Target Gene/Pathway PATHWAY / GENE


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No. KEGG PATHWAY
On map, Yellow: Drug target, Red: All disease-related
KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Tuberculosis 💬
1件: BCL2 💬 D10679 💬 Venetoclax 1件: 28 💬
2 Tuberculosis 💬
1件: C3 💬 D11613 💬 Pegcetacoplan 3件:  2 , 62, 222 💬
3 Tuberculosis 💬
1件: CASP9 💬 D11195 💬 Rimiducid 6件: 19, 60, 65, 284, 285, 326 💬
4 Tuberculosis 💬
1件: CD74 💬 D08944 💬 Milatuzumab 1件: 49 💬
5 Tuberculosis 💬
14件: HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5 💬 D04318 💬 Glatiramer 4件:  2 , 13, 96, 156 💬
6 Tuberculosis 💬
13件: IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09662 💬 Rontalizumab 1件: 49 💬
7 Tuberculosis 💬
13件: IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8 💬 D09668 💬 Sifalimumab 1件: 49 💬
8 Tuberculosis 💬
1件: IFNG 💬 D11120 💬 Emapalumab 2件: 49, 107 💬
9 Tuberculosis 💬
1件: IFNG 💬 D04242 💬 Fontolizumab 1件: 46 💬
10 Tuberculosis 💬
2件: IFNGR1, IFNGR2 💬 D00747 💬 Interferon gamma-1b 7件: 18, 65, 85, 228, 299, 301, 326 💬
11 Tuberculosis 💬
5件: IL10, IL1A, IL1B, IL6, TNF 💬 D01583 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬
12 Tuberculosis 💬
3件: IL12A, IL12B, IL23A 💬 D09214 💬 Ustekinumab 17件: 37, 40, 41, 46, 49, 50, 53, 56, 65, 84, 93, 96, 97, 160, 162, 269, 271 💬
13 Tuberculosis 💬
1件: IL1A 💬 D11253 💬 Bermekimab 1件: 51 💬
14 Tuberculosis 💬
2件: IL1A, IL1B 💬 D06635 💬 Rilonacept 4件: 51, 106, 107, 266 💬
15 Tuberculosis 💬
1件: IL1B 💬 D09315 💬 Canakinumab 10件: 46, 56, 84, 106, 107, 108, 113, 266, 267, 269 💬
16 Tuberculosis 💬
1件: IL1B 💬 D09911 💬 Gevokizumab 4件: 41, 50, 56, 269 💬
17 Tuberculosis 💬
1件: IL23A 💬 D10912 💬 Brazikumab 2件: 96, 97 💬
18 Tuberculosis 💬
1件: IL23A 💬 D10438 💬 Guselkumab 5件: 37, 41, 51, 96, 97 💬
19 Tuberculosis 💬
1件: IL23A 💬 D11123 💬 Mirikizumab 3件: 37, 96, 97 💬
20 Tuberculosis 💬
1件: IL23A 💬 D11052 💬 Risankizumab 4件: 37, 96, 97, 271 💬
21 Tuberculosis 💬
1件: IL23A 💬 D10400 💬 Tildrakizumab 2件: 162, 271 💬
22 Tuberculosis 💬
1件: IL6 💬 D09669 💬 Siltuximab 2件: 28, 331 💬
23 Tuberculosis 💬
1件: IL6 💬 D10080 💬 Sirukumab 2件: 41, 46 💬
24 Tuberculosis 💬
2件: IL6, TNF 💬 D08976 💬 Pomalidomide 6件: 28, 34, 51, 85, 227, 331 💬
25 Tuberculosis 💬
1件: JAK1 💬 D10871 💬 Filgotinib 6件: 46, 53, 96, 97, 222, 271 💬
26 Tuberculosis 💬
1件: JAK1 💬 D10944 💬 Itacitinib 5件: 46, 51, 60, 97, 228 💬
27 Tuberculosis 💬
1件: JAK1 💬 D10994 💬 Upadacitinib 8件: 40, 41, 46, 49, 96, 97, 107, 271 💬
28 Tuberculosis 💬
2件: JAK1, JAK2 💬 D10308 💬 Baricitinib 13件: 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 268, 269, 325 💬
29 Tuberculosis 💬
2件: JAK1, JAK2 💬 D10653 💬 Peficitinib 1件: 46 💬
30 Tuberculosis 💬
2件: JAK1, JAK2 💬 D09959 💬 Ruxolitinib 1件: 228 💬
31 Tuberculosis 💬
2件: JAK1, JAK2 💬 D09970 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 256, 271 💬
32 Tuberculosis 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D09639 💬 Losmapimod 2件: 113, 222 💬
33 Tuberculosis 💬
4件: MAPK11, MAPK12, MAPK13, MAPK14 💬 D10959 💬 Neflamapimod 1件:  8  💬
34 Tuberculosis 💬
1件: NFKB1 💬 D01146 💬 Iguratimod 4件: 46, 51, 53, 271 💬
35 Tuberculosis 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00184 💬 Cyclosporine 44件: 11, 19, 20, 26, 28, 36, 38, 39, 40, 41, 42, 45, 46, 49, 50, 53, 55, 56, 58, 60, 61, 62, 63, 64, 65, 90, 93, 95, 97, 107, 113, 162, 164, 222, 226, 228, 234, 269, 274, 283, 284, 285, 302, 326 💬
36 Tuberculosis 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D05480 💬 Pimecrolimus 1件: 160 💬
37 Tuberculosis 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D00107 💬 Tacrolimus 34件:  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
38 Tuberculosis 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D08556 💬 Tacrolimus 34件:  2 ,  6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬
39 Tuberculosis 💬
5件: PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 D09033 💬 Voclosporin 1件: 222 💬
40 Tuberculosis 💬
1件: RAF1 💬 D06272 💬 Sorafenib 2件: 34, 86 💬
41 Tuberculosis 💬
1件: RAF1 💬 D08524 💬 Sorafenib 2件: 34, 86 💬
42 Tuberculosis 💬
1件: RELA 💬 D12181 💬 Edasalonexent 1件: 113 💬
43 Tuberculosis 💬
1件: SRC 💬 D03252 💬 Bosutinib 2件:  2 , 67 💬
44 Tuberculosis 💬
1件: SRC 💬 D03658 💬 Dasatinib 2件: 51, 85 💬
45 Tuberculosis 💬
1件: SRC 💬 D06414 💬 Dasatinib 2件: 51, 85 💬
46 Tuberculosis 💬
1件: SRC 💬 D09664 💬 Saracatinib 3件:  6 , 89, 272 💬
47 Tuberculosis 💬
1件: SYK 💬 D09347 💬 Fostamatinib 4件: 46, 49, 61, 66 💬
48 Tuberculosis 💬
3件: TGFB1, TGFB2, TGFB3 💬 D09620 💬 Fresolimumab 4件: 51, 85, 222, 274 💬
49 Tuberculosis 💬
1件: TNF 💬 D02597 💬 Adalimumab 18件: 19, 37, 40, 41, 46, 56, 84, 96, 97, 107, 151, 160, 164, 222, 226, 269, 270, 271 💬
50 Tuberculosis 💬
1件: TNF 💬 D03441 💬 Certolizumab pegol 8件: 37, 46, 49, 96, 97, 107, 226, 271 💬
51 Tuberculosis 💬
1件: TNF 💬 D00742 💬 Etanercept 17件: 15, 28, 35, 38, 39, 46, 50, 53, 56, 60, 85, 107, 228, 270, 271, 285, 298 💬
52 Tuberculosis 💬
1件: TNF 💬 D04358 💬 Golimumab 8件: 46, 56, 84, 96, 97, 107, 270, 271 💬
53 Tuberculosis 💬
1件: TNF 💬 D02598 💬 Infliximab 27件: 35, 37, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 55, 56, 65, 84, 85, 95, 96, 97, 98, 107, 162, 164, 269, 270, 271 💬
54 Tuberculosis 💬
1件: TNF 💬 D04687 💬 Lenalidomide 8件: 16, 26, 28, 34, 49, 284, 300, 331 💬
55 Tuberculosis 💬
1件: TNF 💬 D09944 💬 Ozoralizumab 1件: 46 💬
56 Tuberculosis 💬
1件: TNF 💬 D05393 💬 Pegsunercept 1件: 46 💬
57 Tuberculosis 💬
1件: TNF 💬 D00754 💬 Thalidomide 20件:  2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬
58 Tuberculosis 💬
1件: VDR 💬 D01518 💬 Alfacalcidol 8件: 41, 46, 49, 50, 96, 107, 235, 238 💬
59 Tuberculosis 💬
1件: VDR 💬 D00122 💬 Calcifediol 2件: 113, 299 💬
60 Tuberculosis 💬
1件: VDR 💬 D01125 💬 Calcipotriol 2件: 36, 51 💬
61 Tuberculosis 💬
1件: VDR 💬 D00129 💬 Calcitriol 9件: 18, 37, 46, 49, 66, 96, 158, 235, 326 💬
62 Tuberculosis 💬
1件: VDR 💬 D00188 💬 Cholecalciferol 25件:  6 , 13, 19, 20, 28, 34, 46, 49, 51, 53, 56, 60, 65, 75, 84, 85, 96, 97, 98, 162, 202, 228, 271, 298, 299 💬
63 Tuberculosis 💬
1件: VDR 💬 D00299 💬 Dihydrotachysterol 2件:  6 , 85 💬
64 Tuberculosis 💬
1件: VDR 💬 D07578 💬 Eldecalcitol 1件: 46 💬
65 Tuberculosis 💬
1件: VDR 💬 D00187 💬 Ergocalciferol 6件: 46, 49, 84, 96, 97, 299 💬
66 Tuberculosis 💬
1件: VDR 💬 D00930 💬 Paricalcitol 4件: 19, 66, 218, 238 💬