Target Gene/Pathway Pathway / Gene

  

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No. KEGG PATHWAY KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 EGFR tyrosine kinase inhibitor resistance 💬
 3件: AXL, KDR, MET 💬 Cabozantinib 💬 Cabozantinib 1件: 34 💬 💬
2 EGFR tyrosine kinase inhibitor resistance 💬
 1件: BCL2 💬 Venetoclax 💬 Venetoclax 1件: 28 💬 💬
3 EGFR tyrosine kinase inhibitor resistance 💬
 1件: BRAF 💬 Dabrafenib 💬 Dabrafenib 1件: 34 💬 💬
4 EGFR tyrosine kinase inhibitor resistance 💬
 4件: BRAF, KDR, PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib 2件: 34, 86 💬 💬
5 EGFR tyrosine kinase inhibitor resistance 💬
 1件: EGFR 💬 Cetuximab 💬 Cetuximab 2件: 51, 86 💬 💬
6 EGFR tyrosine kinase inhibitor resistance 💬
 1件: EGFR 💬 Erlotinib 💬 Erlotinib 1件: 94 💬 💬
7 EGFR tyrosine kinase inhibitor resistance 💬
 1件: EGFR 💬 Gefitinib 💬 Gefitinib 1件: 75 💬 💬
8 EGFR tyrosine kinase inhibitor resistance 💬
 1件: EGFR 💬 Icotinib 💬 Icotinib 1件: 34 💬 💬
9 EGFR tyrosine kinase inhibitor resistance 💬
 2件: EGFR, ERBB2 💬 Lapatinib 💬 Lapatinib 3件: 34, 74, 75 💬 💬
10 EGFR tyrosine kinase inhibitor resistance 💬
 2件: EGFR, ERBB2 💬 Neratinib 💬 Neratinib 1件: 34 💬 💬
11 EGFR tyrosine kinase inhibitor resistance 💬
 3件: EGFR, ERBB2, KDR 💬 Tesevatinib 💬 Tesevatinib 1件: 67 💬 💬
12 EGFR tyrosine kinase inhibitor resistance 💬
 1件: FGFR2 💬 Palifermin 💬 Palifermin 5件: 13, 36, 38, 39, 65 💬 💬
13 EGFR tyrosine kinase inhibitor resistance 💬
 2件: FGFR2, FGFR3 💬 Infigratinib 💬 Infigratinib 1件: 276 💬 💬
14 EGFR tyrosine kinase inhibitor resistance 💬
 5件: FGFR2, FGFR3, KDR, PDGFRA, PDGFRB 💬 Nintedanib 💬 Nintedanib 5件: 51, 85, 89, 227, 228 💬 💬
15 EGFR tyrosine kinase inhibitor resistance 💬
 1件: IGF1R 💬 Linsitinib 💬 Linsitinib 1件: 232 💬 💬
16 EGFR tyrosine kinase inhibitor resistance 💬
 1件: IGF1R 💬 Mecasermin 💬 Mecasermin 6件: 65, 78, 96, 168, 265, 299 💬 💬
17 EGFR tyrosine kinase inhibitor resistance 💬
 1件: IGF1R 💬 Teprotumumab 💬 Teprotumumab 1件: 51 💬 💬
18 EGFR tyrosine kinase inhibitor resistance 💬
 1件: IL6 💬 Olokizumab 💬 Olokizumab 2件: 46, 96 💬 💬
19 EGFR tyrosine kinase inhibitor resistance 💬
 1件: IL6 💬 Pirfenidone 💬 Pirfenidone 11件: 13, 34, 46, 50, 51, 58, 84, 85, 164, 222, 228 💬 💬
20 EGFR tyrosine kinase inhibitor resistance 💬
 1件: IL6 💬 Pomalidomide 💬 Pomalidomide 5件: 28, 51, 85, 227, 331 💬 💬
21 EGFR tyrosine kinase inhibitor resistance 💬
 1件: IL6 💬 Siltuximab 💬 Siltuximab 2件: 28, 331 💬 💬
22 EGFR tyrosine kinase inhibitor resistance 💬
 1件: IL6 💬 Sirukumab 💬 Sirukumab 2件: 41, 46 💬 💬
23 EGFR tyrosine kinase inhibitor resistance 💬
 1件: IL6R 💬 Sarilumab 💬 Sarilumab 5件: 41, 46, 84, 107, 271 💬 💬
24 EGFR tyrosine kinase inhibitor resistance 💬
 1件: IL6R 💬 Satralizumab 💬 Satralizumab 3件: 11, 13, 86 💬 💬
25 EGFR tyrosine kinase inhibitor resistance 💬
 1件: IL6R 💬 Tocilizumab 💬 Tocilizumab 21件:  2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬 💬
26 EGFR tyrosine kinase inhibitor resistance 💬
 1件: JAK1 💬 Abrocitinib 💬 Abrocitinib 1件: 84 💬 💬
27 EGFR tyrosine kinase inhibitor resistance 💬
 1件: JAK1 💬 Filgotinib 💬 Filgotinib 6件: 46, 53, 96, 97, 222, 271 💬 💬
28 EGFR tyrosine kinase inhibitor resistance 💬
 1件: JAK1 💬 Itacitinib 💬 Itacitinib 4件: 46, 51, 97, 228 💬 💬
29 EGFR tyrosine kinase inhibitor resistance 💬
 1件: JAK1 💬 Upadacitinib 💬 Upadacitinib 8件: 40, 41, 46, 49, 96, 97, 107, 271 💬 💬
30 EGFR tyrosine kinase inhibitor resistance 💬
 2件: JAK1, JAK2 💬 Baricitinib 💬 Baricitinib 13件:  2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬
31 EGFR tyrosine kinase inhibitor resistance 💬
 2件: JAK1, JAK2 💬 Peficitinib 💬 Peficitinib 1件: 46 💬 💬
32 EGFR tyrosine kinase inhibitor resistance 💬
 2件: JAK1, JAK2 💬 Ruxolitinib 💬 Ruxolitinib 3件: 60, 65, 228 💬 💬
33 EGFR tyrosine kinase inhibitor resistance 💬
 2件: JAK1, JAK2 💬 Tofacitinib 💬 Tofacitinib 15件: 11, 40, 44, 46, 49, 50, 51, 53, 65, 84, 96, 97, 107, 271, 300 💬 💬
34 EGFR tyrosine kinase inhibitor resistance 💬
 1件: KDR 💬 Axitinib 💬 Axitinib 1件: 34 💬 💬
35 EGFR tyrosine kinase inhibitor resistance 💬
 1件: KDR 💬 Cediranib 💬 Cediranib 1件: 34 💬 💬
36 EGFR tyrosine kinase inhibitor resistance 💬
 3件: KDR, PDGFRA, PDGFRB 💬 Sunitinib 💬 Sunitinib 2件: 28, 34 💬 💬
37 EGFR tyrosine kinase inhibitor resistance 💬
 2件: MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib 1件: 34 💬 💬
38 EGFR tyrosine kinase inhibitor resistance 💬
 2件: MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib 1件: 280 💬 💬
39 EGFR tyrosine kinase inhibitor resistance 💬
 2件: MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib 1件: 34 💬 💬
40 EGFR tyrosine kinase inhibitor resistance 💬
 2件: MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib 1件: 34 💬 💬
41 EGFR tyrosine kinase inhibitor resistance 💬
 2件: MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib 4件:  2 , 34, 279, 280 💬 💬
42 EGFR tyrosine kinase inhibitor resistance 💬
 1件: MTOR 💬 Everolimus 💬 Everolimus 9件: 34, 67, 89, 96, 137, 157, 158, 228, 277 💬 💬
43 EGFR tyrosine kinase inhibitor resistance 💬
 1件: MTOR 💬 Sirolimus 💬 Sirolimus 40件:  2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬
44 EGFR tyrosine kinase inhibitor resistance 💬
 1件: MTOR 💬 Temsirolimus 💬 Temsirolimus 1件: 13 💬 💬
45 EGFR tyrosine kinase inhibitor resistance 💬
 1件: PDGFRA 💬 Imatinib 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 💬
46 EGFR tyrosine kinase inhibitor resistance 💬
 2件: PDGFRA, PDGFRB 💬 Nilotinib 💬 Nilotinib 5件:  6 ,  8 , 34, 51, 86 💬 💬
47 EGFR tyrosine kinase inhibitor resistance 💬
 2件: PDGFRB, SRC 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬 💬
48 EGFR tyrosine kinase inhibitor resistance 💬
 2件: PDGFRB, SRC 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬 💬
49 EGFR tyrosine kinase inhibitor resistance 💬
 1件: PIK3CA 💬 Alpelisib 💬 Alpelisib 1件: 138 💬 💬
50 EGFR tyrosine kinase inhibitor resistance 💬
 3件: PIK3CA, PIK3CB, PIK3CD 💬 Leniolisib 💬 Leniolisib 2件: 53, 65 💬 💬
51 EGFR tyrosine kinase inhibitor resistance 💬
 1件: PIK3CD 💬 Parsaclisib 💬 Parsaclisib 3件: 35, 53, 61 💬 💬
52 EGFR tyrosine kinase inhibitor resistance 💬
 1件: PRKCB 💬 Enzastaurin 💬 Enzastaurin 1件: 168 💬 💬
53 EGFR tyrosine kinase inhibitor resistance 💬
 1件: SRC 💬 Bosutinib 💬 Bosutinib 2件:  2 , 67 💬 💬
54 EGFR tyrosine kinase inhibitor resistance 💬
 1件: SRC 💬 Saracatinib 💬 Saracatinib 3件:  6 , 89, 272 💬 💬
55 EGFR tyrosine kinase inhibitor resistance 💬
 1件: VEGFA 💬 Aflibercept 💬 Aflibercept 2件: 90, 166 💬 💬
56 EGFR tyrosine kinase inhibitor resistance 💬
 1件: VEGFA 💬 Bevacizumab 💬 Bevacizumab 6件: 13, 34, 85, 87, 227, 280 💬 💬
57 EGFR tyrosine kinase inhibitor resistance 💬
 1件: VEGFA 💬 Ranibizumab 💬 Ranibizumab 4件: 34, 166, 227, 301 💬 💬