DDrare diagram
Disease Drug Target Gene/Pathway
[ Japanese / English ]

 Data ver. Nov 2019 - Updated on Sep 25, 2020

 Disease                            Sitemap

 Drug                                 Sitemap

 Target Gene/Pathway     Sitemap

 News 

    Sep 25, 2020: DDrare - Database of developing drugs, target genes and pathways for rare diseases - is added to References.
    Sep 25, 2020: Sitemaps for the three entrances (Disease, Drug and Target Gene/Pathway) are equipped.
    Sep 9, 2020: A few drug names were corrected (12,172 drugs -> 12,170 drugs).
    Jun 29, 2020: Drugs and target genes shown in Target Gene/Pathway for each disease are now limited to those for the diesase (i.e. Drugs and target genes only for other diseases in a pathway are not shown.). (e.g. Spinal and bulbar muscular atrophy)
    Jun 22, 2020: English version has opened.

 About 

    DDrare (Database of Drug Development for Rare Diseases) is a database that provides information on drugs developed in clinical trials, and their target genes and pathways, targeting the intractable diseases (mostly rare diseases) designated by the Ministry of Health, Labour and Welfare (MHLW), Japan. A list of disease names in English, including synonyms and subclass names, was created for the diseases of MHLW (333 diseases on Nov 2019). Using the list as a query, data of clinical trials with drug information (DrugBank) was extracted from four major clinical trial registries: JPRN (Japan), ClinicalTrials.gov (US), EU-CTR (Europe), and ChiCTR (China), through WHO-ICTRP website. Information of drug target genes and pathways (KEGG) is associated with the extracted drug information. This enables cross-reference of disease, drug, and target gene/pathway information, to be utilized for drug discovery research, especially for drug repositioning.

 References 

 Disclaimer 

    The information on this website is provided for research purposes only and does not replace the advice or consultation of a doctor. In principle, all rights relating to the information on this website belong to the National Institutes of Biomedical Innovation, Health and Nutrition. Please contact us in advance if you would like to use the information on this website. Information on this website is subject to change without notice. In any case, we will not be liable for any damages arising from the use of the information on this website.

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