Target Gene/Pathway Pathway / Gene

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KEGG GENES

KEGG PATHWAY

KEGG DRUG

DrugBank

Disease ID

1

[18] Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathwa ...

[9] 2, 3, 5, 8, 13, 17, 18, 203, 206 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
3	Spinal muscular atrophy
5	Progressive supranuclear palsy
8	Huntington disease
13	Multiple sclerosis/Neuromyelitis optica
17	Multiple system atrophy
18	Spinocerebellar degeneration
203	22q11.2 deletion syndrome
206	Fragile X syndrome

2

[18] Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathwa ...

Dextromethorphan 💬

Dextromethorphan

[11] 2, 6, 8, 13, 21, 46, 78, 85, 96, 97, 156 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
6	Parkinson disease
8	Huntington disease
13	Multiple sclerosis/Neuromyelitis optica
21	Mitochondrial disease
46	Malignant rheumatoid arthritis
78	Hypopituitarism
85	Idiopathic interstitial pneumonia
96	Crohn disease
97	Ulcerative colitis
156	Rett syndrome

3

[18] Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathwa ...

Acamprosate 💬

[2] 6, 206 💬

4

[18] Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathwa ...

Esketamine 💬

[3] 2, 4, 70 💬

5

[18] Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathwa ...

Amantadine 💬

[4] 6, 8, 13, 127 💬

6

[18] Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathwa ...

[8] 2, 4, 6, 13, 70, 113, 156, 215 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
4	Primary lateral sclerosis
6	Parkinson disease
13	Multiple sclerosis/Neuromyelitis optica
70	Spinal stenosis
113	Muscular dystrophy
156	Rett syndrome
215	Tetralogy of Fallot

7

[18] Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathwa ...

[8] 2, 6, 8, 13, 49, 127, 205, 206 💬

Disease ID	Name
2	Amyotrophic lateral sclerosis
6	Parkinson disease
8	Huntington disease
13	Multiple sclerosis/Neuromyelitis optica
49	Systemic lupus erythematosus
127	Frontotemporal lobar degeneration
205	Fragile X syndrome related disease
206	Fragile X syndrome

8

[18] Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathwa ...

Latrepirdine 💬

[1] 8 💬

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