Target Gene/Pathway Pathway / Gene
Search results
No. | KEGG PATHWAY | KEGG GENES | KEGG DRUG | DrugBank | Disease ID |
---|---|---|---|---|---|
1 | Acute myeloid leukemia 💬 17 genes, 30 drugs (DrugBank) and 62 diseases |
KIT [1] KIT 💬 |
Masitinib Masitinib 💬 |
Masitinib | 002 [6] 2 , 5 , 6 , 13, 46, 96 💬 💬 |
2 | Acute myeloid leukemia 💬 17 genes, 30 drugs (DrugBank) and 62 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
3 | Acute myeloid leukemia 💬 17 genes, 30 drugs (DrugBank) and 62 diseases |
MPO [1] MPO 💬 |
Verdiperstat Verdiperstat 💬 |
Verdiperstat | 002 [3] 2 , 17, 127 💬 💬 |
4 | Acute myeloid leukemia 💬 17 genes, 30 drugs (DrugBank) and 62 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
5 | Acute myeloid leukemia 💬 17 genes, 30 drugs (DrugBank) and 62 diseases |
PML [2] PML, RARA 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
6 | Adherens junction 💬 9 genes, 19 drugs (DrugBank) and 23 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
7 | Adipocytokine signaling pathway 💬 16 genes, 31 drugs (DrugBank) and 95 diseases |
JAK2 [1] JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
8 | Adipocytokine signaling pathway 💬 16 genes, 31 drugs (DrugBank) and 95 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
9 | Adipocytokine signaling pathway 💬 16 genes, 31 drugs (DrugBank) and 95 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
10 | Adipocytokine signaling pathway 💬 16 genes, 31 drugs (DrugBank) and 95 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
11 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
ADRA1A [3] ADRA1A, ADRA1B, ADRA1D 💬 |
Olanzapine Olanzapine 💬 |
Olanzapine | 002 [2] 2 , 8 💬 💬 |
12 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
ADRB2 [1] ADRB2 💬 |
Clenbuterol Clenbuterol 💬 |
Clenbuterol | 001 [5] 1 , 2 , 6 , 13, 256 💬 💬 |
13 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
KCNQ1 [1] KCNQ1 💬 |
Ezogabine Ezogabine 💬 |
Ezogabine | 002 [2] 2 , 144 💬 💬 |
14 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
SCN5A [1] SCN5A 💬 |
Mexiletine Mexiletine 💬 |
Mexiletine | 001 [5] 1 , 2 , 10, 113, 114 💬 💬 |
15 | Adrenergic signaling in cardiomyocytes 💬 27 genes, 80 drugs (DrugBank) and 71 diseases |
SCN5A [1] SCN5A 💬 |
Quinidine Quinidine 💬 |
Quinidine | 002 [3] 2 , 8 , 13 💬 💬 |
16 | African trypanosomiasis 💬 9 genes, 22 drugs (DrugBank) and 59 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
17 | AGE-RAGE signaling pathway in diabetic complications 💬 26 genes, 45 drugs (DrugBank) and 83 diseases |
JAK2 [1] JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
18 | AGE-RAGE signaling pathway in diabetic complications 💬 26 genes, 45 drugs (DrugBank) and 83 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
19 | Alanine, aspartate and glutamate metabolism 💬 5 genes, 3 drugs (DrugBank) and 19 diseases |
ABAT [4] ABAT, ALDH5A1, GAD1, GAD2 💬 |
Valproic acid Valproic acid 💬 |
Valproic acid | 002 [14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬 |
20 | Alcoholic liver disease 💬 39 genes, 46 drugs (DrugBank) and 87 diseases |
C3 [1] C3 💬 |
Pegcetacoplan Pegcetacoplan 💬 |
Pegcetacoplan | 002 [4] 2 , 61, 62, 222 💬 💬 |
21 | Alcoholic liver disease 💬 39 genes, 46 drugs (DrugBank) and 87 diseases |
C5 [1] C5 💬 |
Ravulizumab Ravulizumab 💬 |
Ravulizumab | 002 [7] 2 , 11, 13, 50, 62, 66, 109 💬 💬 |
22 | Alcoholic liver disease 💬 39 genes, 46 drugs (DrugBank) and 87 diseases |
C5 [1] C5 💬 |
Zilucoplan Zilucoplan 💬 |
Zilucoplan | 002 [3] 2 , 11, 62 💬 💬 |
23 | Alcoholic liver disease 💬 39 genes, 46 drugs (DrugBank) and 87 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
24 | Alcoholic liver disease 💬 39 genes, 46 drugs (DrugBank) and 87 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
25 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
ADORA2A [1] ADORA2A 💬 |
Caffeine Caffeine 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
26 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
ADORA2A [1] ADORA2A 💬 |
Caffeine hydrate Caffeine hydrate 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
27 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
DRD1 [2] DRD1, DRD2 💬 |
Dexpramipexole Dexpramipexole 💬 |
Dexpramipexole | 002 [1] 2 💬 💬 |
28 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
DRD2 [1] DRD2 💬 |
Olanzapine Olanzapine 💬 |
Olanzapine | 002 [2] 2 , 8 💬 💬 |
29 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
DRD2 [1] DRD2 💬 |
Pimozide Pimozide 💬 |
Pimozide | 002 [1] 2 💬 💬 |
30 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
DRD2 [1] DRD2 💬 |
Pramipexole Pramipexole 💬 |
Pramipexole | 002 [3] 2 , 6 , 20 💬 💬 |
31 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
DRD2 [1] DRD2 💬 |
Pridopidine Pridopidine 💬 |
Pridopidine | 002 [3] 2 , 6 , 8 💬 💬 |
32 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
DRD2 [1] DRD2 💬 |
Ropinirole Ropinirole 💬 |
Ropinirole | 002 [4] 2 , 6 , 74, 309 💬 💬 |
33 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Dextromethorphan Dextromethorphan 💬 |
Dextromethorphan | 002 [11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬 💬 |
34 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Esketamine Esketamine 💬 |
Esketamine | 002 [3] 2 , 4 , 70 💬 💬 |
35 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
36 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Memantine Memantine 💬 |
Memantine | 002 [8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬 💬 |
37 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
38 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
39 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
40 | Alcoholism 💬 28 genes, 75 drugs (DrugBank) and 53 diseases |
MAP2K1 [1] MAP2K1 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
41 | Aldosterone synthesis and secretion 💬 20 genes, 38 drugs (DrugBank) and 62 diseases |
CACNA1G [3] CACNA1G, CACNA1H, CACNA1I 💬 |
Valproic acid Valproic acid 💬 |
Valproic acid | 002 [14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬 |
42 | Aldosterone synthesis and secretion 💬 20 genes, 38 drugs (DrugBank) and 62 diseases |
MC2R [1] MC2R 💬 |
Corticotropin Corticotropin 💬 |
Corticotropin | 002 [12] 2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬 💬 |
43 | Aldosterone synthesis and secretion 💬 20 genes, 38 drugs (DrugBank) and 62 diseases |
PDE2A [1] PDE2A 💬 |
Caffeine Caffeine 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
44 | Aldosterone synthesis and secretion 💬 20 genes, 38 drugs (DrugBank) and 62 diseases |
PDE2A [1] PDE2A 💬 |
Caffeine hydrate Caffeine hydrate 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
45 | Allograft rejection 💬 11 genes, 23 drugs (DrugBank) and 56 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
46 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
CHRM1 [3] CHRM1, CHRM3, CHRM5 💬 |
Atropine Atropine 💬 |
Atropine | 002 [2] 2 , 299 💬 💬 |
47 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
CHRM1 [3] CHRM1, CHRM3, CHRM5 💬 |
Scopolamine Scopolamine 💬 |
Scopolamine | 002 [1] 2 💬 💬 |
48 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Dextromethorphan Dextromethorphan 💬 |
Dextromethorphan | 002 [11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬 💬 |
49 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Esketamine Esketamine 💬 |
Esketamine | 002 [3] 2 , 4 , 70 💬 💬 |
50 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
51 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Memantine Memantine 💬 |
Memantine | 002 [8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬 💬 |
52 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
53 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
54 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
55 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
56 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
57 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
PTGS2 [1] PTGS2 💬 |
Celecoxib Celecoxib 💬 |
Celecoxib | 002 [10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 💬 |
58 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
RTN4 [1] RTN4 💬 |
Ozanezumab Ozanezumab 💬 |
Ozanezumab | 002 [1] 2 💬 💬 |
59 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
60 | Alzheimer disease 💬 55 genes, 116 drugs (DrugBank) and 122 diseases |
TUBB [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 |
Colchicine Colchicine 💬 |
Colchicine | 002 [7] 2 , 42, 46, 56, 93, 210, 266 💬 💬 |
61 | Amoebiasis 💬 19 genes, 29 drugs (DrugBank) and 63 diseases |
IL1R1 [2] IL1R1, IL1R2 💬 |
Anakinra Anakinra 💬 |
Anakinra | 002 [18] 2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 💬 |
62 | Amoebiasis 💬 19 genes, 29 drugs (DrugBank) and 63 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
63 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
DRD1 [1] DRD1 💬 |
Dexpramipexole Dexpramipexole 💬 |
Dexpramipexole | 002 [1] 2 💬 💬 |
64 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
GRIA1 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 |
Perampanel Perampanel 💬 |
Perampanel | 002 [3] 2 , 6 , 144 💬 💬 |
65 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
GRIA1 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 |
Talampanel Talampanel 💬 |
Talampanel | 002 [2] 2 , 6 💬 💬 |
66 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
GRIA1 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
67 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Dextromethorphan Dextromethorphan 💬 |
Dextromethorphan | 002 [11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬 💬 |
68 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Esketamine Esketamine 💬 |
Esketamine | 002 [3] 2 , 4 , 70 💬 💬 |
69 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
70 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Memantine Memantine 💬 |
Memantine | 002 [8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬 💬 |
71 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
72 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
73 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
74 | Amphetamine addiction 💬 25 genes, 51 drugs (DrugBank) and 91 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
75 | AMPK signaling pathway 💬 16 genes, 49 drugs (DrugBank) and 93 diseases |
ADRA1A [1] ADRA1A 💬 |
Olanzapine Olanzapine 💬 |
Olanzapine | 002 [2] 2 , 8 💬 💬 |
76 | AMPK signaling pathway 💬 16 genes, 49 drugs (DrugBank) and 93 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
77 | AMPK signaling pathway 💬 16 genes, 49 drugs (DrugBank) and 93 diseases |
PPARG [1] PPARG 💬 |
Pioglitazone Pioglitazone 💬 |
Pioglitazone | 002 [17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 💬 |
78 | AMPK signaling pathway 💬 16 genes, 49 drugs (DrugBank) and 93 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
79 | Amyotrophic lateral sclerosis 💬 35 genes, 48 drugs (DrugBank) and 108 diseases |
GRIA1 [2] GRIA1, GRIA2 💬 |
Perampanel Perampanel 💬 |
Perampanel | 002 [3] 2 , 6 , 144 💬 💬 |
80 | Amyotrophic lateral sclerosis 💬 35 genes, 48 drugs (DrugBank) and 108 diseases |
GRIA1 [2] GRIA1, GRIA2 💬 |
Talampanel Talampanel 💬 |
Talampanel | 002 [2] 2 , 6 💬 💬 |
81 | Amyotrophic lateral sclerosis 💬 35 genes, 48 drugs (DrugBank) and 108 diseases |
GRIA1 [7] GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
82 | Amyotrophic lateral sclerosis 💬 35 genes, 48 drugs (DrugBank) and 108 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Esketamine Esketamine 💬 |
Esketamine | 002 [3] 2 , 4 , 70 💬 💬 |
83 | Amyotrophic lateral sclerosis 💬 35 genes, 48 drugs (DrugBank) and 108 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
84 | Amyotrophic lateral sclerosis 💬 35 genes, 48 drugs (DrugBank) and 108 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Memantine Memantine 💬 |
Memantine | 002 [8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬 💬 |
85 | Amyotrophic lateral sclerosis 💬 35 genes, 48 drugs (DrugBank) and 108 diseases |
GRIN1 [6] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, SIGMAR1 💬 |
Dextromethorphan Dextromethorphan 💬 |
Dextromethorphan | 002 [11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬 💬 |
86 | Amyotrophic lateral sclerosis 💬 35 genes, 48 drugs (DrugBank) and 108 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
87 | Amyotrophic lateral sclerosis 💬 35 genes, 48 drugs (DrugBank) and 108 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
88 | Amyotrophic lateral sclerosis 💬 35 genes, 48 drugs (DrugBank) and 108 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
89 | Amyotrophic lateral sclerosis 💬 35 genes, 48 drugs (DrugBank) and 108 diseases |
SOD1 [1] SOD1 💬 |
Tofersen Tofersen 💬 |
Tofersen | 002 [1] 2 💬 💬 |
90 | Amyotrophic lateral sclerosis 💬 35 genes, 48 drugs (DrugBank) and 108 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
91 | Amyotrophic lateral sclerosis 💬 35 genes, 48 drugs (DrugBank) and 108 diseases |
TUBB [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 |
Colchicine Colchicine 💬 |
Colchicine | 002 [7] 2 , 42, 46, 56, 93, 210, 266 💬 💬 |
92 | Antifolate resistance 💬 8 genes, 21 drugs (DrugBank) and 66 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
93 | Antigen processing and presentation 💬 4 genes, 15 drugs (DrugBank) and 52 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
94 | Apelin signaling pathway 💬 12 genes, 30 drugs (DrugBank) and 72 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
95 | Apelin signaling pathway 💬 12 genes, 30 drugs (DrugBank) and 72 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
96 | Apelin signaling pathway 💬 12 genes, 30 drugs (DrugBank) and 72 diseases |
PDE3B [1] PDE3B 💬 |
Caffeine Caffeine 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
97 | Apelin signaling pathway 💬 12 genes, 30 drugs (DrugBank) and 72 diseases |
PDE3B [1] PDE3B 💬 |
Caffeine hydrate Caffeine hydrate 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
98 | Apelin signaling pathway 💬 12 genes, 30 drugs (DrugBank) and 72 diseases |
PDE3B [1] PDE3B 💬 |
Ibudilast Ibudilast 💬 |
Ibudilast | 002 [2] 2 , 13 💬 💬 |
99 | Apelin signaling pathway 💬 12 genes, 30 drugs (DrugBank) and 72 diseases |
PDE3B [1] PDE3B 💬 |
Levosimendan Levosimendan 💬 |
Levosimendan | 002 [1] 2 💬 💬 |
100 | Apelin signaling pathway 💬 12 genes, 30 drugs (DrugBank) and 72 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
101 | Apoptosis 💬 16 genes, 28 drugs (DrugBank) and 59 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
102 | Apoptosis 💬 16 genes, 28 drugs (DrugBank) and 59 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
103 | Arachidonic acid metabolism 💬 4 genes, 26 drugs (DrugBank) and 43 diseases |
PTGS2 [1] PTGS2 💬 |
Celecoxib Celecoxib 💬 |
Celecoxib | 002 [10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 💬 |
104 | Arginine and proline metabolism 💬 3 genes, 8 drugs (DrugBank) and 8 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
105 | Arginine and proline metabolism 💬 3 genes, 8 drugs (DrugBank) and 8 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
106 | Asthma 💬 8 genes, 22 drugs (DrugBank) and 55 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
107 | Autophagy - animal 💬 13 genes, 18 drugs (DrugBank) and 62 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
108 | Autophagy - animal 💬 13 genes, 18 drugs (DrugBank) and 62 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
109 | Autophagy - animal 💬 13 genes, 18 drugs (DrugBank) and 62 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
110 | Autophagy - other 💬 1 gene, 3 drugs (DrugBank) and 41 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
111 | Axon guidance 💬 20 genes, 21 drugs (DrugBank) and 70 diseases |
ABL1 [2] ABL1, SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
112 | Axon guidance 💬 20 genes, 21 drugs (DrugBank) and 70 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
113 | Axon guidance 💬 20 genes, 21 drugs (DrugBank) and 70 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
114 | Axon guidance 💬 20 genes, 21 drugs (DrugBank) and 70 diseases |
ROCK1 [2] ROCK1, ROCK2 💬 |
Fasudil Fasudil 💬 |
Fasudil | 002 [4] 2 , 5 , 7 , 51 💬 💬 |
115 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
116 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
117 | B cell receptor signaling pathway 💬 19 genes, 29 drugs (DrugBank) and 68 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
118 | Bacterial invasion of epithelial cells 💬 5 genes, 7 drugs (DrugBank) and 13 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
119 | beta-Alanine metabolism 💬 4 genes, 3 drugs (DrugBank) and 17 diseases |
ABAT [3] ABAT, GAD1, GAD2 💬 |
Valproic acid Valproic acid 💬 |
Valproic acid | 002 [14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬 |
120 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
121 | Bladder cancer 💬 10 genes, 23 drugs (DrugBank) and 22 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
122 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Tamoxifen Tamoxifen 💬 |
Tamoxifen | 002 [3] 2 , 113, 227 💬 💬 |
123 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
KIT [1] KIT 💬 |
Masitinib Masitinib 💬 |
Masitinib | 002 [6] 2 , 5 , 6 , 13, 46, 96 💬 💬 |
124 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
125 | Breast cancer 💬 21 genes, 60 drugs (DrugBank) and 74 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
126 | Butanoate metabolism 💬 4 genes, 2 drugs (DrugBank) and 16 diseases |
ABAT [4] ABAT, ALDH5A1, GAD1, GAD2 💬 |
Valproic acid Valproic acid 💬 |
Valproic acid | 002 [14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬 |
127 | C-type lectin receptor signaling pathway 💬 26 genes, 64 drugs (DrugBank) and 99 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
128 | C-type lectin receptor signaling pathway 💬 26 genes, 64 drugs (DrugBank) and 99 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
129 | C-type lectin receptor signaling pathway 💬 26 genes, 64 drugs (DrugBank) and 99 diseases |
PTGS2 [1] PTGS2 💬 |
Celecoxib Celecoxib 💬 |
Celecoxib | 002 [10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 💬 |
130 | C-type lectin receptor signaling pathway 💬 26 genes, 64 drugs (DrugBank) and 99 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
131 | C-type lectin receptor signaling pathway 💬 26 genes, 64 drugs (DrugBank) and 99 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
132 | Caffeine metabolism 💬 1 gene, 2 drugs (DrugBank) and 9 diseases |
XDH [1] XDH 💬 |
Febuxostat Febuxostat 💬 |
Febuxostat | 002 [3] 2 , 6 , 13 💬 💬 |
133 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
ADORA2A [2] ADORA2A, PDE1B 💬 |
Caffeine Caffeine 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
134 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
ADORA2A [2] ADORA2A, PDE1B 💬 |
Caffeine hydrate Caffeine hydrate 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
135 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
ADRA1A [8] ADRA1A, ADRA1B, ADRA1D, HRH1, HTR2A, HTR2B, HTR2C, HTR6 💬 |
Olanzapine Olanzapine 💬 |
Olanzapine | 002 [2] 2 , 8 💬 💬 |
136 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
ADRB2 [1] ADRB2 💬 |
Clenbuterol Clenbuterol 💬 |
Clenbuterol | 001 [5] 1 , 2 , 6 , 13, 256 💬 💬 |
137 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
CACNA1G [3] CACNA1G, CACNA1H, CACNA1I 💬 |
Valproic acid Valproic acid 💬 |
Valproic acid | 002 [14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬 |
138 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
CHRM1 [4] CHRM1, CHRM2, CHRM3, CHRM5 💬 |
Atropine Atropine 💬 |
Atropine | 002 [2] 2 , 299 💬 💬 |
139 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
CHRM1 [4] CHRM1, CHRM2, CHRM3, CHRM5 💬 |
Scopolamine Scopolamine 💬 |
Scopolamine | 002 [1] 2 💬 💬 |
140 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
CYSLTR1 [1] CYSLTR1 💬 |
Ibudilast Ibudilast 💬 |
Ibudilast | 002 [2] 2 , 13 💬 💬 |
141 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
DRD1 [2] DRD1, DRD5 💬 |
Dexpramipexole Dexpramipexole 💬 |
Dexpramipexole | 002 [1] 2 💬 💬 |
142 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
GRIN1 [4] GRIN1, GRIN2A, GRIN2C, GRIN2D 💬 |
Dextromethorphan Dextromethorphan 💬 |
Dextromethorphan | 002 [11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬 💬 |
143 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
GRIN1 [4] GRIN1, GRIN2A, GRIN2C, GRIN2D 💬 |
Esketamine Esketamine 💬 |
Esketamine | 002 [3] 2 , 4 , 70 💬 💬 |
144 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
GRIN1 [4] GRIN1, GRIN2A, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
145 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
GRIN1 [4] GRIN1, GRIN2A, GRIN2C, GRIN2D 💬 |
Memantine Memantine 💬 |
Memantine | 002 [8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬 💬 |
146 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
GRIN1 [4] GRIN1, GRIN2A, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
147 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
HRH2 [1] HRH2 💬 |
Cimetidine Cimetidine 💬 |
Cimetidine | 002 [2] 2 , 254 💬 💬 |
148 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
HTR2A [3] HTR2A, HTR2B, HTR2C 💬 |
Trazodone Trazodone 💬 |
Trazodone | 002 [1] 2 💬 💬 |
149 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
150 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
151 | Calcium signaling pathway 💬 79 genes, 187 drugs (DrugBank) and 134 diseases |
TNNC2 [1] TNNC2 💬 |
Reldesemtiv Reldesemtiv 💬 |
Reldesemtiv | 002 [2] 2 , 3 💬 💬 |
152 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
ADORA1 [8] ADORA1, ADORA2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 |
Caffeine Caffeine 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
153 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
ADORA1 [8] ADORA1, ADORA2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 |
Caffeine hydrate Caffeine hydrate 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
154 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
ADRB2 [1] ADRB2 💬 |
Clenbuterol Clenbuterol 💬 |
Clenbuterol | 001 [5] 1 , 2 , 6 , 13, 256 💬 💬 |
155 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
CHRM1 [2] CHRM1, CHRM2 💬 |
Atropine Atropine 💬 |
Atropine | 002 [2] 2 , 299 💬 💬 |
156 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
CHRM1 [2] CHRM1, CHRM2 💬 |
Scopolamine Scopolamine 💬 |
Scopolamine | 002 [1] 2 💬 💬 |
157 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
DRD1 [3] DRD1, DRD2, DRD5 💬 |
Dexpramipexole Dexpramipexole 💬 |
Dexpramipexole | 002 [1] 2 💬 💬 |
158 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
DRD2 [1] DRD2 💬 |
Pimozide Pimozide 💬 |
Pimozide | 002 [1] 2 💬 💬 |
159 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
DRD2 [1] DRD2 💬 |
Pramipexole Pramipexole 💬 |
Pramipexole | 002 [3] 2 , 6 , 20 💬 💬 |
160 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
DRD2 [1] DRD2 💬 |
Pridopidine Pridopidine 💬 |
Pridopidine | 002 [3] 2 , 6 , 8 💬 💬 |
161 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
DRD2 [1] DRD2 💬 |
Ropinirole Ropinirole 💬 |
Ropinirole | 002 [4] 2 , 6 , 74, 309 💬 💬 |
162 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
DRD2 [2] DRD2, HTR6 💬 |
Olanzapine Olanzapine 💬 |
Olanzapine | 002 [2] 2 , 8 💬 💬 |
163 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
GABBR1 [2] GABBR1, GABBR2 💬 |
Baclofen Baclofen 💬 |
Baclofen | 002 [8] 2 , 10, 13, 18, 65, 70, 149, 206 💬 💬 |
164 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
GRIA1 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 |
Perampanel Perampanel 💬 |
Perampanel | 002 [3] 2 , 6 , 144 💬 💬 |
165 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
GRIA1 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 |
Talampanel Talampanel 💬 |
Talampanel | 002 [2] 2 , 6 💬 💬 |
166 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
GRIA1 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
167 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Dextromethorphan Dextromethorphan 💬 |
Dextromethorphan | 002 [11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬 💬 |
168 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Esketamine Esketamine 💬 |
Esketamine | 002 [3] 2 , 4 , 70 💬 💬 |
169 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
170 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Memantine Memantine 💬 |
Memantine | 002 [8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬 💬 |
171 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
172 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
MC2R [1] MC2R 💬 |
Corticotropin Corticotropin 💬 |
Corticotropin | 002 [12] 2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬 💬 |
173 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
PDE3A [2] PDE3A, PDE3B 💬 |
Levosimendan Levosimendan 💬 |
Levosimendan | 002 [1] 2 💬 💬 |
174 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
PDE3A [6] PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 |
Ibudilast Ibudilast 💬 |
Ibudilast | 002 [2] 2 , 13 💬 💬 |
175 | cAMP signaling pathway 💬 67 genes, 171 drugs (DrugBank) and 114 diseases |
ROCK1 [2] ROCK1, ROCK2 💬 |
Fasudil Fasudil 💬 |
Fasudil | 002 [4] 2 , 5 , 7 , 51 💬 💬 |
176 | Cell cycle 💬 10 genes, 9 drugs (DrugBank) and 21 diseases |
ABL1 [1] ABL1 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
177 | Cellular senescence 💬 26 genes, 40 drugs (DrugBank) and 92 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
178 | Cellular senescence 💬 26 genes, 40 drugs (DrugBank) and 92 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
179 | Cellular senescence 💬 26 genes, 40 drugs (DrugBank) and 92 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
180 | Cellular senescence 💬 26 genes, 40 drugs (DrugBank) and 92 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
181 | Central carbon metabolism in cancer 💬 18 genes, 29 drugs (DrugBank) and 56 diseases |
KIT [1] KIT 💬 |
Masitinib Masitinib 💬 |
Masitinib | 002 [6] 2 , 5 , 6 , 13, 46, 96 💬 💬 |
182 | Central carbon metabolism in cancer 💬 18 genes, 29 drugs (DrugBank) and 56 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
183 | Central carbon metabolism in cancer 💬 18 genes, 29 drugs (DrugBank) and 56 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
184 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
ADORA1 [5] ADORA1, PDE2A, PDE3A, PDE3B, PDE5A 💬 |
Caffeine Caffeine 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
185 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
ADORA1 [5] ADORA1, PDE2A, PDE3A, PDE3B, PDE5A 💬 |
Caffeine hydrate Caffeine hydrate 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
186 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
ADRA1A [3] ADRA1A, ADRA1B, ADRA1D 💬 |
Olanzapine Olanzapine 💬 |
Olanzapine | 002 [2] 2 , 8 💬 💬 |
187 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
ADRA2A [1] ADRA2A 💬 |
Pimozide Pimozide 💬 |
Pimozide | 002 [1] 2 💬 💬 |
188 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
ADRA2A [3] ADRA2A, ADRA2B, ADRA2C 💬 |
Dexmedetomidine Dexmedetomidine 💬 |
Dexmedetomidine | 002 [14] 2 , 4 , 6 , 21, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬 💬 |
189 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
ADRA2A [3] ADRA2A, ADRA2B, ADRA2C 💬 |
Guanabenz Guanabenz 💬 |
Guanabenz | 002 [2] 2 , 13 💬 💬 |
190 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
ADRB2 [1] ADRB2 💬 |
Clenbuterol Clenbuterol 💬 |
Clenbuterol | 001 [5] 1 , 2 , 6 , 13, 256 💬 💬 |
191 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
192 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
PDE3A [2] PDE3A, PDE3B 💬 |
Ibudilast Ibudilast 💬 |
Ibudilast | 002 [2] 2 , 13 💬 💬 |
193 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
PDE3A [2] PDE3A, PDE3B 💬 |
Levosimendan Levosimendan 💬 |
Levosimendan | 002 [1] 2 💬 💬 |
194 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
195 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
196 | cGMP-PKG signaling pathway 💬 46 genes, 119 drugs (DrugBank) and 118 diseases |
ROCK1 [2] ROCK1, ROCK2 💬 |
Fasudil Fasudil 💬 |
Fasudil | 002 [4] 2 , 5 , 7 , 51 💬 💬 |
197 | Chagas disease 💬 28 genes, 44 drugs (DrugBank) and 77 diseases |
C3 [1] C3 💬 |
Pegcetacoplan Pegcetacoplan 💬 |
Pegcetacoplan | 002 [4] 2 , 61, 62, 222 💬 💬 |
198 | Chagas disease 💬 28 genes, 44 drugs (DrugBank) and 77 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
199 | Chemical carcinogenesis - DNA adducts 💬 1 gene, 24 drugs (DrugBank) and 40 diseases |
PTGS2 [1] PTGS2 💬 |
Celecoxib Celecoxib 💬 |
Celecoxib | 002 [10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 💬 |
200 | Chemical carcinogenesis - reactive oxygen species 💬 25 genes, 37 drugs (DrugBank) and 42 diseases |
ABL1 [2] ABL1, SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
201 | Chemical carcinogenesis - reactive oxygen species 💬 25 genes, 37 drugs (DrugBank) and 42 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
202 | Chemical carcinogenesis - reactive oxygen species 💬 25 genes, 37 drugs (DrugBank) and 42 diseases |
SOD1 [1] SOD1 💬 |
Tofersen Tofersen 💬 |
Tofersen | 002 [1] 2 💬 💬 |
203 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
ADRB2 [1] ADRB2 💬 |
Clenbuterol Clenbuterol 💬 |
Clenbuterol | 001 [5] 1 , 2 , 6 , 13, 256 💬 💬 |
204 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
AR [1] AR 💬 |
Calusterone Calusterone 💬 |
Calusterone | 002 [1] 2 💬 💬 |
205 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
AR [1] AR 💬 |
Testosterone Testosterone 💬 |
Testosterone | 001 [8] 1 , 2 , 3 , 13, 60, 76, 78, 113 💬 💬 |
206 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Tamoxifen Tamoxifen 💬 |
Tamoxifen | 002 [3] 2 , 113, 227 💬 💬 |
207 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
JAK2 [1] JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
208 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
209 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
210 | Chemical carcinogenesis - receptor activation 💬 39 genes, 126 drugs (DrugBank) and 116 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
211 | Chemokine signaling pathway 💬 22 genes, 29 drugs (DrugBank) and 51 diseases |
JAK2 [1] JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
212 | Chemokine signaling pathway 💬 22 genes, 29 drugs (DrugBank) and 51 diseases |
MAP2K1 [1] MAP2K1 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
213 | Chemokine signaling pathway 💬 22 genes, 29 drugs (DrugBank) and 51 diseases |
ROCK1 [2] ROCK1, ROCK2 💬 |
Fasudil Fasudil 💬 |
Fasudil | 002 [4] 2 , 5 , 7 , 51 💬 💬 |
214 | Chemokine signaling pathway 💬 22 genes, 29 drugs (DrugBank) and 51 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
215 | Cholesterol metabolism 💬 6 genes, 8 drugs (DrugBank) and 6 diseases |
SORT1 [1] SORT1 💬 |
Latozinemab Latozinemab 💬 |
Latozinemab | 002 [2] 2 , 127 💬 💬 |
216 | Choline metabolism in cancer 💬 11 genes, 25 drugs (DrugBank) and 53 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
217 | Choline metabolism in cancer 💬 11 genes, 25 drugs (DrugBank) and 53 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
218 | Cholinergic synapse 💬 32 genes, 48 drugs (DrugBank) and 59 diseases |
CHRM1 [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 |
Atropine Atropine 💬 |
Atropine | 002 [2] 2 , 299 💬 💬 |
219 | Cholinergic synapse 💬 32 genes, 48 drugs (DrugBank) and 59 diseases |
CHRM1 [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 |
Scopolamine Scopolamine 💬 |
Scopolamine | 002 [1] 2 💬 💬 |
220 | Cholinergic synapse 💬 32 genes, 48 drugs (DrugBank) and 59 diseases |
JAK2 [1] JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
221 | Cholinergic synapse 💬 32 genes, 48 drugs (DrugBank) and 59 diseases |
KCNQ1 [5] KCNQ1, KCNQ2, KCNQ3, KCNQ4, KCNQ5 💬 |
Ezogabine Ezogabine 💬 |
Ezogabine | 002 [2] 2 , 144 💬 💬 |
222 | Cholinergic synapse 💬 32 genes, 48 drugs (DrugBank) and 59 diseases |
MAP2K1 [1] MAP2K1 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
223 | Chronic myeloid leukemia 💬 17 genes, 20 drugs (DrugBank) and 29 diseases |
ABL1 [1] ABL1 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
224 | Chronic myeloid leukemia 💬 17 genes, 20 drugs (DrugBank) and 29 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
225 | Circadian entrainment 💬 22 genes, 32 drugs (DrugBank) and 55 diseases |
CACNA1G [3] CACNA1G, CACNA1H, CACNA1I 💬 |
Valproic acid Valproic acid 💬 |
Valproic acid | 002 [14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬 |
226 | Circadian entrainment 💬 22 genes, 32 drugs (DrugBank) and 55 diseases |
GRIA1 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 |
Perampanel Perampanel 💬 |
Perampanel | 002 [3] 2 , 6 , 144 💬 💬 |
227 | Circadian entrainment 💬 22 genes, 32 drugs (DrugBank) and 55 diseases |
GRIA1 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 |
Talampanel Talampanel 💬 |
Talampanel | 002 [2] 2 , 6 💬 💬 |
228 | Circadian entrainment 💬 22 genes, 32 drugs (DrugBank) and 55 diseases |
GRIA1 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
229 | Circadian entrainment 💬 22 genes, 32 drugs (DrugBank) and 55 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Dextromethorphan Dextromethorphan 💬 |
Dextromethorphan | 002 [11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬 💬 |
230 | Circadian entrainment 💬 22 genes, 32 drugs (DrugBank) and 55 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Esketamine Esketamine 💬 |
Esketamine | 002 [3] 2 , 4 , 70 💬 💬 |
231 | Circadian entrainment 💬 22 genes, 32 drugs (DrugBank) and 55 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
232 | Circadian entrainment 💬 22 genes, 32 drugs (DrugBank) and 55 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Memantine Memantine 💬 |
Memantine | 002 [8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬 💬 |
233 | Circadian rhythm 💬 2 genes, 1 drug (DrugBank) and 25 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
234 | Cocaine addiction 💬 15 genes, 63 drugs (DrugBank) and 52 diseases |
DRD1 [2] DRD1, DRD2 💬 |
Dexpramipexole Dexpramipexole 💬 |
Dexpramipexole | 002 [1] 2 💬 💬 |
235 | Cocaine addiction 💬 15 genes, 63 drugs (DrugBank) and 52 diseases |
DRD2 [1] DRD2 💬 |
Olanzapine Olanzapine 💬 |
Olanzapine | 002 [2] 2 , 8 💬 💬 |
236 | Cocaine addiction 💬 15 genes, 63 drugs (DrugBank) and 52 diseases |
DRD2 [1] DRD2 💬 |
Pimozide Pimozide 💬 |
Pimozide | 002 [1] 2 💬 💬 |
237 | Cocaine addiction 💬 15 genes, 63 drugs (DrugBank) and 52 diseases |
DRD2 [1] DRD2 💬 |
Pramipexole Pramipexole 💬 |
Pramipexole | 002 [3] 2 , 6 , 20 💬 💬 |
238 | Cocaine addiction 💬 15 genes, 63 drugs (DrugBank) and 52 diseases |
DRD2 [1] DRD2 💬 |
Pridopidine Pridopidine 💬 |
Pridopidine | 002 [3] 2 , 6 , 8 💬 💬 |
239 | Cocaine addiction 💬 15 genes, 63 drugs (DrugBank) and 52 diseases |
DRD2 [1] DRD2 💬 |
Ropinirole Ropinirole 💬 |
Ropinirole | 002 [4] 2 , 6 , 74, 309 💬 💬 |
240 | Cocaine addiction 💬 15 genes, 63 drugs (DrugBank) and 52 diseases |
GRIA2 [1] GRIA2 💬 |
Perampanel Perampanel 💬 |
Perampanel | 002 [3] 2 , 6 , 144 💬 💬 |
241 | Cocaine addiction 💬 15 genes, 63 drugs (DrugBank) and 52 diseases |
GRIA2 [1] GRIA2 💬 |
Talampanel Talampanel 💬 |
Talampanel | 002 [2] 2 , 6 💬 💬 |
242 | Cocaine addiction 💬 15 genes, 63 drugs (DrugBank) and 52 diseases |
GRIA2 [6] GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
243 | Cocaine addiction 💬 15 genes, 63 drugs (DrugBank) and 52 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Dextromethorphan Dextromethorphan 💬 |
Dextromethorphan | 002 [11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬 💬 |
244 | Cocaine addiction 💬 15 genes, 63 drugs (DrugBank) and 52 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Esketamine Esketamine 💬 |
Esketamine | 002 [3] 2 , 4 , 70 💬 💬 |
245 | Cocaine addiction 💬 15 genes, 63 drugs (DrugBank) and 52 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
246 | Cocaine addiction 💬 15 genes, 63 drugs (DrugBank) and 52 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Memantine Memantine 💬 |
Memantine | 002 [8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬 💬 |
247 | Cocaine addiction 💬 15 genes, 63 drugs (DrugBank) and 52 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
248 | Cocaine addiction 💬 15 genes, 63 drugs (DrugBank) and 52 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
249 | Collecting duct acid secretion 💬 3 genes, 11 drugs (DrugBank) and 35 diseases |
ATP4A [2] ATP4A, ATP4B 💬 |
Rabeprazole Rabeprazole 💬 |
Rabeprazole | 002 [2] 2 , 51 💬 💬 |
250 | Colorectal cancer 💬 14 genes, 23 drugs (DrugBank) and 49 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
251 | Colorectal cancer 💬 14 genes, 23 drugs (DrugBank) and 49 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
252 | Complement and coagulation cascades 💬 17 genes, 29 drugs (DrugBank) and 44 diseases |
C3 [1] C3 💬 |
Pegcetacoplan Pegcetacoplan 💬 |
Pegcetacoplan | 002 [4] 2 , 61, 62, 222 💬 💬 |
253 | Complement and coagulation cascades 💬 17 genes, 29 drugs (DrugBank) and 44 diseases |
C5 [1] C5 💬 |
Ravulizumab Ravulizumab 💬 |
Ravulizumab | 002 [7] 2 , 11, 13, 50, 62, 66, 109 💬 💬 |
254 | Complement and coagulation cascades 💬 17 genes, 29 drugs (DrugBank) and 44 diseases |
C5 [1] C5 💬 |
Zilucoplan Zilucoplan 💬 |
Zilucoplan | 002 [3] 2 , 11, 62 💬 💬 |
255 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
C3 [1] C3 💬 |
Pegcetacoplan Pegcetacoplan 💬 |
Pegcetacoplan | 002 [4] 2 , 61, 62, 222 💬 💬 |
256 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
C5 [1] C5 💬 |
Ravulizumab Ravulizumab 💬 |
Ravulizumab | 002 [7] 2 , 11, 13, 50, 62, 66, 109 💬 💬 |
257 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
C5 [1] C5 💬 |
Zilucoplan Zilucoplan 💬 |
Zilucoplan | 002 [3] 2 , 11, 62 💬 💬 |
258 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
IL6R [1] IL6R 💬 |
Tocilizumab Tocilizumab 💬 |
Tocilizumab | 002 [21] 2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬 💬 |
259 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
JAK1 [1] JAK1 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
260 | Coronavirus disease - COVID-19 💬 51 genes, 94 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
261 | Cortisol synthesis and secretion 💬 15 genes, 33 drugs (DrugBank) and 61 diseases |
CACNA1G [3] CACNA1G, CACNA1H, CACNA1I 💬 |
Valproic acid Valproic acid 💬 |
Valproic acid | 002 [14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬 |
262 | Cortisol synthesis and secretion 💬 15 genes, 33 drugs (DrugBank) and 61 diseases |
MC2R [1] MC2R 💬 |
Corticotropin Corticotropin 💬 |
Corticotropin | 002 [12] 2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬 💬 |
263 | Cushing syndrome 💬 24 genes, 50 drugs (DrugBank) and 66 diseases |
CACNA1G [3] CACNA1G, CACNA1H, CACNA1I 💬 |
Valproic acid Valproic acid 💬 |
Valproic acid | 002 [14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬 |
264 | Cushing syndrome 💬 24 genes, 50 drugs (DrugBank) and 66 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
265 | Cushing syndrome 💬 24 genes, 50 drugs (DrugBank) and 66 diseases |
MC2R [1] MC2R 💬 |
Corticotropin Corticotropin 💬 |
Corticotropin | 002 [12] 2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬 💬 |
266 | Cytokine-cytokine receptor interaction 💬 81 genes, 114 drugs (DrugBank) and 92 diseases |
CSF3R [1] CSF3R 💬 |
Filgrastim Filgrastim 💬 |
Filgrastim | 002 [35] 2 , 6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬 💬 |
267 | Cytokine-cytokine receptor interaction 💬 81 genes, 114 drugs (DrugBank) and 92 diseases |
CSF3R [1] CSF3R 💬 |
Lenograstim Lenograstim 💬 |
Lenograstim | 002 [7] 2 , 13, 16, 18, 19, 57, 65 💬 💬 |
268 | Cytokine-cytokine receptor interaction 💬 81 genes, 114 drugs (DrugBank) and 92 diseases |
IL1R1 [2] IL1R1, IL1R2 💬 |
Anakinra Anakinra 💬 |
Anakinra | 002 [18] 2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 💬 |
269 | Cytokine-cytokine receptor interaction 💬 81 genes, 114 drugs (DrugBank) and 92 diseases |
IL2RA [1] IL2RA 💬 |
Basiliximab Basiliximab 💬 |
Basiliximab | 002 [6] 2 , 50, 66, 97, 222, 228 💬 💬 |
270 | Cytokine-cytokine receptor interaction 💬 81 genes, 114 drugs (DrugBank) and 92 diseases |
IL2RA [3] IL2RA, IL2RB, IL2RG 💬 |
Aldesleukin Aldesleukin 💬 |
Aldesleukin | 002 [6] 2 , 35, 49, 65, 96, 97 💬 💬 |
271 | Cytokine-cytokine receptor interaction 💬 81 genes, 114 drugs (DrugBank) and 92 diseases |
IL6R [1] IL6R 💬 |
Tocilizumab Tocilizumab 💬 |
Tocilizumab | 002 [21] 2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬 💬 |
272 | Cytokine-cytokine receptor interaction 💬 81 genes, 114 drugs (DrugBank) and 92 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
273 | Diabetic cardiomyopathy 💬 26 genes, 42 drugs (DrugBank) and 73 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
274 | Dilated cardiomyopathy 💬 17 genes, 55 drugs (DrugBank) and 83 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
275 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
DRD1 [5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 |
Dexpramipexole Dexpramipexole 💬 |
Dexpramipexole | 002 [1] 2 💬 💬 |
276 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
DRD2 [1] DRD2 💬 |
Pimozide Pimozide 💬 |
Pimozide | 002 [1] 2 💬 💬 |
277 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
DRD2 [1] DRD2 💬 |
Pridopidine Pridopidine 💬 |
Pridopidine | 002 [3] 2 , 6 , 8 💬 💬 |
278 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
DRD2 [3] DRD2, DRD3, DRD4 💬 |
Olanzapine Olanzapine 💬 |
Olanzapine | 002 [2] 2 , 8 💬 💬 |
279 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
DRD2 [3] DRD2, DRD3, DRD4 💬 |
Pramipexole Pramipexole 💬 |
Pramipexole | 002 [3] 2 , 6 , 20 💬 💬 |
280 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
DRD2 [3] DRD2, DRD3, DRD4 💬 |
Ropinirole Ropinirole 💬 |
Ropinirole | 002 [4] 2 , 6 , 74, 309 💬 💬 |
281 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
GRIA1 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 |
Perampanel Perampanel 💬 |
Perampanel | 002 [3] 2 , 6 , 144 💬 💬 |
282 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
GRIA1 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 |
Talampanel Talampanel 💬 |
Talampanel | 002 [2] 2 , 6 💬 💬 |
283 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
GRIA1 [6] GRIA1, GRIA2, GRIA3, GRIA4, GRIN2A, GRIN2B 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
284 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
GRIN2A [2] GRIN2A, GRIN2B 💬 |
Dextromethorphan Dextromethorphan 💬 |
Dextromethorphan | 002 [11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬 💬 |
285 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
GRIN2A [2] GRIN2A, GRIN2B 💬 |
Esketamine Esketamine 💬 |
Esketamine | 002 [3] 2 , 4 , 70 💬 💬 |
286 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
GRIN2A [2] GRIN2A, GRIN2B 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
287 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
GRIN2A [2] GRIN2A, GRIN2B 💬 |
Memantine Memantine 💬 |
Memantine | 002 [8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬 💬 |
288 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
289 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
290 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
PPP3CA [3] PPP3CA, PPP3CB, PPP3CC 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
291 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
PPP3CA [3] PPP3CA, PPP3CB, PPP3CC 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
292 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
SCN1A [1] SCN1A 💬 |
Mexiletine Mexiletine 💬 |
Mexiletine | 001 [5] 1 , 2 , 10, 113, 114 💬 💬 |
293 | Dopaminergic synapse 💬 31 genes, 99 drugs (DrugBank) and 101 diseases |
SCN1A [1] SCN1A 💬 |
Quinidine Quinidine 💬 |
Quinidine | 002 [3] 2 , 8 , 13 💬 💬 |
294 | Drug metabolism - cytochrome P450 💬 5 genes, 8 drugs (DrugBank) and 8 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
295 | Drug metabolism - cytochrome P450 💬 5 genes, 8 drugs (DrugBank) and 8 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
296 | Drug metabolism - other enzymes 💬 8 genes, 13 drugs (DrugBank) and 48 diseases |
IMPDH1 [2] IMPDH1, IMPDH2 💬 |
Mycophenolate mofetil Mycophenolate mofetil 💬 |
Mycophenolate mofetil | 002 [34] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬 💬 |
297 | Drug metabolism - other enzymes 💬 8 genes, 13 drugs (DrugBank) and 48 diseases |
IMPDH1 [2] IMPDH1, IMPDH2 💬 |
Mycophenolic acid Mycophenolic acid 💬 |
Mycophenolic acid | 002 [36] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬 💬 |
298 | Drug metabolism - other enzymes 💬 8 genes, 13 drugs (DrugBank) and 48 diseases |
MPO [1] MPO 💬 |
Verdiperstat Verdiperstat 💬 |
Verdiperstat | 002 [3] 2 , 17, 127 💬 💬 |
299 | Drug metabolism - other enzymes 💬 8 genes, 13 drugs (DrugBank) and 48 diseases |
XDH [1] XDH 💬 |
Febuxostat Febuxostat 💬 |
Febuxostat | 002 [3] 2 , 6 , 13 💬 💬 |
300 | ECM-receptor interaction 💬 6 genes, 9 drugs (DrugBank) and 15 diseases |
SV2A [1] SV2A 💬 |
Levetiracetam Levetiracetam 💬 |
Levetiracetam | 002 [5] 2 , 4 , 6 , 13, 307 💬 💬 |
301 | EGFR tyrosine kinase inhibitor resistance 💬 26 genes, 56 drugs (DrugBank) and 83 diseases |
IL6R [1] IL6R 💬 |
Tocilizumab Tocilizumab 💬 |
Tocilizumab | 002 [21] 2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬 💬 |
302 | EGFR tyrosine kinase inhibitor resistance 💬 26 genes, 56 drugs (DrugBank) and 83 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
303 | EGFR tyrosine kinase inhibitor resistance 💬 26 genes, 56 drugs (DrugBank) and 83 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
304 | EGFR tyrosine kinase inhibitor resistance 💬 26 genes, 56 drugs (DrugBank) and 83 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
305 | EGFR tyrosine kinase inhibitor resistance 💬 26 genes, 56 drugs (DrugBank) and 83 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
306 | Endocrine and other factor-regulated calcium reabsorption 💬 8 genes, 27 drugs (DrugBank) and 55 diseases |
ESR1 [1] ESR1 💬 |
Tamoxifen Tamoxifen 💬 |
Tamoxifen | 002 [3] 2 , 113, 227 💬 💬 |
307 | Endocrine resistance 💬 20 genes, 43 drugs (DrugBank) and 62 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Tamoxifen Tamoxifen 💬 |
Tamoxifen | 002 [3] 2 , 113, 227 💬 💬 |
308 | Endocrine resistance 💬 20 genes, 43 drugs (DrugBank) and 62 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
309 | Endocrine resistance 💬 20 genes, 43 drugs (DrugBank) and 62 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
310 | Endocrine resistance 💬 20 genes, 43 drugs (DrugBank) and 62 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
311 | Endocytosis 💬 15 genes, 28 drugs (DrugBank) and 51 diseases |
IL2RA [1] IL2RA 💬 |
Basiliximab Basiliximab 💬 |
Basiliximab | 002 [6] 2 , 50, 66, 97, 222, 228 💬 💬 |
312 | Endocytosis 💬 15 genes, 28 drugs (DrugBank) and 51 diseases |
IL2RA [3] IL2RA, IL2RB, IL2RG 💬 |
Aldesleukin Aldesleukin 💬 |
Aldesleukin | 002 [6] 2 , 35, 49, 65, 96, 97 💬 💬 |
313 | Endocytosis 💬 15 genes, 28 drugs (DrugBank) and 51 diseases |
PML [1] PML 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
314 | Endocytosis 💬 15 genes, 28 drugs (DrugBank) and 51 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
315 | Endometrial cancer 💬 10 genes, 18 drugs (DrugBank) and 20 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
316 | Epithelial cell signaling in Helicobacter pylori infection 💬 12 genes, 17 drugs (DrugBank) and 21 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
317 | Epstein-Barr virus infection 💬 44 genes, 62 drugs (DrugBank) and 66 diseases |
JAK1 [1] JAK1 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
318 | Epstein-Barr virus infection 💬 44 genes, 62 drugs (DrugBank) and 66 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
319 | ErbB signaling pathway 💬 14 genes, 26 drugs (DrugBank) and 53 diseases |
ABL1 [2] ABL1, SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
320 | ErbB signaling pathway 💬 14 genes, 26 drugs (DrugBank) and 53 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
321 | ErbB signaling pathway 💬 14 genes, 26 drugs (DrugBank) and 53 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
322 | Estrogen signaling pathway 💬 19 genes, 74 drugs (DrugBank) and 64 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Tamoxifen Tamoxifen 💬 |
Tamoxifen | 002 [3] 2 , 113, 227 💬 💬 |
323 | Estrogen signaling pathway 💬 19 genes, 74 drugs (DrugBank) and 64 diseases |
GABBR1 [2] GABBR1, GABBR2 💬 |
Baclofen Baclofen 💬 |
Baclofen | 002 [8] 2 , 10, 13, 18, 65, 70, 149, 206 💬 💬 |
324 | Estrogen signaling pathway 💬 19 genes, 74 drugs (DrugBank) and 64 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
325 | Estrogen signaling pathway 💬 19 genes, 74 drugs (DrugBank) and 64 diseases |
RARA [1] RARA 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
326 | Estrogen signaling pathway 💬 19 genes, 74 drugs (DrugBank) and 64 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
327 | Fc epsilon RI signaling pathway 💬 20 genes, 42 drugs (DrugBank) and 62 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
328 | Fc epsilon RI signaling pathway 💬 20 genes, 42 drugs (DrugBank) and 62 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
329 | Fc gamma R-mediated phagocytosis 💬 9 genes, 12 drugs (DrugBank) and 15 diseases |
MAP2K1 [1] MAP2K1 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
330 | Fluid shear stress and atherosclerosis 💬 29 genes, 48 drugs (DrugBank) and 86 diseases |
IL1R1 [2] IL1R1, IL1R2 💬 |
Anakinra Anakinra 💬 |
Anakinra | 002 [18] 2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 💬 |
331 | Fluid shear stress and atherosclerosis 💬 29 genes, 48 drugs (DrugBank) and 86 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
332 | Fluid shear stress and atherosclerosis 💬 29 genes, 48 drugs (DrugBank) and 86 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
333 | Fluid shear stress and atherosclerosis 💬 29 genes, 48 drugs (DrugBank) and 86 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
334 | Focal adhesion 💬 27 genes, 43 drugs (DrugBank) and 44 diseases |
MAP2K1 [1] MAP2K1 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
335 | Focal adhesion 💬 27 genes, 43 drugs (DrugBank) and 44 diseases |
ROCK1 [2] ROCK1, ROCK2 💬 |
Fasudil Fasudil 💬 |
Fasudil | 002 [4] 2 , 5 , 7 , 51 💬 💬 |
336 | Focal adhesion 💬 27 genes, 43 drugs (DrugBank) and 44 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
337 | FoxO signaling pathway 💬 24 genes, 40 drugs (DrugBank) and 54 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
338 | FoxO signaling pathway 💬 24 genes, 40 drugs (DrugBank) and 54 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
339 | GABAergic synapse 💬 29 genes, 38 drugs (DrugBank) and 55 diseases |
ABAT [3] ABAT, GAD1, GAD2 💬 |
Valproic acid Valproic acid 💬 |
Valproic acid | 002 [14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬 |
340 | GABAergic synapse 💬 29 genes, 38 drugs (DrugBank) and 55 diseases |
GABBR1 [2] GABBR1, GABBR2 💬 |
Baclofen Baclofen 💬 |
Baclofen | 002 [8] 2 , 10, 13, 18, 65, 70, 149, 206 💬 💬 |
341 | GABAergic synapse 💬 29 genes, 38 drugs (DrugBank) and 55 diseases |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
Midazolam Midazolam 💬 |
Midazolam | 002 [12] 2 , 3 , 6 , 13, 21, 46, 70, 96, 97, 272, 298, 299 💬 💬 |
342 | GABAergic synapse 💬 29 genes, 38 drugs (DrugBank) and 55 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
343 | Gap junction 💬 26 genes, 87 drugs (DrugBank) and 77 diseases |
DRD1 [2] DRD1, DRD2 💬 |
Dexpramipexole Dexpramipexole 💬 |
Dexpramipexole | 002 [1] 2 💬 💬 |
344 | Gap junction 💬 26 genes, 87 drugs (DrugBank) and 77 diseases |
DRD2 [1] DRD2 💬 |
Pimozide Pimozide 💬 |
Pimozide | 002 [1] 2 💬 💬 |
345 | Gap junction 💬 26 genes, 87 drugs (DrugBank) and 77 diseases |
DRD2 [1] DRD2 💬 |
Pramipexole Pramipexole 💬 |
Pramipexole | 002 [3] 2 , 6 , 20 💬 💬 |
346 | Gap junction 💬 26 genes, 87 drugs (DrugBank) and 77 diseases |
DRD2 [1] DRD2 💬 |
Pridopidine Pridopidine 💬 |
Pridopidine | 002 [3] 2 , 6 , 8 💬 💬 |
347 | Gap junction 💬 26 genes, 87 drugs (DrugBank) and 77 diseases |
DRD2 [1] DRD2 💬 |
Ropinirole Ropinirole 💬 |
Ropinirole | 002 [4] 2 , 6 , 74, 309 💬 💬 |
348 | Gap junction 💬 26 genes, 87 drugs (DrugBank) and 77 diseases |
DRD2 [4] DRD2, HTR2A, HTR2B, HTR2C 💬 |
Olanzapine Olanzapine 💬 |
Olanzapine | 002 [2] 2 , 8 💬 💬 |
349 | Gap junction 💬 26 genes, 87 drugs (DrugBank) and 77 diseases |
HTR2A [3] HTR2A, HTR2B, HTR2C 💬 |
Trazodone Trazodone 💬 |
Trazodone | 002 [1] 2 💬 💬 |
350 | Gap junction 💬 26 genes, 87 drugs (DrugBank) and 77 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
351 | Gap junction 💬 26 genes, 87 drugs (DrugBank) and 77 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
352 | Gap junction 💬 26 genes, 87 drugs (DrugBank) and 77 diseases |
TUBB [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 |
Colchicine Colchicine 💬 |
Colchicine | 002 [7] 2 , 42, 46, 56, 93, 210, 266 💬 💬 |
353 | Gastric acid secretion 💬 14 genes, 43 drugs (DrugBank) and 52 diseases |
ATP4A [2] ATP4A, ATP4B 💬 |
Rabeprazole Rabeprazole 💬 |
Rabeprazole | 002 [2] 2 , 51 💬 💬 |
354 | Gastric acid secretion 💬 14 genes, 43 drugs (DrugBank) and 52 diseases |
CHRM3 [1] CHRM3 💬 |
Atropine Atropine 💬 |
Atropine | 002 [2] 2 , 299 💬 💬 |
355 | Gastric acid secretion 💬 14 genes, 43 drugs (DrugBank) and 52 diseases |
CHRM3 [1] CHRM3 💬 |
Scopolamine Scopolamine 💬 |
Scopolamine | 002 [1] 2 💬 💬 |
356 | Gastric acid secretion 💬 14 genes, 43 drugs (DrugBank) and 52 diseases |
HRH2 [1] HRH2 💬 |
Cimetidine Cimetidine 💬 |
Cimetidine | 002 [2] 2 , 254 💬 💬 |
357 | Gastric acid secretion 💬 14 genes, 43 drugs (DrugBank) and 52 diseases |
KCNQ1 [1] KCNQ1 💬 |
Ezogabine Ezogabine 💬 |
Ezogabine | 002 [2] 2 , 144 💬 💬 |
358 | Gastric cancer 💬 21 genes, 34 drugs (DrugBank) and 57 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
359 | Gastric cancer 💬 21 genes, 34 drugs (DrugBank) and 57 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
360 | Gastric cancer 💬 21 genes, 34 drugs (DrugBank) and 57 diseases |
RARB [1] RARB 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
361 | Glioma 💬 15 genes, 30 drugs (DrugBank) and 57 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
362 | Glioma 💬 15 genes, 30 drugs (DrugBank) and 57 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
363 | Glucagon signaling pathway 💬 12 genes, 19 drugs (DrugBank) and 83 diseases |
PDE3B [1] PDE3B 💬 |
Caffeine Caffeine 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
364 | Glucagon signaling pathway 💬 12 genes, 19 drugs (DrugBank) and 83 diseases |
PDE3B [1] PDE3B 💬 |
Caffeine hydrate Caffeine hydrate 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
365 | Glucagon signaling pathway 💬 12 genes, 19 drugs (DrugBank) and 83 diseases |
PDE3B [1] PDE3B 💬 |
Ibudilast Ibudilast 💬 |
Ibudilast | 002 [2] 2 , 13 💬 💬 |
366 | Glucagon signaling pathway 💬 12 genes, 19 drugs (DrugBank) and 83 diseases |
PDE3B [1] PDE3B 💬 |
Levosimendan Levosimendan 💬 |
Levosimendan | 002 [1] 2 💬 💬 |
367 | Glucagon signaling pathway 💬 12 genes, 19 drugs (DrugBank) and 83 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
368 | Glucagon signaling pathway 💬 12 genes, 19 drugs (DrugBank) and 83 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
369 | Glucagon signaling pathway 💬 12 genes, 19 drugs (DrugBank) and 83 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
370 | Glutamatergic synapse 💬 23 genes, 27 drugs (DrugBank) and 83 diseases |
GRIA1 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 |
Perampanel Perampanel 💬 |
Perampanel | 002 [3] 2 , 6 , 144 💬 💬 |
371 | Glutamatergic synapse 💬 23 genes, 27 drugs (DrugBank) and 83 diseases |
GRIA1 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 |
Talampanel Talampanel 💬 |
Talampanel | 002 [2] 2 , 6 💬 💬 |
372 | Glutamatergic synapse 💬 23 genes, 27 drugs (DrugBank) and 83 diseases |
GRIA1 [14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
373 | Glutamatergic synapse 💬 23 genes, 27 drugs (DrugBank) and 83 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Dextromethorphan Dextromethorphan 💬 |
Dextromethorphan | 002 [11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬 💬 |
374 | Glutamatergic synapse 💬 23 genes, 27 drugs (DrugBank) and 83 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Esketamine Esketamine 💬 |
Esketamine | 002 [3] 2 , 4 , 70 💬 💬 |
375 | Glutamatergic synapse 💬 23 genes, 27 drugs (DrugBank) and 83 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
376 | Glutamatergic synapse 💬 23 genes, 27 drugs (DrugBank) and 83 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Memantine Memantine 💬 |
Memantine | 002 [8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬 💬 |
377 | Glutamatergic synapse 💬 23 genes, 27 drugs (DrugBank) and 83 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
378 | Glutamatergic synapse 💬 23 genes, 27 drugs (DrugBank) and 83 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
379 | Glycine, serine and threonine metabolism 💬 5 genes, 10 drugs (DrugBank) and 9 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
380 | Glycine, serine and threonine metabolism 💬 5 genes, 10 drugs (DrugBank) and 9 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
381 | GnRH secretion 💬 20 genes, 42 drugs (DrugBank) and 54 diseases |
CACNA1G [3] CACNA1G, CACNA1H, CACNA1I 💬 |
Valproic acid Valproic acid 💬 |
Valproic acid | 002 [14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬 |
382 | GnRH secretion 💬 20 genes, 42 drugs (DrugBank) and 54 diseases |
ESR2 [1] ESR2 💬 |
Tamoxifen Tamoxifen 💬 |
Tamoxifen | 002 [3] 2 , 113, 227 💬 💬 |
383 | GnRH secretion 💬 20 genes, 42 drugs (DrugBank) and 54 diseases |
GABBR1 [2] GABBR1, GABBR2 💬 |
Baclofen Baclofen 💬 |
Baclofen | 002 [8] 2 , 10, 13, 18, 65, 70, 149, 206 💬 💬 |
384 | GnRH secretion 💬 20 genes, 42 drugs (DrugBank) and 54 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
385 | GnRH signaling pathway 💬 16 genes, 36 drugs (DrugBank) and 37 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
386 | GnRH signaling pathway 💬 16 genes, 36 drugs (DrugBank) and 37 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
387 | Graft-versus-host disease 💬 7 genes, 22 drugs (DrugBank) and 60 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
388 | Growth hormone synthesis, secretion and action 💬 24 genes, 41 drugs (DrugBank) and 76 diseases |
JAK2 [1] JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
389 | Growth hormone synthesis, secretion and action 💬 24 genes, 41 drugs (DrugBank) and 76 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
390 | Growth hormone synthesis, secretion and action 💬 24 genes, 41 drugs (DrugBank) and 76 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
391 | Hematopoietic cell lineage 💬 32 genes, 70 drugs (DrugBank) and 90 diseases |
CSF3R [1] CSF3R 💬 |
Filgrastim Filgrastim 💬 |
Filgrastim | 002 [35] 2 , 6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬 💬 |
392 | Hematopoietic cell lineage 💬 32 genes, 70 drugs (DrugBank) and 90 diseases |
CSF3R [1] CSF3R 💬 |
Lenograstim Lenograstim 💬 |
Lenograstim | 002 [7] 2 , 13, 16, 18, 19, 57, 65 💬 💬 |
393 | Hematopoietic cell lineage 💬 32 genes, 70 drugs (DrugBank) and 90 diseases |
IL1R1 [2] IL1R1, IL1R2 💬 |
Anakinra Anakinra 💬 |
Anakinra | 002 [18] 2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 💬 |
394 | Hematopoietic cell lineage 💬 32 genes, 70 drugs (DrugBank) and 90 diseases |
IL2RA [1] IL2RA 💬 |
Aldesleukin Aldesleukin 💬 |
Aldesleukin | 002 [6] 2 , 35, 49, 65, 96, 97 💬 💬 |
395 | Hematopoietic cell lineage 💬 32 genes, 70 drugs (DrugBank) and 90 diseases |
IL2RA [1] IL2RA 💬 |
Basiliximab Basiliximab 💬 |
Basiliximab | 002 [6] 2 , 50, 66, 97, 222, 228 💬 💬 |
396 | Hematopoietic cell lineage 💬 32 genes, 70 drugs (DrugBank) and 90 diseases |
IL6R [1] IL6R 💬 |
Tocilizumab Tocilizumab 💬 |
Tocilizumab | 002 [21] 2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬 💬 |
397 | Hematopoietic cell lineage 💬 32 genes, 70 drugs (DrugBank) and 90 diseases |
KIT [1] KIT 💬 |
Masitinib Masitinib 💬 |
Masitinib | 002 [6] 2 , 5 , 6 , 13, 46, 96 💬 💬 |
398 | Hematopoietic cell lineage 💬 32 genes, 70 drugs (DrugBank) and 90 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
399 | Hepatitis B 💬 41 genes, 54 drugs (DrugBank) and 73 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
400 | Hepatitis B 💬 41 genes, 54 drugs (DrugBank) and 73 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
401 | Hepatitis B 💬 41 genes, 54 drugs (DrugBank) and 73 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
402 | Hepatitis B 💬 41 genes, 54 drugs (DrugBank) and 73 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
403 | Hepatitis C 💬 34 genes, 59 drugs (DrugBank) and 72 diseases |
JAK1 [1] JAK1 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
404 | Hepatitis C 💬 34 genes, 59 drugs (DrugBank) and 72 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
405 | Hepatitis C 💬 34 genes, 59 drugs (DrugBank) and 72 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
406 | Hepatocellular carcinoma 💬 21 genes, 31 drugs (DrugBank) and 57 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
407 | Hepatocellular carcinoma 💬 21 genes, 31 drugs (DrugBank) and 57 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
408 | Herpes simplex virus 1 infection 💬 43 genes, 65 drugs (DrugBank) and 94 diseases |
C3 [1] C3 💬 |
Pegcetacoplan Pegcetacoplan 💬 |
Pegcetacoplan | 002 [4] 2 , 61, 62, 222 💬 💬 |
409 | Herpes simplex virus 1 infection 💬 43 genes, 65 drugs (DrugBank) and 94 diseases |
C5 [1] C5 💬 |
Ravulizumab Ravulizumab 💬 |
Ravulizumab | 002 [7] 2 , 11, 13, 50, 62, 66, 109 💬 💬 |
410 | Herpes simplex virus 1 infection 💬 43 genes, 65 drugs (DrugBank) and 94 diseases |
C5 [1] C5 💬 |
Zilucoplan Zilucoplan 💬 |
Zilucoplan | 002 [3] 2 , 11, 62 💬 💬 |
411 | Herpes simplex virus 1 infection 💬 43 genes, 65 drugs (DrugBank) and 94 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
412 | Herpes simplex virus 1 infection 💬 43 genes, 65 drugs (DrugBank) and 94 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
413 | Herpes simplex virus 1 infection 💬 43 genes, 65 drugs (DrugBank) and 94 diseases |
PML [1] PML 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
414 | Herpes simplex virus 1 infection 💬 43 genes, 65 drugs (DrugBank) and 94 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
415 | Herpes simplex virus 1 infection 💬 43 genes, 65 drugs (DrugBank) and 94 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
416 | HIF-1 signaling pathway 💬 23 genes, 48 drugs (DrugBank) and 76 diseases |
IL6R [1] IL6R 💬 |
Tocilizumab Tocilizumab 💬 |
Tocilizumab | 002 [21] 2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬 💬 |
417 | HIF-1 signaling pathway 💬 23 genes, 48 drugs (DrugBank) and 76 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
418 | HIF-1 signaling pathway 💬 23 genes, 48 drugs (DrugBank) and 76 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
419 | Histidine metabolism 💬 2 genes, 7 drugs (DrugBank) and 7 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
420 | Histidine metabolism 💬 2 genes, 7 drugs (DrugBank) and 7 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
421 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
IL1R1 [1] IL1R1 💬 |
Anakinra Anakinra 💬 |
Anakinra | 002 [18] 2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 💬 |
422 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
IL6R [1] IL6R 💬 |
Tocilizumab Tocilizumab 💬 |
Tocilizumab | 002 [21] 2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬 💬 |
423 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
JAK1 [1] JAK1 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
424 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
425 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
426 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
427 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
428 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
PTGS2 [1] PTGS2 💬 |
Celecoxib Celecoxib 💬 |
Celecoxib | 002 [10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 💬 |
429 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
ROCK1 [2] ROCK1, ROCK2 💬 |
Fasudil Fasudil 💬 |
Fasudil | 002 [4] 2 , 5 , 7 , 51 💬 💬 |
430 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
431 | Human cytomegalovirus infection 💬 56 genes, 104 drugs (DrugBank) and 120 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
432 | Human immunodeficiency virus 1 infection 💬 41 genes, 43 drugs (DrugBank) and 89 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
433 | Human immunodeficiency virus 1 infection 💬 41 genes, 43 drugs (DrugBank) and 89 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
434 | Human immunodeficiency virus 1 infection 💬 41 genes, 43 drugs (DrugBank) and 89 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
435 | Human immunodeficiency virus 1 infection 💬 41 genes, 43 drugs (DrugBank) and 89 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
436 | Human immunodeficiency virus 1 infection 💬 41 genes, 43 drugs (DrugBank) and 89 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
437 | Human papillomavirus infection 💬 40 genes, 91 drugs (DrugBank) and 105 diseases |
JAK1 [1] JAK1 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
438 | Human papillomavirus infection 💬 40 genes, 91 drugs (DrugBank) and 105 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
439 | Human papillomavirus infection 💬 40 genes, 91 drugs (DrugBank) and 105 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
440 | Human papillomavirus infection 💬 40 genes, 91 drugs (DrugBank) and 105 diseases |
PTGS2 [1] PTGS2 💬 |
Celecoxib Celecoxib 💬 |
Celecoxib | 002 [10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 💬 |
441 | Human papillomavirus infection 💬 40 genes, 91 drugs (DrugBank) and 105 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
442 | Human T-cell leukemia virus 1 infection 💬 37 genes, 59 drugs (DrugBank) and 84 diseases |
IL1R1 [2] IL1R1, IL1R2 💬 |
Anakinra Anakinra 💬 |
Anakinra | 002 [18] 2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 💬 |
443 | Human T-cell leukemia virus 1 infection 💬 37 genes, 59 drugs (DrugBank) and 84 diseases |
IL2RA [1] IL2RA 💬 |
Basiliximab Basiliximab 💬 |
Basiliximab | 002 [6] 2 , 50, 66, 97, 222, 228 💬 💬 |
444 | Human T-cell leukemia virus 1 infection 💬 37 genes, 59 drugs (DrugBank) and 84 diseases |
IL2RA [3] IL2RA, IL2RB, IL2RG 💬 |
Aldesleukin Aldesleukin 💬 |
Aldesleukin | 002 [6] 2 , 35, 49, 65, 96, 97 💬 💬 |
445 | Human T-cell leukemia virus 1 infection 💬 37 genes, 59 drugs (DrugBank) and 84 diseases |
JAK1 [1] JAK1 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
446 | Human T-cell leukemia virus 1 infection 💬 37 genes, 59 drugs (DrugBank) and 84 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
447 | Human T-cell leukemia virus 1 infection 💬 37 genes, 59 drugs (DrugBank) and 84 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
448 | Human T-cell leukemia virus 1 infection 💬 37 genes, 59 drugs (DrugBank) and 84 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
449 | Human T-cell leukemia virus 1 infection 💬 37 genes, 59 drugs (DrugBank) and 84 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
450 | Huntington disease 💬 24 genes, 33 drugs (DrugBank) and 82 diseases |
GRIA1 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 |
Perampanel Perampanel 💬 |
Perampanel | 002 [3] 2 , 6 , 144 💬 💬 |
451 | Huntington disease 💬 24 genes, 33 drugs (DrugBank) and 82 diseases |
GRIA1 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 |
Talampanel Talampanel 💬 |
Talampanel | 002 [2] 2 , 6 💬 💬 |
452 | Huntington disease 💬 24 genes, 33 drugs (DrugBank) and 82 diseases |
GRIA1 [6] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2B 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
453 | Huntington disease 💬 24 genes, 33 drugs (DrugBank) and 82 diseases |
GRIN1 [2] GRIN1, GRIN2B 💬 |
Dextromethorphan Dextromethorphan 💬 |
Dextromethorphan | 002 [11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬 💬 |
454 | Huntington disease 💬 24 genes, 33 drugs (DrugBank) and 82 diseases |
GRIN1 [2] GRIN1, GRIN2B 💬 |
Esketamine Esketamine 💬 |
Esketamine | 002 [3] 2 , 4 , 70 💬 💬 |
455 | Huntington disease 💬 24 genes, 33 drugs (DrugBank) and 82 diseases |
GRIN1 [2] GRIN1, GRIN2B 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
456 | Huntington disease 💬 24 genes, 33 drugs (DrugBank) and 82 diseases |
GRIN1 [2] GRIN1, GRIN2B 💬 |
Memantine Memantine 💬 |
Memantine | 002 [8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬 💬 |
457 | Huntington disease 💬 24 genes, 33 drugs (DrugBank) and 82 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
458 | Huntington disease 💬 24 genes, 33 drugs (DrugBank) and 82 diseases |
PPARG [1] PPARG 💬 |
Pioglitazone Pioglitazone 💬 |
Pioglitazone | 002 [17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 💬 |
459 | Huntington disease 💬 24 genes, 33 drugs (DrugBank) and 82 diseases |
SOD1 [1] SOD1 💬 |
Tofersen Tofersen 💬 |
Tofersen | 002 [1] 2 💬 💬 |
460 | Huntington disease 💬 24 genes, 33 drugs (DrugBank) and 82 diseases |
TUBB [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 |
Colchicine Colchicine 💬 |
Colchicine | 002 [7] 2 , 42, 46, 56, 93, 210, 266 💬 💬 |
461 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
462 | Hypertrophic cardiomyopathy 💬 20 genes, 51 drugs (DrugBank) and 87 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
463 | IL-17 signaling pathway 💬 20 genes, 60 drugs (DrugBank) and 83 diseases |
PTGS2 [1] PTGS2 💬 |
Celecoxib Celecoxib 💬 |
Celecoxib | 002 [10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 💬 |
464 | IL-17 signaling pathway 💬 20 genes, 60 drugs (DrugBank) and 83 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
465 | Inflammatory bowel disease 💬 24 genes, 43 drugs (DrugBank) and 64 diseases |
IL2RG [1] IL2RG 💬 |
Aldesleukin Aldesleukin 💬 |
Aldesleukin | 002 [6] 2 , 35, 49, 65, 96, 97 💬 💬 |
466 | Inflammatory bowel disease 💬 24 genes, 43 drugs (DrugBank) and 64 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
467 | Inflammatory mediator regulation of TRP channels 💬 23 genes, 43 drugs (DrugBank) and 59 diseases |
HRH1 [4] HRH1, HTR2A, HTR2B, HTR2C 💬 |
Olanzapine Olanzapine 💬 |
Olanzapine | 002 [2] 2 , 8 💬 💬 |
468 | Inflammatory mediator regulation of TRP channels 💬 23 genes, 43 drugs (DrugBank) and 59 diseases |
HTR2A [3] HTR2A, HTR2B, HTR2C 💬 |
Trazodone Trazodone 💬 |
Trazodone | 002 [1] 2 💬 💬 |
469 | Inflammatory mediator regulation of TRP channels 💬 23 genes, 43 drugs (DrugBank) and 59 diseases |
IL1R1 [1] IL1R1 💬 |
Anakinra Anakinra 💬 |
Anakinra | 002 [18] 2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 💬 |
470 | Inflammatory mediator regulation of TRP channels 💬 23 genes, 43 drugs (DrugBank) and 59 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
471 | Influenza A 💬 45 genes, 63 drugs (DrugBank) and 85 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
472 | Influenza A 💬 45 genes, 63 drugs (DrugBank) and 85 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
473 | Influenza A 💬 45 genes, 63 drugs (DrugBank) and 85 diseases |
PML [1] PML 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
474 | Influenza A 💬 45 genes, 63 drugs (DrugBank) and 85 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
475 | Insulin resistance 💬 18 genes, 33 drugs (DrugBank) and 95 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
476 | Insulin resistance 💬 18 genes, 33 drugs (DrugBank) and 95 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
477 | Insulin resistance 💬 18 genes, 33 drugs (DrugBank) and 95 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
478 | Insulin secretion 💬 14 genes, 39 drugs (DrugBank) and 44 diseases |
CHRM3 [1] CHRM3 💬 |
Atropine Atropine 💬 |
Atropine | 002 [2] 2 , 299 💬 💬 |
479 | Insulin secretion 💬 14 genes, 39 drugs (DrugBank) and 44 diseases |
CHRM3 [1] CHRM3 💬 |
Scopolamine Scopolamine 💬 |
Scopolamine | 002 [1] 2 💬 💬 |
480 | Insulin secretion 💬 14 genes, 39 drugs (DrugBank) and 44 diseases |
SNAP25 [1] SNAP25 💬 |
Botulinum toxin type A Botulinum toxin type A 💬 |
Botulinum toxin type A | 002 [14] 2 , 5 , 6 , 7 , 13, 15, 17, 36, 47, 51, 70, 113, 149, 226 💬 💬 |
481 | Insulin secretion 💬 14 genes, 39 drugs (DrugBank) and 44 diseases |
SNAP25 [1] SNAP25 💬 |
Rimabotulinumtoxin B Rimabotulinumtoxin B 💬 |
Botulinum toxin type B | 002 [4] 2 , 6 , 13, 51 💬 💬 |
482 | Insulin signaling pathway 💬 12 genes, 26 drugs (DrugBank) and 66 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
483 | Insulin signaling pathway 💬 12 genes, 26 drugs (DrugBank) and 66 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
484 | Insulin signaling pathway 💬 12 genes, 26 drugs (DrugBank) and 66 diseases |
PDE3B [1] PDE3B 💬 |
Caffeine Caffeine 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
485 | Insulin signaling pathway 💬 12 genes, 26 drugs (DrugBank) and 66 diseases |
PDE3B [1] PDE3B 💬 |
Caffeine hydrate Caffeine hydrate 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
486 | Insulin signaling pathway 💬 12 genes, 26 drugs (DrugBank) and 66 diseases |
PDE3B [1] PDE3B 💬 |
Ibudilast Ibudilast 💬 |
Ibudilast | 002 [2] 2 , 13 💬 💬 |
487 | Insulin signaling pathway 💬 12 genes, 26 drugs (DrugBank) and 66 diseases |
PDE3B [1] PDE3B 💬 |
Levosimendan Levosimendan 💬 |
Levosimendan | 002 [1] 2 💬 💬 |
488 | Insulin signaling pathway 💬 12 genes, 26 drugs (DrugBank) and 66 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
489 | JAK-STAT signaling pathway 💬 58 genes, 91 drugs (DrugBank) and 96 diseases |
CSF3R [1] CSF3R 💬 |
Filgrastim Filgrastim 💬 |
Filgrastim | 002 [35] 2 , 6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬 💬 |
490 | JAK-STAT signaling pathway 💬 58 genes, 91 drugs (DrugBank) and 96 diseases |
CSF3R [1] CSF3R 💬 |
Lenograstim Lenograstim 💬 |
Lenograstim | 002 [7] 2 , 13, 16, 18, 19, 57, 65 💬 💬 |
491 | JAK-STAT signaling pathway 💬 58 genes, 91 drugs (DrugBank) and 96 diseases |
IL2RA [1] IL2RA 💬 |
Basiliximab Basiliximab 💬 |
Basiliximab | 002 [6] 2 , 50, 66, 97, 222, 228 💬 💬 |
492 | JAK-STAT signaling pathway 💬 58 genes, 91 drugs (DrugBank) and 96 diseases |
IL2RA [3] IL2RA, IL2RB, IL2RG 💬 |
Aldesleukin Aldesleukin 💬 |
Aldesleukin | 002 [6] 2 , 35, 49, 65, 96, 97 💬 💬 |
493 | JAK-STAT signaling pathway 💬 58 genes, 91 drugs (DrugBank) and 96 diseases |
IL6R [1] IL6R 💬 |
Tocilizumab Tocilizumab 💬 |
Tocilizumab | 002 [21] 2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬 💬 |
494 | JAK-STAT signaling pathway 💬 58 genes, 91 drugs (DrugBank) and 96 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
495 | JAK-STAT signaling pathway 💬 58 genes, 91 drugs (DrugBank) and 96 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
496 | Kaposi sarcoma-associated herpesvirus infection 💬 50 genes, 84 drugs (DrugBank) and 108 diseases |
C3 [1] C3 💬 |
Pegcetacoplan Pegcetacoplan 💬 |
Pegcetacoplan | 002 [4] 2 , 61, 62, 222 💬 💬 |
497 | Kaposi sarcoma-associated herpesvirus infection 💬 50 genes, 84 drugs (DrugBank) and 108 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
498 | Kaposi sarcoma-associated herpesvirus infection 💬 50 genes, 84 drugs (DrugBank) and 108 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
499 | Kaposi sarcoma-associated herpesvirus infection 💬 50 genes, 84 drugs (DrugBank) and 108 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
500 | Kaposi sarcoma-associated herpesvirus infection 💬 50 genes, 84 drugs (DrugBank) and 108 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
501 | Kaposi sarcoma-associated herpesvirus infection 💬 50 genes, 84 drugs (DrugBank) and 108 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
502 | Kaposi sarcoma-associated herpesvirus infection 💬 50 genes, 84 drugs (DrugBank) and 108 diseases |
PTGS2 [1] PTGS2 💬 |
Celecoxib Celecoxib 💬 |
Celecoxib | 002 [10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 💬 |
503 | Kaposi sarcoma-associated herpesvirus infection 💬 50 genes, 84 drugs (DrugBank) and 108 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
504 | Legionellosis 💬 9 genes, 22 drugs (DrugBank) and 61 diseases |
C3 [1] C3 💬 |
Pegcetacoplan Pegcetacoplan 💬 |
Pegcetacoplan | 002 [4] 2 , 61, 62, 222 💬 💬 |
505 | Legionellosis 💬 9 genes, 22 drugs (DrugBank) and 61 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
506 | Leishmaniasis 💬 25 genes, 63 drugs (DrugBank) and 93 diseases |
C3 [1] C3 💬 |
Pegcetacoplan Pegcetacoplan 💬 |
Pegcetacoplan | 002 [4] 2 , 61, 62, 222 💬 💬 |
507 | Leishmaniasis 💬 25 genes, 63 drugs (DrugBank) and 93 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
508 | Leishmaniasis 💬 25 genes, 63 drugs (DrugBank) and 93 diseases |
PTGS2 [1] PTGS2 💬 |
Celecoxib Celecoxib 💬 |
Celecoxib | 002 [10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 💬 |
509 | Leishmaniasis 💬 25 genes, 63 drugs (DrugBank) and 93 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
510 | Leukocyte transendothelial migration 💬 13 genes, 14 drugs (DrugBank) and 30 diseases |
ROCK1 [2] ROCK1, ROCK2 💬 |
Fasudil Fasudil 💬 |
Fasudil | 002 [4] 2 , 5 , 7 , 51 💬 💬 |
511 | Lipid and atherosclerosis 💬 46 genes, 56 drugs (DrugBank) and 93 diseases |
JAK2 [1] JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
512 | Lipid and atherosclerosis 💬 46 genes, 56 drugs (DrugBank) and 93 diseases |
PPARG [1] PPARG 💬 |
Pioglitazone Pioglitazone 💬 |
Pioglitazone | 002 [17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 💬 |
513 | Lipid and atherosclerosis 💬 46 genes, 56 drugs (DrugBank) and 93 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
514 | Lipid and atherosclerosis 💬 46 genes, 56 drugs (DrugBank) and 93 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
515 | Lipid and atherosclerosis 💬 46 genes, 56 drugs (DrugBank) and 93 diseases |
ROCK2 [1] ROCK2 💬 |
Fasudil Fasudil 💬 |
Fasudil | 002 [4] 2 , 5 , 7 , 51 💬 💬 |
516 | Lipid and atherosclerosis 💬 46 genes, 56 drugs (DrugBank) and 93 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
517 | Lipid and atherosclerosis 💬 46 genes, 56 drugs (DrugBank) and 93 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
518 | Long-term depression 💬 13 genes, 19 drugs (DrugBank) and 32 diseases |
GRIA1 [3] GRIA1, GRIA2, GRIA3 💬 |
Perampanel Perampanel 💬 |
Perampanel | 002 [3] 2 , 6 , 144 💬 💬 |
519 | Long-term depression 💬 13 genes, 19 drugs (DrugBank) and 32 diseases |
GRIA1 [3] GRIA1, GRIA2, GRIA3 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
520 | Long-term depression 💬 13 genes, 19 drugs (DrugBank) and 32 diseases |
GRIA1 [3] GRIA1, GRIA2, GRIA3 💬 |
Talampanel Talampanel 💬 |
Talampanel | 002 [2] 2 , 6 💬 💬 |
521 | Long-term depression 💬 13 genes, 19 drugs (DrugBank) and 32 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
522 | Long-term potentiation 💬 18 genes, 33 drugs (DrugBank) and 86 diseases |
GRIA1 [2] GRIA1, GRIA2 💬 |
Perampanel Perampanel 💬 |
Perampanel | 002 [3] 2 , 6 , 144 💬 💬 |
523 | Long-term potentiation 💬 18 genes, 33 drugs (DrugBank) and 86 diseases |
GRIA1 [2] GRIA1, GRIA2 💬 |
Talampanel Talampanel 💬 |
Talampanel | 002 [2] 2 , 6 💬 💬 |
524 | Long-term potentiation 💬 18 genes, 33 drugs (DrugBank) and 86 diseases |
GRIA1 [7] GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
525 | Long-term potentiation 💬 18 genes, 33 drugs (DrugBank) and 86 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Dextromethorphan Dextromethorphan 💬 |
Dextromethorphan | 002 [11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬 💬 |
526 | Long-term potentiation 💬 18 genes, 33 drugs (DrugBank) and 86 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Esketamine Esketamine 💬 |
Esketamine | 002 [3] 2 , 4 , 70 💬 💬 |
527 | Long-term potentiation 💬 18 genes, 33 drugs (DrugBank) and 86 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
528 | Long-term potentiation 💬 18 genes, 33 drugs (DrugBank) and 86 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Memantine Memantine 💬 |
Memantine | 002 [8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬 💬 |
529 | Long-term potentiation 💬 18 genes, 33 drugs (DrugBank) and 86 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
530 | Long-term potentiation 💬 18 genes, 33 drugs (DrugBank) and 86 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
531 | Long-term potentiation 💬 18 genes, 33 drugs (DrugBank) and 86 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
532 | Longevity regulating pathway 💬 11 genes, 20 drugs (DrugBank) and 68 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
533 | Longevity regulating pathway 💬 11 genes, 20 drugs (DrugBank) and 68 diseases |
PPARG [1] PPARG 💬 |
Pioglitazone Pioglitazone 💬 |
Pioglitazone | 002 [17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 💬 |
534 | Longevity regulating pathway 💬 11 genes, 20 drugs (DrugBank) and 68 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
535 | Longevity regulating pathway - multiple species 💬 11 genes, 15 drugs (DrugBank) and 62 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
536 | Longevity regulating pathway - multiple species 💬 11 genes, 15 drugs (DrugBank) and 62 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
537 | Longevity regulating pathway - multiple species 💬 11 genes, 15 drugs (DrugBank) and 62 diseases |
SOD1 [1] SOD1 💬 |
Tofersen Tofersen 💬 |
Tofersen | 002 [1] 2 💬 💬 |
538 | Lysosome 💬 14 genes, 24 drugs (DrugBank) and 6 diseases |
SORT1 [1] SORT1 💬 |
Latozinemab Latozinemab 💬 |
Latozinemab | 002 [2] 2 , 127 💬 💬 |
539 | Malaria 💬 15 genes, 28 drugs (DrugBank) and 61 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
540 | MAPK signaling pathway 💬 61 genes, 85 drugs (DrugBank) and 110 diseases |
CACNA1G [3] CACNA1G, CACNA1H, CACNA1I 💬 |
Valproic acid Valproic acid 💬 |
Valproic acid | 002 [14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬 |
541 | MAPK signaling pathway 💬 61 genes, 85 drugs (DrugBank) and 110 diseases |
IL1R1 [1] IL1R1 💬 |
Anakinra Anakinra 💬 |
Anakinra | 002 [18] 2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 💬 |
542 | MAPK signaling pathway 💬 61 genes, 85 drugs (DrugBank) and 110 diseases |
KIT [1] KIT 💬 |
Masitinib Masitinib 💬 |
Masitinib | 002 [6] 2 , 5 , 6 , 13, 46, 96 💬 💬 |
543 | MAPK signaling pathway 💬 61 genes, 85 drugs (DrugBank) and 110 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
544 | MAPK signaling pathway 💬 61 genes, 85 drugs (DrugBank) and 110 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
545 | MAPK signaling pathway 💬 61 genes, 85 drugs (DrugBank) and 110 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
546 | MAPK signaling pathway 💬 61 genes, 85 drugs (DrugBank) and 110 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
547 | Measles 💬 40 genes, 44 drugs (DrugBank) and 52 diseases |
IL2RA [1] IL2RA 💬 |
Basiliximab Basiliximab 💬 |
Basiliximab | 002 [6] 2 , 50, 66, 97, 222, 228 💬 💬 |
548 | Measles 💬 40 genes, 44 drugs (DrugBank) and 52 diseases |
IL2RA [3] IL2RA, IL2RB, IL2RG 💬 |
Aldesleukin Aldesleukin 💬 |
Aldesleukin | 002 [6] 2 , 35, 49, 65, 96, 97 💬 💬 |
549 | Measles 💬 40 genes, 44 drugs (DrugBank) and 52 diseases |
JAK1 [1] JAK1 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
550 | Melanogenesis 💬 7 genes, 16 drugs (DrugBank) and 29 diseases |
KIT [1] KIT 💬 |
Masitinib Masitinib 💬 |
Masitinib | 002 [6] 2 , 5 , 6 , 13, 46, 96 💬 💬 |
551 | Melanogenesis 💬 7 genes, 16 drugs (DrugBank) and 29 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
552 | Melanoma 💬 16 genes, 29 drugs (DrugBank) and 35 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
553 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
ABAT [4] ABAT, ALDH5A1, GAD1, GAD2 💬 |
Valproic acid Valproic acid 💬 |
Valproic acid | 002 [14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬 |
554 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
ATP4A [2] ATP4A, ATP4B 💬 |
Rabeprazole Rabeprazole 💬 |
Rabeprazole | 002 [2] 2 , 51 💬 💬 |
555 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
IMPDH1 [2] IMPDH1, IMPDH2 💬 |
Mycophenolate mofetil Mycophenolate mofetil 💬 |
Mycophenolate mofetil | 002 [34] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬 💬 |
556 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
IMPDH1 [2] IMPDH1, IMPDH2 💬 |
Mycophenolic acid Mycophenolic acid 💬 |
Mycophenolic acid | 002 [36] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬 💬 |
557 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
558 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
559 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
PDE1B [9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬 |
Caffeine Caffeine 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
560 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
PDE1B [9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬 |
Caffeine hydrate Caffeine hydrate 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
561 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
PDE3A [2] PDE3A, PDE3B 💬 |
Levosimendan Levosimendan 💬 |
Levosimendan | 002 [1] 2 💬 💬 |
562 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
PDE3A [6] PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 |
Ibudilast Ibudilast 💬 |
Ibudilast | 002 [2] 2 , 13 💬 💬 |
563 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
PTGS2 [1] PTGS2 💬 |
Celecoxib Celecoxib 💬 |
Celecoxib | 002 [10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 💬 |
564 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
SRD5A1 [2] SRD5A1, SRD5A2 💬 |
Dutasteride Dutasteride 💬 |
Dutasteride | 001 [2] 1 , 2 💬 💬 |
565 | Metabolic pathways 💬 111 genes, 155 drugs (DrugBank) and 137 diseases |
XDH [1] XDH 💬 |
Febuxostat Febuxostat 💬 |
Febuxostat | 002 [3] 2 , 6 , 13 💬 💬 |
566 | MicroRNAs in cancer 💬 31 genes, 65 drugs (DrugBank) and 85 diseases |
ABL1 [1] ABL1 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
567 | MicroRNAs in cancer 💬 31 genes, 65 drugs (DrugBank) and 85 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
568 | MicroRNAs in cancer 💬 31 genes, 65 drugs (DrugBank) and 85 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
569 | MicroRNAs in cancer 💬 31 genes, 65 drugs (DrugBank) and 85 diseases |
PTGS2 [1] PTGS2 💬 |
Celecoxib Celecoxib 💬 |
Celecoxib | 002 [10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 💬 |
570 | MicroRNAs in cancer 💬 31 genes, 65 drugs (DrugBank) and 85 diseases |
ROCK1 [1] ROCK1 💬 |
Fasudil Fasudil 💬 |
Fasudil | 002 [4] 2 , 5 , 7 , 51 💬 💬 |
571 | Mitophagy - animal 💬 2 genes, 4 drugs (DrugBank) and 8 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
572 | Morphine addiction 💬 41 genes, 65 drugs (DrugBank) and 73 diseases |
ADORA1 [9] ADORA1, PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 |
Caffeine Caffeine 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
573 | Morphine addiction 💬 41 genes, 65 drugs (DrugBank) and 73 diseases |
ADORA1 [9] ADORA1, PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 |
Caffeine hydrate Caffeine hydrate 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
574 | Morphine addiction 💬 41 genes, 65 drugs (DrugBank) and 73 diseases |
DRD1 [1] DRD1 💬 |
Dexpramipexole Dexpramipexole 💬 |
Dexpramipexole | 002 [1] 2 💬 💬 |
575 | Morphine addiction 💬 41 genes, 65 drugs (DrugBank) and 73 diseases |
GABBR1 [2] GABBR1, GABBR2 💬 |
Baclofen Baclofen 💬 |
Baclofen | 002 [8] 2 , 10, 13, 18, 65, 70, 149, 206 💬 💬 |
576 | Morphine addiction 💬 41 genes, 65 drugs (DrugBank) and 73 diseases |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
Midazolam Midazolam 💬 |
Midazolam | 002 [12] 2 , 3 , 6 , 13, 21, 46, 70, 96, 97, 272, 298, 299 💬 💬 |
577 | Morphine addiction 💬 41 genes, 65 drugs (DrugBank) and 73 diseases |
PDE3A [2] PDE3A, PDE3B 💬 |
Levosimendan Levosimendan 💬 |
Levosimendan | 002 [1] 2 💬 💬 |
578 | Morphine addiction 💬 41 genes, 65 drugs (DrugBank) and 73 diseases |
PDE3A [6] PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 |
Ibudilast Ibudilast 💬 |
Ibudilast | 002 [2] 2 , 13 💬 💬 |
579 | mTOR signaling pathway 💬 14 genes, 32 drugs (DrugBank) and 91 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
580 | mTOR signaling pathway 💬 14 genes, 32 drugs (DrugBank) and 91 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
581 | mTOR signaling pathway 💬 14 genes, 32 drugs (DrugBank) and 91 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
582 | mTOR signaling pathway 💬 14 genes, 32 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
583 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
584 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
585 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
586 | Natural killer cell mediated cytotoxicity 💬 37 genes, 42 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
587 | Necroptosis 💬 28 genes, 39 drugs (DrugBank) and 68 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
588 | Necroptosis 💬 28 genes, 39 drugs (DrugBank) and 68 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
589 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
ADORA1 [2] ADORA1, ADORA2A 💬 |
Caffeine Caffeine 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
590 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
ADORA1 [2] ADORA1, ADORA2A 💬 |
Caffeine hydrate Caffeine hydrate 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
591 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
ADRA1A [11] ADRA1A, ADRA1B, ADRA1D, DRD2, DRD3, DRD4, HRH1, HTR2A, HTR2B, HTR2C, HTR6 💬 |
Olanzapine Olanzapine 💬 |
Olanzapine | 002 [2] 2 , 8 💬 💬 |
592 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
ADRA2A [3] ADRA2A, ADRA2B, ADRA2C 💬 |
Dexmedetomidine Dexmedetomidine 💬 |
Dexmedetomidine | 002 [14] 2 , 4 , 6 , 21, 34, 46, 70, 107, 113, 171, 212, 215, 226, 280 💬 💬 |
593 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
ADRA2A [3] ADRA2A, ADRA2B, ADRA2C 💬 |
Guanabenz Guanabenz 💬 |
Guanabenz | 002 [2] 2 , 13 💬 💬 |
594 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
ADRA2A [2] ADRA2A, DRD2 💬 |
Pimozide Pimozide 💬 |
Pimozide | 002 [1] 2 💬 💬 |
595 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
ADRB2 [1] ADRB2 💬 |
Clenbuterol Clenbuterol 💬 |
Clenbuterol | 001 [5] 1 , 2 , 6 , 13, 256 💬 💬 |
596 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
C3 [1] C3 💬 |
Pegcetacoplan Pegcetacoplan 💬 |
Pegcetacoplan | 002 [4] 2 , 61, 62, 222 💬 💬 |
597 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
C5 [1] C5 💬 |
Ravulizumab Ravulizumab 💬 |
Ravulizumab | 002 [7] 2 , 11, 13, 50, 62, 66, 109 💬 💬 |
598 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
C5 [1] C5 💬 |
Zilucoplan Zilucoplan 💬 |
Zilucoplan | 002 [3] 2 , 11, 62 💬 💬 |
599 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
CHRM1 [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 |
Atropine Atropine 💬 |
Atropine | 002 [2] 2 , 299 💬 💬 |
600 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
CHRM1 [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 |
Scopolamine Scopolamine 💬 |
Scopolamine | 002 [1] 2 💬 💬 |
601 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
CNR1 [2] CNR1, CNR2 💬 |
Cannabidiol Cannabidiol 💬 |
Cannabidiol | 002 [20] 2 , 6 , 8 , 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 💬 |
602 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
CNR1 [2] CNR1, CNR2 💬 |
Dronabinol Dronabinol 💬 |
Dronabinol | 002 [8] 2 , 8 , 13, 36, 46, 96, 271, 298 💬 💬 |
603 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
CYSLTR1 [2] CYSLTR1, PTGIR 💬 |
Ibudilast Ibudilast 💬 |
Ibudilast | 002 [2] 2 , 13 💬 💬 |
604 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
DRD1 [5] DRD1, DRD2, DRD3, DRD4, DRD5 💬 |
Dexpramipexole Dexpramipexole 💬 |
Dexpramipexole | 002 [1] 2 💬 💬 |
605 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
DRD2 [1] DRD2 💬 |
Pridopidine Pridopidine 💬 |
Pridopidine | 002 [3] 2 , 6 , 8 💬 💬 |
606 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
DRD2 [3] DRD2, DRD3, DRD4 💬 |
Pramipexole Pramipexole 💬 |
Pramipexole | 002 [3] 2 , 6 , 20 💬 💬 |
607 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
DRD2 [3] DRD2, DRD3, DRD4 💬 |
Ropinirole Ropinirole 💬 |
Ropinirole | 002 [4] 2 , 6 , 74, 309 💬 💬 |
608 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
GABBR1 [2] GABBR1, GABBR2 💬 |
Baclofen Baclofen 💬 |
Baclofen | 002 [8] 2 , 10, 13, 18, 65, 70, 149, 206 💬 💬 |
609 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
Midazolam Midazolam 💬 |
Midazolam | 002 [12] 2 , 3 , 6 , 13, 21, 46, 70, 96, 97, 272, 298, 299 💬 💬 |
610 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
GRIA1 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 |
Perampanel Perampanel 💬 |
Perampanel | 002 [3] 2 , 6 , 144 💬 💬 |
611 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
GRIA1 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 |
Talampanel Talampanel 💬 |
Talampanel | 002 [2] 2 , 6 💬 💬 |
612 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
GRIA1 [14] GRIA1, GRIA2, GRIA3, GRIA4, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
613 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Dextromethorphan Dextromethorphan 💬 |
Dextromethorphan | 002 [11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬 💬 |
614 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Esketamine Esketamine 💬 |
Esketamine | 002 [3] 2 , 4 , 70 💬 💬 |
615 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
616 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Memantine Memantine 💬 |
Memantine | 002 [8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬 💬 |
617 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
HRH2 [1] HRH2 💬 |
Cimetidine Cimetidine 💬 |
Cimetidine | 002 [2] 2 , 254 💬 💬 |
618 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
HTR2A [3] HTR2A, HTR2B, HTR2C 💬 |
Trazodone Trazodone 💬 |
Trazodone | 002 [1] 2 💬 💬 |
619 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
MC2R [1] MC2R 💬 |
Corticotropin Corticotropin 💬 |
Corticotropin | 002 [12] 2 , 13, 14, 46, 49, 50, 66, 75, 81, 84, 145, 222 💬 💬 |
620 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
NR3C1 [1] NR3C1 💬 |
Betamethasone Betamethasone 💬 |
Betamethasone | 002 [8] 2 , 28, 46, 65, 83, 90, 96, 235 💬 💬 |
621 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
NR3C1 [1] NR3C1 💬 |
Methylprednisolone Methylprednisolone 💬 |
Methylprednisolone | 002 [46] 2 , 11, 13, 14, 18, 19, 25, 26, 35, 38, 39, 40, 41, 42, 43, 45, 46, 49, 50, 51, 60, 62, 63, 64, 65, 66, 83, 84, 85, 86, 93, 95, 96, 97, 145, 162, 164, 211, 220, 222, 224, 271, 283, 284, 285, 296 💬 💬 |
622 | Neuroactive ligand-receptor interaction 💬 149 genes, 320 drugs (DrugBank) and 153 diseases |
NR3C1 [1] NR3C1 💬 |
Prednisone Prednisone 💬 |
Prednisone | 002 [45] 2 , 11, 13, 14, 19, 26, 35, 40, 41, 42, 43, 44, 45, 46, 49, 50, 51, 53, 61, 63, 64, 65, 66, 79, 81, 84, 85, 86, 95, 96, 97, 113, 162, 164, 205, 222, 224, 228, 283, 284, 288, 299, 300, 307, 331 💬 💬 |
623 | Neurotrophin signaling pathway 💬 21 genes, 26 drugs (DrugBank) and 32 diseases |
ABL1 [1] ABL1 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
624 | Neurotrophin signaling pathway 💬 21 genes, 26 drugs (DrugBank) and 32 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
625 | Neurotrophin signaling pathway 💬 21 genes, 26 drugs (DrugBank) and 32 diseases |
SORT1 [1] SORT1 💬 |
Latozinemab Latozinemab 💬 |
Latozinemab | 002 [2] 2 , 127 💬 💬 |
626 | Neutrophil extracellular trap formation 💬 35 genes, 36 drugs (DrugBank) and 61 diseases |
C3 [1] C3 💬 |
Pegcetacoplan Pegcetacoplan 💬 |
Pegcetacoplan | 002 [4] 2 , 61, 62, 222 💬 💬 |
627 | Neutrophil extracellular trap formation 💬 35 genes, 36 drugs (DrugBank) and 61 diseases |
C5 [1] C5 💬 |
Ravulizumab Ravulizumab 💬 |
Ravulizumab | 002 [7] 2 , 11, 13, 50, 62, 66, 109 💬 💬 |
628 | Neutrophil extracellular trap formation 💬 35 genes, 36 drugs (DrugBank) and 61 diseases |
C5 [1] C5 💬 |
Zilucoplan Zilucoplan 💬 |
Zilucoplan | 002 [3] 2 , 11, 62 💬 💬 |
629 | Neutrophil extracellular trap formation 💬 35 genes, 36 drugs (DrugBank) and 61 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
630 | Neutrophil extracellular trap formation 💬 35 genes, 36 drugs (DrugBank) and 61 diseases |
MPO [1] MPO 💬 |
Verdiperstat Verdiperstat 💬 |
Verdiperstat | 002 [3] 2 , 17, 127 💬 💬 |
631 | Neutrophil extracellular trap formation 💬 35 genes, 36 drugs (DrugBank) and 61 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
632 | Neutrophil extracellular trap formation 💬 35 genes, 36 drugs (DrugBank) and 61 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
633 | NF-kappa B signaling pathway 💬 20 genes, 67 drugs (DrugBank) and 87 diseases |
IL1R1 [1] IL1R1 💬 |
Anakinra Anakinra 💬 |
Anakinra | 002 [18] 2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 💬 |
634 | NF-kappa B signaling pathway 💬 20 genes, 67 drugs (DrugBank) and 87 diseases |
PTGS2 [1] PTGS2 💬 |
Celecoxib Celecoxib 💬 |
Celecoxib | 002 [10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 💬 |
635 | NF-kappa B signaling pathway 💬 20 genes, 67 drugs (DrugBank) and 87 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
636 | Nicotine addiction 💬 30 genes, 30 drugs (DrugBank) and 44 diseases |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
Midazolam Midazolam 💬 |
Midazolam | 002 [12] 2 , 3 , 6 , 13, 21, 46, 70, 96, 97, 272, 298, 299 💬 💬 |
637 | Nicotine addiction 💬 30 genes, 30 drugs (DrugBank) and 44 diseases |
GRIA1 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 |
Perampanel Perampanel 💬 |
Perampanel | 002 [3] 2 , 6 , 144 💬 💬 |
638 | Nicotine addiction 💬 30 genes, 30 drugs (DrugBank) and 44 diseases |
GRIA1 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 |
Talampanel Talampanel 💬 |
Talampanel | 002 [2] 2 , 6 💬 💬 |
639 | Nicotine addiction 💬 30 genes, 30 drugs (DrugBank) and 44 diseases |
GRIA1 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
640 | Nicotine addiction 💬 30 genes, 30 drugs (DrugBank) and 44 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Dextromethorphan Dextromethorphan 💬 |
Dextromethorphan | 002 [11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬 💬 |
641 | Nicotine addiction 💬 30 genes, 30 drugs (DrugBank) and 44 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Esketamine Esketamine 💬 |
Esketamine | 002 [3] 2 , 4 , 70 💬 💬 |
642 | Nicotine addiction 💬 30 genes, 30 drugs (DrugBank) and 44 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
643 | Nicotine addiction 💬 30 genes, 30 drugs (DrugBank) and 44 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Memantine Memantine 💬 |
Memantine | 002 [8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬 💬 |
644 | NOD-like receptor signaling pathway 💬 30 genes, 42 drugs (DrugBank) and 65 diseases |
JAK1 [1] JAK1 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
645 | NOD-like receptor signaling pathway 💬 30 genes, 42 drugs (DrugBank) and 65 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
646 | Non-alcoholic fatty liver disease 💬 23 genes, 47 drugs (DrugBank) and 86 diseases |
IL6R [1] IL6R 💬 |
Tocilizumab Tocilizumab 💬 |
Tocilizumab | 002 [21] 2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬 💬 |
647 | Non-alcoholic fatty liver disease 💬 23 genes, 47 drugs (DrugBank) and 86 diseases |
PPARG [1] PPARG 💬 |
Pioglitazone Pioglitazone 💬 |
Pioglitazone | 002 [17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 💬 |
648 | Non-alcoholic fatty liver disease 💬 23 genes, 47 drugs (DrugBank) and 86 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
649 | Non-alcoholic fatty liver disease 💬 23 genes, 47 drugs (DrugBank) and 86 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
650 | Non-small cell lung cancer 💬 21 genes, 33 drugs (DrugBank) and 45 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
651 | Non-small cell lung cancer 💬 21 genes, 33 drugs (DrugBank) and 45 diseases |
RARB [1] RARB 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
652 | Nucleotide metabolism 💬 7 genes, 12 drugs (DrugBank) and 46 diseases |
IMPDH1 [2] IMPDH1, IMPDH2 💬 |
Mycophenolate mofetil Mycophenolate mofetil 💬 |
Mycophenolate mofetil | 002 [34] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬 💬 |
653 | Nucleotide metabolism 💬 7 genes, 12 drugs (DrugBank) and 46 diseases |
IMPDH1 [2] IMPDH1, IMPDH2 💬 |
Mycophenolic acid Mycophenolic acid 💬 |
Mycophenolic acid | 002 [36] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬 💬 |
654 | Nucleotide metabolism 💬 7 genes, 12 drugs (DrugBank) and 46 diseases |
XDH [1] XDH 💬 |
Febuxostat Febuxostat 💬 |
Febuxostat | 002 [3] 2 , 6 , 13 💬 💬 |
655 | Olfactory transduction 💬 4 genes, 5 drugs (DrugBank) and 13 diseases |
PDE1B [2] PDE1B, PDE2A 💬 |
Caffeine Caffeine 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
656 | Olfactory transduction 💬 4 genes, 5 drugs (DrugBank) and 13 diseases |
PDE1B [2] PDE1B, PDE2A 💬 |
Caffeine hydrate Caffeine hydrate 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
657 | Oocyte meiosis 💬 14 genes, 41 drugs (DrugBank) and 77 diseases |
AR [1] AR 💬 |
Calusterone Calusterone 💬 |
Calusterone | 002 [1] 2 💬 💬 |
658 | Oocyte meiosis 💬 14 genes, 41 drugs (DrugBank) and 77 diseases |
AR [1] AR 💬 |
Testosterone Testosterone 💬 |
Testosterone | 001 [8] 1 , 2 , 3 , 13, 60, 76, 78, 113 💬 💬 |
659 | Oocyte meiosis 💬 14 genes, 41 drugs (DrugBank) and 77 diseases |
MAP2K1 [1] MAP2K1 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
660 | Oocyte meiosis 💬 14 genes, 41 drugs (DrugBank) and 77 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
661 | Oocyte meiosis 💬 14 genes, 41 drugs (DrugBank) and 77 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
662 | Osteoclast differentiation 💬 36 genes, 71 drugs (DrugBank) and 93 diseases |
IL1R1 [1] IL1R1 💬 |
Anakinra Anakinra 💬 |
Anakinra | 002 [18] 2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 💬 |
663 | Osteoclast differentiation 💬 36 genes, 71 drugs (DrugBank) and 93 diseases |
JAK1 [1] JAK1 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
664 | Osteoclast differentiation 💬 36 genes, 71 drugs (DrugBank) and 93 diseases |
MAP2K1 [1] MAP2K1 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
665 | Osteoclast differentiation 💬 36 genes, 71 drugs (DrugBank) and 93 diseases |
PPARG [1] PPARG 💬 |
Pioglitazone Pioglitazone 💬 |
Pioglitazone | 002 [17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 💬 |
666 | Osteoclast differentiation 💬 36 genes, 71 drugs (DrugBank) and 93 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
667 | Osteoclast differentiation 💬 36 genes, 71 drugs (DrugBank) and 93 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
668 | Osteoclast differentiation 💬 36 genes, 71 drugs (DrugBank) and 93 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
669 | Ovarian steroidogenesis 💬 7 genes, 36 drugs (DrugBank) and 52 diseases |
PTGS2 [1] PTGS2 💬 |
Celecoxib Celecoxib 💬 |
Celecoxib | 002 [10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 💬 |
670 | Oxidative phosphorylation 💬 2 genes, 7 drugs (DrugBank) and 25 diseases |
ATP4A [2] ATP4A, ATP4B 💬 |
Rabeprazole Rabeprazole 💬 |
Rabeprazole | 002 [2] 2 , 51 💬 💬 |
671 | Oxytocin signaling pathway 💬 34 genes, 73 drugs (DrugBank) and 108 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
672 | Oxytocin signaling pathway 💬 34 genes, 73 drugs (DrugBank) and 108 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
673 | Oxytocin signaling pathway 💬 34 genes, 73 drugs (DrugBank) and 108 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
674 | Oxytocin signaling pathway 💬 34 genes, 73 drugs (DrugBank) and 108 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
675 | Oxytocin signaling pathway 💬 34 genes, 73 drugs (DrugBank) and 108 diseases |
PTGS2 [1] PTGS2 💬 |
Celecoxib Celecoxib 💬 |
Celecoxib | 002 [10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 💬 |
676 | Oxytocin signaling pathway 💬 34 genes, 73 drugs (DrugBank) and 108 diseases |
ROCK1 [2] ROCK1, ROCK2 💬 |
Fasudil Fasudil 💬 |
Fasudil | 002 [4] 2 , 5 , 7 , 51 💬 💬 |
677 | Oxytocin signaling pathway 💬 34 genes, 73 drugs (DrugBank) and 108 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
678 | Pancreatic cancer 💬 19 genes, 36 drugs (DrugBank) and 67 diseases |
JAK1 [1] JAK1 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
679 | Pancreatic cancer 💬 19 genes, 36 drugs (DrugBank) and 67 diseases |
MAP2K1 [1] MAP2K1 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
680 | Pancreatic cancer 💬 19 genes, 36 drugs (DrugBank) and 67 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
681 | Pancreatic secretion 💬 13 genes, 35 drugs (DrugBank) and 36 diseases |
CHRM3 [1] CHRM3 💬 |
Atropine Atropine 💬 |
Atropine | 002 [2] 2 , 299 💬 💬 |
682 | Pancreatic secretion 💬 13 genes, 35 drugs (DrugBank) and 36 diseases |
CHRM3 [1] CHRM3 💬 |
Scopolamine Scopolamine 💬 |
Scopolamine | 002 [1] 2 💬 💬 |
683 | Pancreatic secretion 💬 13 genes, 35 drugs (DrugBank) and 36 diseases |
KCNQ1 [1] KCNQ1 💬 |
Ezogabine Ezogabine 💬 |
Ezogabine | 002 [2] 2 , 144 💬 💬 |
684 | Parathyroid hormone synthesis, secretion and action 💬 21 genes, 48 drugs (DrugBank) and 65 diseases |
MAP2K1 [1] MAP2K1 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
685 | Parathyroid hormone synthesis, secretion and action 💬 21 genes, 48 drugs (DrugBank) and 65 diseases |
PDE4A [4] PDE4A, PDE4B, PDE4C, PDE4D 💬 |
Caffeine Caffeine 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
686 | Parathyroid hormone synthesis, secretion and action 💬 21 genes, 48 drugs (DrugBank) and 65 diseases |
PDE4A [4] PDE4A, PDE4B, PDE4C, PDE4D 💬 |
Caffeine hydrate Caffeine hydrate 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
687 | Parathyroid hormone synthesis, secretion and action 💬 21 genes, 48 drugs (DrugBank) and 65 diseases |
PDE4A [4] PDE4A, PDE4B, PDE4C, PDE4D 💬 |
Ibudilast Ibudilast 💬 |
Ibudilast | 002 [2] 2 , 13 💬 💬 |
688 | Parkinson disease 💬 24 genes, 73 drugs (DrugBank) and 66 diseases |
ADORA2A [1] ADORA2A 💬 |
Caffeine Caffeine 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
689 | Parkinson disease 💬 24 genes, 73 drugs (DrugBank) and 66 diseases |
ADORA2A [1] ADORA2A 💬 |
Caffeine hydrate Caffeine hydrate 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
690 | Parkinson disease 💬 24 genes, 73 drugs (DrugBank) and 66 diseases |
DRD1 [2] DRD1, DRD2 💬 |
Dexpramipexole Dexpramipexole 💬 |
Dexpramipexole | 002 [1] 2 💬 💬 |
691 | Parkinson disease 💬 24 genes, 73 drugs (DrugBank) and 66 diseases |
DRD2 [1] DRD2 💬 |
Olanzapine Olanzapine 💬 |
Olanzapine | 002 [2] 2 , 8 💬 💬 |
692 | Parkinson disease 💬 24 genes, 73 drugs (DrugBank) and 66 diseases |
DRD2 [1] DRD2 💬 |
Pimozide Pimozide 💬 |
Pimozide | 002 [1] 2 💬 💬 |
693 | Parkinson disease 💬 24 genes, 73 drugs (DrugBank) and 66 diseases |
DRD2 [1] DRD2 💬 |
Pramipexole Pramipexole 💬 |
Pramipexole | 002 [3] 2 , 6 , 20 💬 💬 |
694 | Parkinson disease 💬 24 genes, 73 drugs (DrugBank) and 66 diseases |
DRD2 [1] DRD2 💬 |
Pridopidine Pridopidine 💬 |
Pridopidine | 002 [3] 2 , 6 , 8 💬 💬 |
695 | Parkinson disease 💬 24 genes, 73 drugs (DrugBank) and 66 diseases |
DRD2 [1] DRD2 💬 |
Ropinirole Ropinirole 💬 |
Ropinirole | 002 [4] 2 , 6 , 74, 309 💬 💬 |
696 | Parkinson disease 💬 24 genes, 73 drugs (DrugBank) and 66 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
697 | Parkinson disease 💬 24 genes, 73 drugs (DrugBank) and 66 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
698 | Parkinson disease 💬 24 genes, 73 drugs (DrugBank) and 66 diseases |
SOD1 [1] SOD1 💬 |
Tofersen Tofersen 💬 |
Tofersen | 002 [1] 2 💬 💬 |
699 | Parkinson disease 💬 24 genes, 73 drugs (DrugBank) and 66 diseases |
TUBB [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 |
Colchicine Colchicine 💬 |
Colchicine | 002 [7] 2 , 42, 46, 56, 93, 210, 266 💬 💬 |
700 | Pathogenic Escherichia coli infection 💬 26 genes, 39 drugs (DrugBank) and 74 diseases |
ABL1 [2] ABL1, SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
701 | Pathogenic Escherichia coli infection 💬 26 genes, 39 drugs (DrugBank) and 74 diseases |
IL1R1 [1] IL1R1 💬 |
Anakinra Anakinra 💬 |
Anakinra | 002 [18] 2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 💬 |
702 | Pathogenic Escherichia coli infection 💬 26 genes, 39 drugs (DrugBank) and 74 diseases |
ROCK1 [2] ROCK1, ROCK2 💬 |
Fasudil Fasudil 💬 |
Fasudil | 002 [4] 2 , 5 , 7 , 51 💬 💬 |
703 | Pathogenic Escherichia coli infection 💬 26 genes, 39 drugs (DrugBank) and 74 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
704 | Pathogenic Escherichia coli infection 💬 26 genes, 39 drugs (DrugBank) and 74 diseases |
TUBB [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 |
Colchicine Colchicine 💬 |
Colchicine | 002 [7] 2 , 42, 46, 56, 93, 210, 266 💬 💬 |
705 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
ABL1 [1] ABL1 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
706 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
AR [1] AR 💬 |
Calusterone Calusterone 💬 |
Calusterone | 002 [1] 2 💬 💬 |
707 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
AR [1] AR 💬 |
Testosterone Testosterone 💬 |
Testosterone | 001 [8] 1 , 2 , 3 , 13, 60, 76, 78, 113 💬 💬 |
708 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
CSF3R [1] CSF3R 💬 |
Filgrastim Filgrastim 💬 |
Filgrastim | 002 [35] 2 , 6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬 💬 |
709 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
CSF3R [1] CSF3R 💬 |
Lenograstim Lenograstim 💬 |
Lenograstim | 002 [7] 2 , 13, 16, 18, 19, 57, 65 💬 💬 |
710 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Tamoxifen Tamoxifen 💬 |
Tamoxifen | 002 [3] 2 , 113, 227 💬 💬 |
711 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
IL2RA [1] IL2RA 💬 |
Basiliximab Basiliximab 💬 |
Basiliximab | 002 [6] 2 , 50, 66, 97, 222, 228 💬 💬 |
712 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
IL2RA [3] IL2RA, IL2RB, IL2RG 💬 |
Aldesleukin Aldesleukin 💬 |
Aldesleukin | 002 [6] 2 , 35, 49, 65, 96, 97 💬 💬 |
713 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
IL6R [1] IL6R 💬 |
Tocilizumab Tocilizumab 💬 |
Tocilizumab | 002 [21] 2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬 💬 |
714 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
715 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
KIT [1] KIT 💬 |
Masitinib Masitinib 💬 |
Masitinib | 002 [6] 2 , 5 , 6 , 13, 46, 96 💬 💬 |
716 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
717 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
718 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
PML [3] PML, RARA, RARB 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
719 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
PPARG [1] PPARG 💬 |
Pioglitazone Pioglitazone 💬 |
Pioglitazone | 002 [17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 💬 |
720 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
PTGS2 [1] PTGS2 💬 |
Celecoxib Celecoxib 💬 |
Celecoxib | 002 [10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 💬 |
721 | Pathways in cancer 💬 104 genes, 194 drugs (DrugBank) and 133 diseases |
ROCK1 [2] ROCK1, ROCK2 💬 |
Fasudil Fasudil 💬 |
Fasudil | 002 [4] 2 , 5 , 7 , 51 💬 💬 |
722 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
CHRM1 [3] CHRM1, CHRM3, CHRM5 💬 |
Atropine Atropine 💬 |
Atropine | 002 [2] 2 , 299 💬 💬 |
723 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
CHRM1 [3] CHRM1, CHRM3, CHRM5 💬 |
Scopolamine Scopolamine 💬 |
Scopolamine | 002 [1] 2 💬 💬 |
724 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
GRIA1 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 |
Perampanel Perampanel 💬 |
Perampanel | 002 [3] 2 , 6 , 144 💬 💬 |
725 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
GRIA1 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 |
Talampanel Talampanel 💬 |
Talampanel | 002 [2] 2 , 6 💬 💬 |
726 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
GRIA1 [9] GRIA1, GRIA2, GRIA3, GRIA4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
727 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Esketamine Esketamine 💬 |
Esketamine | 002 [3] 2 , 4 , 70 💬 💬 |
728 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
729 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Memantine Memantine 💬 |
Memantine | 002 [8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬 💬 |
730 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
GRIN1 [6] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, SIGMAR1 💬 |
Dextromethorphan Dextromethorphan 💬 |
Dextromethorphan | 002 [11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬 💬 |
731 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
732 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
733 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
734 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
735 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
PTGS2 [1] PTGS2 💬 |
Celecoxib Celecoxib 💬 |
Celecoxib | 002 [10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 💬 |
736 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
SOD1 [1] SOD1 💬 |
Tofersen Tofersen 💬 |
Tofersen | 002 [1] 2 💬 💬 |
737 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
738 | Pathways of neurodegeneration - multiple diseases 💬 59 genes, 120 drugs (DrugBank) and 125 diseases |
TUBB [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 |
Colchicine Colchicine 💬 |
Colchicine | 002 [7] 2 , 42, 46, 56, 93, 210, 266 💬 💬 |
739 | PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 34 genes, 51 drugs (DrugBank) and 92 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
740 | PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 34 genes, 51 drugs (DrugBank) and 92 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
741 | PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 34 genes, 51 drugs (DrugBank) and 92 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
742 | PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 34 genes, 51 drugs (DrugBank) and 92 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
743 | PD-L1 expression and PD-1 checkpoint pathway in cancer 💬 34 genes, 51 drugs (DrugBank) and 92 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
744 | Peroxisome 💬 4 genes, 5 drugs (DrugBank) and 11 diseases |
SOD1 [1] SOD1 💬 |
Tofersen Tofersen 💬 |
Tofersen | 002 [1] 2 💬 💬 |
745 | Peroxisome 💬 4 genes, 5 drugs (DrugBank) and 11 diseases |
XDH [1] XDH 💬 |
Febuxostat Febuxostat 💬 |
Febuxostat | 002 [3] 2 , 6 , 13 💬 💬 |
746 | Pertussis 💬 18 genes, 38 drugs (DrugBank) and 66 diseases |
C3 [1] C3 💬 |
Pegcetacoplan Pegcetacoplan 💬 |
Pegcetacoplan | 002 [4] 2 , 61, 62, 222 💬 💬 |
747 | Pertussis 💬 18 genes, 38 drugs (DrugBank) and 66 diseases |
C5 [1] C5 💬 |
Ravulizumab Ravulizumab 💬 |
Ravulizumab | 002 [7] 2 , 11, 13, 50, 62, 66, 109 💬 💬 |
748 | Pertussis 💬 18 genes, 38 drugs (DrugBank) and 66 diseases |
C5 [1] C5 💬 |
Zilucoplan Zilucoplan 💬 |
Zilucoplan | 002 [3] 2 , 11, 62 💬 💬 |
749 | Pertussis 💬 18 genes, 38 drugs (DrugBank) and 66 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
750 | Phagosome 💬 13 genes, 10 drugs (DrugBank) and 21 diseases |
C3 [1] C3 💬 |
Pegcetacoplan Pegcetacoplan 💬 |
Pegcetacoplan | 002 [4] 2 , 61, 62, 222 💬 💬 |
751 | Phagosome 💬 13 genes, 10 drugs (DrugBank) and 21 diseases |
MPO [1] MPO 💬 |
Verdiperstat Verdiperstat 💬 |
Verdiperstat | 002 [3] 2 , 17, 127 💬 💬 |
752 | Phagosome 💬 13 genes, 10 drugs (DrugBank) and 21 diseases |
TUBB [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 |
Colchicine Colchicine 💬 |
Colchicine | 002 [7] 2 , 42, 46, 56, 93, 210, 266 💬 💬 |
753 | Phenylalanine metabolism 💬 6 genes, 12 drugs (DrugBank) and 15 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
754 | Phenylalanine metabolism 💬 6 genes, 12 drugs (DrugBank) and 15 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
755 | Phospholipase D signaling pathway 💬 23 genes, 51 drugs (DrugBank) and 76 diseases |
KIT [1] KIT 💬 |
Masitinib Masitinib 💬 |
Masitinib | 002 [6] 2 , 5 , 6 , 13, 46, 96 💬 💬 |
756 | Phospholipase D signaling pathway 💬 23 genes, 51 drugs (DrugBank) and 76 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
757 | Phospholipase D signaling pathway 💬 23 genes, 51 drugs (DrugBank) and 76 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
758 | PI3K-Akt signaling pathway 💬 76 genes, 112 drugs (DrugBank) and 112 diseases |
CHRM1 [2] CHRM1, CHRM2 💬 |
Atropine Atropine 💬 |
Atropine | 002 [2] 2 , 299 💬 💬 |
759 | PI3K-Akt signaling pathway 💬 76 genes, 112 drugs (DrugBank) and 112 diseases |
CHRM1 [2] CHRM1, CHRM2 💬 |
Scopolamine Scopolamine 💬 |
Scopolamine | 002 [1] 2 💬 💬 |
760 | PI3K-Akt signaling pathway 💬 76 genes, 112 drugs (DrugBank) and 112 diseases |
CSF3R [1] CSF3R 💬 |
Filgrastim Filgrastim 💬 |
Filgrastim | 002 [35] 2 , 6 , 11, 13, 16, 22, 25, 26, 28, 34, 35, 36, 38, 40, 41, 42, 45, 46, 47, 49, 51, 57, 60, 62, 65, 85, 96, 113, 164, 256, 283, 284, 285, 296, 331 💬 💬 |
761 | PI3K-Akt signaling pathway 💬 76 genes, 112 drugs (DrugBank) and 112 diseases |
CSF3R [1] CSF3R 💬 |
Lenograstim Lenograstim 💬 |
Lenograstim | 002 [7] 2 , 13, 16, 18, 19, 57, 65 💬 💬 |
762 | PI3K-Akt signaling pathway 💬 76 genes, 112 drugs (DrugBank) and 112 diseases |
IL2RA [1] IL2RA 💬 |
Basiliximab Basiliximab 💬 |
Basiliximab | 002 [6] 2 , 50, 66, 97, 222, 228 💬 💬 |
763 | PI3K-Akt signaling pathway 💬 76 genes, 112 drugs (DrugBank) and 112 diseases |
IL2RA [3] IL2RA, IL2RB, IL2RG 💬 |
Aldesleukin Aldesleukin 💬 |
Aldesleukin | 002 [6] 2 , 35, 49, 65, 96, 97 💬 💬 |
764 | PI3K-Akt signaling pathway 💬 76 genes, 112 drugs (DrugBank) and 112 diseases |
IL6R [1] IL6R 💬 |
Tocilizumab Tocilizumab 💬 |
Tocilizumab | 002 [21] 2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬 💬 |
765 | PI3K-Akt signaling pathway 💬 76 genes, 112 drugs (DrugBank) and 112 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
766 | PI3K-Akt signaling pathway 💬 76 genes, 112 drugs (DrugBank) and 112 diseases |
KIT [1] KIT 💬 |
Masitinib Masitinib 💬 |
Masitinib | 002 [6] 2 , 5 , 6 , 13, 46, 96 💬 💬 |
767 | PI3K-Akt signaling pathway 💬 76 genes, 112 drugs (DrugBank) and 112 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
768 | PI3K-Akt signaling pathway 💬 76 genes, 112 drugs (DrugBank) and 112 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
769 | PI3K-Akt signaling pathway 💬 76 genes, 112 drugs (DrugBank) and 112 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
770 | Platelet activation 💬 22 genes, 51 drugs (DrugBank) and 56 diseases |
PTGIR [1] PTGIR 💬 |
Ibudilast Ibudilast 💬 |
Ibudilast | 002 [2] 2 , 13 💬 💬 |
771 | Platelet activation 💬 22 genes, 51 drugs (DrugBank) and 56 diseases |
ROCK1 [2] ROCK1, ROCK2 💬 |
Fasudil Fasudil 💬 |
Fasudil | 002 [4] 2 , 5 , 7 , 51 💬 💬 |
772 | Platelet activation 💬 22 genes, 51 drugs (DrugBank) and 56 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
773 | PPAR signaling pathway 💬 10 genes, 14 drugs (DrugBank) and 32 diseases |
PPARG [1] PPARG 💬 |
Pioglitazone Pioglitazone 💬 |
Pioglitazone | 002 [17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 💬 |
774 | Primary immunodeficiency 💬 11 genes, 23 drugs (DrugBank) and 26 diseases |
IL2RG [1] IL2RG 💬 |
Aldesleukin Aldesleukin 💬 |
Aldesleukin | 002 [6] 2 , 35, 49, 65, 96, 97 💬 💬 |
775 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
C5 [1] C5 💬 |
Ravulizumab Ravulizumab 💬 |
Ravulizumab | 002 [7] 2 , 11, 13, 50, 62, 66, 109 💬 💬 |
776 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
C5 [1] C5 💬 |
Zilucoplan Zilucoplan 💬 |
Zilucoplan | 002 [3] 2 , 11, 62 💬 💬 |
777 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Dextromethorphan Dextromethorphan 💬 |
Dextromethorphan | 002 [11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬 💬 |
778 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Esketamine Esketamine 💬 |
Esketamine | 002 [3] 2 , 4 , 70 💬 💬 |
779 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
780 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Memantine Memantine 💬 |
Memantine | 002 [8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬 💬 |
781 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
782 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
783 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
784 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
SOD1 [1] SOD1 💬 |
Tofersen Tofersen 💬 |
Tofersen | 002 [1] 2 💬 💬 |
785 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
786 | Prion disease 💬 41 genes, 66 drugs (DrugBank) and 107 diseases |
TUBB [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 |
Colchicine Colchicine 💬 |
Colchicine | 002 [7] 2 , 42, 46, 56, 93, 210, 266 💬 💬 |
787 | Progesterone-mediated oocyte maturation 💬 14 genes, 38 drugs (DrugBank) and 42 diseases |
MAP2K1 [1] MAP2K1 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
788 | Progesterone-mediated oocyte maturation 💬 14 genes, 38 drugs (DrugBank) and 42 diseases |
PDE3B [1] PDE3B 💬 |
Caffeine Caffeine 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
789 | Progesterone-mediated oocyte maturation 💬 14 genes, 38 drugs (DrugBank) and 42 diseases |
PDE3B [1] PDE3B 💬 |
Caffeine hydrate Caffeine hydrate 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
790 | Progesterone-mediated oocyte maturation 💬 14 genes, 38 drugs (DrugBank) and 42 diseases |
PDE3B [1] PDE3B 💬 |
Ibudilast Ibudilast 💬 |
Ibudilast | 002 [2] 2 , 13 💬 💬 |
791 | Progesterone-mediated oocyte maturation 💬 14 genes, 38 drugs (DrugBank) and 42 diseases |
PDE3B [1] PDE3B 💬 |
Levosimendan Levosimendan 💬 |
Levosimendan | 002 [1] 2 💬 💬 |
792 | Prolactin signaling pathway 💬 19 genes, 39 drugs (DrugBank) and 54 diseases |
ESR1 [2] ESR1, ESR2 💬 |
Tamoxifen Tamoxifen 💬 |
Tamoxifen | 002 [3] 2 , 113, 227 💬 💬 |
793 | Prolactin signaling pathway 💬 19 genes, 39 drugs (DrugBank) and 54 diseases |
JAK2 [1] JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
794 | Prolactin signaling pathway 💬 19 genes, 39 drugs (DrugBank) and 54 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
795 | Prolactin signaling pathway 💬 19 genes, 39 drugs (DrugBank) and 54 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
796 | Propanoate metabolism 💬 1 gene, 2 drugs (DrugBank) and 16 diseases |
ABAT [1] ABAT 💬 |
Valproic acid Valproic acid 💬 |
Valproic acid | 002 [14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬 |
797 | Prostate cancer 💬 22 genes, 51 drugs (DrugBank) and 80 diseases |
AR [1] AR 💬 |
Calusterone Calusterone 💬 |
Calusterone | 002 [1] 2 💬 💬 |
798 | Prostate cancer 💬 22 genes, 51 drugs (DrugBank) and 80 diseases |
AR [1] AR 💬 |
Testosterone Testosterone 💬 |
Testosterone | 001 [8] 1 , 2 , 3 , 13, 60, 76, 78, 113 💬 💬 |
799 | Prostate cancer 💬 22 genes, 51 drugs (DrugBank) and 80 diseases |
IL1R2 [1] IL1R2 💬 |
Anakinra Anakinra 💬 |
Anakinra | 002 [18] 2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 💬 |
800 | Prostate cancer 💬 22 genes, 51 drugs (DrugBank) and 80 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
801 | Prostate cancer 💬 22 genes, 51 drugs (DrugBank) and 80 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
802 | Prostate cancer 💬 22 genes, 51 drugs (DrugBank) and 80 diseases |
SRD5A2 [1] SRD5A2 💬 |
Dutasteride Dutasteride 💬 |
Dutasteride | 001 [2] 1 , 2 💬 💬 |
803 | Protein digestion and absorption 💬 7 genes, 7 drugs (DrugBank) and 13 diseases |
KCNQ1 [1] KCNQ1 💬 |
Ezogabine Ezogabine 💬 |
Ezogabine | 002 [2] 2 , 144 💬 💬 |
804 | Proteoglycans in cancer 💬 30 genes, 68 drugs (DrugBank) and 96 diseases |
ESR1 [1] ESR1 💬 |
Tamoxifen Tamoxifen 💬 |
Tamoxifen | 002 [3] 2 , 113, 227 💬 💬 |
805 | Proteoglycans in cancer 💬 30 genes, 68 drugs (DrugBank) and 96 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
806 | Proteoglycans in cancer 💬 30 genes, 68 drugs (DrugBank) and 96 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
807 | Proteoglycans in cancer 💬 30 genes, 68 drugs (DrugBank) and 96 diseases |
ROCK1 [2] ROCK1, ROCK2 💬 |
Fasudil Fasudil 💬 |
Fasudil | 002 [4] 2 , 5 , 7 , 51 💬 💬 |
808 | Proteoglycans in cancer 💬 30 genes, 68 drugs (DrugBank) and 96 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
809 | Proteoglycans in cancer 💬 30 genes, 68 drugs (DrugBank) and 96 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
810 | Purine metabolism 💬 29 genes, 35 drugs (DrugBank) and 73 diseases |
IMPDH1 [2] IMPDH1, IMPDH2 💬 |
Mycophenolate mofetil Mycophenolate mofetil 💬 |
Mycophenolate mofetil | 002 [34] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 85, 93, 95, 96, 162, 164, 222, 224, 226, 234, 283, 284, 285, 300 💬 💬 |
811 | Purine metabolism 💬 29 genes, 35 drugs (DrugBank) and 73 diseases |
IMPDH1 [2] IMPDH1, IMPDH2 💬 |
Mycophenolic acid Mycophenolic acid 💬 |
Mycophenolic acid | 002 [36] 2 , 11, 13, 19, 20, 28, 35, 36, 42, 43, 44, 45, 49, 51, 53, 60, 61, 62, 65, 66, 84, 85, 93, 95, 96, 162, 164, 222, 224, 226, 228, 234, 283, 284, 285, 300 💬 💬 |
812 | Purine metabolism 💬 29 genes, 35 drugs (DrugBank) and 73 diseases |
PDE1B [9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬 |
Caffeine Caffeine 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
813 | Purine metabolism 💬 29 genes, 35 drugs (DrugBank) and 73 diseases |
PDE1B [9] PDE1B, PDE2A, PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A 💬 |
Caffeine hydrate Caffeine hydrate 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
814 | Purine metabolism 💬 29 genes, 35 drugs (DrugBank) and 73 diseases |
PDE3A [2] PDE3A, PDE3B 💬 |
Levosimendan Levosimendan 💬 |
Levosimendan | 002 [1] 2 💬 💬 |
815 | Purine metabolism 💬 29 genes, 35 drugs (DrugBank) and 73 diseases |
PDE3A [6] PDE3A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D 💬 |
Ibudilast Ibudilast 💬 |
Ibudilast | 002 [2] 2 , 13 💬 💬 |
816 | Purine metabolism 💬 29 genes, 35 drugs (DrugBank) and 73 diseases |
XDH [1] XDH 💬 |
Febuxostat Febuxostat 💬 |
Febuxostat | 002 [3] 2 , 6 , 13 💬 💬 |
817 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
ADORA2A [1] ADORA2A 💬 |
Caffeine Caffeine 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
818 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
ADORA2A [1] ADORA2A 💬 |
Caffeine hydrate Caffeine hydrate 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
819 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
CNR1 [1] CNR1 💬 |
Cannabidiol Cannabidiol 💬 |
Cannabidiol | 002 [20] 2 , 6 , 8 , 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 💬 |
820 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
CNR1 [1] CNR1 💬 |
Dronabinol Dronabinol 💬 |
Dronabinol | 002 [8] 2 , 8 , 13, 36, 46, 96, 271, 298 💬 💬 |
821 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
DRD2 [1] DRD2 💬 |
Dexpramipexole Dexpramipexole 💬 |
Dexpramipexole | 002 [1] 2 💬 💬 |
822 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
DRD2 [1] DRD2 💬 |
Olanzapine Olanzapine 💬 |
Olanzapine | 002 [2] 2 , 8 💬 💬 |
823 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
DRD2 [1] DRD2 💬 |
Pimozide Pimozide 💬 |
Pimozide | 002 [1] 2 💬 💬 |
824 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
DRD2 [1] DRD2 💬 |
Pramipexole Pramipexole 💬 |
Pramipexole | 002 [3] 2 , 6 , 20 💬 💬 |
825 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
DRD2 [1] DRD2 💬 |
Pridopidine Pridopidine 💬 |
Pridopidine | 002 [3] 2 , 6 , 8 💬 💬 |
826 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
DRD2 [1] DRD2 💬 |
Ropinirole Ropinirole 💬 |
Ropinirole | 002 [4] 2 , 6 , 74, 309 💬 💬 |
827 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
GRIN1 [3] GRIN1, GRIN2A, GRIN2B 💬 |
Dextromethorphan Dextromethorphan 💬 |
Dextromethorphan | 002 [11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬 💬 |
828 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
GRIN1 [3] GRIN1, GRIN2A, GRIN2B 💬 |
Esketamine Esketamine 💬 |
Esketamine | 002 [3] 2 , 4 , 70 💬 💬 |
829 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
GRIN1 [3] GRIN1, GRIN2A, GRIN2B 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
830 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
GRIN1 [3] GRIN1, GRIN2A, GRIN2B 💬 |
Memantine Memantine 💬 |
Memantine | 002 [8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬 💬 |
831 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
GRIN1 [3] GRIN1, GRIN2A, GRIN2B 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
832 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
KIT [1] KIT 💬 |
Masitinib Masitinib 💬 |
Masitinib | 002 [6] 2 , 5 , 6 , 13, 46, 96 💬 💬 |
833 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
834 | Rap1 signaling pathway 💬 42 genes, 101 drugs (DrugBank) and 85 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
835 | Ras signaling pathway 💬 35 genes, 53 drugs (DrugBank) and 62 diseases |
ABL1 [1] ABL1 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
836 | Ras signaling pathway 💬 35 genes, 53 drugs (DrugBank) and 62 diseases |
GRIN1 [3] GRIN1, GRIN2A, GRIN2B 💬 |
Dextromethorphan Dextromethorphan 💬 |
Dextromethorphan | 002 [11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬 💬 |
837 | Ras signaling pathway 💬 35 genes, 53 drugs (DrugBank) and 62 diseases |
GRIN1 [3] GRIN1, GRIN2A, GRIN2B 💬 |
Esketamine Esketamine 💬 |
Esketamine | 002 [3] 2 , 4 , 70 💬 💬 |
838 | Ras signaling pathway 💬 35 genes, 53 drugs (DrugBank) and 62 diseases |
GRIN1 [3] GRIN1, GRIN2A, GRIN2B 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
839 | Ras signaling pathway 💬 35 genes, 53 drugs (DrugBank) and 62 diseases |
GRIN1 [3] GRIN1, GRIN2A, GRIN2B 💬 |
Memantine Memantine 💬 |
Memantine | 002 [8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬 💬 |
840 | Ras signaling pathway 💬 35 genes, 53 drugs (DrugBank) and 62 diseases |
GRIN1 [3] GRIN1, GRIN2A, GRIN2B 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
841 | Ras signaling pathway 💬 35 genes, 53 drugs (DrugBank) and 62 diseases |
KIT [1] KIT 💬 |
Masitinib Masitinib 💬 |
Masitinib | 002 [6] 2 , 5 , 6 , 13, 46, 96 💬 💬 |
842 | Ras signaling pathway 💬 35 genes, 53 drugs (DrugBank) and 62 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
843 | Regulation of actin cytoskeleton 💬 28 genes, 60 drugs (DrugBank) and 63 diseases |
C5 [1] C5 💬 |
Ravulizumab Ravulizumab 💬 |
Ravulizumab | 002 [7] 2 , 11, 13, 50, 62, 66, 109 💬 💬 |
844 | Regulation of actin cytoskeleton 💬 28 genes, 60 drugs (DrugBank) and 63 diseases |
C5 [1] C5 💬 |
Zilucoplan Zilucoplan 💬 |
Zilucoplan | 002 [3] 2 , 11, 62 💬 💬 |
845 | Regulation of actin cytoskeleton 💬 28 genes, 60 drugs (DrugBank) and 63 diseases |
CHRM1 [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 |
Atropine Atropine 💬 |
Atropine | 002 [2] 2 , 299 💬 💬 |
846 | Regulation of actin cytoskeleton 💬 28 genes, 60 drugs (DrugBank) and 63 diseases |
CHRM1 [5] CHRM1, CHRM2, CHRM3, CHRM4, CHRM5 💬 |
Scopolamine Scopolamine 💬 |
Scopolamine | 002 [1] 2 💬 💬 |
847 | Regulation of actin cytoskeleton 💬 28 genes, 60 drugs (DrugBank) and 63 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
848 | Regulation of actin cytoskeleton 💬 28 genes, 60 drugs (DrugBank) and 63 diseases |
ROCK1 [2] ROCK1, ROCK2 💬 |
Fasudil Fasudil 💬 |
Fasudil | 002 [4] 2 , 5 , 7 , 51 💬 💬 |
849 | Regulation of actin cytoskeleton 💬 28 genes, 60 drugs (DrugBank) and 63 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
850 | Regulation of lipolysis in adipocytes 💬 13 genes, 71 drugs (DrugBank) and 69 diseases |
ADORA1 [2] ADORA1, PDE3B 💬 |
Caffeine Caffeine 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
851 | Regulation of lipolysis in adipocytes 💬 13 genes, 71 drugs (DrugBank) and 69 diseases |
ADORA1 [2] ADORA1, PDE3B 💬 |
Caffeine hydrate Caffeine hydrate 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
852 | Regulation of lipolysis in adipocytes 💬 13 genes, 71 drugs (DrugBank) and 69 diseases |
ADRB2 [1] ADRB2 💬 |
Clenbuterol Clenbuterol 💬 |
Clenbuterol | 001 [5] 1 , 2 , 6 , 13, 256 💬 💬 |
853 | Regulation of lipolysis in adipocytes 💬 13 genes, 71 drugs (DrugBank) and 69 diseases |
PDE3B [1] PDE3B 💬 |
Ibudilast Ibudilast 💬 |
Ibudilast | 002 [2] 2 , 13 💬 💬 |
854 | Regulation of lipolysis in adipocytes 💬 13 genes, 71 drugs (DrugBank) and 69 diseases |
PDE3B [1] PDE3B 💬 |
Levosimendan Levosimendan 💬 |
Levosimendan | 002 [1] 2 💬 💬 |
855 | Regulation of lipolysis in adipocytes 💬 13 genes, 71 drugs (DrugBank) and 69 diseases |
PTGS2 [1] PTGS2 💬 |
Celecoxib Celecoxib 💬 |
Celecoxib | 002 [10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 💬 |
856 | Relaxin signaling pathway 💬 19 genes, 30 drugs (DrugBank) and 38 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
857 | Relaxin signaling pathway 💬 19 genes, 30 drugs (DrugBank) and 38 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
858 | Renal cell carcinoma 💬 12 genes, 15 drugs (DrugBank) and 19 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
859 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
ADORA1 [4] ADORA1, PDE1B, PDE3A, PDE3B 💬 |
Caffeine Caffeine 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
860 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
ADORA1 [4] ADORA1, PDE1B, PDE3A, PDE3B 💬 |
Caffeine hydrate Caffeine hydrate 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
861 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
ADRB2 [1] ADRB2 💬 |
Clenbuterol Clenbuterol 💬 |
Clenbuterol | 001 [5] 1 , 2 , 6 , 13, 256 💬 💬 |
862 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
PDE3A [2] PDE3A, PDE3B 💬 |
Ibudilast Ibudilast 💬 |
Ibudilast | 002 [2] 2 , 13 💬 💬 |
863 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
PDE3A [2] PDE3A, PDE3B 💬 |
Levosimendan Levosimendan 💬 |
Levosimendan | 002 [1] 2 💬 💬 |
864 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
865 | Renin secretion 💬 28 genes, 82 drugs (DrugBank) and 107 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
866 | Retrograde endocannabinoid signaling 💬 34 genes, 62 drugs (DrugBank) and 67 diseases |
CNR1 [1] CNR1 💬 |
Cannabidiol Cannabidiol 💬 |
Cannabidiol | 002 [20] 2 , 6 , 8 , 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 💬 |
867 | Retrograde endocannabinoid signaling 💬 34 genes, 62 drugs (DrugBank) and 67 diseases |
CNR1 [1] CNR1 💬 |
Dronabinol Dronabinol 💬 |
Dronabinol | 002 [8] 2 , 8 , 13, 36, 46, 96, 271, 298 💬 💬 |
868 | Retrograde endocannabinoid signaling 💬 34 genes, 62 drugs (DrugBank) and 67 diseases |
GABRA1 [16] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ 💬 |
Midazolam Midazolam 💬 |
Midazolam | 002 [12] 2 , 3 , 6 , 13, 21, 46, 70, 96, 97, 272, 298, 299 💬 💬 |
869 | Retrograde endocannabinoid signaling 💬 34 genes, 62 drugs (DrugBank) and 67 diseases |
GRIA1 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 |
Perampanel Perampanel 💬 |
Perampanel | 002 [3] 2 , 6 , 144 💬 💬 |
870 | Retrograde endocannabinoid signaling 💬 34 genes, 62 drugs (DrugBank) and 67 diseases |
GRIA1 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
871 | Retrograde endocannabinoid signaling 💬 34 genes, 62 drugs (DrugBank) and 67 diseases |
GRIA1 [4] GRIA1, GRIA2, GRIA3, GRIA4 💬 |
Talampanel Talampanel 💬 |
Talampanel | 002 [2] 2 , 6 💬 💬 |
872 | Retrograde endocannabinoid signaling 💬 34 genes, 62 drugs (DrugBank) and 67 diseases |
PTGS2 [1] PTGS2 💬 |
Celecoxib Celecoxib 💬 |
Celecoxib | 002 [10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 💬 |
873 | Rheumatoid arthritis 💬 22 genes, 49 drugs (DrugBank) and 74 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
874 | RIG-I-like receptor signaling pathway 💬 22 genes, 18 drugs (DrugBank) and 55 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
875 | Salivary secretion 💬 19 genes, 61 drugs (DrugBank) and 56 diseases |
ADRA1A [3] ADRA1A, ADRA1B, ADRA1D 💬 |
Olanzapine Olanzapine 💬 |
Olanzapine | 002 [2] 2 , 8 💬 💬 |
876 | Salivary secretion 💬 19 genes, 61 drugs (DrugBank) and 56 diseases |
ADRB2 [1] ADRB2 💬 |
Clenbuterol Clenbuterol 💬 |
Clenbuterol | 001 [5] 1 , 2 , 6 , 13, 256 💬 💬 |
877 | Salivary secretion 💬 19 genes, 61 drugs (DrugBank) and 56 diseases |
CHRM3 [1] CHRM3 💬 |
Atropine Atropine 💬 |
Atropine | 002 [2] 2 , 299 💬 💬 |
878 | Salivary secretion 💬 19 genes, 61 drugs (DrugBank) and 56 diseases |
CHRM3 [1] CHRM3 💬 |
Scopolamine Scopolamine 💬 |
Scopolamine | 002 [1] 2 💬 💬 |
879 | Salmonella infection 💬 27 genes, 40 drugs (DrugBank) and 66 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
880 | Salmonella infection 💬 27 genes, 40 drugs (DrugBank) and 66 diseases |
ROCK2 [1] ROCK2 💬 |
Fasudil Fasudil 💬 |
Fasudil | 002 [4] 2 , 5 , 7 , 51 💬 💬 |
881 | Salmonella infection 💬 27 genes, 40 drugs (DrugBank) and 66 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
882 | Salmonella infection 💬 27 genes, 40 drugs (DrugBank) and 66 diseases |
TUBB [9] TUBB, TUBB1, TUBB2A, TUBB2B, TUBB3, TUBB4A, TUBB4B, TUBB6, TUBB8 💬 |
Colchicine Colchicine 💬 |
Colchicine | 002 [7] 2 , 42, 46, 56, 93, 210, 266 💬 💬 |
883 | Serotonergic synapse 💬 38 genes, 112 drugs (DrugBank) and 79 diseases |
GABRB1 [3] GABRB1, GABRB2, GABRB3 💬 |
Midazolam Midazolam 💬 |
Midazolam | 002 [12] 2 , 3 , 6 , 13, 21, 46, 70, 96, 97, 272, 298, 299 💬 💬 |
884 | Serotonergic synapse 💬 38 genes, 112 drugs (DrugBank) and 79 diseases |
HTR2A [4] HTR2A, HTR2B, HTR2C, HTR6 💬 |
Olanzapine Olanzapine 💬 |
Olanzapine | 002 [2] 2 , 8 💬 💬 |
885 | Serotonergic synapse 💬 38 genes, 112 drugs (DrugBank) and 79 diseases |
HTR2A [4] HTR2A, HTR2B, HTR2C, SLC6A4 💬 |
Trazodone Trazodone 💬 |
Trazodone | 002 [1] 2 💬 💬 |
886 | Serotonergic synapse 💬 38 genes, 112 drugs (DrugBank) and 79 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
887 | Serotonergic synapse 💬 38 genes, 112 drugs (DrugBank) and 79 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
888 | Serotonergic synapse 💬 38 genes, 112 drugs (DrugBank) and 79 diseases |
MAP2K1 [1] MAP2K1 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
889 | Serotonergic synapse 💬 38 genes, 112 drugs (DrugBank) and 79 diseases |
PTGS2 [1] PTGS2 💬 |
Celecoxib Celecoxib 💬 |
Celecoxib | 002 [10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 💬 |
890 | Serotonergic synapse 💬 38 genes, 112 drugs (DrugBank) and 79 diseases |
SLC6A4 [1] SLC6A4 💬 |
Escitalopram Escitalopram 💬 |
Escitalopram | 002 [4] 2 , 6 , 13, 46 💬 💬 |
891 | Shigellosis 💬 23 genes, 41 drugs (DrugBank) and 86 diseases |
C3 [1] C3 💬 |
Pegcetacoplan Pegcetacoplan 💬 |
Pegcetacoplan | 002 [4] 2 , 61, 62, 222 💬 💬 |
892 | Shigellosis 💬 23 genes, 41 drugs (DrugBank) and 86 diseases |
IL1R1 [1] IL1R1 💬 |
Anakinra Anakinra 💬 |
Anakinra | 002 [18] 2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 💬 |
893 | Shigellosis 💬 23 genes, 41 drugs (DrugBank) and 86 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
894 | Shigellosis 💬 23 genes, 41 drugs (DrugBank) and 86 diseases |
ROCK1 [2] ROCK1, ROCK2 💬 |
Fasudil Fasudil 💬 |
Fasudil | 002 [4] 2 , 5 , 7 , 51 💬 💬 |
895 | Shigellosis 💬 23 genes, 41 drugs (DrugBank) and 86 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
896 | Shigellosis 💬 23 genes, 41 drugs (DrugBank) and 86 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
897 | Signaling pathways regulating pluripotency of stem cells 💬 19 genes, 28 drugs (DrugBank) and 48 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
898 | Signaling pathways regulating pluripotency of stem cells 💬 19 genes, 28 drugs (DrugBank) and 48 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
899 | Small cell lung cancer 💬 14 genes, 39 drugs (DrugBank) and 59 diseases |
PTGS2 [1] PTGS2 💬 |
Celecoxib Celecoxib 💬 |
Celecoxib | 002 [10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 💬 |
900 | Small cell lung cancer 💬 14 genes, 39 drugs (DrugBank) and 59 diseases |
RARB [1] RARB 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
901 | Sphingolipid signaling pathway 💬 30 genes, 52 drugs (DrugBank) and 73 diseases |
ADORA1 [1] ADORA1 💬 |
Caffeine Caffeine 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
902 | Sphingolipid signaling pathway 💬 30 genes, 52 drugs (DrugBank) and 73 diseases |
ADORA1 [1] ADORA1 💬 |
Caffeine hydrate Caffeine hydrate 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
903 | Sphingolipid signaling pathway 💬 30 genes, 52 drugs (DrugBank) and 73 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
904 | Sphingolipid signaling pathway 💬 30 genes, 52 drugs (DrugBank) and 73 diseases |
ROCK1 [2] ROCK1, ROCK2 💬 |
Fasudil Fasudil 💬 |
Fasudil | 002 [4] 2 , 5 , 7 , 51 💬 💬 |
905 | Sphingolipid signaling pathway 💬 30 genes, 52 drugs (DrugBank) and 73 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
906 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
GRIA1 [3] GRIA1, GRIA2, GRIA3 💬 |
Perampanel Perampanel 💬 |
Perampanel | 002 [3] 2 , 6 , 144 💬 💬 |
907 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
GRIA1 [3] GRIA1, GRIA2, GRIA3 💬 |
Talampanel Talampanel 💬 |
Talampanel | 002 [2] 2 , 6 💬 💬 |
908 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
GRIA1 [8] GRIA1, GRIA2, GRIA3, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
909 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Dextromethorphan Dextromethorphan 💬 |
Dextromethorphan | 002 [11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬 💬 |
910 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Esketamine Esketamine 💬 |
Esketamine | 002 [3] 2 , 4 , 70 💬 💬 |
911 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
912 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
GRIN1 [5] GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D 💬 |
Memantine Memantine 💬 |
Memantine | 002 [8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬 💬 |
913 | Spinocerebellar ataxia 💬 17 genes, 25 drugs (DrugBank) and 70 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
914 | Staphylococcus aureus infection 💬 12 genes, 19 drugs (DrugBank) and 34 diseases |
C3 [1] C3 💬 |
Pegcetacoplan Pegcetacoplan 💬 |
Pegcetacoplan | 002 [4] 2 , 61, 62, 222 💬 💬 |
915 | Staphylococcus aureus infection 💬 12 genes, 19 drugs (DrugBank) and 34 diseases |
C5 [1] C5 💬 |
Ravulizumab Ravulizumab 💬 |
Ravulizumab | 002 [7] 2 , 11, 13, 50, 62, 66, 109 💬 💬 |
916 | Staphylococcus aureus infection 💬 12 genes, 19 drugs (DrugBank) and 34 diseases |
C5 [1] C5 💬 |
Zilucoplan Zilucoplan 💬 |
Zilucoplan | 002 [3] 2 , 11, 62 💬 💬 |
917 | Steroid hormone biosynthesis 💬 8 genes, 11 drugs (DrugBank) and 14 diseases |
SRD5A1 [2] SRD5A1, SRD5A2 💬 |
Dutasteride Dutasteride 💬 |
Dutasteride | 001 [2] 1 , 2 💬 💬 |
918 | Synaptic vesicle cycle 💬 7 genes, 30 drugs (DrugBank) and 40 diseases |
SLC6A4 [1] SLC6A4 💬 |
Escitalopram Escitalopram 💬 |
Escitalopram | 002 [4] 2 , 6 , 13, 46 💬 💬 |
919 | Synaptic vesicle cycle 💬 7 genes, 30 drugs (DrugBank) and 40 diseases |
SLC6A4 [1] SLC6A4 💬 |
Trazodone Trazodone 💬 |
Trazodone | 002 [1] 2 💬 💬 |
920 | Synaptic vesicle cycle 💬 7 genes, 30 drugs (DrugBank) and 40 diseases |
SNAP25 [1] SNAP25 💬 |
Botulinum toxin type A Botulinum toxin type A 💬 |
Botulinum toxin type A | 002 [14] 2 , 5 , 6 , 7 , 13, 15, 17, 36, 47, 51, 70, 113, 149, 226 💬 💬 |
921 | Synaptic vesicle cycle 💬 7 genes, 30 drugs (DrugBank) and 40 diseases |
SNAP25 [1] SNAP25 💬 |
Rimabotulinumtoxin B Rimabotulinumtoxin B 💬 |
Botulinum toxin type B | 002 [4] 2 , 6 , 13, 51 💬 💬 |
922 | Systemic lupus erythematosus 💬 14 genes, 38 drugs (DrugBank) and 78 diseases |
C3 [1] C3 💬 |
Pegcetacoplan Pegcetacoplan 💬 |
Pegcetacoplan | 002 [4] 2 , 61, 62, 222 💬 💬 |
923 | Systemic lupus erythematosus 💬 14 genes, 38 drugs (DrugBank) and 78 diseases |
C5 [1] C5 💬 |
Ravulizumab Ravulizumab 💬 |
Ravulizumab | 002 [7] 2 , 11, 13, 50, 62, 66, 109 💬 💬 |
924 | Systemic lupus erythematosus 💬 14 genes, 38 drugs (DrugBank) and 78 diseases |
C5 [1] C5 💬 |
Zilucoplan Zilucoplan 💬 |
Zilucoplan | 002 [3] 2 , 11, 62 💬 💬 |
925 | Systemic lupus erythematosus 💬 14 genes, 38 drugs (DrugBank) and 78 diseases |
GRIN2A [2] GRIN2A, GRIN2B 💬 |
Dextromethorphan Dextromethorphan 💬 |
Dextromethorphan | 002 [11] 2 , 6 , 8 , 13, 21, 46, 78, 85, 96, 97, 156 💬 💬 |
926 | Systemic lupus erythematosus 💬 14 genes, 38 drugs (DrugBank) and 78 diseases |
GRIN2A [2] GRIN2A, GRIN2B 💬 |
Esketamine Esketamine 💬 |
Esketamine | 002 [3] 2 , 4 , 70 💬 💬 |
927 | Systemic lupus erythematosus 💬 14 genes, 38 drugs (DrugBank) and 78 diseases |
GRIN2A [2] GRIN2A, GRIN2B 💬 |
Ketamine Ketamine 💬 |
Ketamine | 002 [8] 2 , 4 , 6 , 13, 70, 113, 156, 215 💬 💬 |
928 | Systemic lupus erythematosus 💬 14 genes, 38 drugs (DrugBank) and 78 diseases |
GRIN2A [2] GRIN2A, GRIN2B 💬 |
Memantine Memantine 💬 |
Memantine | 002 [8] 2 , 6 , 8 , 13, 49, 127, 205, 206 💬 💬 |
929 | Systemic lupus erythematosus 💬 14 genes, 38 drugs (DrugBank) and 78 diseases |
GRIN2A [2] GRIN2A, GRIN2B 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
930 | Systemic lupus erythematosus 💬 14 genes, 38 drugs (DrugBank) and 78 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
931 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
932 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
933 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
934 | T cell receptor signaling pathway 💬 34 genes, 46 drugs (DrugBank) and 80 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
935 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CHRM3 [1] CHRM3 💬 |
Atropine Atropine 💬 |
Atropine | 002 [2] 2 , 299 💬 💬 |
936 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
CHRM3 [1] CHRM3 💬 |
Scopolamine Scopolamine 💬 |
Scopolamine | 002 [1] 2 💬 💬 |
937 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABBR1 [2] GABBR1, GABBR2 💬 |
Baclofen Baclofen 💬 |
Baclofen | 002 [8] 2 , 10, 13, 18, 65, 70, 149, 206 💬 💬 |
938 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
GABRA1 [6] GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6 💬 |
Midazolam Midazolam 💬 |
Midazolam | 002 [12] 2 , 3 , 6 , 13, 21, 46, 70, 96, 97, 272, 298, 299 💬 💬 |
939 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
PDE1B [1] PDE1B 💬 |
Caffeine Caffeine 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
940 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
PDE1B [1] PDE1B 💬 |
Caffeine hydrate Caffeine hydrate 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
941 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCN2A [3] SCN2A, SCN3A, SCN9A 💬 |
Mexiletine Mexiletine 💬 |
Mexiletine | 001 [5] 1 , 2 , 10, 113, 114 💬 💬 |
942 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCN2A [3] SCN2A, SCN3A, SCN9A 💬 |
Quinidine Quinidine 💬 |
Quinidine | 002 [3] 2 , 8 , 13 💬 💬 |
943 | Taste transduction 💬 30 genes, 81 drugs (DrugBank) and 65 diseases |
SCN3A [2] SCN3A, SCN9A 💬 |
Lacosamide Lacosamide 💬 |
Lacosamide | 002 [4] 2 , 46, 149, 298 💬 💬 |
944 | Taurine and hypotaurine metabolism 💬 2 genes, 1 drug (DrugBank) and 14 diseases |
GAD1 [2] GAD1, GAD2 💬 |
Valproic acid Valproic acid 💬 |
Valproic acid | 002 [14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬 |
945 | TGF-beta signaling pathway 💬 10 genes, 20 drugs (DrugBank) and 55 diseases |
ROCK1 [1] ROCK1 💬 |
Fasudil Fasudil 💬 |
Fasudil | 002 [4] 2 , 5 , 7 , 51 💬 💬 |
946 | TGF-beta signaling pathway 💬 10 genes, 20 drugs (DrugBank) and 55 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
947 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
IL2RA [1] IL2RA 💬 |
Basiliximab Basiliximab 💬 |
Basiliximab | 002 [6] 2 , 50, 66, 97, 222, 228 💬 💬 |
948 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
IL2RA [3] IL2RA, IL2RB, IL2RG 💬 |
Aldesleukin Aldesleukin 💬 |
Aldesleukin | 002 [6] 2 , 35, 49, 65, 96, 97 💬 💬 |
949 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
950 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
951 | Th1 and Th2 cell differentiation 💬 33 genes, 37 drugs (DrugBank) and 70 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
952 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL1R1 [1] IL1R1 💬 |
Anakinra Anakinra 💬 |
Anakinra | 002 [18] 2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 💬 |
953 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL2RA [1] IL2RA 💬 |
Basiliximab Basiliximab 💬 |
Basiliximab | 002 [6] 2 , 50, 66, 97, 222, 228 💬 💬 |
954 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL2RA [3] IL2RA, IL2RB, IL2RG 💬 |
Aldesleukin Aldesleukin 💬 |
Aldesleukin | 002 [6] 2 , 35, 49, 65, 96, 97 💬 💬 |
955 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
IL6R [1] IL6R 💬 |
Tocilizumab Tocilizumab 💬 |
Tocilizumab | 002 [21] 2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬 💬 |
956 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
957 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
958 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
959 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
960 | Th17 cell differentiation 💬 43 genes, 66 drugs (DrugBank) and 97 diseases |
RARA [1] RARA 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
961 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
CNR1 [1] CNR1 💬 |
Cannabidiol Cannabidiol 💬 |
Cannabidiol | 002 [20] 2 , 6 , 8 , 13, 36, 46, 51, 95, 96, 97, 140, 144, 145, 156, 157, 158, 193, 206, 226, 271 💬 💬 |
962 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
CNR1 [1] CNR1 💬 |
Dronabinol Dronabinol 💬 |
Dronabinol | 002 [8] 2 , 8 , 13, 36, 46, 96, 271, 298 💬 💬 |
963 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
964 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
PPARG [1] PPARG 💬 |
Pioglitazone Pioglitazone 💬 |
Pioglitazone | 002 [17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 💬 |
965 | Thermogenesis 💬 17 genes, 29 drugs (DrugBank) and 82 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
966 | Thyroid cancer 💬 8 genes, 16 drugs (DrugBank) and 28 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
967 | Thyroid cancer 💬 8 genes, 16 drugs (DrugBank) and 28 diseases |
PPARG [1] PPARG 💬 |
Pioglitazone Pioglitazone 💬 |
Pioglitazone | 002 [17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 💬 |
968 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
ESR1 [1] ESR1 💬 |
Tamoxifen Tamoxifen 💬 |
Tamoxifen | 002 [3] 2 , 113, 227 💬 💬 |
969 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
970 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
971 | Thyroid hormone signaling pathway 💬 24 genes, 41 drugs (DrugBank) and 67 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
972 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
PRKAA1 [2] PRKAA1, PRKAA2 💬 |
Metformin Metformin 💬 |
Metformin | 002 [25] 2 , 6 , 8 , 13, 46, 49, 60, 65, 67, 75, 77, 81, 86, 97, 113, 127, 158, 206, 218, 225, 233, 265, 285, 299, 301 💬 💬 |
973 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
ROCK1 [2] ROCK1, ROCK2 💬 |
Fasudil Fasudil 💬 |
Fasudil | 002 [4] 2 , 5 , 7 , 51 💬 💬 |
974 | Tight junction 💬 11 genes, 29 drugs (DrugBank) and 45 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
975 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
MAP2K1 [1] MAP2K1 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
976 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
PTGS2 [1] PTGS2 💬 |
Celecoxib Celecoxib 💬 |
Celecoxib | 002 [10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 💬 |
977 | TNF signaling pathway 💬 18 genes, 56 drugs (DrugBank) and 84 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
978 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
979 | Toll-like receptor signaling pathway 💬 36 genes, 46 drugs (DrugBank) and 65 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
980 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
981 | Toxoplasmosis 💬 25 genes, 39 drugs (DrugBank) and 64 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
982 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
GRIA3 [1] GRIA3 💬 |
Perampanel Perampanel 💬 |
Perampanel | 002 [3] 2 , 6 , 144 💬 💬 |
983 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
GRIA3 [1] GRIA3 💬 |
Riluzole Riluzole 💬 |
Riluzole | 002 [9] 2 , 3 , 5 , 8 , 13, 17, 18, 203, 206 💬 💬 |
984 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
GRIA3 [1] GRIA3 💬 |
Talampanel Talampanel 💬 |
Talampanel | 002 [2] 2 , 6 💬 💬 |
985 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
IL1R2 [1] IL1R2 💬 |
Anakinra Anakinra 💬 |
Anakinra | 002 [18] 2 , 13, 15, 28, 37, 41, 46, 49, 50, 56, 65, 84, 86, 97, 106, 107, 266, 299 💬 💬 |
986 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
IL2RB [1] IL2RB 💬 |
Aldesleukin Aldesleukin 💬 |
Aldesleukin | 002 [6] 2 , 35, 49, 65, 96, 97 💬 💬 |
987 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
MPO [1] MPO 💬 |
Verdiperstat Verdiperstat 💬 |
Verdiperstat | 002 [3] 2 , 17, 127 💬 💬 |
988 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
PML [2] PML, RARA 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
989 | Transcriptional misregulation in cancer 💬 26 genes, 49 drugs (DrugBank) and 76 diseases |
PPARG [1] PPARG 💬 |
Pioglitazone Pioglitazone 💬 |
Pioglitazone | 002 [17] 2 , 6 , 13, 15, 20, 46, 49, 65, 67, 78, 81, 86, 96, 229, 265, 298, 299 💬 💬 |
990 | Tryptophan metabolism 💬 5 genes, 10 drugs (DrugBank) and 12 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
991 | Tryptophan metabolism 💬 5 genes, 10 drugs (DrugBank) and 12 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
992 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
C3 [1] C3 💬 |
Pegcetacoplan Pegcetacoplan 💬 |
Pegcetacoplan | 002 [4] 2 , 61, 62, 222 💬 💬 |
993 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
JAK1 [2] JAK1, JAK2 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
994 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
995 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
996 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
997 | Tuberculosis 💬 49 genes, 65 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
998 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
GAD1 [2] GAD1, GAD2 💬 |
Valproic acid Valproic acid 💬 |
Valproic acid | 002 [14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬 |
999 | Type I diabetes mellitus 💬 11 genes, 22 drugs (DrugBank) and 68 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
1000 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
CACNA1G [1] CACNA1G 💬 |
Valproic acid Valproic acid 💬 |
Valproic acid | 002 [14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬 |
1001 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
MTOR [1] MTOR 💬 |
Sirolimus Sirolimus 💬 |
Sirolimus | 002 [40] 2 , 13, 15, 17, 19, 34, 35, 36, 46, 49, 51, 53, 60, 61, 62, 63, 65, 66, 67, 84, 85, 86, 89, 96, 98, 137, 157, 158, 192, 193, 222, 256, 277, 278, 279, 280, 281, 283, 300, 331 💬 💬 |
1002 | Type II diabetes mellitus 💬 14 genes, 39 drugs (DrugBank) and 91 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
1003 | Tyrosine metabolism 💬 10 genes, 16 drugs (DrugBank) and 18 diseases |
MAOB [1] MAOB 💬 |
Rasagiline Rasagiline 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
1004 | Tyrosine metabolism 💬 10 genes, 16 drugs (DrugBank) and 18 diseases |
MAOB [1] MAOB 💬 |
Rasagiline tartrate Rasagiline tartrate 💬 |
Rasagiline | 002 [6] 2 , 5 , 6 , 17, 58, 66 💬 💬 |
1005 | Ubiquitin mediated proteolysis 💬 2 genes, 2 drugs (DrugBank) and 11 diseases |
PML [1] PML 💬 |
Tretinoin Tretinoin 💬 |
Tretinoin | 002 [6] 2 , 62, 63, 75, 94, 231 💬 💬 |
1006 | Valine, leucine and isoleucine degradation 💬 1 gene, 2 drugs (DrugBank) and 16 diseases |
ABAT [1] ABAT 💬 |
Valproic acid Valproic acid 💬 |
Valproic acid | 002 [14] 2 , 3 , 5 , 6 , 13, 26, 65, 85, 90, 102, 127, 222, 233, 256 💬 💬 |
1007 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
ADORA2A [1] ADORA2A 💬 |
Caffeine Caffeine 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
1008 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
ADORA2A [1] ADORA2A 💬 |
Caffeine hydrate Caffeine hydrate 💬 |
Caffeine | 002 [8] 2 , 6 , 21, 46, 78, 96, 97, 265 💬 💬 |
1009 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
ADRA1A [3] ADRA1A, ADRA1B, ADRA1D 💬 |
Olanzapine Olanzapine 💬 |
Olanzapine | 002 [2] 2 , 8 💬 💬 |
1010 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
1011 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
PTGIR [1] PTGIR 💬 |
Ibudilast Ibudilast 💬 |
Ibudilast | 002 [2] 2 , 13 💬 💬 |
1012 | Vascular smooth muscle contraction 💬 31 genes, 77 drugs (DrugBank) and 68 diseases |
ROCK1 [2] ROCK1, ROCK2 💬 |
Fasudil Fasudil 💬 |
Fasudil | 002 [4] 2 , 5 , 7 , 51 💬 💬 |
1013 | VEGF signaling pathway 💬 21 genes, 53 drugs (DrugBank) and 90 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
1014 | VEGF signaling pathway 💬 21 genes, 53 drugs (DrugBank) and 90 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
1015 | VEGF signaling pathway 💬 21 genes, 53 drugs (DrugBank) and 90 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
1016 | VEGF signaling pathway 💬 21 genes, 53 drugs (DrugBank) and 90 diseases |
PTGS2 [1] PTGS2 💬 |
Celecoxib Celecoxib 💬 |
Celecoxib | 002 [10] 2 , 3 , 34, 46, 70, 89, 107, 161, 171, 271 💬 💬 |
1017 | VEGF signaling pathway 💬 21 genes, 53 drugs (DrugBank) and 90 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
1018 | Vibrio cholerae infection 💬 3 genes, 10 drugs (DrugBank) and 8 diseases |
KCNQ1 [1] KCNQ1 💬 |
Ezogabine Ezogabine 💬 |
Ezogabine | 002 [2] 2 , 144 💬 💬 |
1019 | Viral carcinogenesis 💬 25 genes, 23 drugs (DrugBank) and 40 diseases |
C3 [1] C3 💬 |
Pegcetacoplan Pegcetacoplan 💬 |
Pegcetacoplan | 002 [4] 2 , 61, 62, 222 💬 💬 |
1020 | Viral carcinogenesis 💬 25 genes, 23 drugs (DrugBank) and 40 diseases |
JAK1 [1] JAK1 💬 |
Baricitinib Baricitinib 💬 |
Baricitinib | 002 [13] 2 , 41, 46, 49, 50, 51, 53, 93, 107, 162, 265, 269, 325 💬 💬 |
1021 | Viral carcinogenesis 💬 25 genes, 23 drugs (DrugBank) and 40 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
1022 | Viral myocarditis 💬 10 genes, 19 drugs (DrugBank) and 46 diseases |
ABL1 [1] ABL1 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
1023 | Viral protein interaction with cytokine and cytokine receptor 💬 17 genes, 29 drugs (DrugBank) and 60 diseases |
IL2RA [1] IL2RA 💬 |
Basiliximab Basiliximab 💬 |
Basiliximab | 002 [6] 2 , 50, 66, 97, 222, 228 💬 💬 |
1024 | Viral protein interaction with cytokine and cytokine receptor 💬 17 genes, 29 drugs (DrugBank) and 60 diseases |
IL2RA [3] IL2RA, IL2RB, IL2RG 💬 |
Aldesleukin Aldesleukin 💬 |
Aldesleukin | 002 [6] 2 , 35, 49, 65, 96, 97 💬 💬 |
1025 | Viral protein interaction with cytokine and cytokine receptor 💬 17 genes, 29 drugs (DrugBank) and 60 diseases |
IL6R [1] IL6R 💬 |
Tocilizumab Tocilizumab 💬 |
Tocilizumab | 002 [21] 2 , 11, 13, 40, 41, 42, 43, 44, 46, 49, 50, 51, 53, 54, 55, 56, 86, 107, 266, 271, 331 💬 💬 |
1026 | Viral protein interaction with cytokine and cytokine receptor 💬 17 genes, 29 drugs (DrugBank) and 60 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |
1027 | Wnt signaling pathway 💬 9 genes, 9 drugs (DrugBank) and 61 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
1028 | Wnt signaling pathway 💬 9 genes, 9 drugs (DrugBank) and 61 diseases |
PPP3CA [5] PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2 💬 |
Tacrolimus Tacrolimus 💬 |
Tacrolimus | 002 [34] 2 , 6 , 11, 13, 36, 46, 49, 50, 51, 53, 56, 60, 61, 62, 65, 66, 85, 95, 96, 97, 113, 151, 158, 164, 222, 224, 226, 227, 228, 283, 284, 285, 286, 299 💬 💬 |
1029 | Wnt signaling pathway 💬 9 genes, 9 drugs (DrugBank) and 61 diseases |
ROCK2 [1] ROCK2 💬 |
Fasudil Fasudil 💬 |
Fasudil | 002 [4] 2 , 5 , 7 , 51 💬 💬 |
1030 | Yersinia infection 💬 22 genes, 39 drugs (DrugBank) and 69 diseases |
MAP2K1 [2] MAP2K1, MAP2K2 💬 |
Trametinib Trametinib 💬 |
Trametinib | 002 [4] 2 , 34, 279, 280 💬 💬 |
1031 | Yersinia infection 💬 22 genes, 39 drugs (DrugBank) and 69 diseases |
ROCK1 [2] ROCK1, ROCK2 💬 |
Fasudil Fasudil 💬 |
Fasudil | 002 [4] 2 , 5 , 7 , 51 💬 💬 |
1032 | Yersinia infection 💬 22 genes, 39 drugs (DrugBank) and 69 diseases |
SRC [1] SRC 💬 |
Bosutinib Bosutinib 💬 |
Bosutinib | 002 [2] 2 , 67 💬 💬 |
1033 | Yersinia infection 💬 22 genes, 39 drugs (DrugBank) and 69 diseases |
TNF [1] TNF 💬 |
Thalidomide Thalidomide 💬 |
Thalidomide | 002 [20] 2 , 16, 20, 28, 49, 51, 53, 56, 65, 84, 85, 94, 96, 97, 227, 271, 280, 298, 300, 331 💬 💬 |