KEGG DRUG

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DrugBank

Drug (Description in trials)

KEGG DRUG

KEGG GENES

KEGG PATHWAY

Disease ID

Acetaminophen

[4] Acetaminophen; PARACETAMOL; Tylenol; Ultracet

[1] Acetaminophen 💬

[2] PTGS1,
PTGS2 💬

[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemi ...

[15] 3, 6, 11, 13, 34, 35, 46, 49, 51, 70, 86, 222, 256, 271, 337 💬

Disease ID	Name
3	Spinal muscular atrophy
6	Parkinson disease
11	Myasthenia gravis
13	Multiple sclerosis/Neuromyelitis optica
34	Neurofibromatosis
35	Pemphigus
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
51	Scleroderma
70	Spinal stenosis
86	Pulmonary arterial hypertension
222	Primary nephrotic syndrome
256	Muscle glycogenosis
271	Ankylosing spondylitis
337	Homocystinuria

Acetylsalicylic acid
(Acetaminophen Aspirin and Caffeine)

[2] Acetylsalicylic acid; Aspirin

[1] Aspirin 💬

[2] PTGS1,
PTGS2 💬

[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemi ...

[14] 13, 22, 46, 49, 51, 58, 64, 86, 97, 113, 158, 210, 231, 251 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica
22	Moyamoya disease
46	Malignant rheumatoid arthritis
49	Systemic lupus erythematosus
51	Scleroderma
58	Hypertrophic cardiomyopathy
64	Thrombotic thrombocytopenic purpura
86	Pulmonary arterial hypertension
97	Ulcerative colitis
113	Muscular dystrophy
158	Tuberous sclerosis
210	Single Ventricle
231	Alpha-1-antitrypsin deficiency
251	Urea cycle disorder

Caffeine
(Acetaminophen Relief Regular Strength)

[1] Caffeine

[2] Caffeine ,
Caffeine hydrate 💬

[11] ADORA1,
ADORA2A,
PDE1B,
PDE2A,
PDE3A,
PDE3B,
PDE4A,
PDE4B,
PDE4C,
PDE4D,
PDE5A 💬

Name	Full Name
ADORA1	adenosine A1 receptor
ADORA2A	adenosine A2a receptor
PDE1B	phosphodiesterase 1B
PDE2A	phosphodiesterase 2A
PDE3A	phosphodiesterase 3A
PDE3B	phosphodiesterase 3B
PDE4A	phosphodiesterase 4A
PDE4B	phosphodiesterase 4B
PDE4C	phosphodiesterase 4C
PDE4D	phosphodiesterase 4D
PDE5A	phosphodiesterase 5A

[22] Alcoholism, Aldosterone synthesis and secretion, Apelin signaling pathway, Calcium signaling pa ...

[8] 2, 6, 21, 46, 78, 96, 97, 265 💬

Dextromethorphan
(Acetaminophen/dextromethorphan/pseudoephedrine)

[4] Dextromethorphan; Dextromethorphan hydrobromide; Dextrometorfano; Nuedexta

[1] Dextromethorphan 💬

[6] GRIN1,
GRIN2A,
GRIN2B,
GRIN2C,
GRIN2D,
SIGMAR1 💬

Name	Full Name
GRIN1	glutamate ionotropic receptor NMDA type subunit 1
GRIN2A	glutamate ionotropic receptor NMDA type subunit 2A
GRIN2B	glutamate ionotropic receptor NMDA type subunit 2B
GRIN2C	glutamate ionotropic receptor NMDA type subunit 2C
GRIN2D	glutamate ionotropic receptor NMDA type subunit 2D
SIGMAR1	sigma non-opioid intracellular receptor 1

[20] Alcoholism, Alzheimer disease, Amphetamine addiction, Amyotrophic lateral sclerosis, Calcium si ...

[11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
6	Parkinson disease
8	Huntington disease
13	Multiple sclerosis/Neuromyelitis optica
21	Mitochondrial disease
46	Malignant rheumatoid arthritis
78	Hypopituitarism
85	Idiopathic interstitial pneumonia
96	Crohn disease
97	Ulcerative colitis
156	Rett syndrome

Diphenhydramine
(Harris Teeter Acetaminophen PM)

[2] Diphenhydramine; Diphenhydramine hydrochloride

[1] Diphenhydramine 💬

[1] HRH1 💬

[3] Calcium signaling pathway, Inflammatory mediator regulation of TRP channels, Neuroactive ligand- ...

[8] 11, 13, 49, 51, 70, 86, 222, 256 💬

Disease ID	Name
11	Myasthenia gravis
13	Multiple sclerosis/Neuromyelitis optica
49	Systemic lupus erythematosus
51	Scleroderma
70	Spinal stenosis
86	Pulmonary arterial hypertension
222	Primary nephrotic syndrome
256	Muscle glycogenosis

Ibuprofen
(Advil Plus Acetaminophen)

[2] Ibuprofen; IBUPROFEN 200MG

[1] Ibuprofen 💬

[2] PTGS1,
PTGS2 💬

[23] Alzheimer disease, Arachidonic acid metabolism, C-type lectin receptor signaling pathway, Chemi ...

[7] 13, 46, 65, 107, 113, 271, 299 💬

Disease ID	Name
13	Multiple sclerosis/Neuromyelitis optica
46	Malignant rheumatoid arthritis
65	Primary immunodeficiency
107	Juvenile idiopathic arthritis
113	Muscular dystrophy
271	Ankylosing spondylitis
299	Cystic fibrosis

Oxycodone
(Oxycodone Hydrochloride and Acetaminophen)

[2] OXYCODONE; OXYCODONE HYDROCHLORIDE

[1] Oxycodone 💬

[3] OPRD1,
OPRK1,
OPRM1 💬

[5] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction, Sphingo ...

[5] 6, 13, 70, 226, 298 💬

Phenylephrine
(Acetaminophen Sinus Congestion and Pain Daytime)

[1] Phenylephrine

[1] Phenylephrine 💬

[3] ADRA1A,
ADRA1B,
ADRA1D 💬

[7] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Neuro ...

[1] 22 💬

Pseudoephedrine
(Cough Syrup DM-D-E With Acetaminophen Extra Strength)

[1] Pseudoephedrine

[1] Pseudoephedrine 💬

[9] ADRA1A,
ADRA1B,
ADRA1D,
ADRA2A,
ADRA2B,
ADRA2C,
ADRB1,
ADRB2,
ADRB3 💬

Name	Full Name
ADRA1A	adrenoceptor alpha 1A
ADRA1B	adrenoceptor alpha 1B
ADRA1D	adrenoceptor alpha 1D
ADRA2A	adrenoceptor alpha 2A
ADRA2B	adrenoceptor alpha 2B
ADRA2C	adrenoceptor alpha 2C
ADRB1	adrenoceptor beta 1
ADRB2	adrenoceptor beta 2
ADRB3	adrenoceptor beta 3

[14] AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Calcium signaling pathway, Chem ...

[1] 17 💬

Tramadol
(Auro-tramadol/acetaminophen)

[2] Tramadol; Ultracet

[1] Tramadol 💬

[1] OPRM1 💬

[3] Estrogen signaling pathway, Morphine addiction, Neuroactive ligand-receptor interaction 💬

[5] 46, 70, 78, 226, 271 💬

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