, 1 drug (DrugBank) and 18 diseases shown 
 1件: GHR   D02691   Somatotropin   18件: 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 10  Glucagon signaling pathway 
 1 gene, 1 drug (DrugBank) and 2 diseases shown 
 1件: PDE3B   D00371   Theophylline   2件: 236, 299 
 D01712 
 D02017 
 D06103 
 D06104 
 11  Growth hormone synthesis, secretion and action 
 1 gene, 1 drug (DrugBank) and 18 diseases shown 
 1件: GHR   D02691   Somatotropin   18件: 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 12  Insulin signaling pathway 
 1 gene, 1 drug (DrugBank) and 2 diseases shown 
 1件: PDE3B   D00371   Theophylline   2件: 236, 299 
 D01712 
 D02017 
 D06103 
 D06104 
 13  JAK-STAT signaling pathway 
 1 gene, 1 drug (DrugBank) and 18 diseases shown 
 1件: GHR   D02691   Somatotropin   18件: 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 14  Metabolic pathways 
 16 genes, 1 drug (DrugBank) and 2 diseases shown 
 16件: PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B   D00371   Theophylline   2件: 236, 299 
 D01712 
 D02017 
 D06103 
 D06104 
 15  Morphine addiction 
 17 genes, 1 drug (DrugBank) and 2 diseases shown 
 17件: ADORA1, PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B   D00371   Theophylline   2件: 236, 299 
 D01712 
 D02017 
 D06103 
 D06104 
 16  Neuroactive ligand-receptor interaction 
 4 genes, 2 drugs (DrugBank) and 18 diseases shown 
 2件: ADORA1, ADORA2A   D02017   Theophylline   2件: 236, 299 
 2件: ADORA1, ADORA2B   D00371   Theophylline   2件: 236, 299 
 D01712 
 D06103 
 D06104 
 1件: GHR   D02691   Somatotropin   18件: 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 17  Olfactory transduction 
 4 genes, 1 drug (DrugBank) and 2 diseases shown 
 4件: PDE1A, PDE1B, PDE1C, PDE2A   D00371   Theophylline   2件: 236, 299 
 D01712 
 D02017 
 D06103 
 D06104 
 18  Parathyroid hormone synthesis, secretion and action 
 4 genes, 1 drug (DrugBank) and 2 diseases shown 
 4件: PDE4A, PDE4B, PDE4C, PDE4D   D00371   Theophylline   2件: 236, 299 
 D01712 
 D02017 
 D06103 
 D06104 
 19  Parkinson disease 
 1 gene, 1 drug (DrugBank) and 2 diseases shown 
 1件: ADORA2A   D02017   Theophylline   2件: 236, 299 
 20  PI3K-Akt signaling pathway 
 1 gene, 1 drug (DrugBank) and 18 diseases shown 
 1件: GHR   D02691   Somatotropin   18件: 2, 3, 13, 19, 46, 74, 75, 78, 96, 113, 191, 193, 195, 236, 265, 274, 276, 299 
 21  Progesterone-mediated oocyte maturation 
 1 gene, 1 drug (DrugBank) and 2 diseases shown 
 1件: PDE3B   D00371   Theophylline   2件: 236, 299 
 D01712 
 D02017 
 D06103 
 D06104 
 22  Purine metabolism 
 16 genes, 1 drug (DrugBank) and 2 diseases shown 
 16件: PDE10A, PDE11A, PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B   D00371   Theophylline   2件: 236, 299 
 D01712 
 D02017 
 D06103 
 D06104 
 23  Rap1 signaling pathway 
 2 genes, 1 drug (DrugBank) and 2 diseases shown 
 1件: ADORA2A   D02017   Theophylline   2件: 236, 299 
 1件: ADORA2B   D00371   Theophylline   2件: 236, 299 
 D01712 
 D06103 
 D06104 
 24  Regulation of lipolysis in adipocytes 
 2 genes, 1 drug (DrugBank) and 2 diseases shown 
 2件: ADORA1, PDE3B   D00371   Theophylline   2件: 236, 299 
 D01712 
 D02017 
 D06103 
 D06104 
 25  Renin secretion 
 6 genes, 1 drug (DrugBank) and 2 diseases shown 
 6件: ADORA1, PDE1A, PDE1B, PDE1C, PDE3A, PDE3B   D00371   Theophylline   2件: 236, 299 
 D01712 
 D02017 
 D06103 
 D06104 
 26  Sphingolipid signaling pathway 
 1 gene, 1 drug (DrugBank) and 2 diseases shown 
 1件: ADORA1   D00371   Theophylline   2件: 236, 299 
 D01712 
 D02017 
 D06103 
 D06104 
 27  Taste transduction 
 3 genes, 1 drug (DrugBank) and 2 diseases shown 
 3件: PDE1A, PDE1B, PDE1C   D00371   Theophylline   2件: 236, 299 
 D01712 
 D02017 
 D06103 
 D06104 
 28  Vascular smooth muscle contraction 
 2 genes, 1 drug (DrugBank) and 2 diseases shown 
 1件: ADORA2A   D02017   Theophylline   2件: 236, 299 
 1件: ADORA2B   D00371   Theophylline   2件: 236, 299 
 D01712 
 D06103 
 D06104 

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