Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Leishmaniasis 💬
1件: C3 💬 D11613 💬 Pegcetacoplan 3件:  2 , 62, 222 💬
2 Leishmaniasis 💬
14件: HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5 💬 D04318 💬 Glatiramer 4件:  2 , 13, 96, 156 💬
3 Leishmaniasis 💬
1件: IFNG 💬 D11120 💬 Emapalumab 2件: 49, 107 💬
4 Leishmaniasis 💬
1件: IFNG 💬 D04242 💬 Fontolizumab 1件: 46 💬
5 Leishmaniasis 💬
2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
6 Leishmaniasis 💬
4件: IL10, IL1A, IL1B, TNF 💬 D01583 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
7 Leishmaniasis 💬
2件: IL12A, IL12B 💬 D09214 💬 Ustekinumab 17件: 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
8 Leishmaniasis 💬
1件: IL1A 💬 D11253 💬 Bermekimab 1件: 51 💬
9 Leishmaniasis 💬
2件: IL1A, IL1B 💬 D06635 💬 Rilonacept 4件: 51, 106, 107, 266 💬
10 Leishmaniasis 💬
1件: IL1B 💬 D09315 💬 Canakinumab 10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
11 Leishmaniasis 💬
1件: IL1B 💬 D09911 💬 Gevokizumab 4件: 41, 50, 56, 269 💬
12 Leishmaniasis 💬
1件: IL4 💬 D03117 💬 Binetrakin 1件: 46 💬
13 Leishmaniasis 💬
1件: ITGA4 💬 D10540 💬 Abrilumab 2件: 96, 97 💬
14 Leishmaniasis 💬
1件: ITGA4 💬 D06590 💬 Firategrast 1件: 13 💬
15 Leishmaniasis 💬
1件: ITGA4 💬 D06886 💬 Natalizumab 6件: 13, 15, 25, 46, 63, 96 💬
16 Leishmaniasis 💬
1件: ITGA4 💬 D08083 💬 Vedolizumab 3件: 94, 96, 97 💬
17 Leishmaniasis 💬
1件: JAK1 💬 D10871 💬 Filgotinib 6件: 46, 53, 96, 97, 222, 271 💬
18 Leishmaniasis 💬
1件: JAK1 💬 D10944 💬 Itacitinib 5件: 46, 51, 60, 97, 228 💬
19 Leishmaniasis 💬
1件: JAK1 💬 D10994 💬 Upadacitinib 8件: 40, 41, 46, 49, 96, 97, 107, 271 💬
20 Leishmaniasis 💬
2件: JAK1, JAK2 💬 D10308 💬 Baricitinib 13件: 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325 💬
21 Leishmaniasis 💬
2件: JAK1, JAK2 💬 D10653 💬 Peficitinib 1件: 46 💬
22 Leishmaniasis 💬
2件: JAK1, JAK2 💬 D09959 💬 Ruxolitinib 1件: 228 💬
23 Leishmaniasis 💬
2件: JAK1, JAK2 💬 D09970 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271 💬
24 Leishmaniasis 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod 2件: 113, 222 💬
25 Leishmaniasis 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod 1件:  8  💬
26 Leishmaniasis 💬
1件: NFKB1 💬 D01146 💬 Iguratimod 4件: 46, 51, 53, 271 💬
27 Leishmaniasis 💬
1件: PTGS2 💬 D01545 💬 Aceclofenac 1件: 46 💬
28 Leishmaniasis 💬
1件: PTGS2 💬 D00217 💬 Acetaminophen 18件:  3 ,  6 , 11, 13, 34, 35, 46, 49, 51, 70, 86, 96, 222, 231, 256, 271, 300, 337 💬
29 Leishmaniasis 💬
1件: PTGS2 💬 D00109 💬 Acetylsalicylic acid 15件: 13, 22, 34, 46, 49, 51, 58, 86, 96, 97, 113, 158, 210, 231, 251 💬
30 Leishmaniasis 💬
1件: PTGS2 💬 D00567 💬 Celecoxib 10件:  2 ,  3 , 34, 46, 70, 89, 107, 161, 171, 271 💬
31 Leishmaniasis 💬
1件: PTGS2 💬 D00903 💬 Diclofenac 5件: 13, 34, 46, 78, 271 💬
32 Leishmaniasis 💬
1件: PTGS2 💬 D00904 💬 Diclofenac 5件: 13, 34, 46, 78, 271 💬
33 Leishmaniasis 💬
1件: PTGS2 💬 D07816 💬 Diclofenac 5件: 13, 34, 46, 78, 271 💬
34 Leishmaniasis 💬
1件: PTGS2 💬 D00130 💬 Diflunisal 1件: 28 💬
35 Leishmaniasis 💬
1件: PTGS2 💬 D00315 💬 Etodolac 1件: 46 💬
36 Leishmaniasis 💬
1件: PTGS2 💬 D03710 💬 Etoricoxib 2件: 46, 271 💬
37 Leishmaniasis 💬
1件: PTGS2 💬 D00330 💬 Flurbiprofen 3件: 13, 21, 46 💬
38 Leishmaniasis 💬
1件: PTGS2 💬 D01475 💬 Flurbiprofen 3件: 13, 21, 46 💬
39 Leishmaniasis 💬
1件: PTGS2 💬 D02290 💬 Flurbiprofen 3件: 13, 21, 46 💬
40 Leishmaniasis 💬
1件: PTGS2 💬 D00126 💬 Ibuprofen 7件: 13, 46, 65, 107, 113, 271, 299 💬
41 Leishmaniasis 💬
1件: PTGS2 💬 D01122 💬 Ibuprofen 7件: 13, 46, 65, 107, 113, 271, 299 💬
42 Leishmaniasis 💬
1件: PTGS2 💬 D04490 💬 Ibuprofen 7件: 13, 46, 65, 107, 113, 271, 299 💬
43 Leishmaniasis 💬
1件: PTGS2 💬 D06606 💬 Ibuprofen 7件: 13, 46, 65, 107, 113, 271, 299 💬
44 Leishmaniasis 💬
1件: PTGS2 💬 D00141 💬 Indomethacin 3件: 225, 271, 298 💬
45 Leishmaniasis 💬
1件: PTGS2 💬 D01565 💬 Indomethacin 3件: 225, 271, 298 💬
46 Leishmaniasis 💬
1件: PTGS2 💬 D02110 💬 Indomethacin 3件: 225, 271, 298 💬
47 Leishmaniasis 💬
1件: PTGS2 💬 D00132 💬 Ketoprofen 1件: 46 💬
48 Leishmaniasis 💬
1件: PTGS2 💬 D00813 💬 Ketorolac 2件: 70, 226 💬
49 Leishmaniasis 💬
1件: PTGS2 💬 D08104 💬 Ketorolac 2件: 70, 226 💬
50 Leishmaniasis 💬
1件: PTGS2 💬 D08149 💬 Loxoprofen 2件: 46, 271 💬
51 Leishmaniasis 💬
1件: PTGS2 💬 D03714 💬 Lumiracoxib 1件: 46 💬
52 Leishmaniasis 💬
1件: PTGS2 💬 D00969 💬 Meloxicam 4件: 46, 49, 271, 296 💬
53 Leishmaniasis 💬
1件: PTGS2 💬 D00118 💬 Naproxen 4件: 13, 46, 107, 271 💬
54 Leishmaniasis 💬
1件: PTGS2 💬 D01049 💬 Nimesulide 1件: 46 💬
55 Leishmaniasis 💬
1件: PTGS2 💬 D03716 💬 Parecoxib 2件: 46, 271 💬
56 Leishmaniasis 💬
1件: PTGS2 💬 D00568 💬 Rofecoxib 1件: 46 💬
57 Leishmaniasis 💬
1件: PTGS2 💬 D00428 💬 Salsalate 1件:  5  💬
58 Leishmaniasis 💬
1件: PTGS2 💬 D00120 💬 Sulindac 1件: 206 💬
59 Leishmaniasis 💬
1件: PTGS2 💬 D01183 💬 Tolfenamic acid 1件:  5  💬
60 Leishmaniasis 💬
1件: PTGS2 💬 D02709 💬 Valdecoxib 1件: 46 💬
61 Leishmaniasis 💬
1件: RELA 💬 D12181 💬 Edasalonexent 1件: 113 💬
62 Leishmaniasis 💬
3件: TGFB1, TGFB2, TGFB3 💬 D09620 💬 Fresolimumab 4件: 51, 85, 222, 274 💬
63 Leishmaniasis 💬
1件: TNF 💬 D02597 💬 Adalimumab 18件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
64 Leishmaniasis 💬
1件: TNF 💬 D03441 💬 Certolizumab pegol 8件: 37, 46, 49, 96, 97, 107, 226, 271 💬
65 Leishmaniasis 💬
1件: TNF 💬 D00742 💬 Etanercept 17件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
66 Leishmaniasis 💬
1件: TNF 💬 D04358 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
67 Leishmaniasis 💬
1件: TNF 💬 D02598 💬 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
68 Leishmaniasis 💬
1件: TNF 💬 D04687 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
69 Leishmaniasis 💬
1件: TNF 💬 D09944 💬 Ozoralizumab 1件: 46 💬
70 Leishmaniasis 💬
1件: TNF 💬 D05393 💬 Pegsunercept 1件: 46 💬
71 Leishmaniasis 💬
1件: TNF 💬 D08976 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
72 Leishmaniasis 💬
1件: TNF 💬 D00754 💬 Thalidomide 20件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬