Target Gene/Pathway Pathway / Gene


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No. KEGG PATHWAY KEGG GENES KEGG DRUG DrugBank 指定難病告示番号
1 Gap junction 💬
1件: ADRB1 💬 Amiodarone 💬 Amiodarone 2件: 28, 127 💬 💬
2 Gap junction 💬
1件: ADRB1 💬 Atenolol 💬 Atenolol 1件: 167 💬 💬
3 Gap junction 💬
1件: ADRB1 💬 Bisoprolol 💬 Bisoprolol 4件: 58, 67, 86, 113 💬 💬
4 Gap junction 💬
1件: ADRB1 💬 Carvedilol 💬 Carvedilol 4件: 57, 86, 113, 210 💬 💬
5 Gap junction 💬
1件: ADRB1 💬 Celiprolol 💬 Celiprolol 1件: 168 💬 💬
6 Gap junction 💬
1件: ADRB1 💬 Dipivefrin 💬 Dipivefrin 1件:  6  💬 💬
7 Gap junction 💬
1件: ADRB1 💬 Dobutamine 💬 Dobutamine 4件: 57, 58, 86, 215 💬 💬
8 Gap junction 💬
1件: ADRB1 💬 Droxidopa 💬 Droxidopa 5件:  5 ,  6 , 17, 169, 170 💬 💬
9 Gap junction 💬
1件: ADRB1 💬 Ephedrine 💬 Ephedrine 1件: 11 💬 💬
10 Gap junction 💬
1件: ADRB1 💬 Epinephrine 💬 Epinephrine 3件: 46, 70, 96 💬 💬
11 Gap junction 💬
1件: ADRB1 💬 Esmolol 💬 Esmolol 1件: 58 💬 💬
12 Gap junction 💬
1件: ADRB1 💬 Metoprolol 💬 Metoprolol 6件: 17, 57, 58, 113, 193, 226 💬 💬
13 Gap junction 💬
1件: ADRB1 💬 Nadolol 💬 Nadolol 1件:  6  💬 💬
14 Gap junction 💬
1件: ADRB1 💬 Nebivolol 💬 Nebivolol 4件: 17, 85, 113, 167 💬 💬
15 Gap junction 💬
1件: ADRB1 💬 Noradrenaline 💬 Norepinephrine 2件: 22, 296 💬 💬
16 Gap junction 💬
1件: ADRB1 💬 Propranolol 💬 Propranolol 6件:  6 , 158, 167, 227, 278, 296 💬 💬
17 Gap junction 💬
1件: ADRB1 💬 Pseudoephedrine 💬 Pseudoephedrine 1件: 17 💬 💬
18 Gap junction 💬
1件: ADRB1 💬 Timolol 💬 Timolol 2件: 157, 227 💬 💬
19 Gap junction 💬
1件: ADRB1 💬 Timolol 💬 Timolol 2件: 157, 227 💬 💬
20 Gap junction 💬
1件: DRD1 💬 Tavapadon 💬 Tavapadon 1件:  6  💬 💬
21 Gap junction 💬
2件: DRD1, DRD2 💬 Apomorphine 💬 Apomorphine 3件:  5 ,  6 ,  7  💬 💬
22 Gap junction 💬
2件: DRD1, DRD2 💬 Dexpramipexole 💬 Dexpramipexole 1件:  2  💬 💬
23 Gap junction 💬
2件: DRD1, DRD2 💬 Dopamine 💬 Dopamine 4件:  6 ,  7 , 74, 299 💬 💬
24 Gap junction 💬
2件: DRD1, DRD2 💬 Flupentixol 💬 Flupentixol 1件: 97 💬 💬
25 Gap junction 💬
2件: DRD1, DRD2 💬 Foslevodopa 💬 Foslevodopa 1件:  6  💬 💬
26 Gap junction 💬
2件: DRD1, DRD2 💬 Levodopa 💬 Levodopa 6件:  6 , 17, 90, 140, 164, 201 💬 💬
27 Gap junction 💬
2件: DRD1, DRD2 💬 Pergolide 💬 Pergolide 1件:  6  💬 💬
28 Gap junction 💬
1件: DRD2 💬 Bromocriptine 💬 Bromocriptine 2件:  6 , 74 💬 💬
29 Gap junction 💬
1件: DRD2 💬 Buspirone 💬 Buspirone 2件:  6 , 51 💬 💬
30 Gap junction 💬
1件: DRD2 💬 Cabergoline 💬 Cabergoline 3件:  6 , 74, 75 💬 💬
31 Gap junction 💬
1件: DRD2 💬 Domperidone 💬 Domperidone 5件:  6 , 13, 17, 51, 230 💬 💬
32 Gap junction 💬
1件: DRD2 💬 Domperidone maleate 💬 Domperidone 5件:  6 , 13, 17, 51, 230 💬 💬
33 Gap junction 💬
1件: DRD2 💬 Haloperidol 💬 Haloperidol 1件:  8  💬 💬
34 Gap junction 💬
1件: DRD2 💬 Lisuride 💬 Lisuride 2件:  6 , 86 💬 💬
35 Gap junction 💬
1件: DRD2 💬 Melperone 💬 Melperone 1件:  6  💬 💬
36 Gap junction 💬
1件: DRD2 💬 Metoclopramide 💬 Metoclopramide 2件: 46, 51 💬 💬
37 Gap junction 💬
1件: DRD2 💬 Pardoprunox 💬 Pardoprunox 1件:  6  💬 💬
38 Gap junction 💬
1件: DRD2 💬 Pimozide 💬 Pimozide 1件:  2  💬 💬
39 Gap junction 💬
1件: DRD2 💬 Piribedil 💬 Piribedil 1件:  6  💬 💬
40 Gap junction 💬
1件: DRD2 💬 Pramipexole 💬 Pramipexole 3件:  2 ,  6 , 20 💬 💬
41 Gap junction 💬
1件: DRD2 💬 Pridopidine 💬 Pridopidine 3件:  2 ,  6 ,  8  💬 💬
42 Gap junction 💬
1件: DRD2 💬 Ropinirole 💬 Ropinirole 4件:  2 ,  6 , 74, 309 💬 💬
43 Gap junction 💬
1件: DRD2 💬 Rotigotine 💬 Rotigotine 1件:  6  💬 💬
44 Gap junction 💬
1件: DRD2 💬 Sulpiride 💬 Sulpiride 2件:  6 , 70 💬 💬
45 Gap junction 💬
1件: DRD2 💬 Terguride 💬 Terguride 2件: 51, 86 💬 💬
46 Gap junction 💬
1件: DRD2 💬 Tiapride 💬 Tiapride 1件:  8  💬 💬
47 Gap junction 💬
1件: DRD2 💬 Trifluoperazine maleate 💬 Trifluoperazine 2件: 283, 284 💬 💬
48 Gap junction 💬
1件: DRD2 💬 Trifluoperazine 💬 Trifluoperazine 2件: 283, 284 💬 💬
49 Gap junction 💬
2件: DRD2, HTR2A 💬 Aripiprazole 💬 Aripiprazole 2件:  6 , 206 💬 💬
50 Gap junction 💬
2件: DRD2, HTR2A 💬 Cariprazine 💬 Cariprazine 1件: 21 💬 💬
51 Gap junction 💬
2件: DRD2, HTR2A 💬 Quetiapine 💬 Quetiapine 2件:  6 , 13 💬 💬
52 Gap junction 💬
2件: DRD2, HTR2A 💬 Risperidone 💬 Risperidone 5件:  8 , 156, 179, 187, 206 💬 💬
53 Gap junction 💬
4件: DRD2, HTR2A, HTR2B, HTR2C 💬 Chlorpromazine 💬 Chlorpromazine 1件: 254 💬 💬
54 Gap junction 💬
4件: DRD2, HTR2A, HTR2B, HTR2C 💬 Iloperidone 💬 Iloperidone 1件:  6  💬 💬
55 Gap junction 💬
4件: DRD2, HTR2A, HTR2B, HTR2C 💬 Olanzapine 💬 Olanzapine 2件:  2 ,  8  💬 💬
56 Gap junction 💬
1件: EGFR 💬 Cetuximab 💬 Cetuximab 2件: 51, 86 💬 💬
57 Gap junction 💬
1件: EGFR 💬 Erlotinib 💬 Erlotinib 1件: 94 💬 💬
58 Gap junction 💬
1件: EGFR 💬 Gefitinib 💬 Gefitinib 1件: 75 💬 💬
59 Gap junction 💬
1件: EGFR 💬 Icotinib 💬 Icotinib 1件: 34 💬 💬
60 Gap junction 💬
1件: EGFR 💬 Lapatinib 💬 Lapatinib 3件: 34, 74, 75 💬 💬
61 Gap junction 💬
1件: EGFR 💬 Neratinib 💬 Neratinib 1件: 34 💬 💬
62 Gap junction 💬
1件: EGFR 💬 Tesevatinib 💬 Tesevatinib 1件: 67 💬 💬
63 Gap junction 💬
3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 Amyl nitrite 💬 Amyl Nitrite 1件: 58 💬 💬
64 Gap junction 💬
3件: GUCY1A1, GUCY1A2, GUCY1B1 💬 Riociguat 💬 Riociguat 6件: 51, 84, 86, 88, 225, 299 💬 💬
65 Gap junction 💬
1件: HTR2A 💬 Cisapride 💬 Cisapride 1件: 13 💬 💬
66 Gap junction 💬
1件: HTR2A 💬 Cisapride 💬 Cisapride 1件: 13 💬 💬
67 Gap junction 💬
1件: HTR2A 💬 Nelotanserin 💬 Nelotanserin 1件:  6  💬 💬
68 Gap junction 💬
3件: HTR2A, HTR2B, HTR2C 💬 Trazodone 💬 Trazodone 1件:  2  💬 💬
69 Gap junction 💬
2件: HTR2A, HTR2C 💬 Clozapine 💬 Clozapine 1件:  6  💬 💬
70 Gap junction 💬
2件: HTR2A, HTR2C 💬 Fenfluramine 💬 Fenfluramine 4件: 140, 144, 145, 149 💬 💬
71 Gap junction 💬
1件: HTR2C 💬 Agomelatine 💬 Agomelatine 1件:  6  💬 💬
72 Gap junction 💬
2件: MAP2K1, MAP2K2 💬 Binimetinib 💬 Binimetinib 1件: 34 💬 💬
73 Gap junction 💬
2件: MAP2K1, MAP2K2 💬 Cobimetinib 💬 Cobimetinib 1件: 280 💬 💬
74 Gap junction 💬
2件: MAP2K1, MAP2K2 💬 Mirdametinib 💬 Mirdametinib 1件: 34 💬 💬
75 Gap junction 💬
2件: MAP2K1, MAP2K2 💬 Selumetinib 💬 Selumetinib 1件: 34 💬 💬
76 Gap junction 💬
2件: MAP2K1, MAP2K2 💬 Trametinib 💬 Trametinib 4件:  2 , 34, 279, 280 💬 💬
77 Gap junction 💬
1件: PDGFRA 💬 Imatinib 💬 Imatinib 12件: 13, 28, 34, 35, 46, 51, 85, 86, 87, 88, 89, 162 💬 💬
78 Gap junction 💬
2件: PDGFRA, PDGFRB 💬 Nilotinib 💬 Nilotinib 5件:  6 ,  8 , 34, 51, 86 💬 💬
79 Gap junction 💬
2件: PDGFRA, PDGFRB 💬 Nintedanib 💬 Nintedanib 5件: 51, 85, 89, 227, 228 💬 💬
80 Gap junction 💬
2件: PDGFRA, PDGFRB 💬 Sunitinib 💬 Sunitinib 2件: 28, 34 💬 💬
81 Gap junction 💬
2件: PDGFRB, RAF1 💬 Sorafenib 💬 Sorafenib 2件: 34, 86 💬 💬
82 Gap junction 💬
2件: PDGFRB, SRC 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬 💬
83 Gap junction 💬
2件: PDGFRB, SRC 💬 Dasatinib 💬 Dasatinib 2件: 51, 85 💬 💬
84 Gap junction 💬
1件: PRKCB 💬 Enzastaurin 💬 Enzastaurin 1件: 168 💬 💬
85 Gap junction 💬
1件: SRC 💬 Bosutinib 💬 Bosutinib 2件:  2 , 67 💬 💬
86 Gap junction 💬
1件: SRC 💬 Saracatinib 💬 Saracatinib 3件:  6 , 89, 272 💬 💬
87 Gap junction 💬
9件: TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Belantamab mafodotin 💬 Belantamab mafodotin 1件: 28 💬 💬
88 Gap junction 💬
9件: TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Brentuximab vedotin 💬 Brentuximab vedotin 2件: 49, 51 💬 💬
89 Gap junction 💬
9件: TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Colchicine 💬 Colchicine 7件:  2 , 42, 46, 56, 93, 210, 266 💬 💬
90 Gap junction 💬
9件: TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Paclitaxel 💬 Paclitaxel 2件: 46, 85 💬 💬
91 Gap junction 💬
9件: TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Vinblastine 💬 Vinblastine 2件: 34, 65 💬 💬
92 Gap junction 💬
9件: TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 Vincristine 💬 Vincristine 4件: 26, 34, 65, 331 💬 💬